Induction of cytotoxic T-cell responses against culture filtrate antigens in Mycobacterium bovis bacillus Calmette-Guérin-infected mice.

abstract：:Three parameters of rotavirus infection, i.e., clinical disease, viral antigen in infected intestines, and infectious virus in feces, were assessed in infant mice nursed by mothers with or without preexisting rotavirus antibody. Diarrhea was the only consistent sign of clinical disease, and its course followed that of...

journal_title：Infection and immunity

authors： Little LM,Shadduck JA

更新日期：1982-11-01 00:00:00

abstract：:Development of an effective vaccine against Leishmania infection is a priority of tropical disease research. We have recently demonstrated protection against Leishmania major in the murine and nonhuman primate models with individual or combinations of purified leishmanial recombinant antigens delivered as plasmid DNA ...

journal_title：Infection and immunity

authors： Coler RN,Skeiky YA,Bernards K,Greeson K,Carter D,Cornellison CD,Modabber F,Campos-Neto A,Reed SG

更新日期：2002-08-01 00:00:00

abstract：:Binding of the complement-downregulating protein factor H (fH) to the surface of the meningococcus is important for survival of the organism in human serum. The meningococcal vaccine candidate factor H binding protein (fHbp) is an important ligand for human fH. While some fHbp-specific monoclonal antibodies (MAbs) blo...

journal_title：Infection and immunity

authors： Giuntini S,Reason DC,Granoff DM

更新日期：2011-09-01 00:00:00

abstract：:Porphyromonas gingivalis forms communities with antecedent oral biofilm constituent streptococci. P. gingivalis major fimbriae bind to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) present on the streptococcal surface, and this interaction plays an important role in P. gingivalis colonization. This study identified...

journal_title：Infection and immunity

authors： Nagata H,Iwasaki M,Maeda K,Kuboniwa M,Hashino E,Toe M,Minamino N,Kuwahara H,Shizukuishi S

更新日期：2009-11-01 00:00:00

abstract：:CS31A is a K88-related capsule-like surface protein that mediates Escherichia coli and Klebsiella pneumoniae adhesion to the human Caco-2 and Intestine-407 cell lines. In this study, we demonstrate that ClpG, the major subunit of CS31A, contains the adhesive domain of the polymerized structure. We mapped this domain w...

journal_title：Infection and immunity

authors： Di Martino P,Girardeau JP,Der Vartanian M,Joly B,Darfeuille-Michaud A

更新日期：1997-02-01 00:00:00

abstract：:Immunization with ribosomal preparations from Haemophilus influenzae type b elicited protective immunity in mice. Ribosomes from disrupted cells where isolated by differential centrifugation using sodium dodecyl sulfate. The washed ribosomes contained 25% protein and 75% ribonucleic acid and sedimented as a single pea...

journal_title：Infection and immunity

authors： Lynn M,Tewari RP,Solotorovsky M

更新日期：1977-02-01 00:00:00

abstract：:Passive transfer of antibody may be useful for preexposure prophylaxis against biological agents used as weapons of terror, such as Bacillus anthracis. Studies were performed to evaluate the ability of anthrax antiprotective antigen (anti-PA) and antilethal factor (anti-LF) neutralizing monoclonal antibodies (mAbs) to...

journal_title：Infection and immunity

authors： Staats HF,Alam SM,Scearce RM,Kirwan SM,Zhang JX,Gwinn WM,Haynes BF

更新日期：2007-11-01 00:00:00

abstract：:A large-scale DNA vaccination trial was performed with sheep to investigate whether an antigen targeted by CTLA-4 enhanced and accelerated the humoral immune response. Vaccination with genetically detoxified phospholipase D (DeltaPLD) has been shown to be effective, at least partially, against Corynebacterium pseudotu...

journal_title：Infection and immunity

authors： Chaplin PJ,De Rose R,Boyle JS,McWaters P,Kelly J,Tennent JM,Lew AM,Scheerlinck JP

更新日期：1999-12-01 00:00:00

abstract：:The listeriolysin gene from a weakly hemolytic but virulent strain of Listeria monocytogenes serotype 1/2a was cloned in Escherichia coli K-12. Recombinants were identified on the basis of their cross-reactivities to hyperimmune antisera raised against streptolysin O and listeriolysin. Low levels of hemolytic activity...

journal_title：Infection and immunity

authors： Leimeister-Wächter M,Chakraborty T

更新日期：1989-08-01 00:00:00

abstract：:Each of the serotypes of Haemophilus influenzae (types a to f) may colonize the respiratory tract of humans, but only type b strains commonly cause invasive systemic infections. To investigate the role of complement in immunity to encapsulated non-type b strains, rats were depleted of C3 with cobra venom factor and ch...

journal_title：Infection and immunity

authors： Corrall CJ,Winkelstein JA,Moxon ER

更新日期：1982-03-01 00:00:00

abstract：:Yersinia pestis causes a rapid, lethal disease referred to as plague. Y. pestis actively inhibits the innate immune system to generate a noninflammatory environment during early stages of infection to promote colonization. The ability of Y. pestis to create this early noninflammatory environment is in part due to the ...

journal_title：Infection and immunity

authors： Pulsifer AR,Vashishta A,Reeves SA,Wolfe JK,Palace SG,Proulx MK,Goguen J,Bodduluri SR,Haribabu B,Uriarte SM,Lawrenz MB

更新日期：2020-02-20 00:00:00

abstract：:Neisseria gonorrhoeae is the causative agent of the sexually transmitted disease gonorrhea, and infection with this organism is typically associated with an intense inflammatory response. In many individuals, however, the infection is asymptomatic and can progress to serious secondary complications. The type IV pili o...

journal_title：Infection and immunity

authors： Plant LJ,Jonsson AB

更新日期：2006-01-01 00:00:00

abstract：:The bacterial pathogen Clostridium difficle synthesizes two high-molecular-weight toxins (A and B), which exhibit toxic effects in vivo and in vitro. Here, we present evidence that the major intracellular targets of these two toxins are the Rho GTPases. Overexpression of RhoA, RhoB, or RhoC GTPases in transfected HeLa...

journal_title：Infection and immunity

authors： Giry M,Popoff MR,von Eichel-Streiber C,Boquet P

更新日期：1995-10-01 00:00:00

abstract：:Encapsulated Staphylococcus aureus strains are more virulent than unencapsulated staphylococci, and this phenomenon has been associated with decreased opsonization of encapsulated bacteria by normal human serum. Peptidoglycan, a major cell wall component of S. aureus, has been shown to promote opsonization of this bac...

journal_title：Infection and immunity

authors： Wilkinson BJ,Sisson SP,Kim Y,Peterson PK

更新日期：1979-12-01 00:00:00

abstract：:Inoculation of neonatal CD-1 mice by multiple routes with an amyocarditic temperature-sensitive (ts) mutant (ts 1) derived from a myocarditic parent variant of coxsackievirus B3 (CVB3(m)) resulted in approximately half of the neonates surviving to adolescence. Challenge of the ts 1 survivors with CVB3(m) did not induc...

journal_title：Infection and immunity

authors： Gauntt CJ,Paque RE,Trousdale MD,Gudvangen RJ,Barr DT,Lipotich GJ,Nealon TJ,Duffey PS

更新日期：1983-02-01 00:00:00

abstract：:Hamster trachea organ cultres were shown to consume measurable amounts of oxygen when incubated in a closed micro-chamber. Several simple and complex media were evaluated, and the optimal system involved incubating 2 to 4 mg of tracheal tissue in Tyrodes balanced salt solution at 37 C for 60 min, with oxygen activity ...

journal_title：Infection and immunity

authors： Gabridge MG

更新日期：1975-09-01 00:00:00

abstract：:Pseudomonas aeruginosa elastase rapidly inactivates alpha 1-proteinase inhibitor by splitting its Pro-357-Met-358 peptide bond. The present study was aimed at testing whether this reaction takes place in the presence of leukocyte elastase. To this end was added alpha 1-proteinase inhibitor to a mixture of the two elas...

journal_title：Infection and immunity

authors： Padrines M,Bieth JG

更新日期：1989-12-01 00:00:00

abstract：:In this study we found that serum inhibitory activity against Blastomyces dermatitidis was principally mediated by albumin. This was confirmed in experiments using albumin from several mammalian species. Analbuminemic rat serum did not inhibit B. dermatitidis growth in vivo; however, the addition of albumin restored i...

journal_title：Infection and immunity

authors： Giles S,Czuprynski C

更新日期：2003-11-01 00:00:00

abstract：:In this communication, we examine the specificity of anti-herpes simplex virus (HSV) cytotoxic T lymphocytes (CTL). Serological studies of the two related HSV serotypes (HSV-1 and HSV-2) have revealed both type-specific and cross-reactive antigenic determinants in the viral envelope and on the surface of infected cell...

journal_title：Infection and immunity

authors： Eberle R,Russell RG,Rouse BT

更新日期：1981-12-01 00:00:00

abstract：:Neutrophils are the main inflammatory cell present in lesions involving the central nervous system (CNS) during human and murine listeriosis. In this study, administration of the neutrophil-depleting monoclonal antibody RB6-8C5 during experimental murine listeriosis facilitated the multiplication of Listeria monocytog...

journal_title：Infection and immunity

authors： López S,Marco AJ,Prats N,Czuprynski CJ

更新日期：2000-08-01 00:00:00

abstract：:Antioxidants are protective against septic shock in animal models. Recently, free radical scavengers have been found to inhibit the activation of the NF-kappa B protein in a number of cell lines. This transcriptional regulatory protein binds to the promoters of the proinflammatory cytokines tumor necrosis factor, inte...

journal_title：Infection and immunity

authors： Kelly KA,Hill MR,Youkhana K,Wanker F,Gimble JM

更新日期：1994-08-01 00:00:00

abstract：:Thirty-one Kanagawa-positive and -negative Vibrio parahaemolyticus isolates from patient stools and seafood were examined for plasmid deoxyribonucleic acid content, culture characteristics, and indices of pathogenicity. No significant correlation was found between plasmid deoxyribonucleic acid contents and indices of ...

journal_title：Infection and immunity

authors： Twedt RM,Brown DF,Zink DL

更新日期：1981-07-01 00:00:00

abstract：:Groups of female C57BL/6 and C3H/St mice were inoculated intraperitoneally (i.p.) with 10(9), 10(7), and 10(5) bacilli and into the right hind footpad with 10(7) and 10(5) bacilli of Mycobacterium lepraemurium. The incidence of death from leprosy and the mean survival time of leprous mice were recorded. In addition, t...

journal_title：Infection and immunity

authors： Turcotte R

更新日期：1980-06-01 00:00:00

abstract：:The mechanism of in vitro synergistic lysis of sheep erythrocytes by Corynebacterium ovis and Corynebacterium equi was investigated. Hemolysis required (i) the action of phospholipase D from C. ovis, (ii) the action of an extracellular protein of C. equi, and (iii) Mg2+. Maximum lysis required imposition on the system...

journal_title：Infection and immunity

authors： Bernheimer AW,Linder R,Avigad LS

更新日期：1980-07-01 00:00:00

abstract：:The purpose of our study was to characterize the properties of the interaction of pertussis toxin with human polymorphonuclear leukocytes for the modulation of leukotriene generation and metabolism. The cells were stimulated with either the Ca ionophore A23187, opsonized zymosan, or the bacterial peptide formyl-methio...

journal_title：Infection and immunity

authors： Hensler T,Raulf M,Megret F,Alouf JE,König W

更新日期：1989-10-01 00:00:00

abstract：:Tuberculosis continues to ravage humanity, killing 2 million people yearly. Most cases occur in areas of the world to which the disease is endemic, where almost everyone is vaccinated early in life with Mycobacterium bovis BCG, the currently available vaccine against tuberculosis. Thus, while more-potent vaccines are ...

journal_title：Infection and immunity

authors： Horwitz MA,Harth G,Dillon BJ,Maslesa-Galic S

更新日期：2005-08-01 00:00:00

abstract：:Loss of the actin filament capping protein CapG has no apparent effect on the phenotype of mice maintained under sterile conditions; however, bone marrow-derived macrophages from CapG(-/-) mice exhibited distinct motility defects. We examined the ability of CapG(-/-) mice to clear two intracellular bacteria, Listeria ...

journal_title：Infection and immunity

authors： Parikh SS,Litherland SA,Clare-Salzler MJ,Li W,Gulig PA,Southwick FS

更新日期：2003-11-01 00:00:00

abstract：:Previous studies in our laboratory have indicated that naturally resistant, inbred DBA/2J mice mount a greater serum antibody response to Pseudomonas aeruginosa 19660 than susceptible C57BL/6J mice. However, the specificity of the antibody produced was not known. The present study examines the specificity and kinetics...

journal_title：Infection and immunity

authors： Preston MJ,Berk JM,Hazlett LD,Berk RS

更新日期：1991-06-01 00:00:00

abstract：:The Alexander hepatoma cell line, PLC/PRF/5, was studied for evidence of hepatitis B virus markers and alpha-fetoprotein. Only hepatitis B surface antigen and alpha-fetoprotein were detected. Induction experiments with 5-iodo-2'-deoxyuridine and inoculation of chimpanzees with whole cells or tissue culture fluid did n...

journal_title：Infection and immunity

authors： Daemer RJ,Feinstone SM,Alexander JJ,Tully JG,London WT,Wong DC,Purcell RH

更新日期：1980-11-01 00:00:00

abstract：:The opportunistic pathogen Pseudomonas aeruginosa is a major cause of sepsis in severely burned patients. If it is not eradicated from the wound, it translocates to the bloodstream, causing sepsis, multiorgan failure, and death. We recently described the P. aeruginosa heparinase-encoding gene, hepP, whose expression w...

journal_title：Infection and immunity

authors： Dzvova N,Colmer-Hamood JA,Griswold JA,Hamood AN

更新日期：2017-12-19 00:00:00