Immune response to Campylobacter jejuni and Campylobacter coli in a cohort of children from birth to 2 years of age.

Abstract:

:A cohort of 111 children from Bangui, Central African Republic, was surveyed for enteric Campylobacter infections from birth to the age of 2 years; stools were examined biweekly in these children until 6 months of age and at least four times per year thereafter until 2 years of age and after each diarrheal episode. Blood samples were obtained at birth and at 3, 6, 9, 12, 18, and 24 months of age. Antibodies against glycine-extracted membrane antigens, purified flagella, and cholera toxin (CT) were assayed by an enzyme-linked immunosorbent assay. The results showed that titers of antibody against the three tested antigens increased in children between 6 and 12 months of age and that nearly all children were immunized by the age of 2 years. A significant fall in anti-flagellum (P less than 0.001) and anti-glycine extract antibodies (P less than 0.001) occurred between birth and age 3 months, and children who had Campylobacter infections during the first 6 months of life had significantly (P less than 0.02) less anti-flagellum antibodies at birth than did those who did not have Campylobacter infections during that time. Three-month-interval stratification showed that CT antibody titers at birth were significantly lower in children who developed Campylobacter infection than in controls (P = 0.05). Comparison of the immune response to a single Campylobacter episode showed that 46.6% of children with asymptomatic carriage did not respond to CT while only 5% of children with diarrhea-producing infection did not respond to CT (P less than 0.01), compared with 30% (P = 0.065) and 56% (P less than 0.01), respectively, of the age-matched controls. Antibodies to flagella seem to protect against enteric colonization by Campylobacter jejuni and Campylobacter coli.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Martin PM,Mathiot J,Ipero J,Kirimat M,Georges AJ,Georges-Courbot MC

doi

10.1128/IAI.57.8.2542-2546.1989

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

2542-6

issue

8

eissn

0019-9567

issn

1098-5522

journal_volume

57

pub_type

杂志文章
  • X-linked immunodeficient mice as a model for testing the protective efficacy of monoclonal antibodies against Pseudomonas aeruginosa.

    abstract::(DBA/N[female] X CBA/2[male])F1 males have been reported to be deficient in producing antibodies against a number of antigens, including carbohydrates (I. Scher, Adv. Immunol. 35:1-71, 1982). We show that F1 male mice, in contrast to females, made less lipopolysaccharide (LPS)-specific antibodies after immunization wi...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.56.5.1209-1214.1988

    authors: Zweerink HJ,Gammon MC,Hutchison CF,Jackson JJ,Pier GB,Puckett JM,Sewell TJ,Sigal NH

    更新日期:1988-05-01 00:00:00

  • A murine model for infection with Burkholderia cepacia with sustained persistence in the spleen.

    abstract::Burkholderia cepacia is an opportunistic pathogen that causes severe systemic infections in patients with chronic granulomatous disease (CGD) or with cystic fibrosis (CF), but its mechanisms of virulence are poorly understood. We developed a murine model of systemic infection in wild-type (WT) and gamma interferon kno...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.67.8.4027-4032.1999

    authors: Speert DP,Steen B,Halsey K,Kwan E

    更新日期:1999-08-01 00:00:00

  • Identification of a new variable sequence in the P1 cytadhesin gene of Mycoplasma pneumoniae: evidence for the generation of antigenic variation by DNA recombination between repetitive sequences.

    abstract::A Mycoplasma pneumoniae cytadhesin P1 gene with novel nucleotide sequence variation has been identified. Four clinical strains of M. pneumoniae were found to carry this type of P1 gene. This new P1 gene is similar to the known group II P1 genes but possesses novel sequence variation of approximately 300 bp in the RepM...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.67.9.4557-4562.1999

    authors: Kenri T,Taniguchi R,Sasaki Y,Okazaki N,Narita M,Izumikawa K,Umetsu M,Sasaki T

    更新日期:1999-09-01 00:00:00

  • Replication of rubella virus in human mononuclear blood cells.

    abstract::Rubella virus was capable of replicating in both unstimulated and phytohemagglutinin-stimulated cultures of human mononuclear blood cells. Monocyte-derived macrophages were the main cell type responsible for viral replication. The susceptibility of macrophages increased during cultivation. Phytohemagglutinin-stimulate...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.27.2.309-314.1980

    authors: van der Logt JT,van Loon AM,van der Veen J

    更新日期:1980-02-01 00:00:00

  • Susceptibility to reinfection after a primary chlamydial genital infection is associated with a decrease of antigen-specific T cells in the genital tract.

    abstract::We tested the hypothesis that the intensity of specific antichlamydial T cell-mediated immunity in the genital tract of female guinea pigs infected intravaginally with the chlamydial agent of guinea pig inclusion conjunctivitis would determine the resistance or susceptibility to reinfection after a primary chlamydial ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.59.4.1346-1351.1991

    authors: Igietseme JU,Rank RG

    更新日期:1991-04-01 00:00:00

  • Lipopolysaccharide structures in Enterobacteriaceae, Pseudomonas aeruginosa, and Vibrio cholerae are immunologically related to Campylobacter spp.

    abstract::To determine whether lipopolysaccharide (LPS) structures of Campylobacter species are immunologically related to those of 11 other gram-negative organisms, we immunoblotted from polyacrylamide gels the LPS of these strains with immune rabbit serum raised against six Campylobacter jejuni strains and two Campylobacter f...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.51.1.204-208.1986

    authors: Perez-Perez GI,Hopkins JA,Blaser MJ

    更新日期:1986-01-01 00:00:00

  • Comparative evaluation of low-molecular-mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant T-cell antigens.

    abstract::Culture filtrate from Mycobacterium tuberculosis contains protective antigens of relevance for the generation of a new antituberculosis vaccine. We have identified two previously uncharacterized M. tuberculosis proteins (TB7.3 and TB10.4) from the highly active low-mass fraction of culture filtrate. The molecules were...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.68.1.214-220.2000

    authors: Skjøt RL,Oettinger T,Rosenkrands I,Ravn P,Brock I,Jacobsen S,Andersen P

    更新日期:2000-01-01 00:00:00

  • Experimental infection of severe combined immunodeficient beige mice with Mycobacterium paratuberculosis of bovine origin.

    abstract::Severe combined immunodeficient beige mice were inoculated orally and intraperitoneally with a bovine strain of Mycobacterium paratuberculosis to explore their potential as laboratory animal models in the study of paratuberculosis (Johne's disease). Control animals were similarly inoculated with heat-killed M. paratub...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.60.10.4074-4079.1992

    authors: Mutwiri GK,Butler DG,Rosendal S,Yager J

    更新日期:1992-10-01 00:00:00

  • Enterococcus faecalis Gluconate Phosphotransferase System Accelerates Experimental Colitis and Bacterial Killing by Macrophages.

    abstract::Enterococcus faecalis strains are resident intestinal bacteria associated with invasive infections, inflammatory bowel diseases, and colon cancer. Although factors promoting E. faecalis colonization of intestines are not fully known, one implicated pathway is a phosphotransferase system (PTS) in E. faecalis strain OG1...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00080-19

    authors: Fan TJ,Goeser L,Naziripour A,Redinbo MR,Hansen JJ

    更新日期:2019-06-20 00:00:00

  • Induction of specific T-cell responses, opsonizing antibodies, and protection against Plasmodium chabaudi adami infection in mice vaccinated with genomic expression libraries expressed in targeted and secretory DNA vectors.

    abstract::It has been proposed that a multivalent malaria vaccine is necessary to mimic the naturally acquired resistance to this disease observed in humans. A major experimental challenge is to identify the optimal components to be used in such a multivalent vaccine. Expression library immunization (ELI) is a method for screen...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.71.8.4506-4515.2003

    authors: Rainczuk A,Scorza T,Smooker PM,Spithill TW

    更新日期:2003-08-01 00:00:00

  • Infection with Mycobacterium avium induces production of interleukin-10 (IL-10), and administration of anti-IL-10 antibody is associated with enhanced resistance to infection in mice.

    abstract::Organisms of the Mycobacterium avium complex are associated with disseminated infection in patients with AIDS. The mechanisms that account for the survival of the intracellular bacteria are unknown. We document here that infection of C57BL/6 black mice with M. avium 101 triggered interleukin-10 (IL-10) production. The...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.61.7.3093-3097.1993

    authors: Bermudez LE,Champsi J

    更新日期:1993-07-01 00:00:00

  • Immunogenic properties of Klebsiella pneumoniae type 2 capsular polysaccharide.

    abstract::The immunoprotective activity of Klebsiella pneumoniae K2 cell surface preparations and purified capsular polysaccharide was tested in mice. The 50% protective dose (PD50), expressed as capsular polysaccharide content, was 2 ng for cell surface preparations and 50 ng for purified capsular polysaccharide. Both preparat...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.54.2.365-370.1986

    authors: Robert A,Jouin H,Fournier JM

    更新日期:1986-11-01 00:00:00

  • Biochemical properties of polymorphonuclear neutrophils from venous blood and peritoneal exudates of rabbits.

    abstract::The biochemical properties of polymorphonuclear neutrophils from blood and peritoneal exudates of rabbits were compared. All enzymes measured showed almost identical activities in both types of cells, except for alkaline phosphodiesterase, the activity of which was seven times higher in peritoneal neutrophils. During ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:

    authors: Takamori K,Yamashita T

    更新日期:1980-08-01 00:00:00

  • Effect of urea on the hemagglutinating and complement-fixing antigens of type 2 Dengue virus.

    abstract::Sephadex G-200 filtration was used for fractionating dengue type 2 (DEN-2)-infected suckling mouse brain (SMB) supernatant fluids. The high-molecular-weight fraction, which was eluted in the void volume, showed no increase in type specificity when tested against immune ascitic fluid to the four prototype dengue viruse...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.6.6.952-957.1972

    authors: Cornesky RA,Hammon WM,Atchison RW,Sather GE

    更新日期:1972-12-01 00:00:00

  • Passive transfer of resistance to frambesial infection in hamsters.

    abstract::The immune mechanism by which hamsters acquire resistance to infection with Treponema pertenue, the causative agent of frambesia, or yaws, has not been elucidated. Serum or cells (spleen or lymph node) obtained from hamsters resistant to frambesial infection were transferred to normal syngenic recipients, who are subs...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.21.2.430-435.1978

    authors: Schell RF,Le Frock JL,Babu JP

    更新日期:1978-08-01 00:00:00

  • Role of viremia in the suppression of T-cell function during murine cytomegalovirus infection.

    abstract::The suppression of T-cell deoxyribonucleic acid (DNA) synthesis by serum from mice acutely with murine cytomegalovirus (MCMV) was investigated. Spleen cells from uninfected mice were exposed to concanavalin A in the presence of serum taken from mice at various times after infection with MCMV. The capacity of the serum...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.17.2.378-381.1977

    authors: Booss J,Wheelock EF

    更新日期:1977-08-01 00:00:00

  • Avirulent uracil auxotrophs based on disruption of orotidine-5'-monophosphate decarboxylase elicit protective immunity to Toxoplasma gondii.

    abstract::The orotidine-5'-monophosphate decarboxylase (OMPDC) gene, encoding the final enzyme of the de novo pyrimidine biosynthesis pathway, was deleted using Toxoplasma gondii KU80 knockouts to develop an avirulent nonreverting pyrimidine auxotroph strain. Additionally, to functionally address the role of the pyrimidine salv...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00287-10

    authors: Fox BA,Bzik DJ

    更新日期:2010-09-01 00:00:00

  • Localization of distinct surface antigens on Chlamydia trachomatis HAR-13 by immune electron microscopy with monoclonal antibodies.

    abstract::Monoclonal antibodies were produced against the HAR-13 strain (A) of Chlamydia trachomatis. By an indirect immunofluorescence technique, three clones (1-7, 2-8, 9F) were found to produce antibody that reacted only with serotype A strains. Clone 3-5 produced antibody that cross-reacted with serotypes A, C, H, I, and J....

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.38.3.1273-1278.1982

    authors: Clark RB,Nachamkin I,Schatzki PF,Dalton HP

    更新日期:1982-12-01 00:00:00

  • Effect of indomethacin on intestinal water transport in salmonella-infected rhesus monkeys.

    abstract::Indomethacin, a nonsteroidal anti-inflammatory agent, will abolish salmonella-induced rabbit ileal secretion when given prior to the establishment of infection. In the present study, we assessed whether indomethacin can inhibit salmonella-induced intestinal secretion when administered after infection and net intestina...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.17.1.136-139.1977

    authors: Giannella RA,Rout WR,Formal SB

    更新日期:1977-07-01 00:00:00

  • Comparative infectivity of trachoma organisms in HeLa 229 cells and egg cultures.

    abstract::Thirty-two trachoma strains were simultaneously titrated in the yolk sac of embryonated chicken eggs and in HeLa 229 cells pretreated with diethylaminoethyl-dextran to determine the relative sensitivity of the two culture systems for detection of the infection. The strains tested were both yolk sac- and HeLa cell-esta...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.12.5.1078-1082.1975

    authors: Kuo CC,Wang SP,Grayston JT

    更新日期:1975-11-01 00:00:00

  • Analysis of the immunological responses to transferrin and lactoferrin receptor proteins from Moraxella catarrhalis.

    abstract::Moraxella catarrhalis expresses surface receptor proteins that specifically bind host transferrin (Tf) and lactoferrin (Lf) in the first step of the iron acquisition pathway. Acute- and convalescent-phase antisera from a series of patients with M. catarrhalis pulmonary infections were tested against Tf and Lf receptor...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.67.8.3793-3799.1999

    authors: Yu RH,Bonnah RA,Ainsworth S,Schryvers AB

    更新日期:1999-08-01 00:00:00

  • Endotoxin-induced tumor necrosis factor alpha synthesis in murine embryo fibroblasts.

    abstract::Murine embryo fibroblasts (MEF) were found to secrete tumor necrosis factor (TNF) in response to stimulation with endotoxin. Endotoxin-induced TNF production by MEF was inhibited by cycloheximide. However, reversal of the effect of this inhibitor on protein synthesis results in TNF being secreted in amounts equivalent...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.61.5.1630-1635.1993

    authors: Havell EA,Rogerson BJ

    更新日期:1993-05-01 00:00:00

  • Interaction of Bartonella henselae with endothelial cells promotes monocyte/macrophage chemoattractant protein 1 gene expression and protein production and triggers monocyte migration.

    abstract::Bacillary angiomatosis (BA), one of the many clinical manifestations resulting from infection with the facultative intracellular bacterium Bartonella henselae, is characterized by angiogenic lesions. Macrophages have been identified as important effector cells contributing to the angiogenic process during B. henselae ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.73.9.5735-5742.2005

    authors: McCord AM,Burgess AW,Whaley MJ,Anderson BE

    更新日期:2005-09-01 00:00:00

  • Failure of CD4 T Cell-Deficient Hosts To Control Chronic Nontyphoidal Salmonella Infection Leads to Exacerbated Inflammation, Chronic Anemia, and Altered Myelopoiesis.

    abstract::Immunocompromised patients are more susceptible to recurrent nontyphoidal Salmonella (NTS) bacteremia. A key manifestation of HIV infection is the loss of CD4 T cells, which are crucial for immunity to Salmonella infection. We characterized the consequences of CD4 T cell depletion in mice where virulent Salmonella est...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00417-20

    authors: Loomis WP,Delaney MA,Johnson ML,Cookson BT

    更新日期:2020-12-15 00:00:00

  • Contribution of cloned virulence factors from uropathogenic Escherichia coli strains to nephropathogenicity in an experimental rat pyelonephritis model.

    abstract::Escherichia coli 536 (O6:K15:H31), which was isolated from a case of urinary tract infection, determines high nephropathogenicity in a rat pyelonephritis system as measured by renal bacterial counts 7 days after infection. The loss of S fimbrial adhesin formation (Sfa-) (mannose-resistant hemagglutination [Mrh-] and f...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.54.3.761-767.1986

    authors: Marre R,Hacker J,Henkel W,Goebel W

    更新日期:1986-12-01 00:00:00

  • Extracellular and cytoplasmic CuZn superoxide dismutases from Brugia lymphatic filarial nematode parasites.

    abstract::We have isolated full-length cDNAs encoding two distinct types of CuZn superoxide dismutases (SODs) from the filarial nematode parasite Brugia pahangi. The derived amino acid sequences suggested that one class of cDNAs represented a cytoplasmic form of SOD and the second class represented an extracellular (EC) variant...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.62.3.961-967.1994

    authors: Tang L,Ou X,Henkle-Dührsen K,Selkirk ME

    更新日期:1994-03-01 00:00:00

  • Detection of fibrils associated with Rickettsia rickettsii.

    abstract::The ultrastructural appearance of the "halozone" formed at the interface between the spotted fever agent Rickettsia rickettsii and the cytoplasm of persistently infected cultured vole cells (Microtus pennsylvanicus) was studied by transmission electron microscopy. In sections of epoxy-embedded specimens stained with u...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.41.3.1252-1260.1983

    authors: Todd WJ,Burgdorfer W,Wray GP

    更新日期:1983-09-01 00:00:00

  • Rapid development of a gamma interferon-secreting glycolipid/CD1d-specific Valpha14+ NK1.1- T-cell subset after bacterial infection.

    abstract::The phenotypic and functional changes of glycolipid presented by CD1d(glycolipid/CD1d) specific Valpha14+ T cells in the liver of mice at early stages of bacterial infection were investigated. After Listeria monocytogenes infection or interleukin-12 (IL-12) treatment, alpha-galactosylceramide/CD1d tetramer-reactive (a...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00311-06

    authors: Emoto M,Yoshizawa I,Emoto Y,Miamoto M,Hurwitz R,Kaufmann SH

    更新日期:2006-10-01 00:00:00

  • In vivo lysogenic conversion of Tox(-) Streptococcus pyogenes to Tox(+) with Lysogenic Streptococci or free phage.

    abstract::Temperate bacteriophage can transfer toxin-encoding genes between bacteria, often resulting in acquired pathogenicity. However, little is known regarding the effects of the eukaryotic host on the phage-pathogen interaction. Using Streptococcus pyogenes as a model, we demonstrate, both in vitro and in vivo, that the eu...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.71.7.3782-3786.2003

    authors: Broudy TB,Fischetti VA

    更新日期:2003-07-01 00:00:00

  • Serum amyloid P component bound to gram-negative bacteria prevents lipopolysaccharide-mediated classical pathway complement activation.

    abstract::Although serum amyloid P component (SAP) is known to bind many ligands, its biological function is not yet clear. Recently, it was demonstrated that SAP binds to lipopolysaccharide (LPS). In the present study, SAP was shown to bind to gram-negative bacteria expressing short types of LPS or lipo-oligosaccharide (LOS), ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.68.4.1753-1759.2000

    authors: de Haas CJ,van Leeuwen EM,van Bommel T,Verhoef J,van Kessel KP,van Strijp JA

    更新日期:2000-04-01 00:00:00