Specific and common antigens of Trichomonas vaginalis detected by monoclonal antibodies.

abstract：:Several monoclonal antibodies directed against gonococcal pili have been used to investigate the potential contribution of anti-pilus antibodies to host defense against gonococcal infection. Included were two antibodies (SM1 and SM2) which reacted with conserved determinants present on pili from all strains tested and...

journal_title：Infection and immunity

authors： Virji M,Heckels JE

更新日期：1985-09-01 00:00:00

abstract：:The nitrate dissimilation pathway is important for anaerobic growth in Pseudomonas aeruginosa. In addition, this pathway contributes to P. aeruginosa virulence by using the nematode Caenorhabditis elegans as a model host, as well as biofilm formation and motility. We used a set of nitrate dissimilation pathway mutants...

journal_title：Infection and immunity

authors： Van Alst NE,Wellington M,Clark VL,Haidaris CG,Iglewski BH

更新日期：2009-10-01 00:00:00

abstract：:Recent evidence suggests that immune-mediated gastric epithelial cell apoptosis through Fas-Fas ligand interactions participates in Helicobacter pylori disease pathogenesis. To define the role of Fas signaling in vivo, H. pylori strain SS1 infection in C57BL/6 mice was compared to that in mice deficient in the Fas lig...

journal_title：Infection and immunity

authors： Jones NL,Day AS,Jennings H,Shannon PT,Galindo-Mata E,Sherman PM

更新日期：2002-05-01 00:00:00

abstract：:Campylobacter fetus surface layer proteins (SLPs), encoded by sapA homologues, are important in virulence. In wild-type C. fetus strain 23D, all eight sapA homologues are located in the 54-kb sap island, and SLP expression reflects the position of a unique sapA promoter in relation to the sapA homologues. The extensiv...

journal_title：Infection and immunity

authors： Tu ZC,Hui J,Blaser MJ

更新日期：2004-03-01 00:00:00

abstract：:Current efforts to develop plague vaccines focus on LcrV, a polypeptide that resides at the tip of type III secretion needles. LcrV-specific antibodies block Yersinia pestis type III injection of Yop effectors into host immune cells, thereby enabling phagocytes to kill the invading pathogen. Earlier work reported that...

journal_title：Infection and immunity

authors： Miller NC,Quenee LE,Elli D,Ciletti NA,Schneewind O

更新日期：2012-04-01 00:00:00

abstract：:Ocular inflammation is one of the consequences of infection with the protozoan parasite Toxoplasma gondii. Even if lesions are self-healing in immunocompetent persons, they pose a lifetime risk of reactivation and are a serious threat to vision. As there are virtually no immunological data on reactivating ocular toxop...

journal_title：Infection and immunity

authors： Rochet É,Brunet J,Sabou M,Marcellin L,Bourcier T,Candolfi E,Pfaff AW

更新日期：2015-05-01 00:00:00

abstract：:Neisseria gonorrhoeae is the causative agent of the sexually transmitted disease gonorrhea, and infection with this organism is typically associated with an intense inflammatory response. In many individuals, however, the infection is asymptomatic and can progress to serious secondary complications. The type IV pili o...

journal_title：Infection and immunity

authors： Plant LJ,Jonsson AB

更新日期：2006-01-01 00:00:00

abstract：:We report here on the isolation of isogenic strains of Aeromonas hydrophila AB3 deleted for a segment of the aerolysin gene. All aer mutants obtained lacked the 49-kilodalton aerolysin gene product and were neither hemolytic for blood erythrocytes nor cytotoxic for Chinese hamster ovary tissue culture cells. One such ...

journal_title：Infection and immunity

authors： Chakraborty T,Huhle B,Hof H,Bergbauer H,Goebel W

更新日期：1987-09-01 00:00:00

abstract：:The production and role of tumor necrosis factor alpha (TNF-alpha) in pneumococcal pneumonia were investigated in a mouse pneumonia model. When approximately 10(6) CFU of Streptococcus pneumoniae TUM19 were used to inoculate CBA/J mice intranasally, TNF-alpha levels in the lungs and serum began to increase from 1 and ...

journal_title：Infection and immunity

authors： Takashima K,Tateda K,Matsumoto T,Iizawa Y,Nakao M,Yamaguchi K

更新日期：1997-01-01 00:00:00

abstract：:Both interleukin-17A (IL-17A) and IL-17F are proinflammatory cytokines that have an important role in intestinal homeostasis via receptor signaling. These cytokines have been characterized in chickens, but very little is known about their receptors and their functional activity. We provide here the first description o...

journal_title：Infection and immunity

authors： Kim WH,Jeong J,Park AR,Yim D,Kim S,Chang HH,Yang SH,Kim DH,Lillehoj HS,Min W

更新日期：2014-09-01 00:00:00

abstract：:By using a suckling mouse assay, heat-stable enterotoxin (ST) was purified from the culture filtrate of Yersinia enterocolitica isolated from a diarrheal patient. The purification procedures involve ultrafiltration with an Amicon HIP-10 hollow fiber, ethanol fractionation, protamine sulfate treatment, diethylaminoethy...

journal_title：Infection and immunity

authors： Okamoto K,Inoue T,Ichikawa H,Kawamoto Y,Miyama A

更新日期：1981-02-01 00:00:00

abstract：:Murine monoclonal antibodies were generated against streptolysin O. One out of 10 tested immunoglobulin clones exhibited strong neutralizing activity; in solution, the presence of approximately two to four antibody molecules per toxin monomer effected 50% neutralization of hemolytic toxin activity. An enzyme-linked im...

journal_title：Infection and immunity

authors： Hugo F,Reichwein J,Arvand M,Krämer S,Bhakdi S

更新日期：1986-12-01 00:00:00

abstract：:Mutation of purR was previously shown to enhance the virulence of Staphylococcus aureus in a murine sepsis model, and this cannot be fully explained by increased expression of genes within the purine biosynthesis pathway. Rather, the increased production of specific S. aureus virulence factors, including alpha toxin a...

journal_title：Infection and immunity

authors： Alkam D,Jenjaroenpun P,Ramirez AM,Beenken KE,Spencer HJ,Smeltzer MS

更新日期：2021-01-19 00:00:00

abstract：:The effects of treatment with live or inactivated Shope fibroma virus on host cell deoxyribonucleic acid (DNA) synthesis were determined. The incorporation of (3)H-thymidine into nuclear DNA was suppressed by both active and inactivated virus, although live virus was more effective. During the early phase of infection...

journal_title：Infection and immunity

authors： Chan JC,Hodes ME

更新日期：1973-04-01 00:00:00

abstract：:Human monocytic ehrlichiosis (HME) is caused by a tick-borne obligate intracellular pathogen of the order Rickettsiales. HME disease can range from mild to a fatal, toxic shock-like syndrome, yet the mechanisms regulating pathogenesis are not well understood. We define a central role for type I interferons (alpha inte...

journal_title：Infection and immunity

authors： Zhang Y,Thai V,McCabe A,Jones M,MacNamara KC

更新日期：2014-04-01 00:00:00

abstract：:Borrelia burgdorferi sensu stricto is the major causative agent of Lyme disease in the United States, while B. garinii and B. afzelii are more prevalent in Europe. The highly complex genome of B. burgdorferi is comprised of a linear chromosome and a large number of variably sized linear and circular plasmids. Many pla...

journal_title：Infection and immunity

authors： Chan K,Casjens S,Parveen N

更新日期：2012-04-01 00:00:00

abstract：:Streptococcus iniae causes systemic infection characterized by meningitis and sepsis. Here, we report a larval zebrafish model of S. iniae infection. Injection of wild-type S. iniae into the otic vesicle induced a lethal infection by 24 h postinfection. In contrast, an S. iniae mutant deficient in polysaccharide capsu...

journal_title：Infection and immunity

authors： Harvie EA,Green JM,Neely MN,Huttenlocher A

更新日期：2013-01-01 00:00:00

abstract：:The quantity of membrane-bound and extracellular exotoxin A in four strains of Pseudomonas aeruginosa was investigated. In strain PA-103, which is the prototype strain used for toxin production, all of the toxin was released into the growth medium and little toxin remained with the cell envelope. In a virulent strain ...

journal_title：Infection and immunity

authors： Fernandes PB,Cundy KR

更新日期：1980-05-01 00:00:00

abstract：:The results of this study show that recombinant interleukin-8 (IL-8) enhances the intracellular killing of Mycobacterium fortuitum by human granulocytes. This chemokine did not stimulate the phagocytosis of M. fortuitum by granulocytes at various bacterium-to-cell ratios. The killing process was not affected by the NA...

journal_title：Infection and immunity

authors： Nibbering PH,Pos O,Stevenhagen A,Van Furth R

更新日期：1993-08-01 00:00:00

abstract：:Q fever has been associated with granulomatous changes in clinical biopsy material obtained from liver and bone marrow. Local reactions to skin testing have been described in previously sensitized humans, but histological studies of such reactions have not been reported. We note that delayed hypersensitivity reactions...

journal_title：Infection and immunity

authors： Ascher MS,Berman MA,Parker D,Turk JL

更新日期：1983-01-01 00:00:00

abstract：:Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by a strong Th1 response that leads to skin lesion development. In areas where L. braziliensis transmission is endemic, up to 15% of healthy subjects have tested positive for delayed-type hypersensitivity to soluble leishmania antigen (SLA...

journal_title：Infection and immunity

authors： Cardoso TM,Machado Á,Costa DL,Carvalho LP,Queiroz A,Machado P,Scott P,Carvalho EM,Bacellar O

更新日期：2015-03-01 00:00:00

abstract：:Human lactoferrin (hLf), a glycoprotein released from neutrophil granules during inflammation, and the lipopolysaccharide (LPS)-binding protein (LBP), an acute-phase serum protein, are known to bind to the lipid A of LPS. The LPS-binding sites are located in the N-terminal regions of both proteins, at amino acid resid...

journal_title：Infection and immunity

authors： Elass-Rochard E,Legrand D,Salmon V,Roseanu A,Trif M,Tobias PS,Mazurier J,Spik G

更新日期：1998-02-01 00:00:00

abstract：:The route of pathogen inoculation by needle has been shown to influence the outcome of infection. Employing needle inoculation of the obligately intracellular parasite Leishmania major, which is transmitted in nature following intradermal (i.d.) deposition of parasites by the bite of an infected sand fly, we identifie...

journal_title：Infection and immunity

authors： Ribeiro-Gomes FL,Roma EH,Carneiro MB,Doria NA,Sacks DL,Peters NC

更新日期：2014-07-01 00:00:00

abstract：:The effect of respiratory syncytial virus (RSV) or mixtures of RSV and its specific antibody on the oxidative metabolic activity of human polymorphonuclear leukocytes was studied by the technique of luminol-dependent chemiluminescence. Peripheral blood neutrophils obtained from normal healthy donors were used. RSV alo...

journal_title：Infection and immunity

authors： Kaul TN,Faden H,Ogra PL

更新日期：1981-05-01 00:00:00

abstract：:Clostridium piliforme induces enterohepatic disease in many domestic and laboratory animal species. Susceptibility to infection is known to vary with the immune status and strain of the host, but little is known about specific immune mechanisms that regulate this disease. To evaluate host control of C. piliforme infec...

journal_title：Infection and immunity

authors： Van Andel RA,Hook RR Jr,Franklin CL,Besch-Williford CL,Riley LK

更新日期：1998-10-01 00:00:00

abstract：:Blood mononuclear cells (lymphocytes and monocytes) were isolated from infected calves during in vivo control of acute anaplasmosis and cultured with Anaplasma marginale organisms. Supernatants from the cultures reduced the proportion of erythrocytes containing viable A. marginale in vitro, indicating that an antibody...

journal_title：Infection and immunity

authors： Wyatt CR,Davis WC,Knowles DP,Goff WL,Palmer GH,McGuire TC

更新日期：1996-11-01 00:00:00

abstract：:Our knowledge of pathogenesis has benefited from a better understanding of the roles of specific virulence factors in disease. To determine the role of the virulence factor ZapA, a 54-kDa metalloproteinase of Proteus mirabilis, in prostatitis, rats were infected with either wild-type (WT) P. mirabilis or its isogenic ...

journal_title：Infection and immunity

authors： Phan V,Belas R,Gilmore BF,Ceri H

更新日期：2008-11-01 00:00:00

abstract：:A 46-kDa hemolytic protein, referred to as cystalysin, from Treponema denticola ATCC 35404 was overexpressed in Escherichia coli LC-67. Both the native and recombinant 46-kDa proteins were purified to homogeneity. Both proteins expressed identical biological and functional characteristics. In addition to its biologica...

journal_title：Infection and immunity

authors： Chu L,Ebersole JL,Kurzban GP,Holt SC

更新日期：1997-08-01 00:00:00

abstract：:Borrelia burgdorferi, the causative agent of Lyme disease, loses its ability to infect and cause disease in mammalian hosts after repeated in vitro passage. To identify proteins preferentially expressed by the low-passage strain and thus representing potential virulence factors, the polypeptide profiles of virulent, l...

journal_title：Infection and immunity

authors： Norris SJ,Carter CJ,Howell JK,Barbour AG

更新日期：1992-11-01 00:00:00

abstract：:The 18-kilodalton (kDa) antigen of Mycobacterium leprae was expressed as a fusion protein with a 2-kDa leader peptide and used in proliferation assays with peripheral blood cells. Fifty percent of untreated tuberculoid leprosy patients and 93% of long-term leprosy contacts responded to the recombinant protein in lymph...

journal_title：Infection and immunity

authors： Dockrell HM,Stoker NG,Lee SP,Jackson M,Grant KA,Jouy NF,Lucas SB,Hasan R,Hussain R,McAdam KP

更新日期：1989-07-01 00:00:00