Molecular chimerization of Pasteurella haemolytica leukotoxin to interleukin-2: effects on cytokine and antigen function.

abstract：:Thirty-two clinical isolates of Shiga-like toxin (SLT)-producing Escherichia coli associated with single cases or outbreaks of bloody diarrhea, hemorrhagic colitis, the hemolytic uremic syndrome, or edema disease of swine were examined for multiple copies of genes belonging to the slt-I or slt-II toxin families. Five ...

journal_title：Infection and immunity

authors： Schmitt CK,McKee ML,O'Brien AD

更新日期：1991-03-01 00:00:00

abstract：:In its canonical role the reverse transcriptase telomerase recovers the telomeric repeats that are lost during DNA replication. Other locations and activities have been recently described for the telomerase protein subunit TERT in mammalian cells. In the present work, using biochemistry, molecular biology, and electro...

journal_title：Infection and immunity

authors： Campelo R,Díaz Lozano I,Figarella K,Osuna A,Ramírez JL

更新日期：2015-01-01 00:00:00

abstract：:The surface antigen makeup of metacyclic trypomastigote forms of strain G of Trypanosoma cruzi, which produce a subpatent infection in mice, differed from those of the virulent strains Y and CL. A 100,000-molecular-weight protein, barely detectable on the Y or CL cell surface, appeared as the main surface antigen of t...

journal_title：Infection and immunity

authors： Yoshida N

更新日期：1983-05-01 00:00:00

abstract：:Oral treponemes are considered to be important in the development and progression of periodontal diseases. We investigated the mechanisms of recognition and activation of human gingival epithelial cells (HGEC) with the oral treponemes Treponema denticola, Treponema vincentii, and Treponema medium and their outer membr...

journal_title：Infection and immunity

authors： Asai Y,Jinno T,Ogawa T

更新日期：2003-02-01 00:00:00

abstract：:Cytomegalovirus (CMV) infections are common in renal transplant recipients. We studied 23 recipients prospectively to determine whether infections by other herpes-group and non-herpes-group viruses were also present. Sera, obtained at the time of surgery and periodically thereafter, were tested for antibody to CMV, he...

journal_title：Infection and immunity

authors： Armstrong JA,Evans AS,Rao N,Ho M

更新日期：1976-10-01 00:00:00

abstract：:Vaccine adjuvants exert critical and unique influences on the quality of immune responses induced during active immunizations. We investigated the mechanisms of action of immunological adjuvants in terms of their requirements for cytokine-mediated pathways for adjuvanticity. Antibody responses potentiated by several a...

journal_title：Infection and immunity

authors： Hui GS,Hashimoto CN

更新日期：1998-11-01 00:00:00

abstract：:A purified human granulocyte colony-stimulating factor (hG-CSF) was studied for its protective effect on the induction of neutropenia and enhanced susceptibility to microbial infections in mice receiving cyclophosphamide (CPA). A severe reduction in peripheral blood neutrophils was induced 4 days after injection with ...

journal_title：Infection and immunity

authors： Matsumoto M,Matsubara S,Matsuno T,Tamura M,Hattori K,Nomura H,Ono M,Yokota T

更新日期：1987-11-01 00:00:00

abstract：:The facultative intracellular bacterial pathogen Listeria monocytogenes induces severe fetal infection during pregnancy. Little is known about the molecular mechanisms allowing the maternofetal transmission of bacteria. In this work, we studied fetoplacental invasion by infecting mice with various mutants lacking viru...

journal_title：Infection and immunity

authors： Le Monnier A,Autret N,Join-Lambert OF,Jaubert F,Charbit A,Berche P,Kayal S

更新日期：2007-02-01 00:00:00

abstract：:Monoclonal antibodies to Trichomonas vaginalis were prepared by immunizing mice with a cloned isolate of T. vaginalis. Eight antibodies reacted with the same four isolates or strains but did not react with the other T. vaginalis strains or isolates tested. All eight antibodies reacted uniformly with both the body and ...

journal_title：Infection and immunity

authors： Torian BE,Connelly RJ,Stephens RS,Stibbs HH

更新日期：1984-01-01 00:00:00

abstract：:Sera from adult periodontitis patients were analyzed for antibody activity against surface antigens of Bacteroides gingivalis by immunoblotting analysis. ...

journal_title：Infection and immunity

authors： Naito Y,Okuda K,Takazoe I

更新日期：1987-03-01 00:00:00

abstract：:Obligate vacuolar pathogens produce proteins that localize to the host cell-derived membranes of the vacuoles in which they reside, yielding unique organelles that are optimally suited for pathogen survival. Anaplasma phagocytophilum is an obligate vacuolar bacterium that infects neutrophils and causes the emerging an...

journal_title：Infection and immunity

authors： Huang B,Troese MJ,Ye S,Sims JT,Galloway NL,Borjesson DL,Carlyon JA

更新日期：2010-05-01 00:00:00

abstract：:Recognition of microbial patterns by host receptors is the first step in a multistep sequence leading to neutrophil-dependent host resistance. Although the role of membrane-bound sensors in bacterial recognition has been examined in detail, the importance of cytosolic sensors in the lungs is largely unexplored. In thi...

journal_title：Infection and immunity

authors： Balamayooran T,Batra S,Balamayooran G,Cai S,Kobayashi KS,Flavell RA,Jeyaseelan S

更新日期：2011-11-01 00:00:00

abstract：:Murine cerebral malaria (CM) induced by Plasmodium berghei ANKA kills susceptible mice within 24 to 48 h of onset of symptoms and is characterized by the production of inflammatory cytokines in the brain. C57BL/6J mice are sensitive to lethal CM, while A/J mice are resistant. These strains of mice were immunized with ...

journal_title：Infection and immunity

authors： Jennings VM,Lal AA,Hunter RL

更新日期：1998-12-01 00:00:00

abstract：:L929 cell populations persistently infected for more than 600 days exhibited cell cycle distributions and generation times similar to those of uninfected cells. The RNA and protein contents of these long-term-infected cells, as determined by flow cytometry and correlated with the cell cycle, were likewise approximatel...

journal_title：Infection and immunity

authors： Baca OG,Crissman HA

更新日期：1987-07-01 00:00:00

abstract：:The mechanisms linking the immune response to cutaneous and mucosal leishmaniasis (CL and ML, respectively) lesions and the response to treatment are incompletely understood. Our aims were to prospectively assess, by quantitative reverse transcription-PCR, the levels of mRNA for gamma interferon, tumor necrosis factor...

journal_title：Infection and immunity

authors： Maurer-Cecchini A,Decuypere S,Chappuis F,Alexandrenne C,De Doncker S,Boelaert M,Dujardin JC,Loutan L,Dayer JM,Tulliano G,Arevalo J,Llanos-Cuentas A,Chizzolini C

更新日期：2009-05-01 00:00:00

abstract：:The ultrastructural appearance of the "halozone" formed at the interface between the spotted fever agent Rickettsia rickettsii and the cytoplasm of persistently infected cultured vole cells (Microtus pennsylvanicus) was studied by transmission electron microscopy. In sections of epoxy-embedded specimens stained with u...

journal_title：Infection and immunity

authors： Todd WJ,Burgdorfer W,Wray GP

更新日期：1983-09-01 00:00:00

abstract：:We have determined the nucleotide sequence of the 1.4-kilobase DNA fragment containing the plasminogen activator gene (pla) of Yersinia pestis, which determines both plasminogen activator and coagulase activities of the species. The sequence revealed the presence of a 936-base-pair open reading frame that constitutes ...

journal_title：Infection and immunity

authors： Sodeinde OA,Goguen JD

更新日期：1989-05-01 00:00:00

abstract：:The innate immune response to Pneumocystis infection is not well understood. In this study, normal C57BL/6 mouse alveolar macrophages were found to respond to Pneumocystis murina organisms through Toll-like receptor 2 (TLR2), leading to the nuclear translocation of NF-kappaB and the production of proinflammatory cytok...

journal_title：Infection and immunity

authors： Zhang C,Wang SH,Lasbury ME,Tschang D,Liao CP,Durant PJ,Lee CH

更新日期：2006-03-01 00:00:00

abstract：:A large body of evidence has convincingly shown that Toll-like receptors are necessary sensors for infections with pathogens, but their activation was also suggested to generate autoimmunity. During experimental infections, the lack of these sensors or of their signaling molecules should lead to a deficient immune res...

journal_title：Infection and immunity

authors： Woods A,Soulas-Sprauel P,Jaulhac B,Arditi B,Knapp AM,Pasquali JL,Korganow AS,Martin T

更新日期：2008-04-01 00:00:00

abstract：:We report on the colonization of murine trigeminal ganglia after sequential infection of mice by herpes simplex viruses (HSVs). In preliminary studies, we have established that whereas the HSV-1(F) strain efficiently colonizes ganglia when inoculated by either the ear or eye routes, the HSV-1 X HSV-2 recombinant C7D c...

journal_title：Infection and immunity

authors： Meignier B,Norrild B,Roizman B

更新日期：1983-08-01 00:00:00

abstract：:The P8 proteoglycolipid complex (P8 PGLC) is a glyconjugate expressed by Leishmania mexicana complex parasites. We previously have shown that vaccination with P8 PGLC provides protection against cutaneous leishmaniasis in susceptible BALB/c mice. However, the biological importance of this complex remains unknown. Here...

journal_title：Infection and immunity

authors： Whitaker SM,Colmenares M,Pestana KG,McMahon-Pratt D

更新日期：2008-05-01 00:00:00

abstract：:Increased incidence of bovine tuberculosis (TB) in the United Kingdom caused by infection with Mycobacterium bovis is a cause of considerable economic loss to farmers and the government. The Eurasian badger (Meles meles) represents a wildlife source of recurrent M. bovis infections of cattle in the United Kingdom, and...

journal_title：Infection and immunity

authors： Clark S,Cross ML,Nadian A,Vipond J,Court P,Williams A,Hewinson RG,Aldwell FE,Chambers MA

更新日期：2008-08-01 00:00:00

abstract：:Nasopharyngeal colonization represents the initial interaction between Haemophilus influenzae and its human host. Factors that influence bacterial carriage likely affect transmission and incidence of infection. Therefore, we investigated host factors involved in limiting H. influenzae colonization in BALB/c mice, as c...

journal_title：Infection and immunity

authors： Zola TA,Lysenko ES,Weiser JN

更新日期：2009-08-01 00:00:00

abstract：:Transgenic tobacco plants stably expressing recombinant FaeG, which is the major subunit and adhesin of K88ad fimbriae, were obtained. Analysis of sera from immunized mice indicates that in mice, the immunogenicity induced by plant-derived FaeG protein is comparable to that generated with traditional approaches. ...

journal_title：Infection and immunity

authors： Huang Y,Liang W,Pan A,Zhou Z,Huang C,Chen J,Zhang D

更新日期：2003-09-01 00:00:00

abstract：:The purpose of our experiment was to evaluate the destructive potential of a strain of Actinomyces viscosus on the periodontium of sensitized rodents, describing the induced lesions on the basis of quantitative cytology. The experimental design comprised in principle the following procedures. Young germfree rats were ...

journal_title：Infection and immunity

authors： Guggenheim B,Schroeder HE

更新日期：1974-09-01 00:00:00

abstract：:Thirty-one Kanagawa-positive and -negative Vibrio parahaemolyticus isolates from patient stools and seafood were examined for plasmid deoxyribonucleic acid content, culture characteristics, and indices of pathogenicity. No significant correlation was found between plasmid deoxyribonucleic acid contents and indices of ...

journal_title：Infection and immunity

authors： Twedt RM,Brown DF,Zink DL

更新日期：1981-07-01 00:00:00

abstract：:Pro- and anti-inflammatory cytokines and their signaling pathways play key roles in protection from and pathogenesis of mycobacterial infection, and their balance and dynamic changes may control or predict clinical outcome. Peripheral blood cells' capacity to produce proinflammatory (tumor necrosis factor alpha [TNF-a...

journal_title：Infection and immunity

authors： Sahiratmadja E,Alisjahbana B,de Boer T,Adnan I,Maya A,Danusantoso H,Nelwan RH,Marzuki S,van der Meer JW,van Crevel R,van de Vosse E,Ottenhoff TH

更新日期：2007-02-01 00:00:00

abstract：:Vibrio cholerae O1 bacteria harvested directly from ligated or nonligated intestines of rabbits with experimental cholera expressed at least 7 to 8 novel, in vivo-specific cell envelope (env) proteins that were not found on vibrios after in vitro culture in various ordinary liquid media. At the same time, several of t...

journal_title：Infection and immunity

authors： Jonson G,Svennerholm AM,Holmgren J

更新日期：1989-06-01 00:00:00

abstract：:Infection with tissue-migrating helminths is frequently associated with intense granulocyte infiltrations. Several host-derived factors are known to mediate granulocyte recruitment to the tissues, but less attention has been paid to how parasite-derived products trigger this process. Parasite-derived chemotactic facto...

journal_title：Infection and immunity

authors： Falcone FH,Rossi AG,Sharkey R,Brown AP,Pritchard DI,Maizels RM

更新日期：2001-06-01 00:00:00

abstract：:Various features of salmonellosis were examined in a burned-mouse model. In this model, which uses an outbred mouse strain, a challenge dose of ca. 100 CFU with any of several strains of Salmonella typhimurium caused a fatal infection. A variety of mutated strains attenuated for virulence in Salmonella-susceptible par...

journal_title：Infection and immunity

authors： Carsiotis M,Stocker BA,Holder IA

更新日期：1989-09-01 00:00:00