Antimicrobial activity of murine lung cells against Staphylococcus aureus is increased in vitro and in vivo after elafin gene transfer.

abstract：:In the murine model of urinary tract infections (UTI), cystitis by uropathogenic Escherichia coli (UPEC) occurs through an intimate relationship with the bladder superficial umbrella cell entailing cycles of adherence, invasion, intracellular bacterial community (IBC) formation, and dispersal (fluxing) from the intrac...

journal_title：Infection and immunity

authors： Wright KJ,Seed PC,Hultgren SJ

更新日期：2005-11-01 00:00:00

abstract：:Complement-containing immune complexes can be presented to phagocytes by human erythrocytes bearing complement receptor 1 (CR1). Although this has long been assumed to be a mechanism by which humans are able to protect themselves from "extracellular" bacteria such as pneumococci, there is little direct evidence. In th...

journal_title：Infection and immunity

authors： Li J,Wang JP,Ghiran I,Cerny A,Szalai AJ,Briles DE,Finberg RW

更新日期：2010-07-01 00:00:00

abstract：:The Fcγ receptor IIIb (FcγRIIIb) is a low-affinity receptor of IgG and is essential in neutrophil-mediated effector functions. Different allelic forms of FcγRIIIb carrying human neutrophil antigen (HNA-1a, -1b, -1c, and -1d) have been identified. Here, we have generated stable transfected HEK293 cell lines expressing ...

journal_title：Infection and immunity

authors： Simtong P,Romphruk AV,Traum A,Burg-Roderfeld M,Bein G,Jakubowski K,Dominik A,Theisen M,Kana IH,Sachs UJ,Santoso S

更新日期：2018-07-23 00:00:00

abstract：:In this study we demonstrate the capability of Chlamydia trachomatis to infect cultured human mesothelial cell (MC) monolayers and to induce the production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-8. Seventy-two hours after initial infection, both the procoagulant activity of MC and the act...

journal_title：Infection and immunity

authors： van Westreenen M,Pronk A,Diepersloot RJ,de Groot PG,Leguit P

更新日期：1998-05-01 00:00:00

abstract：:A GroEL-like protein from Bordetella pertussis was purified. This protein was found to have the tetradecameric subunit structure typical of the GroEL family of proteins and to contain epitopes similar to those of other members of this family, including a human GroEL-like protein. Active immunization of neonatal mice w...

journal_title：Infection and immunity

authors： Burns DL,Gould-Kostka JL,Kessel M,Arciniega JL

更新日期：1991-04-01 00:00:00

abstract：:The tetrasaccharide 3-deoxy-alpha-D-manno-2-octulosonic acid (alpha-KDO) (2----8)-alpha-KDO(2----4)-alpha-KDO(2----6)-beta GlcNAc, a partial structure of chlamydial lipopolysaccharide (LPS) representing a genus-specific epitope, was synthesized and covalently linked to bovine serum albumin, resulting in an artificial ...

journal_title：Infection and immunity

authors： Fu Y,Baumann M,Kosma P,Brade L,Brade H

更新日期：1992-04-01 00:00:00

abstract：:Mesocricetus auratus (golden hamsters) infected with leishmania developed characteristic B cell immune responses that depended on the infecting species of leishmania. Thus, hamsters infected with viscerotropic leishmania (Leishmania donovani) developed antileishmania antibodies and hypergammaglobulinemia due to polycl...

journal_title：Infection and immunity

authors： Campos-Neto A,Bunn-Moreno MM

更新日期：1982-12-01 00:00:00

abstract：:Infection with the intracellular protozoan parasite Toxoplasma gondii causes serious public health problems and is of great economic importance worldwide. The micronemal protein MIC3, which is a potent adhesin of T. gondii, could be a significant candidate vaccine against toxoplasmosis. In this study, all CBA/J mice i...

journal_title：Infection and immunity

authors： Ismael AB,Sekkai D,Collin C,Bout D,Mévélec MN

更新日期：2003-11-01 00:00:00

abstract：:Pulmonary washings from rabbits were freed of cells and added to the monolayers of homologous alveolar macrophages (AM). At 1 h after incubation with the pulmonary washings, many more cells adhered to glass, spread out, and showed enhanced Nitro Blue Tetrazolium reduction. The maximal effect of the pulmonary washings ...

journal_title：Infection and immunity

authors： Ando M,Suga M,Shima K,Sugimoto M,Tokuomi H

更新日期：1978-05-01 00:00:00

abstract：:Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections. These bacteria undertake a multistage infection cycle involving invasion of and proliferation within urinary tract epithelial cells, leading to the rupture of the host cell and dispersal of the bacteria, some of which have a highly...

journal_title：Infection and immunity

authors： Iosifidis G,Duggin IG

更新日期：2020-08-19 00:00:00

abstract：:The generation of leukotrienes (LTC4, LTD4, LTE4, and LTB4; 12-epi-LTB4 isomer) from human granulocytes by thiol-activated toxins (streptolysin O, alveolysin from Bacillus alvei, and theta toxin from Clostridium perfringens) is described. The release occurs under noncytolytic conditions. Although LTB4 is the major com...

journal_title：Infection and immunity

authors： Bremm KD,König W,Pfeiffer P,Rauschen I,Theobald K,Thelestam M,Alouf JE

更新日期：1985-12-01 00:00:00

abstract：:Pneumolysin, the cholesterol-dependent cytolysin of Streptococcus pneumoniae, induces inflammatory and apoptotic events in mammalian cells. Toll-like receptor 4 (TLR4) confers resistance to pneumococcal infection via its interaction with pneumolysin, but the underlying mechanisms remain to be identified. In the presen...

journal_title：Infection and immunity

authors： Srivastava A,Henneke P,Visintin A,Morse SC,Martin V,Watkins C,Paton JC,Wessels MR,Golenbock DT,Malley R

更新日期：2005-10-01 00:00:00

abstract：:The nitrate dissimilation pathway is important for anaerobic growth in Pseudomonas aeruginosa. In addition, this pathway contributes to P. aeruginosa virulence by using the nematode Caenorhabditis elegans as a model host, as well as biofilm formation and motility. We used a set of nitrate dissimilation pathway mutants...

journal_title：Infection and immunity

authors： Van Alst NE,Wellington M,Clark VL,Haidaris CG,Iglewski BH

更新日期：2009-10-01 00:00:00

abstract：:Bacterial adherence to mucosal surfaces is an important virulence trait of pathogenic bacteria. Adhesion of enterotoxigenic Escherichia coli (ETEC) to the intestine is mediated by a number of antigenically distinct colonization factors (CFs). One of the most common CFs is CFA/I. This has a fimbrial structure composed ...

journal_title：Infection and immunity

authors： Jansson L,Tobias J,Lebens M,Svennerholm AM,Teneberg S

更新日期：2006-06-01 00:00:00

abstract：:Vibrio parahaemolyticus is a leading cause of seafood-borne gastroenteritis; however, its virulence mechanisms are not well understood. The identification of type III secreted proteins has provided candidate virulence factors whose functions are still being elucidated. Genotypic strain variability contributes a level ...

journal_title：Infection and immunity

authors： Casselli T,Lynch T,Southward CM,Jones BW,DeVinney R

更新日期：2008-05-01 00:00:00

abstract：:Using microarray technology, we studied the early differential expression of 3,528 genes in human meningothelial cells in response to meningococcal challenge. Thirty-two genes were up-regulated, and four were down-regulated. Those up-regulated included the tumor necrosis factor alpha, interleukin-6 (IL-6), and IL-8 (b...

journal_title：Infection and immunity

authors： Wells DB,Tighe PJ,Wooldridge KG,Robinson K,Ala' Aldeen DA

更新日期：2001-04-01 00:00:00

abstract：:The purpose of this investigation was to examine gamma interferon potentiation of lipopolysaccharide (LPS) responses in human monocytes by using phenol-water-extracted (unfractionated) and highly purified LPS preparations isolated from Bacteroides intermedius and Salmonella typhimurium. Phenol-water-extracted LPS prep...

journal_title：Infection and immunity

authors： Nichols FC,Peluso JF,Tempro PJ,Garrison SW,Payne JB

更新日期：1991-01-01 00:00:00

abstract：:The tetraspanins are a superfamily of transmembrane proteins with diverse functions and can form extended microdomains within the plasma membrane in conjunction with partner proteins, which probably includes receptors for bacterial adhesins. Neisseria meningitidis, the causative agent of meningococcal disease, attache...

journal_title：Infection and immunity

authors： Green LR,Monk PN,Partridge LJ,Morris P,Gorringe AR,Read RC

更新日期：2011-06-01 00:00:00

abstract：:Tritium-labeled, water-soluble components of Streptococcus pyogenes type M6 absorbed to cardiac tissue in vitro. Tissue binding was time dependent, saturable, and reversible. Chromatography of the crude bacterial extract on Bio-Gel P-300 indicated a molecular weight greater than 300,000 for the heart-binding component...

journal_title：Infection and immunity

authors： Stinson MW,Bergey EJ

更新日期：1982-01-01 00:00:00

abstract：:When Streptococcus pyogenes group A type 3 strain C203 (M+) and its M-protein-lacking derivative, strain C203S (M-), were treated with normal human serum in the presence of magnesium-EGTA [ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid], virulent M+ bacteria bound only 10 to 30% as much C3 and f...

journal_title：Infection and immunity

authors： Hong K,Kinoshita T,Takeda J,Kozono H,Pramoonjago P,Kim YU,Inoue K

更新日期：1990-08-01 00:00:00

abstract：:Chronic lung infections with Pseudomonas aeruginosa biofilms are associated with refractory and fatal pneumonia in cystic fibrosis (CF). In this study, a group of genomically diverse P. aeruginosa isolates were compared with the reference strain PAO1 to assess the roles of motility, twitching, growth rate, and overpro...

journal_title：Infection and immunity

authors： Head NE,Yu H

更新日期：2004-01-01 00:00:00

abstract：:Photobacterium damselae subsp. damselae causes infections and fatal disease in marine animals and in humans. Highly hemolytic strains produce damselysin (Dly) and plasmid-encoded HlyA (HlyA(pl)). These hemolysins are encoded by plasmid pPHDD1 and contribute to hemolysis and virulence for fish and mice. In this study, ...

journal_title：Infection and immunity

authors： Rivas AJ,Balado M,Lemos ML,Osorio CR

更新日期：2013-09-01 00:00:00

abstract：:Cyclic dimeric GMP (c-di-GMP), a bacterial second messenger, is known to regulate bacterial biofilm and sessility. Replication of an obligatory intracellular pathogen, Ehrlichia chaffeensis, is characterized by formation of bacterial aggregates called morulae inside membrane-bound inclusions. When E. chaffeensis matur...

journal_title：Infection and immunity

authors： Kumagai Y,Matsuo J,Cheng Z,Hayakawa Y,Rikihisa Y

更新日期：2011-10-01 00:00:00

abstract：:Fifty Borellia burgdorferi strains isolated from humans and ticks in Europe and the United States were analyzed by multilocus enzyme electrophoresis. Eleven genetic loci were characterized on the basis of the electrophoretic mobilities of their products. Ten loci were polymorphic. The average number of alleles per loc...

journal_title：Infection and immunity

authors： Boerlin P,Peter O,Bretz AG,Postic D,Baranton G,Piffaretti JC

更新日期：1992-04-01 00:00:00

abstract：:The 23-membered Esx protein family is involved in the host-pathogen interactions of Mycobacterium tuberculosis. These secreted proteins are among the most immunodominant antigens recognized by the human immune system and have thus been used to develop vaccines and immunodiagnostic tests for tuberculosis (TB). Gene pai...

journal_title：Infection and immunity

authors： Uplekar S,Heym B,Friocourt V,Rougemont J,Cole ST

更新日期：2011-10-01 00:00:00

abstract：:Factors which control the levels of catalase within yeast cells of Histoplasma capsulatum were studied. Only a small fraction of the total catalase activity could be detected in whole cells. The bulk of the activity was revealed in cell-free extracts or in cells permeabilized with acetone. The formation of the enzyme ...

journal_title：Infection and immunity

authors： Howard DH

更新日期：1983-03-01 00:00:00

abstract：:A hamster immunization challenge assay described in the accompanying paper (M. F. Barile, D. K. F. Chandler, H. Yoshida, M. W. Grabowski, R. Harasawa, and S. Razin, Infect. Immun. 56:2443-2449, 1988) was used to examine protection against Mycoplasma pneumoniae disease by passive immunization and to evaluate the protec...

journal_title：Infection and immunity

authors： Barile MF,Chandler DK,Yoshida H,Grabowski MW,Razin S

更新日期：1988-09-01 00:00:00

abstract：:Escherichia coli O157:H7 is an important pathogen of humans. Cattle are most frequently identified as the primary source of infection, and therefore, reduction in E. coli O157:H7 prevalence in cattle by vaccination represents an attractive strategy for reducing the incidence of human disease. H7 flagella have been imp...

journal_title：Infection and immunity

authors： McNeilly TN,Naylor SW,Mahajan A,Mitchell MC,McAteer S,Deane D,Smith DG,Low JC,Gally DL,Huntley JF

更新日期：2008-06-01 00:00:00

abstract：:Rabbit lymphoid cells from spleen, peripheral blood, and peritoneal cavity lacked killer (K)-cell activity against cell lines of rabbit and human origin, including virus-infected human tumor cells. This lack of activity was not affected by antibody concentration, source of antibodies, effector/target cell ratio, or le...

journal_title：Infection and immunity

authors： Karavodin LM,Sidell N,Woan MC,Tompkins WA

更新日期：1982-02-01 00:00:00

abstract：:An important role for immunoglobulin M (IgM) during early acute virulent Toxoplasma gondii infection was identified using IgM-/- mice that lack surface and secretory IgM but maintain normal B-cell functionality and isotype class switching. Following intraperitoneal inoculation with the virulent RH strain, IgM-/- mice ...

journal_title：Infection and immunity

authors： Couper KN,Roberts CW,Brombacher F,Alexander J,Johnson LL

更新日期：2005-12-01 00:00:00