Abstract:
:A cohort of 111 children from Bangui, Central African Republic, was surveyed for enteric Campylobacter infections from birth to the age of 2 years; stools were examined biweekly in these children until 6 months of age and at least four times per year thereafter until 2 years of age and after each diarrheal episode. Blood samples were obtained at birth and at 3, 6, 9, 12, 18, and 24 months of age. Antibodies against glycine-extracted membrane antigens, purified flagella, and cholera toxin (CT) were assayed by an enzyme-linked immunosorbent assay. The results showed that titers of antibody against the three tested antigens increased in children between 6 and 12 months of age and that nearly all children were immunized by the age of 2 years. A significant fall in anti-flagellum (P less than 0.001) and anti-glycine extract antibodies (P less than 0.001) occurred between birth and age 3 months, and children who had Campylobacter infections during the first 6 months of life had significantly (P less than 0.02) less anti-flagellum antibodies at birth than did those who did not have Campylobacter infections during that time. Three-month-interval stratification showed that CT antibody titers at birth were significantly lower in children who developed Campylobacter infection than in controls (P = 0.05). Comparison of the immune response to a single Campylobacter episode showed that 46.6% of children with asymptomatic carriage did not respond to CT while only 5% of children with diarrhea-producing infection did not respond to CT (P less than 0.01), compared with 30% (P = 0.065) and 56% (P less than 0.01), respectively, of the age-matched controls. Antibodies to flagella seem to protect against enteric colonization by Campylobacter jejuni and Campylobacter coli.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Martin PM,Mathiot J,Ipero J,Kirimat M,Georges AJ,Georges-Courbot MCdoi
10.1128/IAI.57.8.2542-2546.1989subject
Has Abstractpub_date
1989-08-01 00:00:00pages
2542-6issue
8eissn
0019-9567issn
1098-5522journal_volume
57pub_type
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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pub_type: 杂志文章
doi:10.1128/IAI.54.2.365-370.1986
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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doi:10.1128/IAI.21.2.430-435.1978
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.17.2.378-381.1977
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