Evaluation of the role of LcrV-Toll-like receptor 2-mediated immunomodulation in the virulence of Yersinia pestis.

abstract：:Expression of ace (adhesin to collagen of Enterococcus faecalis), encoding a virulence factor in endocarditis and urinary tract infection models, has been shown to increase under certain conditions, such as in the presence of serum, bile salts, urine, and collagen and at 46 °C. However, the mechanism of ace/Ace regula...

journal_title：Infection and immunity

authors： Roh JH,Singh KV,La Rosa SL,Cohen AL,Murray BE

更新日期：2015-01-01 00:00:00

abstract：:Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of beta(1-6)glucosamine disaccharide mono- or diphosphates showed high activities in most in vitro assays, and the lethality of a diphosphate derivative to galactosami...

journal_title：Infection and immunity

authors： Kotani S,Takada H,Tsujimoto M,Ogawa T,Harada K,Mori Y,Kawasaki A,Tanaka A,Nagao S,Tanaka S

更新日期：1984-07-01 00:00:00

abstract：:The ability of intracellular pathogens to sense and adapt to the hostile environment of the host is an important factor governing virulence. We have sequenced the operon encoding the major heat shock proteins GroES and GroEL in the gram-positive food-borne pathogen Listeria monocytogenes. The operon has a conserved or...

journal_title：Infection and immunity

authors： Gahan CG,O'Mahony J,Hill C

更新日期：2001-06-01 00:00:00

abstract：:Previous passive antibody transfer experiments have indicated that immunity to a 46-kilodalton membrane glycoprotein (M-2) of Leishmania amazonensis may protect against infection with this parasite. In the studies described in this paper, we investigated the ability of the purified M-2 molecule to elicit a protective ...

journal_title：Infection and immunity

authors： Champsi J,McMahon-Pratt D

更新日期：1988-12-01 00:00:00

abstract：:Sera from adult periodontitis patients were analyzed for antibody activity against surface antigens of Bacteroides gingivalis by immunoblotting analysis. ...

journal_title：Infection and immunity

authors： Naito Y,Okuda K,Takazoe I

更新日期：1987-03-01 00:00:00

abstract：:The Corynebacterium diphtheriae hmuO gene encodes a heme oxygenase that is involved in the utilization of heme as an iron source. Transcription of hmuO is activated by heme or hemoglobin and repressed by iron and DtxR. Previous studies with Escherichia coli showed that heme-dependent transcriptional activation of an h...

journal_title：Infection and immunity

authors： Bibb LA,King ND,Kunkle CA,Schmitt MP

更新日期：2005-11-01 00:00:00

abstract：:In this study, we report on a novel approach based on modification of the intestinal surface to prevent diarrhea caused by enterotoxigenic Escherichia coli (ETEC). The removable intestinal tie adult rabbit diarrhea (RITARD) model was used to test the efficacy of an enteric-coated protease preparation (Detach; Enzacor ...

journal_title：Infection and immunity

authors： Mynott TL,Chandler DS,Luke RK

更新日期：1991-10-01 00:00:00

abstract：:Clostridium difficile is recognized as the major cause of antibiotic-associated colitis. C. difficile produces two toxins, A (enterotoxin) and B (cytotoxin), that are implicated in the pathogenesis of the colitis. We examined the dose responses, time course, and synergism of these two toxins in ligated rabbit intestin...

journal_title：Infection and immunity

authors： Lima AA,Lyerly DM,Wilkins TD,Innes DJ,Guerrant RL

更新日期：1988-03-01 00:00:00

abstract：:Protection by surface antigen TF1.17 of Tritrichomonas foetus was investigated because it reacted with a monoclonal antibody which immobilized and mediated complement killing of the organism and prevented adherence to vaginal epithelial cells. This monoclonal antibody was used to demonstrate conservation of the antige...

journal_title：Infection and immunity

authors： BonDurant RH,Corbeil RR,Corbeil LB

更新日期：1993-04-01 00:00:00

abstract：:Murine monoclonal and rabbit, murine, and human polyclonal antibodies against chlamydial lipopolysaccharide (LPS) were characterized by the passive hemolysis and passive hemolysis inhibition assays and by absorption experiments with LPSs of Chlamydia psittaci, Chlamydia trachomatis, and a recombinant strain of Salmone...

journal_title：Infection and immunity

authors： Brade L,Holst O,Kosma P,Zhang YX,Paulsen H,Krausse R,Brade H

更新日期：1990-01-01 00:00:00

abstract：:Clostridium difficile is the leading cause of nosocomial bacterial diarrhea. Glutamine and its stable and highly soluble derivative alanyl-glutamine, have been beneficial in models of intestinal injury. In this study, we extend our work on the mechanisms of Clostridium difficile toxin A (TxA)-induced apoptosis in huma...

journal_title：Infection and immunity

authors： Carneiro BA,Fujii J,Brito GA,Alcantara C,Oriá RB,Lima AA,Obrig T,Guerrant RL

更新日期：2006-01-01 00:00:00

abstract：:Using a PCR-based strategy and degenerate oligonucleotides, we isolated a Legionella pneumophila gene that showed high sequence similarity to members of the fliI gene family. An insertion mutation that disrupted the fliI open reading frame was recombined onto the L. pneumophila chromosome and analyzed for its effects ...

journal_title：Infection and immunity

authors： Merriam JJ,Mathur R,Maxfield-Boumil R,Isberg RR

更新日期：1997-06-01 00:00:00

abstract：:Intracellular bacterial infections affect all vertebrates. Cultured fish are particularly vulnerable because no effective protection measures have been established since such infections emerged approximately 50 years ago. As in other vertebrates, the induction of cell-mediated immunity (CMI) plays an important role in...

journal_title：Infection and immunity

authors： Matsumoto M,Kubota T,Fujita S,Shiozaki K,Kishida S,Yamamoto A

更新日期：2019-10-18 00:00:00

abstract：:Human lactoferrin is an iron-binding glycoprotein that is particularly prominent in exocrine secretions and leukocytes and is also found in serum, especially during inflammation. It is able to sequester iron from microbes and has immunomodulatory functions, including inhibition of both complement activation and cytoki...

journal_title：Infection and immunity

authors： Håkansson A,Roche H,Mirza S,McDaniel LS,Brooks-Walter A,Briles DE

更新日期：2001-05-01 00:00:00

abstract：:Toll-like receptors (TLRs) are a major component of the pattern recognition receptor repertoire that detect invading microorganisms and direct the vertebrate immune system to eliminate infection. In chickens, the differential biology of Salmonella serovars (systemic versus gut-restricted localization) correlates with ...

journal_title：Infection and immunity

authors： Iqbal M,Philbin VJ,Withanage GS,Wigley P,Beal RK,Goodchild MJ,Barrow P,McConnell I,Maskell DJ,Young J,Bumstead N,Boyd Y,Smith AL

更新日期：2005-04-01 00:00:00

abstract：:The immunogenicity of a single dose of a whole-cell vaccine of inactivated Borrelia burgdorferi HSF (human spinal fluid isolate) was evaluated. Syrian hamsters were vaccinated subcutaneously and challenged by the intraperitoneal injection of 1,000 50% infectious doses of B. burgdorferi HSF 30 or 90 days postvaccinatio...

journal_title：Infection and immunity

authors： Johnson RC,Kodner C,Russell M

更新日期：1986-12-01 00:00:00

abstract：:Bacterial strains of Haemophilus species and Streptococcus pneumoniae were examined for synthesis of the enzyme immunoglobulin A1 (IgA1) protease. Of 36 H. influenzae strains examined, 35 produced IgA1 protease; strains included all six capsular types, unencapsulated variants of types b and d, and untypable H. influen...

journal_title：Infection and immunity

authors： Male CJ

更新日期：1979-10-01 00:00:00

abstract：:Gamma interferon (IFN-gamma)-activated macrophages use an alternative processing mechanism to present Salmonella antigens to CD8(+) T lymphocytes. This pathway involves processing of antigen in a vacuolar compartment followed by secretion and loading of antigenic peptides to major histocompatibility complex class I (M...

journal_title：Infection and immunity

authors： Rosales-Reyes R,Alpuche-Aranda C,Ramírez-Aguilar Mde L,Castro-Eguiluz AD,Ortiz-Navarrete V

更新日期：2005-07-01 00:00:00

abstract：:Actinobacillus pleuropneumoniae, the causative agent of swine pleuropneumonia, secretes a hemolytic activity which is thought to be a factor involved in the pathogenesis of the disease. The biosynthesis of hemolysin by serotype 1 strain 4074 was strongly dependent on the activity of free Ca2+ in the growth medium. At ...

journal_title：Infection and immunity

authors： Frey J,Nicolet J

更新日期：1988-10-01 00:00:00

abstract：:Complement receptor type 3 (CR3) was initially described as an opsonic receptor. Subsequently, CR3-mediated lectin-sugar recognition mechanisms have been shown to play a major role in the nonopsonic phagocytosis of several pathogens, among them Mycobacterium tuberculosis. Little is known about the binding and signal t...

journal_title：Infection and immunity

authors： Le Cabec V,Cols C,Maridonneau-Parini I

更新日期：2000-08-01 00:00:00

abstract：:Di-, tri-, and tetrasaccharides, synthesized according to the chemical structure of pneumococcal polysaccharide type 3 (PS3), were coupled to the cross-reactive material (CRM(197)) of modified diphtheria toxin in different molar carbohydrate/protein ratios using the squarate coupling method. To study protective immuni...

journal_title：Infection and immunity

authors： Benaissa-Trouw B,Lefeber DJ,Kamerling JP,Vliegenthart JF,Kraaijeveld K,Snippe H

更新日期：2001-07-01 00:00:00

abstract：:The mechanism of complement-mediated killing of seven serum-sensitive Pseudomonas aeruginosa strains was examined. All seven strains were sensitive to the bactericidal activity of 20% pooled normal human serum (PNHS) containing magnesium EGTA, which blocks the classical complement pathway (CCP), or 20% PNHS preheated ...

journal_title：Infection and immunity

authors： Schiller NL

更新日期：1988-03-01 00:00:00

abstract：:Uropathogenic Escherichia coli (UPEC) is responsible for the majority of uncomplicated urinary tract infections (UTI) and represents the most common bacterial infection in adults. UPEC utilizes a wide range of virulence factors to colonize the host, including the novel repeat-in-toxin (RTX) protein TosA, which is spec...

journal_title：Infection and immunity

authors： Vigil PD,Wiles TJ,Engstrom MD,Prasov L,Mulvey MA,Mobley HL

更新日期：2012-02-01 00:00:00

abstract：:The inactivation of Coxiella burnetii in suspension or in cultures of guinea pig peritoneal macrophages by ultraviolet (UV) light was studied. The effect of UV treatment on the activity of macrophage organelle marker enzymes and their subsequent equilibration in linear sucrose gradients was also determined. It was sho...

journal_title：Infection and immunity

authors： Little JS,Kishimoto RA,Canonico PG

更新日期：1980-03-01 00:00:00

abstract：:We have recently reported Bacillus anthracis attenuated live vaccine strains efficiently expressing recombinant protective antigen (rPA) and have shown a direct correlation between the level of rPA secreted by these cells and efficacy (S. Cohen, I. Mendelson, Z. Altboum, D. Kobiler, E. Elhanany, T. Bino, M. Leitner, I...

journal_title：Infection and immunity

authors： Gat O,Inbar I,Aloni-Grinstein R,Zahavy E,Kronman C,Mendelson I,Cohen S,Velan B,Shafferman A

更新日期：2003-02-01 00:00:00

abstract：:Bordetella bronchiseptica is a Gram-negative bacterium that infects and causes disease in a wide variety of animals. B. bronchiseptica also infects humans, thereby demonstrating zoonotic transmission. An extensive characterization of human B. bronchiseptica isolates is needed to better understand the distinct genetic ...

journal_title：Infection and immunity

authors： Sukumar N,Nicholson TL,Conover MS,Ganguly T,Deora R

更新日期：2014-04-01 00:00:00

abstract：:Reverse transcriptase PCR analyses have demonstrated that open reading frames (ORFs) PM0298, PM0299, and PM0300 of the animal pathogen Pasteurella multocida constitute a single transcriptional unit. By cloning and overexpression studies in Escherichia coli cells, the product of ORF PM0300 was shown to bind hemoglobin ...

journal_title：Infection and immunity

authors： Bosch M,Garrido ME,Llagostera M,Pérez De Rozas AM,Badiola I,Barbé J

更新日期：2002-11-01 00:00:00

abstract：:The interaction between human neutrophils and wild-type Bordetella pertussis or mutants expressing altered lipopolysaccharide or lacking virulence factors-pertussis toxin, adenylate cyclase toxin, dermonecrotic toxin, filamentous hemagglutinin (FHA), pertactin, or BrkA-was examined. In the absence of antibodies, the w...

journal_title：Infection and immunity

authors： Weingart CL,Weiss AA

更新日期：2000-03-01 00:00:00

abstract：:Apical membrane antigen 1 (AMA-1) is an invasion-related Plasmodium antigen that is expressed during both intracellular and extracellular asexual stages of the parasite's life cycle, making it an ideal target for induction of humoral and cellular immune responses that can protect against malaria. We show here that whe...

journal_title：Infection and immunity

authors： Bouillet LÉ,Dias MO,Dorigo NA,Moura AD,Russell B,Nosten F,Renia L,Braga EM,Gazzinelli RT,Rodrigues MM,Soares IS,Bruna-Romero O

更新日期：2011-09-01 00:00:00

abstract：:Attachment of Mycobacterium avium subsp. paratuberculosis to host tissue and penetration of mucosal surfaces are pivotal events in the pathogenesis of Johne's disease. Fibronectin (FN) binding is required for attachment and internalization of several mycobacteria by epithelial cells in vitro. The objective of this stu...

journal_title：Infection and immunity

authors： Secott TE,Lin TL,Wu CC

更新日期：2001-04-01 00:00:00