Treatment of Dextran Sulfate Sodium-Induced Colitis with Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Inhibitor MI-2 Is Associated with Restoration of Gut Immune Function and the Microbiota.


:Disruption of the healthy intestinal microbiome and homeostasis of the intestinal immune system, which are closely interactive, are two key factors for ulcerative colitis. Here, we show that MI-2, a selective inhibitor of mucosa-associated lymphoid tissue lymphoma translocation-1 (MALT1), alleviated excessive inflammatory responses and was associated with restoration of healthy intestinal microbiome in mice suffering from dextran sulfate sodium (DSS)-induced colitis. We found that the diversity of intestinal microbiome of mice with DSS-induced colitis was significantly lower than that of healthy mice. However, MI-2 treatment in mice with DSS-induced colitis resulted in restored microbially diverse populations. To understand the possibility of the beneficial effect of the restored microbially diverse populations of MI-2-treated mice with DSS-induced colitis, we showed that inserting fecal microbiota from MI-2-treated mice with DSS-induced colitis and healthy control mice into mice with DSS-induced colitis could alleviate symptoms of colitis. The possibility of MI-2 treatment in DSS-induced colitis, associated with restoration of healthy microbially diverse populations in addition to reshaping host immune modulating capacity by reducing inflammatory cytokines (tumor necrosis factor alpha, interleukin-1β [IL-1β], IL-17α, and IL-22), may be considered therapeutic for ulcerative colitis.


Infect Immun


Infection and immunity


Lee KW,Kim M,Lee CH




Has Abstract


2018-11-20 00:00:00












  • Identification of a genetic locus essential for capsule sialylation in type III group B streptococci.

    abstract::The type III capsular polysaccharide of group B streptococci (GBS) consists of a linear backbone with short side chains ending in residues of N-acetylneuraminic acid, or sialic acid. The presence of sialic acid on the surface of the organism inhibits activation of the alternative pathway of complement and is thought t...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Wessels MR,Haft RF,Heggen LM,Rubens CE

    更新日期:1992-02-01 00:00:00

  • Carboxypeptidases B of Anopheles gambiae as targets for a Plasmodium falciparum transmission-blocking vaccine.

    abstract::Anopheles gambiae is the major African vector of Plasmodium falciparum, the most deadly species of human malaria parasite and the most prevalent in Africa. Several strategies are being developed to limit the global impact of malaria via reducing transmission rates, among which are transmission-blocking vaccines (TBVs)...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Lavazec C,Boudin C,Lacroix R,Bonnet S,Diop A,Thiberge S,Boisson B,Tahar R,Bourgouin C

    更新日期:2007-04-01 00:00:00

  • Molecular characterization of the Escherichia coli asymptomatic bacteriuria strain 83972: the taming of a pathogen.

    abstract::Escherichia coli 83972 is a clinical asymptomatia bacteriuric isolate that is able to colonize the human urinary bladder without inducing an immune response. Here we demonstrate that one of the mechanisms by which this strain has become attenuated is through the mutation of its genes encoding type 1 and P fimbriae. ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Klemm P,Roos V,Ulett GC,Svanborg C,Schembri MA

    更新日期:2006-01-01 00:00:00

  • Solubilization and partial characterization of the intestinal receptor for Escherichia coli heat-stable enterotoxin.

    abstract::Binding of Escherichia coli strain 431 heat-stable enterotoxin (STa) and activation of intestinal particulate guanylate cyclase by E. coli STa were studied with rat intestinal epithelial cells and brush border membranes (BBMs). The rates of guanylate cyclase stimulation by 431 STa in cells and BBMs were rapid, with ma...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Dreyfus LA,Robertson DC

    更新日期:1984-11-01 00:00:00

  • Detection of listeriolysin, the thiol-dependent hemolysin in Listeria monocytogenes, Listeria ivanovii, and Listeria seeligeri.

    abstract::The listeriolysin gene from a weakly hemolytic but virulent strain of Listeria monocytogenes serotype 1/2a was cloned in Escherichia coli K-12. Recombinants were identified on the basis of their cross-reactivities to hyperimmune antisera raised against streptolysin O and listeriolysin. Low levels of hemolytic activity...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Leimeister-Wächter M,Chakraborty T

    更新日期:1989-08-01 00:00:00

  • Virulence of the Melioidosis Pathogen Burkholderia pseudomallei Requires the Oxidoreductase Membrane Protein DsbB.

    abstract::The naturally antibiotic-resistant bacterium Burkholderia pseudomallei is the causative agent of melioidosis, a disease with stubbornly high mortality and a complex, protracted treatment regimen. The worldwide incidence of melioidosis is likely grossly underreported, though it is known to be highly endemic in northern...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: McMahon RM,Ireland PM,Sarovich DS,Petit G,Jenkins CH,Sarkar-Tyson M,Currie BJ,Martin JL

    更新日期:2018-04-23 00:00:00

  • Protection against experimental Bordetella bronchiseptica infection in mice by active immunization with killed vaccine.

    abstract::Mice immunized with a killed vaccine of phase I Bordetella bronchiseptica were challenged with various numbers of virulent B. bronchiseptica by intraperitoneal, intracerebral, or intranasal routes. The course of infection was compared among these routes, and the protective effect of vaccination was quantitatively anal...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Sekiya K,Kawahira M,Nakase Y

    更新日期:1983-08-01 00:00:00

  • Rabbit intestinal fluid stimulation by an enterotoxigenic factor of Staphylococcus aureus.

    abstract::An exoprotein of Staphylococcus aureus 100 that elicited a positive ileal loop response in the rabbit model was investigated in this study. The protein, as it occurred in the culture supernatant fluid, could be detected initially in the late log phase of growth under aerobic and anaerobic conditions. It was stable und...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Koupal A,Deibel RH

    更新日期:1977-11-01 00:00:00

  • The kinetoplastid membrane protein 11 of Leishmania donovani and African trypanosomes is a potent stimulator of T-lymphocyte proliferation.

    abstract::Kinetoplastid membrane protein 11 (KMP-11) from Leishmania donovani is an abundant 11-kDa surface membrane glycoprotein. Lymph node cells from mice of six different H-2 haplotypes immunized with KMP-11 or with L. donovani promastigotes were stimulated to proliferate in vitro KMP-11. Primed purified T cells required an...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Tolson DL,Jardim A,Schnur LF,Stebeck C,Tuckey C,Beecroft RP,Teh HS,Olafson RW,Pearson TW

    更新日期:1994-11-01 00:00:00

  • Essential role of chitinase in the development of the filarial nematode Acanthocheilonema viteae.

    abstract::Chitinases of pathogens have been proposed as potential targets of vaccines or specific inhibitors. We studied the genomic organization, transcript levels, developmental expression, and biological function of chitinases in the rodent filarial nematode Acanthocheilonema viteae, a model organism for human-pathogenic fil...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Tachu B,Pillai S,Lucius R,Pogonka T

    更新日期:2008-01-01 00:00:00

  • Modulation of host cytoskeleton function by the enteropathogenic Escherichia coli and Citrobacter rodentium effector protein EspG.

    abstract::EspG is a conserved protein encoded by the locus of enterocyte effacement (LEE) of attaching and effacing (A/E) pathogens, including enteropathogenic and enterohemorrhagic Escherichia coli and Citrobacter rodentium. EspG is delivered into infected host cells by a type III secretion system. The role of EspG in virulenc...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Hardwidge PR,Deng W,Vallance BA,Rodriguez-Escudero I,Cid VJ,Molina M,Finlay BB

    更新日期:2005-05-01 00:00:00

  • Scanning electron microscopic study of virulent and avirulent colonies of Neisseria gonorrhoeae.

    abstract::A preparation procedure for scanning electron microscopy was developed by which gononcoccal colonies can be studied directly on the agar surface. After glutaraldehyde fixation directly in petri dishes, small agar pieces were cut out and dehydrated stepwise in increasing concentrations of ethanol. The blocks were there...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Elmros T,Hörstedt P,Winblad B

    更新日期:1975-09-01 00:00:00

  • Aggregation and adherence of Streptococcus sanguis: role of human salivary immunoglobulin A.

    abstract::Fourteen freshly isolated strains of Streptococcus sanguis were obtained from the dental plaque of five healthy adults. Whole saliva was collected concomitant with the plaque isolates from the five subjects, and a second whole saliva sample was collected 10 weeks later. All possible combinations of the first five sali...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Liljemark WF,Bloomquist CG,Ofstehage JC

    更新日期:1979-12-01 00:00:00

  • Pathogen and host differences in bacterial adherence to human buccal epithelial cells in a northeast Brazilian community.

    abstract::The adherence of several strains of Escherichia coli to human buccal epithelial cells was studied, using cells obtained from five groups: healthy adults, healthy children, children with acute diarrhea, children with persistent diarrhea associated with cryptosporidial parasites, and children with noncryptosporidial per...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Walser BL,Newman RD,Lima AA,Guerrant RL

    更新日期:1992-11-01 00:00:00

  • Shedding of tumor necrosis factor receptor 1 induced by protein A decreases tumor necrosis factor alpha availability and inflammation during systemic Staphylococcus aureus infection.

    abstract::Staphylococcus aureus infections are an important public health concern due to their increasing incidence and high rates of mortality. The success of S. aureus as a pathogen is highly related to its enormous capacity to evade the host immune response. The critical role of tumor necrosis factor alpha (TNF-α) in the ini...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Giai C,Gonzalez C,Ledo C,Garofalo A,Di Genaro MS,Sordelli DO,Gomez MI

    更新日期:2013-11-01 00:00:00

  • Primary murine Chlamydia trachomatis pneumonia in B-cell-deficient mice.

    abstract::Mice were rendered deficient in B-cell activity by treatment with anti-mu antibody from birth. These animals were then infected intranasally with murine Chlamydia trachomatis (murine pneumonitis agent [MoPn]). They produced neither local nor systemic antibody to MoPn but had intact delayed-type hypersensitivity to MoP...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Williams DM,Grubbs B,Schachter J

    更新日期:1987-10-01 00:00:00

  • Specific binding of human fibrinogen fragment D to Aspergillus fumigatus conidia.

    abstract::The interaction of purified human fibrinogen with Aspergillus fumigatus conidia was investigated by immunofluorescence and electron microscopy and binding assays with radiolabeled proteins. We described the localization of the binding sites on the A. fumigatus conidia and on the fibrinogen molecule and determined the ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Annaix V,Bouchara JP,Larcher G,Chabasse D,Tronchin G

    更新日期:1992-05-01 00:00:00

  • Oral immunization of mice with a live recombinant Yersinia enterocolitica O:9 strain that produces the cholera toxin B subunit.

    abstract::The 70-kilobase pYV plasmid of Yersinia enterocolitica encodes a set of proteins called Yops that are produced during infection. To use Y. enterocolitica as a live carrier to present the cholera toxin B (CT-B) subunit to the immune system, we constructed an operon fusion between ctxB and the yop51 gene. This operon fu...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Sory MP,Hermand P,Vaerman JP,Cornelis GR

    更新日期:1990-08-01 00:00:00

  • Role of Vibrio cholerae neuraminidase in the function of cholera toxin.

    abstract::Vibrio cholerae neuraminidase (NANase) is hypothesized to act synergistically with cholera toxin (CT) and increase the severity of a secretory response by increasing the binding and penetration of CT to enterocytes. To test this hypothesis, the NANase gene (nanH) from V. cholerae Ogawa 395 was first cloned and sequenc...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Galen JE,Ketley JM,Fasano A,Richardson SH,Wasserman SS,Kaper JB

    更新日期:1992-02-01 00:00:00

  • In vitro and in vivo characterization of anthrax anti-protective antigen and anti-lethal factor monoclonal antibodies after passive transfer in a mouse lethal toxin challenge model to define correlates of immunity.

    abstract::Passive transfer of antibody may be useful for preexposure prophylaxis against biological agents used as weapons of terror, such as Bacillus anthracis. Studies were performed to evaluate the ability of anthrax antiprotective antigen (anti-PA) and antilethal factor (anti-LF) neutralizing monoclonal antibodies (mAbs) to...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Staats HF,Alam SM,Scearce RM,Kirwan SM,Zhang JX,Gwinn WM,Haynes BF

    更新日期:2007-11-01 00:00:00

  • Apoptosis of renal cortical cells in the hemolytic-uremic syndrome: in vivo and in vitro studies.

    abstract::This study examined apoptotic cell death associated with Shiga-like toxin (Stx)-producing Escherichia coli. Renal cortices from three children with postenteropathic hemolytic-uremic syndrome (HUS) and from mice infected with E. coli O157:H7 and pediatric renal tubular epithelial cells stimulated with Stx and E. coli O...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Karpman D,Håkansson A,Perez MT,Isaksson C,Carlemalm E,Caprioli A,Svanborg C

    更新日期:1998-02-01 00:00:00

  • Characterization of an 18,000-molecular-weight outer membrane protein of Haemophilus ducreyi that contains a conserved surface-exposed epitope.

    abstract::Identification of antigenically conserved surface components of Haemophilus ducreyi may facilitate the development of reagents to diagnose and prevent chancroid. A hybridoma derived from a mouse immunized with nontypeable Haemophilus influenzae produced a monoclonal antibody (MAb), designated 3B9, that bound to 35 of ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Spinola SM,Griffiths GE,Bogdan J,Menegus MA

    更新日期:1992-02-01 00:00:00

  • Listeria monocytogenes activation of human peripheral blood lymphocytes: induction of non-major histocompatibility complex-restricted cytotoxic activity and cytokine production.

    abstract::Gram-negative bacteria have been shown to activate human natural killer (NK) cells. In this report, we show that the gram-positive bacterium Listeria monocytogenes can also activate human NK cells with regard to non-major histocompatibility complex (MHC)-restricted killing and the production of cytokines. Overnight in...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Guo Y,Niesel DW,Ziegler HK,Klimpel GR

    更新日期:1992-05-01 00:00:00

  • Activation of alveolar macrophages exposed to lavage-procured immunoglobulin G obtained from normal rabbit lungs.

    abstract::Pulmonary washings from rabbits were freed of cells and added to the monolayers of homologous alveolar macrophages (AM). At 1 h after incubation with the pulmonary washings, many more cells adhered to glass, spread out, and showed enhanced Nitro Blue Tetrazolium reduction. The maximal effect of the pulmonary washings ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Ando M,Suga M,Shima K,Sugimoto M,Tokuomi H

    更新日期:1978-05-01 00:00:00

  • Staphylococcus aureus superantigens elicit redundant and extensive human Vbeta patterns.

    abstract::Staphylococcus aureus can produce a wide variety of exotoxins, including toxic shock syndrome toxin 1 (TSST-1), staphylococcal enterotoxins, and staphylococcal enterotoxin-like toxins. These toxins share superantigenic activity. To investigate the beta chain (Vbeta) specificities of each of these toxins, TSST-1 and al...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Thomas D,Dauwalder O,Brun V,Badiou C,Ferry T,Etienne J,Vandenesch F,Lina G

    更新日期:2009-05-01 00:00:00

  • CD40 ligand (CD154) does not contribute to lymphocyte-mediated inhibition of virulent Mycobacterium tuberculosis within human monocytes.

    abstract::Human monocytes displayed increased expression of CD40 following infection with virulent Mycobacterium tuberculosis. Nevertheless, soluble CD40 ligand (CD40L; also designated CD154) had no effect on the intracellular growth of the organism. Restriction of the intracellular growth of M. tuberculosis by peripheral blood...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Larkin R,Benjamin CD,Hsu YM,Li Q,Zukowski L,Silver RF

    更新日期:2002-08-01 00:00:00

  • Species-specific inhibition of cerebral malaria in mice coinfected with Plasmodium spp.

    abstract::Recent epidemiological observations suggest that clinical evolution of Plasmodium falciparum infections might be influenced by the concurrent presence of another Plasmodium species, and such mixed-species infections are now known to occur frequently in residents of most areas of endemicity. We used mice infected with ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Voza T,Vigário AM,Belnoue E,Grüner AC,Deschemin JC,Kayibanda M,Delmas F,Janse CJ,Franke-Fayard B,Waters AP,Landau I,Snounou G,Rénia L

    更新日期:2005-08-01 00:00:00

  • Purification and characterization of Vibrio metschnikovii cytolysin.

    abstract::An extracellular cytolysin produced by Vibrio metschnikovii was purified by acid precipitation, phenyl-Sepharose CL-4B chromatography, and rechromatography on a phenyl-Sepharose CL-4B column and high-performance liquid chromatography on a Mono Q (anion-exchange) column. The purified cytolysin had a molecular weight of...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Miyake M,Honda T,Miwatani T

    更新日期:1988-04-01 00:00:00

  • Characterization of an anticryptococcal protein isolated from human serum.

    abstract::Human serum at low concentrations inhibits the growth of Cryptococcus neoformans in vitro. Fractionation of serum yielded a purified inhibitory protein with a molecular mass of approximately 81.8 kDa, a pI of approximately 6.2, and an amino acid sequence that matched that of human transferrin. The inhibitory activity ...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Sridhar S,Ahluwalia M,Brummer E,Stevens DA

    更新日期:2000-06-01 00:00:00

  • Cloning and characterization of the Bacteroides fragilis metalloprotease toxin gene.

    abstract::Strains of Bacteroides fragilis that produce a ca. 20-kDa heat-labile protein toxin (termed B. fragilis toxin [BFT]) have been associated with diarrheal disease of animals and humans. BFT alters the morphology of intestinal epithelial cells both in vitro and in vivo and stimulates secretion in ligated intestinal segme...

    journal_title:Infection and immunity

    pub_type: 杂志文章


    authors: Franco AA,Mundy LM,Trucksis M,Wu S,Kaper JB,Sears CL

    更新日期:1997-03-01 00:00:00