Abstract:
:Experiments were conducted in which rhesus monkeys were infected with mumps virus by inoculation into the parotid gland. Virus was isolated from buccal swab specimens from animals up to 6 days after inoculation. Immunofluorescence staining for mumps antigen was positive, and infectious virus was recovered from tissue biopsies of inoculated glands. Histological examination of biopsied glands revealed lymphocytic infiltration of the tissue. Virus was not isolated from urine, buffy coat, or biopsies of thyroid and spleen. In other experiments, animals were infected by inoculation into the thyroid gland. Virus was not isolated from buccal swabs, urine specimens, or thyroid tissues from these monkeys. All inoculated animals responded immunologically to mumps virus regardless of route of infection. Previously infected animals did not shed virus when challenged with mumps virus. A histological response to challenge in glandular tissue was observed which suggested a hypersensitivity to mumps antigen. The response was qualitatively identical to that in acutely infected tissue but more intense. None of the animals infected developed antibodies to thyroid tissue regardless of route of injection of virus or site of challenge of immune monkeys.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Flanagan TD,Andrada JA,Barron AL,Witebsky Edoi
10.1128/IAI.3.5.642-647.1971keywords:
subject
Has Abstractpub_date
1971-05-01 00:00:00pages
642-7issue
5eissn
0019-9567issn
1098-5522journal_volume
3pub_type
杂志文章abstract::Local gingival immunization was attempted in an effort to confine the immune response to the oral cavity and bypass the systemic immune response. A low-molecular-weight (3.8K) streptococcal antigen (SA) I/II was applied 10 times over a period of 1 year to the gingival crevices of rhesus monkeys. The antigen was mainta...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.52.3.682-687.1986
更新日期:1986-06-01 00:00:00
abstract::Endogenous interleukin-12 (IL-12) mediates protection against Yersinia enterocolitica in C57BL/6 mice by triggering gamma interferon (IFN-gamma) production in NK and CD4+ T cells. Administration of exogenous IL-12 confers protection against yersiniae in Yersinia-susceptible BALB/c mice but exacerbates yersiniosis in r...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.5.2213-2220.1998
更新日期:1998-05-01 00:00:00
abstract::Rhodococcus equi is a facultative intracellular pathogen of macrophages, relying on the presence of a conjugative virulence plasmid harboring a 21-kb pathogenicity island (PAI) for growth in host macrophages. The PAI encodes a family of 6 virulence-associated proteins (Vaps) in addition to 20 other proteins. The contr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00230-15
更新日期:2015-08-01 00:00:00
abstract::The comparative immunogenicity of the two cross-reacting group 6 pneumococcal capsular polysaccharides, type 6A(6) and type 6B(26), was studied with hyperimmune rabbit typing antisera and with sera from adult volunteers injected with polyvalent pneumococcal vaccines containing either 50 mug of type 6A (U.S. designatio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.26.3.1116-1122.1979
更新日期:1979-12-01 00:00:00
abstract::Neutrophil extracellular traps (NETs) are produced by neutrophils as an innate immune defense mechanism to trap and kill microbial pathogens. NETs are comprised of ejected chromatin that forms a lattice structure enmeshed with numerous antimicrobial proteins. In addition to forming the structural backbone of NETs, ext...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00403-18
更新日期:2018-08-22 00:00:00
abstract::We report on the colonization of murine trigeminal ganglia after sequential infection of mice by herpes simplex viruses (HSVs). In preliminary studies, we have established that whereas the HSV-1(F) strain efficiently colonizes ganglia when inoculated by either the ear or eye routes, the HSV-1 X HSV-2 recombinant C7D c...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.2.702-708.1983
更新日期:1983-08-01 00:00:00
abstract::Three antigenic determinants were revealed in H3 hemagglutinin of influenza A viruses isolated from 1968 to 1975. One of them was common for all viruses, and two others specified differences between the viruses possessing H3 hemagglutinin. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.24.3.804-807.1979
更新日期:1979-06-01 00:00:00
abstract::Raising the magnesium level from 0.4 to 1.5 mM in a medium containing only amino acids (2.08%), salts, and vitamins increased enterotoxin B production by Staphylococcus aureus S-6 by about 80%. The level of phosphates in the medium was lowered to one-tenth (to 2.87 mM) the original amount without adversely affecting g...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.20.1.158-160.1978
更新日期:1978-04-01 00:00:00
abstract::The triggering receptor expressed on myeloid cell type 1 (TREM-1) is a cell surface molecule that has been identified on both human and murine polymorphonuclear neutrophils and mature monocytes. The activation of TREM-1 in the presence of microbial components amplifies the inflammatory response and may be responsible ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.5.2823-2830.2006
更新日期:2006-05-01 00:00:00
abstract::Ehrlichia chaffeensis, a tick-borne rickettsial organism, causes the disease human monocytic ehrlichiosis. The pathogen also causes disease in several other vertebrates, including dogs and deer. In this study, we assessed two clonally purified E. chaffeensis mutants with insertions within the genes Ech_0379 and Ech_06...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00487-15
更新日期:2015-07-01 00:00:00
abstract::We examined the intracellular growth of 20 strains within six species of Legionella in thioglycolate-elicited peritoneal macrophages from A/J and C57BL/6 mice and a congenic strain derived from them (A.B Lgn1). With the exception of Legionella pneumophila Togus-1 and Bloomington-2, the intracellular growth of the 15 L...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.5.1842-1845.1996
更新日期:1996-05-01 00:00:00
abstract::Pertussis toxin is secreted from Bordetella pertussis with the assistance of the Ptl transport system, a member of the type IV family of macromolecular transporters. The S1 subunit and the B oligomer combine to form the holotoxin prior to export from the bacterial cell, although the site of assembly is not known. To b...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.3.1193-1201.2002
更新日期:2002-03-01 00:00:00
abstract::The parameters of a persistent-state measles virus infection in BGM/MV cells were examined. The BGM/MV cell line was established by cocultivation of measles virus-infected primary C3H mouse brain cells with a stable line of African green monkey kidney cells (BGM). Initially, a morphologically mixed population of cells...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.1.152-158.1975
更新日期:1975-01-01 00:00:00
abstract::Pneumocystis pneumonia (PcP) is a life-threatening infection that affects immunocompromised individuals. Nearly half of all PcP cases occur in those prescribed effective chemoprophylaxis, suggesting that additional preventive methods are needed. To this end, we have identified a unique mouse Pneumocystis surface prote...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00850-16
更新日期:2017-03-23 00:00:00
abstract::Toll-like receptors and Nod-like receptors (NLR) play an important role in sensing invading microorganisms for pathogen clearance and eliciting adaptive immunity for protection against rechallenge. Nod1 and Nod2, members of the NLR family, are capable of detecting bacterial peptidoglycan motifs in the host cytosol for...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00563-09
更新日期:2009-10-01 00:00:00
abstract::It is currently accepted that malaria-parasitized red blood cells (pRBC) are eliminated, like senescent erythrocytes, phagocytically by macrophages in the red pulp of the spleen. Here, however, we show that self-healing Plasmodium chabaudi malaria activates spleen closure in C57BL/6 mice. Confocal laser scanning micro...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.10.6390-6398.2005
更新日期:2005-10-01 00:00:00
abstract::The in vivo induction of colony-stimulating activity (CSA) by N-acetylmuramyl-L-alanine-D-isoglutamine has been demonstrated recently. In this study we increased our understanding of this property by testing muramyl peptides of several structures and activities for their capacity to induce CSA in vivo. A comparison of...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.46.2.495-500.1984
更新日期:1984-11-01 00:00:00
abstract::The virulence and fitness in vivo of the major human pathogen Staphylococcus aureus are associated with a cell-to-cell signaling mechanism known as quorum sensing (QS). QS coordinates the production of virulence factors via the production and sensing of autoinducing peptide (AIP) signal molecules by the agr locus. Her...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01216-13
更新日期:2014-03-01 00:00:00
abstract::Experiments were performed to investigate the usefulness of an enzyme-linked immunosorbent assay utilizing avidin-biotin interaction as a diagnostic tool for detection of Toxoplasma antigen in blood. The lower limit of sensitivity of the assay by this method was ca. 4 ng/ml, and standard assays provided a linear plot ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.48.1.269-272.1985
更新日期:1985-04-01 00:00:00
abstract::Clostridium perfringens delta toxin was selectively cytotoxic for various rabbit leukocyte populations. The sensitivity of these populations to the toxin varied, depending on the tissue from which they were derived, from 28% (appendix) to 41% (bone marrow) and 32% (spleen). Macrophages were uniformly killed by delta t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.3.860-864.1982
更新日期:1982-12-01 00:00:00
abstract::Escherichia coli O157:H7 is an important pathogen of humans. Cattle are most frequently identified as the primary source of infection, and therefore, reduction in E. coli O157:H7 prevalence in cattle by vaccination represents an attractive strategy for reducing the incidence of human disease. H7 flagella have been imp...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01452-07
更新日期:2008-06-01 00:00:00
abstract::Trypanosoma cruzi species is categorized into six discrete typing units (TcI to TcVI) of which TcI is most abundantly noted in the sylvatic transmission cycle and considered the major cause of human disease. In our study, the TcI strains Colombiana (COL), SylvioX10/4 (SYL), and a cultured clone (TCC) exhibited differe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00193-16
更新日期:2016-05-24 00:00:00
abstract::Lymphocytes derived from 72- to 90-day-old fetal piglet thymuses respond in vitro to phytohemagglutinin quantitatively greater than do spleen cell lymphocytes. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.5.3.337-338.1972
更新日期:1972-03-01 00:00:00
abstract::Our previous studies identified two iron-regulated cytoplasmic membrane proteins of 32 and 36 kDa expressed by both Staphylococcus epidermidis and Staphylococcus aureus. In this study we show by Triton X-114 phase partitioning and tritiated palmitic acid labelling that these proteins are lipoproteins which are anchore...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.8.3767-3774.1998
更新日期:1998-08-01 00:00:00
abstract::Toll-like receptor (TLR) signal transduction is a central component of the innate immune response to pathogenic challenge. Although recent studies have begun to elucidate differences in acquired immunity in tissues of the human female reproductive tract, there is a relative paucity of work regarding innate defense mec...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.10.5799-5806.2004
更新日期:2004-10-01 00:00:00
abstract::The American opossum is the only experimental animal that regularly develops bacterial endocarditis spontaneously. There was no relation between the ability of opossums to clear bacteria from the bloodstream and the subsequent development of endocarditis. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.6.1126-1128.1974
更新日期:1974-06-01 00:00:00
abstract::Four glycoproteins of Treponema pallidum were identified by intrinsic [14C]glucosamine labeling. Only two glycoproteins were demonstrated in T. phagedenis biotype Reiter with the same technique. Glycoproteins of both treponemes were characterized as antigens and shown to be localized within the outer membranes of the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.46.3.867-869.1984
更新日期:1984-12-01 00:00:00
abstract::Nontypeable Haemophilus influenzae (NTHi) causes repeated respiratory infections in patients with chronic lung diseases. These infections are characterized by a brisk inflammatory response which results in the accumulation of polymorphonucleated cells in the lungs and is dependent on the expression and secretion of pr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.8.4430-4440.2000
更新日期:2000-08-01 00:00:00
abstract::Leukosis viruses of seven subgroups were tested for oncogenicity in chickens susceptible to virus infection and to development of lymphoid leukosis (LL) tumors. All subgroup A viruses and the subgroup B virus tested produced a high incidence of LL and other related neoplasms. Viruses of subgroup C and RAV-61 of subgro...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.15.2.423-428.1977
更新日期:1977-02-01 00:00:00
abstract::Glucose has previously been shown to increase the in vitro phagocytosis of unopsonized Pseudomonas aeruginosa by freshly explanted murine peritoneal macrophages (PM) and cultivated alveolar macrophages (AM). This study examined the effect of glucose on the same phagocytosis process in human AM in order to determine wh...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.1.16-21.1999
更新日期:1999-01-01 00:00:00