Characterization of an anticryptococcal protein isolated from human serum.

Abstract:

:Human serum at low concentrations inhibits the growth of Cryptococcus neoformans in vitro. Fractionation of serum yielded a purified inhibitory protein with a molecular mass of approximately 81.8 kDa, a pI of approximately 6.2, and an amino acid sequence that matched that of human transferrin. The inhibitory activity and that of apotransferrin and 5% human serum were reversed by 10 microM freshly prepared FeCl(3).

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Sridhar S,Ahluwalia M,Brummer E,Stevens DA

doi

10.1128/iai.68.6.3787-3791.2000

keywords:

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

3787-91

issue

6

eissn

0019-9567

issn

1098-5522

journal_volume

68

pub_type

杂志文章
  • Type-specific contributions to chromosome size differences in Escherichia coli.

    abstract::The Escherichia coli genome varies in size from 4.5 to 5.5 Mb. It is unclear whether this variation may be distributed finely throughout the genome or is concentrated at just a few chromosomal loci or on plasmids. Further, the functional correlates of size variation in different genome copies are largely unexplored. W...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.67.1.230-236.1999

    authors: Rode CK,Melkerson-Watson LJ,Johnson AT,Bloch CA

    更新日期:1999-01-01 00:00:00

  • Immunoglobulin and complement in tissues of mice infected with Nocardia brasiliensis.

    abstract::Two weeks after mice had been infected in the footpad with cells of Nocardia brasiliensis, immunoglobulin and C3 deposits were observed in tissue from the inoculation site. Both immunoglobulin and C3 were found in the actinomycotic granules that characterize the mycetoma and in the surrounding inflammatory zones, in w...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.40.3.1218-1222.1983

    authors: Conde C,Mancilla R,Fresan M,Ortiz-Ortiz L

    更新日期:1983-06-01 00:00:00

  • Clonal and antigenic analysis of serogroup A Neisseria meningitidis with particular reference to epidemiological features of epidemic meningitis in the People's Republic of China.

    abstract::Representative strains of serogroup A Neisseria meningitidis were chosen from all major meningitis epidemics worldwide since 1960 and subjected to analysis for the electrophoretic variation of 15 cytoplasmic allozymes and four outer membrane proteins. The 290 strains defined 84 unique electrophoretic types which were ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.60.12.5267-5282.1992

    authors: Wang JF,Caugant DA,Li X,Hu X,Poolman JT,Crowe BA,Achtman M

    更新日期:1992-12-01 00:00:00

  • Antibody to virus components in volunteers experimentally infected with human coronavirus 229E group viruses.

    abstract::Antibody rises to various virus subcomponents were measured by enzyme-linked immunosorbent assay in the paired sera of volunteers experimentally infected with human coronavirus 229E group viruses. Most of the antibody made during infection was directed against the virus surface projections, with only small amounts of ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.31.3.845-849.1981

    authors: Macnaughton MR,Hasony HJ,Madge MH,Reed SE

    更新日期:1981-03-01 00:00:00

  • Some structural and biological properties of Brucella endotoxin.

    abstract::Hot phenol-water extraction of smooth Brucella abortus and B. melitensis cells yielded a toxic fraction which was recovered from the phenol phase (fraction 5). Chemically, fractions 5 from both Brucella species were lipid-carbohydrate-protein-2 keto-3-deoxyoctulosonic acid complexes which were stable to heat and resis...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:

    authors: Leong D,Diaz R,Milner K,Rudbach J,Wilson JB

    更新日期:1970-02-01 00:00:00

  • Production of FaeG, the major subunit of K88 fimbriae, in transgenic tobacco plants and its immunogenicity in mice.

    abstract::Transgenic tobacco plants stably expressing recombinant FaeG, which is the major subunit and adhesin of K88ad fimbriae, were obtained. Analysis of sera from immunized mice indicates that in mice, the immunogenicity induced by plant-derived FaeG protein is comparable to that generated with traditional approaches. ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.71.9.5436-5439.2003

    authors: Huang Y,Liang W,Pan A,Zhou Z,Huang C,Chen J,Zhang D

    更新日期:2003-09-01 00:00:00

  • Antibodies to the N-terminal block 2 of Plasmodium falciparum merozoite surface protein 1 are associated with protection against clinical malaria.

    abstract::This longitudinal prospective study shows that antibodies to the N-terminal block 2 region of the Plasmodium falciparum merozoite surface protein 1 (MSP-1) are associated with protection against clinical malaria in an area of stable but seasonal malaria transmission of Ghana. Antibodies to the block 2 region of MSP-1 ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.72.11.6492-6502.2004

    authors: Cavanagh DR,Dodoo D,Hviid L,Kurtzhals JA,Theander TG,Akanmori BD,Polley S,Conway DJ,Koram K,McBride JS

    更新日期:2004-11-01 00:00:00

  • Genetic stability of Borrelia burgdorferi recovered from chronically infected immunocompetent mice.

    abstract::Persistent infection with Borrelia burgdorferi in the presence of a vigorous host immune response has been demonstrated in humans and in animal models of Lyme disease. Long-term persistence of B. burgdorferi was documented recently in our studies of BALB/c and C3H mice infected with cloned and uncloned strains of B. b...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.62.8.3521-3527.1994

    authors: Persing DH,Mathiesen D,Podzorski D,Barthold SW

    更新日期:1994-08-01 00:00:00

  • Effect of environmental pH on enzyme activity and growth of Bacteroides gingivalis W50.

    abstract::Since the pH of the gingival crevice increases from below neutrality in health to above pH 8 in disease, we decided to investigate the effect of environmental pH on the growth and enzyme activity of Bacteroides gingivalis W50. Cells were grown in a chemostat under hemin-excess conditions over a range of pH values; sta...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.56.5.1096-1100.1988

    authors: McDermid AS,McKee AS,Marsh PD

    更新日期:1988-05-01 00:00:00

  • Depression of vaccinal immunity to Marek's disease by infection with reticuloendotheliosis virus.

    abstract::The effect of infection with low-virulence, tissue culture-propagated strains of reticuloendotheliosis virus (REV) on protective vaccinal immunity against Marek's disease (MD) lymphomas was investigated. Vaccinated chickens inoculated at hatching with greater than 10(4) focus-forming units of REV and challenged with M...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.26.1.90-98.1979

    authors: Witter RL,Lee LF,Bacon LD,Smith EJ

    更新日期:1979-10-01 00:00:00

  • Proteome analysis of coinfection of epithelial cells with Filifactor alocis and Porphyromonas gingivalis shows modulation of pathogen and host regulatory pathways.

    abstract::Changes in periodontal status are associated with shifts in the composition of the bacterial community in the periodontal pocket. The relative abundances of several newly recognized microbial species, including Filifactor alocis, as-yet-unculturable organisms, and other fastidious organisms have raised questions on th...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.01727-14

    authors: Aruni AW,Zhang K,Dou Y,Fletcher H

    更新日期:2014-08-01 00:00:00

  • Local host response to chlamydial urethral infection in male guinea pigs.

    abstract::Very little is known about the host response to chlamydial genital infection in the male, particularly about the nature of the local response in the urethra. In this study, the pathological and immunologic responses to urethral infection of the male guinea pig with Chlamydia caviae (Chlamydophila caviae) were characte...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.01339-09

    authors: Wang Y,Nagarajan U,Hennings L,Bowlin AK,Rank RG

    更新日期:2010-04-01 00:00:00

  • Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia.

    abstract::Dendritic cell interactions with pathogenic microbes initiate and direct the development of subsequent adaptive responses. The protozoan pathogen Giardia lamblia infects the mammalian small intestine, leading to nutrient malabsorption and diarrhea but rarely causing inflammation. In order to begin to understand how th...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.00718-08

    authors: Kamda JD,Singer SM

    更新日期:2009-02-01 00:00:00

  • Etiology of chronic pneumonia in rats and a study of the experimental disease in mice.

    abstract::The lungs of conventional rats with chronic pneumonia contained Streptobacillus moniliformis and Mycoplasma pulmonis. These organisms singly and in combination failed to produce lung disease when inoculated into specific pathogen-free rats. On the other hand, diseased lung homogenate not containing cultivable organism...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.6.1.83-91.1972

    authors: Gay FW,Maguire ME,Baskerville A

    更新日期:1972-07-01 00:00:00

  • Different regions of the malaria merozoite surface protein 1 of Plasmodium chabaudi elicit distinct T-cell and antibody isotype responses.

    abstract::In this study we have investigated the antibody and CD4 T-cell responses to the well-characterized malaria vaccine candidate MSP-1 during the course of a primary Plasmodium chabaudi chabaudi (AS) infection. Specific antibody responses can be detected within the first week of infection, and CD4 T cells can be detected ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.69.4.2245-2251.2001

    authors: Quin SJ,Langhorne J

    更新日期:2001-04-01 00:00:00

  • CyaC-mediated activation is important not only for toxic but also for protective activities of Bordetella pertussis adenylate cyclase-hemolysin.

    abstract::Bordetella pertussis adenylate cyclase-hemolysin (AC-Hly), encoded by the cyaA gene, belongs to the RTX family of toxins with extensive glycine-rich repeats in the carboxy-terminal portion. AC-Hly possesses both adenylate cyclase toxic and hemolytic activities that depend on a posttranslational modification mediated b...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.61.9.3583-3589.1993

    authors: Betsou F,Sebo P,Guiso N

    更新日期:1993-09-01 00:00:00

  • Regulation of surface presentation of IcsA, a Shigella protein essential to intracellular movement and spread, is growth phase dependent.

    abstract::After lysing the phagocytic vacuole, Shigella spp. accumulate filaments of polymerized actin on their surface at one pole, leading to the formation of actin tails that enable them to move through the cytoplasm. We have recently demonstrated that the Shigella protein IcsA is located at the pole that is adjacent to the ...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.62.12.5664-5668.1994

    authors: Goldberg MB,Theriot JA,Sansonetti PJ

    更新日期:1994-12-01 00:00:00

  • Biologically active antibodies elicited by a synthetic circumsporozoite peptide of Plasmodium knowlesi administered in saline with a muramyl dipeptide derivative.

    abstract::A synthetic peptide whose sequence was derived from the circumsporozoite protein of Plasmodium knowlesi coupled to bovine gamma globulin has been shown to be immunogenic when administered with Freund complete adjuvant. The present experiments were designed to test the immunogenicity of the peptide when attached to a t...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.48.3.839-842.1985

    authors: Clough ER,Audibert FM,Barnwell JW,Schlesinger DH,Arnon R,Chedid LA

    更新日期:1985-06-01 00:00:00

  • Purification and characterization of an enzyme produced by Treponema denticola capable of hydrolyzing synthetic trypsin substrates.

    abstract::An enzyme from Treponema denticola that hydrolyzes a synthetic trypsin substrate, N-alpha-benzoyl-L-arginine-p-nitroanilide (BAPNA), was purified to near homogeneity, as judged by gel electrophoresis. The molecular weight of the enzyme was estimated to be ca. 69,000 by sodium dodecyl sulfate-polyacrylamide gel electro...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.53.1.213-220.1986

    authors: Ohta K,Makinen KK,Loesche WJ

    更新日期:1986-07-01 00:00:00

  • Variability of low-molecular-weight, heat-modifiable outer membrane proteins of Neisseria meningitidis.

    abstract::Analysis of major outer membrane protein (MOMP) profiles of various meningococci by sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (SDS-PAGE) revealed the presence of 0 to 2 low-molecular-weight, heat-modifiable MOMPs (molecular weight, 25,000 to 32,000) and 1 to 3 high-molecular-weight MOMPs (molecul...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:

    authors: Poolman JT,de Marie S,Zanen HC

    更新日期:1980-12-01 00:00:00

  • Motility is crucial for the infectious life cycle of Borrelia burgdorferi.

    abstract::The Lyme disease spirochete, Borrelia burgdorferi, exists in a zoonotic cycle involving an arthropod tick and mammalian host. Dissemination of the organism within and between these hosts depends upon the spirochete's ability to traverse through complex tissues. Additionally, the spirochete outruns the host immune cell...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.01228-12

    authors: Sultan SZ,Manne A,Stewart PE,Bestor A,Rosa PA,Charon NW,Motaleb MA

    更新日期:2013-06-01 00:00:00

  • Purification of Plasmodium Sporozoites Enhances Parasite-Specific CD8+ T Cell Responses.

    abstract::Malaria infection caused by Plasmodium parasites continues to cause enormous morbidity and mortality in areas where it is endemic, and there is no licensed vaccine capable of inducing sterile protection. Hyperimmunization with attenuated whole sporozoites can induce sterile protective immune responses targeting preery...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.01439-15

    authors: Billman ZP,Seilie AM,Murphy SC

    更新日期:2016-07-21 00:00:00

  • Humoral antibody response against Bacteroides gingivalis-specific antigen recognized by monoclonal antibody in adult periodontal patients.

    abstract::An antigen recognized by monoclonal antibody specific for Bacteroides gingivalis was purified in the presence of 0.5% (wt/vol) beta-octyl-glucoside by immunoadsorbent column chromatography. The purified antigen was homogeneous as judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and silver...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.53.2.366-371.1986

    authors: Miyoshi T,Hanazawa S,Hirose K,Saitoh K,Amano S,Ohmori Y,Kitano S

    更新日期:1986-08-01 00:00:00

  • PmpG303-311, a protective vaccine epitope that elicits persistent cellular immune responses in Chlamydia muridarum-immune mice.

    abstract::Urogenital Chlamydia serovars replicating in reproductive epithelium pose a unique challenge to host immunity and vaccine development. Previous studies have shown that CD4 T cells are necessary and sufficient to clear primary Chlamydia muridarum genital tract infections in the mouse model, making a protective CD4 T ce...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.06339-11

    authors: Johnson RM,Yu H,Kerr MS,Slaven JE,Karunakaran KP,Brunham RC

    更新日期:2012-06-01 00:00:00

  • Bacteriological study of periodontal lesions in two sisters with juvenile periodontitis and their mother.

    abstract::A total of five bacteriological samples from the periodontal pockets of two sisters with localized juvenile periodontitis and their mother with advanced periodontitis was studied. Gram-negative anaerobic rods were predominant in the samples. Bacteroides intermedius and Bacteroides loescheii were the most predominant s...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.45.1.118-121.1984

    authors: Okuda K,Naito Y,Ohta K,Fukumoto Y,Kimura Y,Ishikawa I,Kinoshita S,Takazoe I

    更新日期:1984-07-01 00:00:00

  • Experimental otitis media after nasal inoculation of Streptococcus pneumoniae and influenza A virus in chinchillas.

    abstract::Otitis media developed in 67% of chinchillas inoculated intranasally with type 7 Streptococcus pneumoniae and influenza A virus. Only 4% of chinchillas inoculated with influenza alone and 21% of chinchillas inoculated with S. pneumoniae alone developed otitis media. Among the chinchillas that developed otitis media af...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:

    authors: Giebink GS,Berzins IK,Marker SC,Schiffman G

    更新日期:1980-11-01 00:00:00

  • Lymphocyte function-associated antigen 1 is a receptor for Pasteurella haemolytica leukotoxin in bovine leukocytes.

    abstract::Pasteurella (Mannheimia) haemolytica leukotoxin (Lkt) causes cell type- and species-specific effects in ruminant leukocytes. Recent studies indicate that P. haemolytica Lkt binds to bovine CD18, the common subunit of all beta2 integrins. We designed experiments with the following objectives: to identify which member o...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.68.1.72-79.2000

    authors: Jeyaseelan S,Hsuan SL,Kannan MS,Walcheck B,Wang JF,Kehrli ME,Lally ET,Sieck GC,Maheswaran SK

    更新日期:2000-01-01 00:00:00

  • Cloning and expression in Escherichia coli of the Ibc protein genes of group B streptococci: binding of human immunoglobulin A to the beta antigen.

    abstract::Total-cell DNA isolated from a highly virulent serotype Ic strain of a group B streptococcus was used to construct a gene bank with bacteriophage lambda L47.1 in Escherichia coli K-12. Recombinant phage plaques in the bank were immunoblotted by using anti-alpha- and anti-beta-specific antibodies directed towards the I...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.55.5.1151-1155.1987

    authors: Cleat PH,Timmis KN

    更新日期:1987-05-01 00:00:00

  • Role of cytokines and major histocompatibility complex restriction in mouse resistance to infection with a natural recombinant strain (type I-III) of Toxoplasma gondii.

    abstract::Herein we characterized various genetic markers and the biological behavior of a natural recombinant strain of Toxoplasma gondii (P-Br). From nine genetic markers analyzed, three (B1, ROP1, and SAG1) and three (cS10-A6, GRA6, and SAG3) markers belong to parasites from the type I and type III lineages, respectively. Th...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/iai.71.11.6392-6401.2003

    authors: Fux B,Rodrigues CV,Portela RW,Silva NM,Su C,Sibley D,Vitor RW,Gazzinelli RT

    更新日期:2003-11-01 00:00:00

  • Localization of major histocompatibility complex class II molecules in phagolysosomes of murine macrophages infected with Leishmania amazonensis.

    abstract::Leishmania-infected macrophages are potential antigen-presenting cells for CD4+ T lymphocytes, which recognize parasite antigens bound to major histocompatibility complex class II molecules (Ia). However, the intracellular sites where Ia and antigens may interact are far from clear, since parasites grow within the mod...

    journal_title:Infection and immunity

    pub_type: 杂志文章

    doi:10.1128/IAI.59.3.764-775.1991

    authors: Antoine JC,Jouanne C,Lang T,Prina E,de Chastellier C,Frehel C

    更新日期:1991-03-01 00:00:00