Abstract:
:CD8 T cells are effective mediators of specific immunity to infection by Listeria monocytogenes, a bacterial pathogen that initially infects macrophages in the spleen and liver and subsequently spreads to hepatocytes and unidentified parenchymal cells in the spleen. To identify the in vivo target cells of L. monocytogenes-immune CD8 T cells, adoptive transfer assays were performed with bone marrow chimeric or transgenic host mice which had been manipulated to alter the major histocompatibility complex molecules expressed on macrophages or hepatocytes. L. monocytogenes-immune CD8 T cells mediate significant immunity in BDF1-->beta 2 M-/- chimeras, comparable to that seen in unmanipulated BDF1 recipients. L. monocytogenes-immune CD8 T cells also mediate significant antilisterial immunity in parent-->F1 chimeras when the CD8 T cells are syngeneic with the bone marrow donor. These data demonstrate that bone marrow-derived macrophages are major targets for L. monocytogenes-immune CD8 T cells in adoptive transfer assays. Interestingly, significant immunity was observed in parent-->F1 chimeras when the L. monocytogenes-immune CD8 T cells were not syngeneic with the bone marrow donor, suggesting that recognition of Listeria-infected non-bone-marrow-derived cells such as hepatocytes may also occur in vivo. Consistent with this possibility, H-2Kb-restricted CD8 T cells specific for the listeriolysin O molecule mediate significant immunity in the liver, but not the spleen, in transgenic mice expressing H-2Kb only on hepatocytes. In addition, Listeria-specific CD8 T cells lyse Listeria-infected hepatocyte-like cells in vitro. Thus, Listeria-infected hepatocytes can be recognized by CD8 T cells in vivo and in vitro.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Harty JT,Bevan MJdoi
10.1128/IAI.64.9.3632-3640.1996subject
Has Abstractpub_date
1996-09-01 00:00:00pages
3632-40issue
9eissn
0019-9567issn
1098-5522journal_volume
64pub_type
杂志文章abstract::Disruption of the healthy intestinal microbiome and homeostasis of the intestinal immune system, which are closely interactive, are two key factors for ulcerative colitis. Here, we show that MI-2, a selective inhibitor of mucosa-associated lymphoid tissue lymphoma translocation-1 (MALT1), alleviated excessive inflamma...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00091-18
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pub_type: 杂志文章
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journal_title:Infection and immunity
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更新日期:1985-07-01 00:00:00
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journal_title:Infection and immunity
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更新日期:1973-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.2.2.132-138.1970
更新日期:1970-08-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.33.1.130-135.1981
更新日期:1981-07-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.10.4.851-861.1974
更新日期:1974-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.10.3388-3393.1990
更新日期:1990-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2008-11-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.74.1.167-174.2006
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.21.2.659-662.1978
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.10.4146-4151.1997
更新日期:1997-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.39.1.487-489.1983
更新日期:1983-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2005-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.1.133-138.1983
更新日期:1983-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.42.2.501-509.1983
更新日期:1983-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.1.141-150.2000
更新日期:2000-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1998-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.11.4.835-844.1975
更新日期:1975-04-01 00:00:00