The fine specificity, but not the invasion inhibitory activity, of 19-kilodalton merozoite surface protein 1-specific antibodies is associated with resistance to malarial parasitemia in a cross-sectional survey in The Gambia.

abstract：:Attaching and effacing adhesion to epithelial cells is a pathognomonic feature of infection by both enteropathogenic Escherichia coli (EPEC) and certain strains of verocytotoxin-producing E. coli (VTEC). EPEC adhesion to tissue culture epithelial cells results in activation of the phosphatidylinositol pathway, with el...

journal_title：Infection and immunity

authors： Ismaili A,Philpott DJ,Dytoc MT,Sherman PM

更新日期：1995-09-01 00:00:00

abstract：:The leading malaria vaccine candidate, RTS,S, based on the Plasmodium falciparum circumsporozoite protein (CSP), will likely be the first publicly adopted malaria vaccine. However, this and other subunit vaccines, such as virus-vectored thrombospondin-related adhesive protein (TRAP), provide only intermediate to low l...

journal_title：Infection and immunity

authors： Bauza K,Atcheson E,Malinauskas T,Blagborough AM,Reyes-Sandoval A

更新日期：2015-12-14 00:00:00

abstract：:We have previously reported that a wild strain of Francisella tularensis is much less efficiently killed by human polymorphonuclear leukocytes than is an attenuated strain. In the present study, the killing of the attenuated strain was found to be strictly oxygen dependent. The wild and the attenuated strains both ind...

journal_title：Infection and immunity

authors： Löfgren S,Tärnvik A,Thore M,Carlsson J

更新日期：1984-02-01 00:00:00

abstract：:The response of the intracellular pathogen Rhodococcus equi to H(2)O(2) treatment, a situation potentially encountered after the oxidative burst of alveolar macrophages, was analyzed. Compared to other bacteria, including Deinococcus radiodurans, R. equi showed exceptionally high resistance to this stress. A proteomic...

journal_title：Infection and immunity

authors： Benoit S,Benachour A,Taouji S,Auffray Y,Hartke A

更新日期：2002-07-01 00:00:00

abstract：:Two murine monoclonal antibodies (immunoglobulin M) evoked against human kidney tissue were examined for cross-reactivity with group A streptococci. A glomerulus-specific antibody, PMII.40.H.2, cross-reacted in an enzyme-linked immunosorbent assay with purified pepsin-extracted M proteins from type 6 and 12 streptococ...

journal_title：Infection and immunity

authors： Goroncy-Bermes P,Dale JB,Beachey EH,Opferkuch W

更新日期：1987-10-01 00:00:00

abstract：:The superoxide anion (O2-)-generating activity of guinea pig macrophages stimulated by wheat germ agglutinin (WGA), immune complexes, or phorbol myristate acetate (PMA) was studied after short- and long-term exposures of the cells to muramyl dipeptide (MDP) or lipopolysaccharide (LPS). Neither MDP nor LPS alone induce...

journal_title：Infection and immunity

authors： Yagawa K,Kaku M,Ichinose Y,Nagao S,Tanaka A,Tomoda A

更新日期：1984-07-01 00:00:00

abstract：:Passive transfer of antibody may be useful for preexposure prophylaxis against biological agents used as weapons of terror, such as Bacillus anthracis. Studies were performed to evaluate the ability of anthrax antiprotective antigen (anti-PA) and antilethal factor (anti-LF) neutralizing monoclonal antibodies (mAbs) to...

journal_title：Infection and immunity

authors： Staats HF,Alam SM,Scearce RM,Kirwan SM,Zhang JX,Gwinn WM,Haynes BF

更新日期：2007-11-01 00:00:00

abstract：:Yersinia enterocolitica, Yersinia pseudotuberculosis, and Yersinia pestis deliver different Yop (Yersinia outer proteins) effector proteins into mammalian cells by a type III secretion mechanism. Recently, it was shown that Yersinia producing YopT leads to disruption of the actin cytoskeleton of HeLa cells (M. Iriarte...

journal_title：Infection and immunity

authors： Sorg I,Goehring UM,Aktories K,Schmidt G

更新日期：2001-12-01 00:00:00

abstract：:We have cloned chromosomal genes mediating the aerobactin iron transport system from the enteroinvasive strain Escherichia coli 978-77. The physical map of the region spanning the siderophore biosynthesis genes and the upstream portion of the receptor gene in strain 978-77-derived clones was identical to the correspon...

journal_title：Infection and immunity

authors： Marolda CL,Valvano MA,Crosa JH

更新日期：1991-01-01 00:00:00

abstract：:Shiga toxigenic Escherichia coli (STEC) strains are a diverse group of organisms capable of causing severe gastrointestinal disease in humans. Within the STEC family, eae-positive STEC strains, particularly those belonging to serogroups O157 and O111, appear to have greater virulence for humans. However, in spite of b...

journal_title：Infection and immunity

authors： Paton AW,Paton JC

更新日期：1999-11-01 00:00:00

abstract：:We have developed an animal model for studying mycobacterial pathogenesis using Mycobacterium marinum and the goldfish, Carassius auratus. Goldfish are injected intraperitoneally with doses between 10(2) and 10(9) CFU of M. marinum organisms. Depending on the dose of M. marinum organisms administered, an acute or chro...

journal_title：Infection and immunity

authors： Talaat AM,Reimschuessel R,Wasserman SS,Trucksis M

更新日期：1998-06-01 00:00:00

abstract：:We wished to find a simple, biologically relevant method to evaluate the virulence of dengue viruses for human beings. Since cells of mononuclear phagocyte lineage may be important sites of dengue infection in primates, we evaluated the permissiveness of these cells to dengue virus as a correlate of virus virulence. T...

journal_title：Infection and immunity

authors： Halstead SB,Tom MC,Elm JL Jr

更新日期：1981-01-01 00:00:00

abstract：:We demonstrate that 2-month-old female B10.T(6R) mice are highly resistant to systemic infection with the KIM5 strain of Yersinia pestis and that B10.T(6R) mice become susceptible to Y. pestis infection by the age of 5 months. In this study, young (2-month-old) and middle-aged (5- to 12-month-old) B10.T(6R) mice were ...

journal_title：Infection and immunity

authors： Lambert ND,Langfitt DM,Nilles ML,Bradley DS

更新日期：2011-11-01 00:00:00

abstract：:The population structure of the Bacillus cereus group (52 strains of B. anthracis, B. cereus, and B. thuringiensis) was investigated by sequencing seven gene fragments (rpoB, gyrB, pycA, mdh, mbl, mutS, and plcR). Most of the strains were classifiable into two large subgroups in six housekeeping gene trees but not in ...

journal_title：Infection and immunity

authors： Ko KS,Kim JW,Kim JM,Kim W,Chung SI,Kim IJ,Kook YH

更新日期：2004-09-01 00:00:00

abstract：:A method was developed to study the adhesion of Streptococcus pneumoniae to human pharyngeal epithelial cells. Epithelial cells from healthy persons, pneumococcal strains from patients with otitis media, meningitis, or septicemia, and pneumococcal cells from the nasopharynx of healthy carriers were used. Adhesion was ...

journal_title：Infection and immunity

authors： Andersson B,Eriksson B,Falsen E,Fogh A,Hanson LA,Nylén O,Peterson H,Svanborg Edén C

更新日期：1981-04-01 00:00:00

abstract：:We undertook a morphological and immunochemical comparison of purified outer membrane antigens from oral and nonoral isolates of Bacteroides asaccharolyticus. Electron micrographs of thin sections of whole bacteria revealed a compact, electron-dense capsule external to the outer membrane of oral strains. A loose, web-...

journal_title：Infection and immunity

authors： Mansheim BJ,Coleman SE

更新日期：1980-02-01 00:00:00

abstract：:The role of CD19(+) CD5(+) and CD19(+) CD5(-) B cell subpopulations in the antibody response to pneumococcal capsular polysaccharides (caps-PSs) is controversial. In the present study, we evaluated the role of human CD19(+) CD5(+) and CD19(+) CD5(-) cell populations in the serotype-specific antibody response to caps-P...

journal_title：Infection and immunity

authors： Moens L,Verbinnen B,Covens K,Wuyts G,Johnson M,Roalfe L,Goldblatt D,Meyts I,Bossuyt X

更新日期：2015-07-01 00:00:00

abstract：:The rfb region from Vibrio cholerae O139 strain MO45 was cloned from cosmid gene banks established in Escherichia coli HB101, using an immunoblot assay for screening of the correct clones. Immunoblot analysis of lipopolysaccharide (LPS) preparations revealed the presence of two types of positive clones: (i) those expr...

journal_title：Infection and immunity

authors： Favre D,Cryz SJ Jr,Viret JF

更新日期：1996-09-01 00:00:00

abstract：:Macrophage recognition of Salmonella enterica serovar Typhimurium leads to a cascade of signaling events, including the activation of Src family and Syk kinases and the production of reactive oxygen species (ROS), which are critical for host innate defense during early stages of bacterial infection. ROS production dep...

journal_title：Infection and immunity

authors： Charles JF,Humphrey MB,Zhao X,Quarles E,Nakamura MC,Aderem A,Seaman WE,Smith KD

更新日期：2008-06-01 00:00:00

abstract：:The protection and immune response to infection caused by the parasite Schistosoma mansoni were studied by comparison of two murine irradiated-vaccine models. Mice were exposed from 1 to 4 times to infective-stage cercariae attenuated with either a moderate dose (15 kilorads) or a high dose (50 kilorads) of radiation....

journal_title：Infection and immunity

authors： Reynolds SR,Harn DA

更新日期：1992-01-01 00:00:00

abstract：:Streptococcus equi is the causative agent of strangles, the most frequently diagnosed infectious disease of horses worldwide. The disease is characterized by abscessation and swelling of the lymph nodes of the head and neck, which can literally strangle the horse to death. S. equi produces four recently acquired phage...

journal_title：Infection and immunity

authors： Paillot R,Robinson C,Steward K,Wright N,Jourdan T,Butcher N,Heather Z,Waller AS

更新日期：2010-04-01 00:00:00

abstract：:An improved enterocyte adhesion assay has been used to examine a collection of 44 strains of enterotoxigenic Escherichia coli (ETEC) for their ability to adhere to the brush border of isolated human duodenal enterocytes. Fourteen strains showed good adhesion; in each case the ability to adhere correlated with the prod...

journal_title：Infection and immunity

authors： Knutton S,Lloyd DR,Candy DC,McNeish AS

更新日期：1985-06-01 00:00:00

abstract：:Escherichia coli heat-stable enterotoxin (ST) binds to receptors on rat intestinal cells and brush border membranes (BBM). We devised experiments to examine the reversibility of ST binding. We found that both 125I-labeled ST and native ST were spontaneously dissociable from the BBM receptor. Radiolabeled ST bound to B...

journal_title：Infection and immunity

authors： Cohen MB,Thompson MR,Overmann GJ,Giannella RA

更新日期：1987-02-01 00:00:00

abstract：:Newly hatched chicks were vaccinated orally with a genetically defined Salmonella enteritidis aroA candidate, strain CVL30. In chickens immunized with 10(5) or 10(9) CFU and challenged by the intravenous route with 10(8) CFU of S. enteritidis 109 Nalr at 8 weeks old, there were similar reductions in colonization of th...

journal_title：Infection and immunity

authors： Cooper GL,Venables LM,Woodward MJ,Hormaeche CE

更新日期：1994-11-01 00:00:00

abstract：:Tuberculosis continues to ravage humanity, killing 2 million people yearly. Most cases occur in areas of the world to which the disease is endemic, where almost everyone is vaccinated early in life with Mycobacterium bovis BCG, the currently available vaccine against tuberculosis. Thus, while more-potent vaccines are ...

journal_title：Infection and immunity

authors： Horwitz MA,Harth G,Dillon BJ,Maslesa-Galic S

更新日期：2005-08-01 00:00:00

abstract：:CD8+ T cells are essential for protection against mycobacteria, as is clearly demonstrated by the fatal outcome of experimental infection of beta-2 microglobulin knockout mice. However, the mechanisms and antigens (Ags) leading to CD8+ T-cell activation and regulation have been poorly characterized. Here we show that,...

journal_title：Infection and immunity

authors： Denis O,Lozes E,Huygen K

更新日期：1997-02-01 00:00:00

abstract：:The toxicity of Chlamydia trachomatis was studied with mouse peritoneal macrophage culture. Inoculation of 30 inclusion-forming units of trachoma B/TW-5/OT organisms and 250 inclusion-forming units of lymphogranuloma venereum L2/434/Bu organisms per cell caused immediated toxicity, with the killing of 40 to 90% of the...

journal_title：Infection and immunity

authors： Kuo CC

更新日期：1978-06-01 00:00:00

abstract：:Human serum at low concentrations inhibits the growth of Cryptococcus neoformans in vitro. Fractionation of serum yielded a purified inhibitory protein with a molecular mass of approximately 81.8 kDa, a pI of approximately 6.2, and an amino acid sequence that matched that of human transferrin. The inhibitory activity ...

journal_title：Infection and immunity

authors： Sridhar S,Ahluwalia M,Brummer E,Stevens DA

更新日期：2000-06-01 00:00:00

abstract：:Defining the pattern of lymphokine production associated with Brucella abortus is critical for advancing the development of B. abortus as a vaccine carrier. In the present study we investigated the ability of heat-inactivated B. abortus or lipopolysaccharide from B. abortus to induce lymphokine production from purifie...

journal_title：Infection and immunity

authors： Zaitseva MB,Golding H,Betts M,Yamauchi A,Bloom ET,Butler LE,Stevan L,Golding B

更新日期：1995-07-01 00:00:00

abstract：:Several trivalent cations, including lanthanum (La3+), inhibited the secretion (enterosorption) induced by the enterotoxins of Vibrio cholerae and Escherichia coli in the rabbit ileum in vivo. High concentrations (greater than 10 mM) of La3+ were required to inhibit cholera enterotoxin (CE)-induced enterosorption, pro...

journal_title：Infection and immunity

authors： Leitch GJ,Amer MS

更新日期：1975-05-01 00:00:00