Abstract:
:Three parameters of rotavirus infection, i.e., clinical disease, viral antigen in infected intestines, and infectious virus in feces, were assessed in infant mice nursed by mothers with or without preexisting rotavirus antibody. Diarrhea was the only consistent sign of clinical disease, and its course followed that of infection by about 1 day. Infected intestinal epithelial cells, except crypt cells, were observed by immunofluorescence microscopy in the duodenum, jejunum, ileum, and colon. Infection progressed in a proximal-to-distal direction with time. Viral antigen appeared in intestinal tissue later, was present in lower amounts, and disappeared sooner from infants nursed by mothers with preexisting rotavirus antibody, indicating that protection was passively transferred to these infants although the course of clinical disease was not changed.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Little LM,Shadduck JAdoi
10.1128/IAI.38.2.755-763.1982subject
Has Abstractpub_date
1982-11-01 00:00:00pages
755-63issue
2eissn
0019-9567issn
1098-5522journal_volume
38pub_type
杂志文章abstract::To define the role of nontypeable Haemophilus influenzae (NTHI) lipooligosaccharide (LOS) in the induction of proinflammatory cytokine gene expression during otitis media, we compared the abilities of formalin-killed NTHI strain 2019 and its LOS htrB and rfaD mutants to stimulate human middle ear epithelial (HMEE) cel...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.6.3678-3684.2001
更新日期:2001-06-01 00:00:00
abstract::Mice were inoculated with Legionella pneumophila via an intratracheal route to establish an experimental model of infection. Lung lavage fluid obtained from infected mice contained a cytolytic factor identified as tumor necrosis factor (TNF). Peak levels of TNF were produced at about 24 h postinfection and rapidly dec...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.2.433-437.1987
更新日期:1987-02-01 00:00:00
abstract::The hydrolysis of urea by ureases of oral bacteria in dental plaque can cause a considerable increase in plaque pH, which can inhibit the development of dental caries. There is also indirect evidence that urea metabolism may promote the formation of calculus and that ammonia release from urea could exacerbate periodon...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.12.6670-6676.2000
更新日期:2000-12-01 00:00:00
abstract::We have reported that P388D1 cell line murine macrophages stimulated with lipopolysaccharide (LPS) from Actinobacillus actinomycetemcomitans release interleukin-1 (IL-1) inhibitor. The IL-1 inhibitor was purified from conditioned media of P388D1 cells stimulated with A. actinomycetemcomitans LPS for 72 h to homogeneit...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.2.390-397.1994
更新日期:1994-02-01 00:00:00
abstract::The genetics of resistance to a naturally occurring respiratory infection caused by Sendai virus was examined in F1, F2, and backcross progeny of resistant C57BL/6J and susceptible DBA/2J mice and in 25 recombinant inbred strains. An intranasal inoculum of 0.1 50% tissue culture infective dose (low dose) of Sendai vir...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.1.308-312.1983
更新日期:1983-07-01 00:00:00
abstract::In contrast to Yersinia pestis LcrV, the recombinant V10 (rV10) variant (lacking residues 271 to 300) does not suppress the release of proinflammatory cytokines by immune cells. Immunization with rV10 generates robust antibody responses that protect mice against bubonic plague and pneumonic plague, suggesting that rV1...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01860-05
更新日期:2006-08-01 00:00:00
abstract::A cytoplasmic 75-kDa immunogen from Chlamydia trachomatis serovar L2 has previously been characterized as being similar to the Escherichia coli heat shock protein DnaK. We have localized a linear epitope for one monoclonal antibody specific for C. trachomatis DnaK. By use of a recombinant DNA technique, the epitope wa...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.5.2051-2057.1994
更新日期:1994-05-01 00:00:00
abstract::Vibrio parahaemolyticus is the leading cause of bacterial seafood-borne gastroenteritis worldwide, yet little is known about how this pathogen colonizes the human intestine. The alternative sigma factor RpoN/sigma-54 is a global regulator that controls flagellar synthesis, as well as a wide range of nonflagellar genes...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01210-13
更新日期:2014-02-01 00:00:00
abstract::Protection against colibacillosis in neonatal piglets was obtained by immunization of pregnant dams with procholeragenoid. Procholeragenoid is a stable high-molecular-weight aggregate of cholera toxin formed during the heating of cholera toxin. Procholeragenoid retained approximately 1% of the toxicity of native toxin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.35.3.887-894.1982
更新日期:1982-03-01 00:00:00
abstract::Hemolytic-uremic syndrome (HUS) results from infection by Shiga toxin (Stx)-producing Escherichia coli and is the most common cause of acute renal failure in children. We have developed a mouse model of HUS by administering endotoxin-free Stx2 in multiple doses over 7 to 8 days. At sacrifice, moribund animals demonstr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00592-08
更新日期:2008-10-01 00:00:00
abstract::Mannose-binding lectin (MBL) is an important component of the innate immune system. It binds to the arrays of sugars commonly presented by microorganisms and activates the complement system independently of antibody. Despite detailed knowledge of the stereochemical basis of MBL binding, relatively little is known abou...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.7.3894-3899.2000
更新日期:2000-07-01 00:00:00
abstract::Mice immunized intravenously 10 days earlier (but not those immunized 2 months earlier) with an attenuated Salmonella typhimurium SL3261 aroA live vaccine and tested for delayed-type hypersensitivity by injection of crude Salmonella extracts in the footpad can die within 24 to 48 h of an unexplained allergic reaction....
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.6.2285-2288.1994
更新日期:1994-06-01 00:00:00
abstract::Vaccine candidates against Shigella dysenteriae type 1, which is associated with the most severe cases of bacillary dysentery, were constructed. The rfp and rfb gene clusters, which code for S. dysenteriae 1 O antigen biosynthesis, were randomly integrated into either the chromosome or the virulence plasmid of the rou...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.6.2112-2118.1997
更新日期:1997-06-01 00:00:00
abstract::Anti-NMDA receptor (NMDAR) autoantibodies have been postulated to play a role in the pathogenesis of NMDAR hypofunction, which contributes to the etiology of psychotic symptoms. Toxoplasma gondii is a pathogen implicated in psychiatric disorders and associated with elevation of NMDAR autoantibodies. However, it remain...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00398-18
更新日期:2018-09-21 00:00:00
abstract::Citrobacter rodentium, a murine model pathogen for enteropathogenic Escherichia coli, colonizes the surface of intestinal epithelial cells and causes mucosal inflammation. This bacterium is an ideal model for investigating pathogen-host immune interactions in the gut. It is well known that gene transcripts for Th1 cyt...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01343-09
更新日期:2010-06-01 00:00:00
abstract::An inactivated oral enterotoxigenic Escherichia coli (ETEC) vaccine against ETEC diarrhea was given to 25 adult Swedish volunteers. The vaccine consisted of formalin-killed E. coli bacteria expressing the most common colonization factor antigens (CFAs), i.e., CFA/I, -II, and -IV, and recombinantly produced cholera B s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.7.3311-3316.1998
更新日期:1998-07-01 00:00:00
abstract::T cell-independent antibody responses develop rapidly, within 3 to 4 days, and are critical for preventing blood-borne pathogens from evolving into life-threatening infections. The interaction of BAFF, also known as BLyS, with its receptors BAFFR and TACI on B cells is critical for B cell homeostasis and function. Usi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01147-13
更新日期:2014-01-01 00:00:00
abstract::Subtilase cytotoxin (SubAB) was first isolated from a Shiga toxigenic Escherichia coli (STEC) strain that was responsible for an outbreak of hemolytic-uremic syndrome and is the prototype of a new family of AB(5) cytotoxins. SubAB is a subtilase-like serine protease, and upon uptake by host cells, it is trafficked to ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00801-10
更新日期:2010-11-01 00:00:00
abstract::Mucosal exposure to Escherichia coli elicits an inflammatory response in the urinary tract. Interleukin-6 (IL-6) is secreted into the urine, and polymorphonuclear leukocytes (PMNLs) are recruited to the site of infection. This study analyzed the ability of mucosally administered bacterial components to activate IL-6 a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.12.4357-4362.1991
更新日期:1991-12-01 00:00:00
abstract::Antibodies against feline leukemia virus (FeLV) and the feline oncornavirus-associated cell membrane antigen (FOCMA) were transferred from pregnant cats to their suckling kittens. All of these kittens were protected against infection and oncogenesis by virulent FeLV when challenged at 2 weeks of age. Suckling kittens ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.16.1.54-59.1977
更新日期:1977-04-01 00:00:00
abstract::Despite the high prevalence of cutaneous infections, little is known about the role of host immune responsiveness during Staphylococcus aureus dermatitis. We have recently described a murine model of infectious dermatitis induced by superantigen-producing S. aureus. To assess the role of neutrophils in staphylococcal ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.11.6162-6167.2000
更新日期:2000-11-01 00:00:00
abstract::The leukotrienes and tumor necrosis factor (TNF) play an important role in the pathophysiology of septic shock, in which hypotension, leukopenia, thrombocytopenia, and hemoconcentration are observed. This study was performed to examine the effects of a 5-lipoxygenase inhibitor (AA-861), a selective leukotriene recepto...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.6.2432-2437.1992
更新日期:1992-06-01 00:00:00
abstract::Clostridium perfringens type A food poisoning is the second most commonly identified bacterial food-borne illness. Sporulation contributes to this disease in two ways: (i) most food-poisoning strains form exceptionally resistant spores to facilitate their survival of food-associated stresses, and (ii) the enterotoxin ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00528-10
更新日期:2010-10-01 00:00:00
abstract::Plasmodium ookinetes secrete chitinases to penetrate the acellular, chitin-containing peritrophic matrix of the mosquito midgut en route to invasion of the epithelium. Chitinases are potentially targets that can be used to block malaria transmission. We demonstrate here that chitinases of Plasmodium falciparum and P. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.11.6461-6465.2000
更新日期:2000-11-01 00:00:00
abstract::The selection of influenza B virus recombinants from plaques in bovine kidney cell monolayers is described. Two sets of recombinants were each derived from parents of high and low virulence for humans, respectively. Recombination frequency was apparently high, and reassortment of genes made it possible to obtain atten...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.15.2.347-353.1977
更新日期:1977-02-01 00:00:00
abstract::Seven cathepsin B-like cysteine proteases (CBLs) were identified from the immunoprotective excretory-secretory products of Haemonchus contortus. Two-dimensional (2-D) zymography and biotinylated inhibitors were employed to localize active CBLs in 2-D protein gels. Mass spectrometry provided the identification of AC-4,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.3.1989-1993.2006
更新日期:2006-03-01 00:00:00
abstract::Immune responses of mice to Streptococcus mutans serotype c were analyzed by means of the enzyme-linked immunospot assay to determine the predominant specificities of the antibodies developed. In general, the numbers of splenic antibody-secreting cells correlated with serum antibody levels. A low dose (10(8) CFU) of k...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.53.2.317-323.1986
更新日期:1986-08-01 00:00:00
abstract::The capacity of Candida albicans to switch reversibly between the white phenotype and the opaque phenotype is required for the fungus to mate. It also influences virulence during hematogenously disseminated candidiasis. We investigated the roles of the mating type loci (MTL) and white-opaque switching in the capacity ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00774-17
更新日期:2018-05-22 00:00:00
abstract::Clostridium perfringens delta toxin was selectively cytotoxic for various rabbit leukocyte populations. The sensitivity of these populations to the toxin varied, depending on the tissue from which they were derived, from 28% (appendix) to 41% (bone marrow) and 32% (spleen). Macrophages were uniformly killed by delta t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.38.3.860-864.1982
更新日期:1982-12-01 00:00:00
abstract::Bacteria have evolved strategies to resist killing by antimicrobial peptides (APs), important effectors of innate immunity. The sap (sensitivity to antimicrobial peptides) operon confers resistance to AP-mediated killing of Salmonella. We have recently shown that sapA gene expression is upregulated in the middle ear i...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.1.599-608.2005
更新日期:2005-01-01 00:00:00