Serum amyloid P component bound to gram-negative bacteria prevents lipopolysaccharide-mediated classical pathway complement activation.

abstract：:Escherichia coli O45 isolates associated with swine postweaning diarrhea in Québec were characterized with respect to virulence determinants genetically and investigated for their attaching and effacing (A/E) activities by experimental inoculation of gnotobiotic piglets and by the HEp-2 cell adherence assay. All of 32...

journal_title：Infection and immunity

authors： Zhu C,Harel J,Jacques M,Desautels C,Donnenberg MS,Beaudry M,Fairbrother JM

更新日期：1994-10-01 00:00:00

abstract：:Severe pediatric malaria is an important risk factor for developing disseminated infections with nontyphoidal Salmonella serotypes (NTS). While recent animal studies on this subject are lacking, early work suggests that an increased risk for developing systemic NTS infection during malaria is caused by hemolytic anemi...

journal_title：Infection and immunity

authors： Roux CM,Butler BP,Chau JY,Paixao TA,Cheung KW,Santos RL,Luckhart S,Tsolis RM

更新日期：2010-04-01 00:00:00

abstract：:Detoxified mutants of the Escherichia coli heat-labile toxin (LT) act as mucosal adjuvants to intranasally presented coadministered antigens. Here, we compare the adjuvant activity of a panel of detoxified derivatives of LT, using both intranasal (i.n.) and oral (p.o.) routes of administration. The mutants used as adj...

journal_title：Infection and immunity

authors： Douce G,Giannelli V,Pizza M,Lewis D,Everest P,Rappuoli R,Dougan G

更新日期：1999-09-01 00:00:00

abstract：:Brucella abortus endotoxin preparations, containing approximately 5 to 6% protein, induce strong immune and adjuvant immunoglobulin G (IgG) responses as compared with Escherichia coli endotoxin preparations, with equivalent amounts of protein, which induce responses in which IgM antibody predominates. Using an enzyme-...

journal_title：Infection and immunity

authors： Kurtz RS,Berman DT

更新日期：1986-12-01 00:00:00

abstract：:Clostridium difficile toxins A and B (TcdA and TcdB) are the causative agents of antibiotic-associated pseudomembranous colitis. Mucosal mast cells play a crucial role in the inflammatory processes underlying this disease. We studied the direct effects of TcdA and TcdB on the human mast cell line HMC-1 with respect to...

journal_title：Infection and immunity

authors： Meyer GK,Neetz A,Brandes G,Tsikas D,Butterfield JH,Just I,Gerhard R

更新日期：2007-08-01 00:00:00

abstract：:We examined the immunobiological responses to Histoplasma capsulatum in lungs of gamma interferon (IFN-gamma) knockout mice (GKO mice). Naive GKO mice succumbed by day 9 to intranasal challenge with 2.5 x 10(6) yeasts, whereas all wild-type (WT) mice survived for 45 days. Compared to lungs of WT mice, the lungs of acu...

journal_title：Infection and immunity

authors： Allendoerfer R,Deepe GS Jr

更新日期：1997-07-01 00:00:00

abstract：:Two hybrid clones producing monoclonal antibodies (MAbs) raised against the purified enterotoxic hemolysin-phospholipase C (HlyPC) bifunctional molecule of a Vibrio cholerae O139 strain were used to study its enterotoxicity in relation to its hemolytic and enzymatic activities. Fab fragments of MAbs from ascites produ...

journal_title：Infection and immunity

authors： Pal S,Datta A,Nair GB,Guhathakurta B

更新日期：1998-08-01 00:00:00

abstract：:We have developed an in vitro assay to study the intramacrophage replication of Mycobacterium tuberculosis or Mycobacterium bovis BCG. In this assay, extracellular mycobacterial replication was avoided by using a small infecting inoculum and a new method for efficiently removing nonphagocytocytized bacilli. The abilit...

journal_title：Infection and immunity

authors： Zlotnik A,Crowle AJ

更新日期：1982-08-01 00:00:00

abstract：:Human genital Chlamydia infection is a major public health concern due to the serious reproductive system complications. Chlamydia binds several receptor tyrosine kinases (RTKs) on host cells, including the epidermal growth factor receptor (EGFR), and activates cellular signaling cascades for host invasion, cytoskelet...

journal_title：Infection and immunity

authors： Igietseme JU,Partin J,George Z,Omosun Y,Goldstein J,Joseph K,Ellerson D,Eko FO,Pohl J,Bandea C,Black CM

更新日期：2020-03-23 00:00:00

abstract：:The lipid A portion has been identified as the active center responsible for lipopolysaccharide (LPS)-induced macrophage activation. However, we found that Salmonella (Salmonella enterica serovars Abortusequi, Minnesota, and Typhimurium) lipid A is inactive in human macrophages, despite its LPS being highly active. Th...

journal_title：Infection and immunity

authors： Muroi M,Tanamoto K

更新日期：2002-11-01 00:00:00

abstract：:Naegleria fowleri produces fatal meningoencephalitis in humans and in experimentally infected laboratory animals. The course of the disease in mice is dependent upon the infecting dose of amoebae, route of inoculation, and prior exposure to Naegleria antigens. DUB/ICR mice were immunized by various routes and antigen ...

journal_title：Infection and immunity

authors： John DT,Weik RR,Adams AC

更新日期：1977-06-01 00:00:00

abstract：:N-Acetyl-muramyl-L-alanyl-D-isoglutamine (MDP), a structurally defined fragment of bacterial peptidoglycan, stimulated significant release of previously incorporated 45Ca from fetal rat bones in tissue culture over the concentration range of 0.1 to 10.0 micrograms/ml. MDP-Stimulated bone resorption was not inhibited b...

journal_title：Infection and immunity

authors： Dewhirst FE

更新日期：1982-01-01 00:00:00

abstract：:Little data are available regarding L-form phagocyte interactions. Due to difficulty with more conventional methods, a serum-free technique of surface phagocytosis employing cellulose ester micropore filters, fluorochrome staining, and reflecting fluorescence microscopy was developed. Intracellular localization of L-f...

journal_title：Infection and immunity

authors： Harwick HJ,Barajas L,Montgomerie JZ,Kalmanson GM,Guze LB

更新日期：1972-06-01 00:00:00

abstract：:Science has a critical role to play in addressing humanity's most important challenges in the twenty-first century. However, the contemporary scientific enterprise has developed in ways that prevent it from reaching maximum effectiveness and detract from the appeal of a research career. To be effective, the methodolog...

journal_title：Infection and immunity

authors： Fang FC,Casadevall A

更新日期：2012-03-01 00:00:00

abstract：:Botulinum neurotoxins (BoNTs) and tetanus toxin (TeNT) are the most potent toxins for humans and elicit unique pathologies due to their ability to traffic within motor neurons. BoNTs act locally within motor neurons to elicit flaccid paralysis, while retrograde TeNT traffics to inhibitory neurons within the central ne...

journal_title：Infection and immunity

authors： Zuverink M,Chen C,Przedpelski A,Blum FC,Barbieri JT

更新日期：2015-07-01 00:00:00

abstract：:Inbred CBA/J mice were used in developing a defined in vivo model for studying host-parasite relationships in cryptococcosis. Mice were infected either intranasally or intraperitoneally with 10(3) viable Cryptococcus neoformans cells. At weekly intervals over a 92-day period, C. neoformans growth profiles in the lungs...

journal_title：Infection and immunity

authors： Lim TS,Murphy JW,Cauley LK

更新日期：1980-08-01 00:00:00

abstract：:Chronic lung infections with Pseudomonas aeruginosa biofilms are associated with refractory and fatal pneumonia in cystic fibrosis (CF). In this study, a group of genomically diverse P. aeruginosa isolates were compared with the reference strain PAO1 to assess the roles of motility, twitching, growth rate, and overpro...

journal_title：Infection and immunity

authors： Head NE,Yu H

更新日期：2004-01-01 00:00:00

abstract：:Bordetella pertussis extract that contained adenylate cyclase toxin produced large increases in human neutrophil cyclic AMP levels and inhibited their oxidative burst, as reflected by luminol-enhanced chemiluminescence and superoxide release. The adenylate cyclase toxin-containing extract blocked neutrophil-mediated i...

journal_title：Infection and immunity

authors： Galgiani JN,Hewlett EL,Friedman RL

更新日期：1988-04-01 00:00:00

abstract：:White-footed mice (Peromyscus leucopus), the primary reservoir for Borrelia burgdorferi in the northern midwest and northeastern United States, were experimentally inoculated with an infectious strain or a noninfectious strain of the Lyme disease spirochete and examined for their specific antibody response with the en...

journal_title：Infection and immunity

authors： Schwan TG,Kime KK,Schrumpf ME,Coe JE,Simpson WJ

更新日期：1989-11-01 00:00:00

abstract：:Mice were vaccinated with 300 micrograms of BCG cell walls (BCG-CW) in oil-in-water emulsion intravenously or with a high or low dose of living BCG by inhalation (BCG-HD or BCG-LD, respectively). The consequences of vaccination were evaluated in terms of the growth of BCG in the lungs and spleen, lung and spleen weigh...

journal_title：Infection and immunity

authors： Lefford MJ

更新日期：1980-05-01 00:00:00

abstract：:The complete sequence analysis of the 210-kb Shigella flexneri 5a virulence plasmid was determined. Shigella spp. cause dysentery and diarrhea by invasion and spread through the colonic mucosa. Most of the known Shigella virulence determinants are encoded on a large plasmid that is unique to virulent strains of Shigel...

journal_title：Infection and immunity

authors： Venkatesan MM,Goldberg MB,Rose DJ,Grotbeck EJ,Burland V,Blattner FR

更新日期：2001-05-01 00:00:00

abstract：:Escherichia coli O157:H7 carries a chromosomal msbB1 and a plasmid-encoded msbB2 gene. We characterized msbB2 function as a homologue of msbB1 by examination of wild-type organisms and mutant strains that lacked functional msbB1, msbB2, and both msbB1 and msbB2. The msbB double-mutant strain generated pentaacyl lipid ...

journal_title：Infection and immunity

authors： Kim SH,Jia W,Bishop RE,Gyles C

更新日期：2004-02-01 00:00:00

abstract：:Streptococcal protective antigen (Spa) is a newly described surface protein of group A streptococci that was recently shown to evoke protective antibodies (J. B. Dale, E. Y. Chiang, S. Liu, H. S. Courtney, and D. L. Hasty, J. Clin. Investig. 103:1261--1268, 1999). In this study, we have determined the complete sequenc...

journal_title：Infection and immunity

authors： McLellan DG,Chiang EY,Courtney HS,Hasty DL,Wei SC,Hu MC,Walls MA,Bloom JJ,Dale JB

更新日期：2001-05-01 00:00:00

abstract：:Antibiotics suppressed development of aster yellows (AY) disease symptoms in plants of china aster [Callistephus chinensis (L.) Nees.] and annual chrysanthemum (Chrysanthemum carinatum, Schousb.). When inoculated chrysanthemum plants were treated by any of several techniques with tetracycline antibiotics or chloramphe...

journal_title：Infection and immunity

authors： Davis RE,Whitcomb RF

更新日期：1970-08-01 00:00:00

abstract：:The pH 6 antigen (Psa) of Yersinia pestis consists of fimbriae with adhesive properties of potential importance for the pathogenesis of plague, including pneumonic plague. The Psa fimbriae mediate bacterial binding to human alveolar epithelial cells. The Psa fimbriae bound mostly to one component present in the total ...

journal_title：Infection and immunity

authors： Galván EM,Chen H,Schifferli DM

更新日期：2007-03-01 00:00:00

abstract：:Neisseria meningitidis crosses the blood-brain barrier (BBB) following the activation of the β2-adrenergic receptor by the type IV pili (TFP). Two components of the type IV pili recruit the β2-adrenergic receptor, the major pilin PilE and the minor pilin PilV. Here, we report that a strain deleted of PilX, one of the ...

journal_title：Infection and immunity

authors： Brissac T,Mikaty G,Duménil G,Coureuil M,Nassif X

更新日期：2012-09-01 00:00:00

abstract：:Analysis of major outer membrane protein (MOMP) profiles of various meningococci by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (SDS-PAGE) revealed the presence of 0 to 2 low-molecular-weight, heat-modifiable MOMPs (molecular weight, 25,000 to 32,000) and 1 to 3 high-molecular-weight MOMPs (molecul...

journal_title：Infection and immunity

authors： Poolman JT,de Marie S,Zanen HC

更新日期：1980-12-01 00:00:00

abstract：:It is well established that activating-type Fc receptors for immunoglobulin G (FcgammaR), such as FcgammaRI and FcgammaRIII, are essential for inducing inflammatory responses. On the other hand, a unique inhibitory FcgammaR, FcgammaRIIB, inhibits intracellular signaling upon engagement of immunoglobulin G-immune compl...

journal_title：Infection and immunity

authors： Henriques-Pons A,Olivieri BP,Oliveira GM,Daëron M,de Araújo-Jorge TC

更新日期：2005-08-01 00:00:00

abstract：:In vivo expression of pili by Escherichia coli in the urine of 41 adults with lower urinary tract infections was analyzed by immunostaining with polyclonal antiserum to type 1 and P pili. Type 1 pili were detected in 31 of 41 urine specimens, while P pili were detected in 6 of 18 specimens. The piliation status of bac...

journal_title：Infection and immunity

authors： Kisielius PV,Schwan WR,Amundsen SK,Duncan JL,Schaeffer AJ

更新日期：1989-06-01 00:00:00

abstract：:The ability of human clinical isolates of Yersinia enterocolitica to interact with HEp-2 cells was found to vary considerably between the serotypes O:3, O:8, and O:9. Although all three serotypes adhered initially to the cell surface, regardless of incubation temperature of the bacterial inoculum or presence of the 40...

journal_title：Infection and immunity

authors： Lassen J,Kapperud G

更新日期：1986-04-01 00:00:00