ActA is required for crossing of the fetoplacental barrier by Listeria monocytogenes.

abstract：:High levels of Treponema denticola in subgingival dental plaque are associated with severe periodontal disease. T. denticola, along with Porphyromonas gingivalis and Bacteroides forsythus, are the only cultivatable oral microorganisms that produce significant amounts of "trypsin-like" peptidase activity. The ability o...

journal_title：Infection and immunity

authors： Fenno JC,Lee SY,Bayer CH,Ning Y

更新日期：2001-10-01 00:00:00

abstract：:Infection with Histoplasma capsulatum results in a subclinical infection in immunocompetent hosts due to an effective cellular immune response. By contrast, immunodeficient individuals can have a severe disseminated and potentially fatal disease. In a previous study, it was demonstrated that normal mice infected intra...

journal_title：Infection and immunity

authors： Zhou P,Sieve MC,Tewari RP,Seder RA

更新日期：1997-03-01 00:00:00

abstract：:Thirty-two clinical isolates of Shiga-like toxin (SLT)-producing Escherichia coli associated with single cases or outbreaks of bloody diarrhea, hemorrhagic colitis, the hemolytic uremic syndrome, or edema disease of swine were examined for multiple copies of genes belonging to the slt-I or slt-II toxin families. Five ...

journal_title：Infection and immunity

authors： Schmitt CK,McKee ML,O'Brien AD

更新日期：1991-03-01 00:00:00

abstract：:Borrelia burgdorferi, an agent of Lyme disease, establishes persistent infection in immunocompetent animals and humans. Although the infection in humans can be cleared by antibiotic therapy, persistence in reservoir animals is necessary for the maintenance of the bacterium in the natural reservoir host⇔tick vector inf...

journal_title：Infection and immunity

authors： LaFrance ME,Pierce JV,Antonara S,Coburn J

更新日期：2011-08-01 00:00:00

abstract：:Differences in acid tolerance among representative oral streptococci were found to be related more closely to the dynamic permeabilities of the bacteria to protons than to differences in the sensitivities of cell membranes to gross damage caused by environmental acidification. For Streptococcus mutans GS-5, Streptococ...

journal_title：Infection and immunity

authors： Bender GR,Sutton SV,Marquis RE

更新日期：1986-08-01 00:00:00

abstract：:The intestinal mucosa forms the first line of defense against infections mediated by enteric pathogens such as salmonellae. Here we exploited intestinal "organoids" (iHOs) generated from human induced pluripotent stem cells (hIPSCs) to explore the interaction of Salmonella enterica serovar Typhimurium with iHOs. Imagi...

journal_title：Infection and immunity

authors： Forbester JL,Goulding D,Vallier L,Hannan N,Hale C,Pickard D,Mukhopadhyay S,Dougan G

更新日期：2015-07-01 00:00:00

abstract：:Mice were vaccinated with 300 micrograms of BCG cell walls (BCG-CW) in oil-in-water emulsion intravenously or with a high or low dose of living BCG by inhalation (BCG-HD or BCG-LD, respectively). The consequences of vaccination were evaluated in terms of the growth of BCG in the lungs and spleen, lung and spleen weigh...

journal_title：Infection and immunity

authors： Lefford MJ

更新日期：1980-05-01 00:00:00

abstract：:To test the hypothesis that the Staphylococcus aureus enterotoxin gene cluster (egc) can generate new enterotoxin genes by recombination, we analyzed the egc locus in a broad panel of 666 clinical isolates of S. aureus. egc was present in 63% of isolates, confirming its high prevalence. The archetypal organization of ...

journal_title：Infection and immunity

authors： Thomas DY,Jarraud S,Lemercier B,Cozon G,Echasserieau K,Etienne J,Gougeon ML,Lina G,Vandenesch F

更新日期：2006-08-01 00:00:00

abstract：:To determine whether lipopolysaccharide (LPS) structures of Campylobacter species are immunologically related to those of 11 other gram-negative organisms, we immunoblotted from polyacrylamide gels the LPS of these strains with immune rabbit serum raised against six Campylobacter jejuni strains and two Campylobacter f...

journal_title：Infection and immunity

authors： Perez-Perez GI,Hopkins JA,Blaser MJ

更新日期：1986-01-01 00:00:00

abstract：:Several bacterial species recruit the complement regulators C4b-binding protein, factor H, and vitronectin, resulting in resistance against the bactericidal activity of human serum. It was recently demonstrated that bacteria also bind plasminogen, which is converted to plasmin that degrades C3b and C5. In this study, ...

journal_title：Infection and immunity

authors： Singh B,Al-Jubair T,Voraganti C,Andersson T,Mukherjee O,Su YC,Zipfel P,Riesbeck K

更新日期：2015-09-01 00:00:00

abstract：:Attachment and ingestion of Mycobacterium avium subsp. paratuberculosis by two epithelial cell lines were enhanced by soluble fibronectin (FN). Peptide blocking of the FN attachment protein (FAP-P) inhibited the internalization of M. avium subsp. paratuberculosis. Disruption of FAP-P expression significantly reduced a...

journal_title：Infection and immunity

authors： Secott TE,Lin TL,Wu CC

更新日期：2002-05-01 00:00:00

abstract：:Rats kept under germfree conditions showed lower specific lysosomal enzyme activities in liver endothelial cells, but not in Kupffer cells. ...

journal_title：Infection and immunity

authors： Knook DL,Barkway C,Sleyster EC

更新日期：1981-08-01 00:00:00

abstract：:The complement system plays a key role in resistance to cryptococcosis. In the present study, we examined several factors that influence the binding of C3 cleavage fragments to Cryptococcus neoformans. Binding of C3 was determined by using normal human serum supplemented with 125I-labeled C3. Incubation of encapsulate...

journal_title：Infection and immunity

authors： Kozel TR,Pfrommer GS

更新日期：1986-04-01 00:00:00

abstract：:Natural antibodies are those immunoglobulin molecules found in mammalian serum that arise in the absence of exposure to environmental pathogens and may comprise an early host defense against invading pathogens. The spirochete Borrelia burgdorferi first encounters natural antibodies when its arthropod vector, Ixodes sc...

journal_title：Infection and immunity

authors： Belperron AA,Bockenstedt LK

更新日期：2001-10-01 00:00:00

abstract：:A cysteine-containing peptide motif, EWSPCSVTCG, is found highly conserved in the circumsporozoite protein (CSP) and the thrombospondin-related anonymous protein (TRAP) of all the Plasmodium species analyzed so far and has been shown to be crucially involved in the sporozoite invasion of hepatocytes. We have recently ...

journal_title：Infection and immunity

authors： Bharadwaj A,Sharma P,Joshi SK,Singh B,Chauhan VS

更新日期：1998-07-01 00:00:00

abstract：:Streptococcus pneumoniae remains a major causative agent of serious human diseases. The worldwide increase of antibiotic resistant strains revealed the importance of horizontal gene transfer in this pathogen, a scenario that results in the modulation of the species-specific gene pool. We investigated genomic variation...

journal_title：Infection and immunity

authors： Hakenbeck R,Balmelle N,Weber B,Gardès C,Keck W,de Saizieu A

更新日期：2001-04-01 00:00:00

abstract：:We performed ex vivo experiments with Plasmodium falciparum-infected human placentas from primi- and multigravida women from Cameroon. All women, independent of their gravida status, had anti-chondroitin sulfate A (CSA) adhesion antibodies which cross-reacted with heterologous strains, such as FCR3 and Palo-Alto(FUP)1...

journal_title：Infection and immunity

authors： Gysin J,Pouvelle B,Fievet N,Scherf A,Lépolard C

更新日期：1999-12-01 00:00:00

abstract：:Toxoplasma gondii and Neospora caninum (both Apicomplexa) are closely related cyst-forming coccidian parasites that differ significantly in their host ranges and ability to cause disease. Unlike eutherian mammals, Australian marsupials (metatherian mammals) have long been thought to be highly susceptible to toxoplasmo...

journal_title：Infection and immunity

authors： Donahoe SL,Phalen DN,McAllan BM,O'Meally D,McAllister MM,Ellis J,Šlapeta J

更新日期：2017-05-23 00:00:00

abstract：:Of 202 captive hares studied, many of which had lesions on their external genital organs or testicular atrophy or both, 27% had positive serological tests for syphilis although dark-field examination of extracts of atrophic testes was negative. A total of 12 hares that were nonreactive for the serological test for syp...

journal_title：Infection and immunity

authors： Horvath I,Kemenes F,Molnar L,Szeky A,Racz I

更新日期：1980-01-01 00:00:00

abstract：:Streptococcus agalactiae (group B Streptococcus or GBS) is a common colonizer of the gastrointestinal and genital tracts and an important cause of invasive infections in newborn infants and in adults with predisposing chronic conditions or advanced age. Attachment to epithelial surfaces at mucosal sites is a critical ...

journal_title：Infection and immunity

authors： Park SE,Jiang S,Wessels MR

更新日期：2012-11-01 00:00:00

abstract：:Cholera toxin (CT) and the type II heat-labile enterotoxins (HLT) LT-IIa and LT-IIb act as potent systemic and mucosal adjuvants and induce distinct T-helper (Th)-cell cytokine profiles. In the present study, CT and the type II HLT were found to differentially affect cytokine production by anti-CD3-stimulated human pe...

journal_title：Infection and immunity

authors： Martin M,Metzger DJ,Michalek SM,Connell TD,Russell MW

更新日期：2001-07-01 00:00:00

abstract：:In a model of experimental Chagas' disease induced with metacyclic forms of Trypanosoma cruzi, CD4+ but not CD8+ T cells undergo T-cell receptor (TCR)-CD3-mediated activation-induced cell death (AICD) in vitro. CD4+ T cells from T. cruzi-infected mice also developed unresponsiveness in proliferative responses to TCR-C...

journal_title：Infection and immunity

authors： Lopes MF,DosReis GA

更新日期：1996-05-01 00:00:00

abstract：:We identified nonhemolytic mutants of Listeria monocytogenes that were severely deficient in their ability to invade mammalian nonprofessional phagocytes. These mutants were generated spontaneously or by means of transposon Tn916 mutagenesis. In terms of their extracellular proteins, the noninvasive mutants were defic...

journal_title：Infection and immunity

authors： Kathariou S,Pine L,George V,Carlone GM,Holloway BP

更新日期：1990-12-01 00:00:00

abstract：:Subchronic exposure to pharmacological levels of estrogenic compounds, including 17 beta-estradiol, diethylstilbestrol, and alpha-dienestrol, significantly increased the mortality of B6C3F1 female mice after Listeria infection. Compounds with little estrogenic activity, including 5 alpha-dihydrotestosterone, progester...

journal_title：Infection and immunity

authors： Pung OJ,Luster MI,Hayes HT,Rader J

更新日期：1984-11-01 00:00:00

abstract：:Alveolar bone destruction is a characteristic feature of periodontitis. Treponema denticola is known to be involved in periodontitis. To elucidate the role of T. denticola in alveolar bone destruction in periodontitis, the effects of lipooligosaccharide (LOS) from T. denticola on osteoclast formation and on expression...

journal_title：Infection and immunity

authors： Choi BK,Lee HJ,Kang JH,Jeong GJ,Min CK,Yoo YJ

更新日期：2003-01-01 00:00:00

abstract：:Exposure of hamster tracheal rings in organ culture to virulent Mycoplasma pneumoniae organisms leads to alterations in macromolecular biosynthesis and metabolic activity of the respiratory epithelial cells. Avirulent organisms derived from the same parent strain do not produce these effects. During the course of infe...

journal_title：Infection and immunity

authors： Hu PC,Collier AM,Baseman JB

更新日期：1975-04-01 00:00:00

abstract：:Mesocricetus auratus (golden hamsters) infected with leishmania developed characteristic B cell immune responses that depended on the infecting species of leishmania. Thus, hamsters infected with viscerotropic leishmania (Leishmania donovani) developed antileishmania antibodies and hypergammaglobulinemia due to polycl...

journal_title：Infection and immunity

authors： Campos-Neto A,Bunn-Moreno MM

更新日期：1982-12-01 00:00:00

abstract：:Lactoferrin (Lf) is an iron-binding antimicrobial protein present in milk and on mucosal surfaces, with a suggested role in preimmune host defense. Certain strains of Escherichia coli (bacterial whole cells) demonstrate specific interaction with 125I-labeled Lf. A band with a mass of approximately 37 kDa, which was re...

journal_title：Infection and immunity

authors： Erdei J,Forsgren A,Naidu AS

更新日期：1994-04-01 00:00:00

abstract：:The effects of an ornithine-containing lipid [alpha-N-(3-acyloxyacyl)-ornithine (Orn-L)] or a serine-containing lipid [alpha-N-(3-acyloxyacyl)-serine (Ser-L)] from Flavobacterium meningosepticum on lethal endotoxemia in mice were examined. When 500 micrograms of Orn-L was intravenously administered 1 h before intraven...

journal_title：Infection and immunity

authors： Kawai Y,Kaneda K,Morisawa Y,Akagawa K

更新日期：1991-08-01 00:00:00

abstract：:Iron starvation conditions limited the growth of Salmonella typhi, as evidenced by an increase in the lag phase of a culture and a decrease in the number of bacteria reached in the stationary phase. The analysis of the outer membrane of bacteria grown under these conditions identified new protein components with appar...

journal_title：Infection and immunity

authors： Fernandez-Beros ME,Gonzalez C,McIntosh MA,Cabello FC

更新日期：1989-04-01 00:00:00