The increased accumulation of Staphylococcus aureus virulence factors is maximized in a purR mutant by the increased production of SarA and decreased production of extracellular proteases.

abstract：:A common concern with many autoimmune diseases of unknown etiology is the extent to which tissue T-lymphocyte infiltrates, versus a nonspecific infiltrate, reflect a response to the causative agent. Lyme arthritis can histologically resemble rheumatoid synovitis, particularly the prominent infiltration by T lymphocyte...

journal_title：Infection and immunity

authors： Roessner K,Trivedi H,Gaur L,Howard D,Aversa J,Cooper SM,Sigal LH,Budd RC

更新日期：1998-03-01 00:00:00

abstract：:In this study, a novel recombinant attenuated Yersinia pseudotuberculosis PB1+ strain (χ10069) engineered with ΔyopK ΔyopJ Δasd triple mutations was used to deliver a Y. pestis fusion protein, YopE amino acid 1 to 138-LcrV (YopENt138-LcrV), to Swiss Webster mice as a protective antigen against infections by yersiniae....

journal_title：Infection and immunity

authors： Singh AK,Curtiss R 3rd,Sun W

更新日期：2019-09-19 00:00:00

abstract：:Neisseria gonorrhoeae, the etiologic agent of gonorrhea, is frequently asymptomatic in women, often leading to chronic infections. One factor contributing to this may be biofilm formation. N. gonorrhoeae can form biofilms on glass and plastic surfaces. There is also evidence that biofilm formation may occur during nat...

journal_title：Infection and immunity

authors： Falsetta ML,Bair TB,Ku SC,Vanden Hoven RN,Steichen CT,McEwan AG,Jennings MP,Apicella MA

更新日期：2009-09-01 00:00:00

abstract：:Mycobacterium tuberculosis has a unique family of PE-PGRS proteins with conserved N-terminal domains (PE) containing site-specific proline-glutamine residues and polymorphic GC-rich repetitive sequences (PGRS). Tuberculosis (TB) patients produce antibodies against some such proteins, but it is not clear whether these ...

journal_title：Infection and immunity

authors： Koh KW,Soh SE,Seah GT

更新日期：2009-08-01 00:00:00

abstract：:The development of vaccines for prevention of diseases caused by pathogenic species can encounter major obstacles if high sequence diversity is observed between individual strains. Therefore, development might be restricted either to conserved antigens, which are often rare, or to multivalent vaccines, which renders t...

journal_title：Infection and immunity

authors： Nayak A,Schüler W,Seidel S,Gomez I,Meinke A,Comstedt P,Lundberg U

更新日期：2020-03-23 00:00:00

abstract：:The pathogenesis of Staphylococcus aureus infections is influenced by multiple virulence factors that are expressed under variable conditions, and this has complicated the design of an effective vaccine. Clinical trials that targeted the capsule or clumping factor A (ClfA) failed to protect the recipients against stap...

journal_title：Infection and immunity

authors： Tuchscherr LP,Buzzola FR,Alvarez LP,Lee JC,Sordelli DO

更新日期：2008-12-01 00:00:00

abstract：:Ehrlichia chaffeensis is an obligately intracellular gram-negative bacterium and is the etiologic agent of human monocytic ehrlichiosis (HME). Although E. chaffeensis induces the generation of several cytokines and chemokines by leukocytes, E. chaffeensis lacks lipopolysaccharide and peptidoglycan. Bioinfomatic analys...

journal_title：Infection and immunity

authors： Huang H,Lin M,Wang X,Kikuchi T,Mottaz H,Norbeck A,Rikihisa Y

更新日期：2008-08-01 00:00:00

abstract：:Otitis media developed in 67% of chinchillas inoculated intranasally with type 7 Streptococcus pneumoniae and influenza A virus. Only 4% of chinchillas inoculated with influenza alone and 21% of chinchillas inoculated with S. pneumoniae alone developed otitis media. Among the chinchillas that developed otitis media af...

journal_title：Infection and immunity

authors： Giebink GS,Berzins IK,Marker SC,Schiffman G

更新日期：1980-11-01 00:00:00

abstract：:Colonization by Bordetella bronchiseptica results in a variety of inflammatory respiratory infections, including canine kennel cough, porcine atrophic rhinitis, and a whooping cough-like disease in humans. For successful colonization, B. bronchiseptica must acquire iron (Fe) from the infected host. A vast amount of Fe...

journal_title：Infection and immunity

authors： Mocny JC,Olson JS,Connell TD

更新日期：2007-10-01 00:00:00

abstract：:Livers of normal mice trapped over 80% of intravenously injected 51Cr-labeled lipopolysaccharide after 1 h. Liver fractionation studies showed that nearly 45% of the labeled endotoxin was associated with cell nuclei, 20% with the mitochondrial-lysosomal fraction, and approximately 30% with the cell sap. Analysis of th...

journal_title：Infection and immunity

authors： Zlydaszyk JC,Moon RJ

更新日期：1976-07-01 00:00:00

abstract：:Staphylococcus aureus infections are an important public health concern due to their increasing incidence and high rates of mortality. The success of S. aureus as a pathogen is highly related to its enormous capacity to evade the host immune response. The critical role of tumor necrosis factor alpha (TNF-α) in the ini...

journal_title：Infection and immunity

authors： Giai C,Gonzalez C,Ledo C,Garofalo A,Di Genaro MS,Sordelli DO,Gomez MI

更新日期：2013-11-01 00:00:00

abstract：:Elevated levels of immunoglobulin E anti-Candida antibodies were observed in the sera of patients with systemic and vaginal candidiasis and in cervicovaginal washings of the latter. ...

journal_title：Infection and immunity

authors： Mathur S,Goust JM,Horger EO 3rd,Fudenberg HH

更新日期：1977-10-01 00:00:00

abstract：:IL12RB1 is a human gene that is important for resistance to Mycobacterium tuberculosis infection. IL12RB1 is expressed by multiple leukocyte lineages, and encodes a type I transmembrane protein (IL12Rβ1) that associates with IL12p40 and promotes the development of host-protective T(H)1 cells. Recently, we observed tha...

journal_title：Infection and immunity

authors： Ray AA,Fountain JJ,Miller HE,Cooper AM,Robinson RT

更新日期：2015-02-01 00:00:00

abstract：:Thymidine kinase (TK) from herpes simplex virus type 1 (HSV-1) biochemically transformed HeLa cells, purified by affinity chromatography, has been characterized with respect to its electrophoretic mobility, molecular weight, activation energy, substrate specificity, and immunological specificity. TK purified from HSV-...

journal_title：Infection and immunity

authors： Cheng YC,Chadha KC,Hughes RG Jr

更新日期：1977-05-01 00:00:00

abstract：:The gram-negative gastric pathogen Helicobacter pylori is equipped with an extraordinarily large set of outer membrane proteins (OMPs), whose role in the infection process is not well understood. The Hop (Helicobacter outer membrane porins) and Hor (Hop-related proteins) groups constitute a large paralogous family con...

journal_title：Infection and immunity

authors： Odenbreit S,Swoboda K,Barwig I,Ruhl S,Borén T,Koletzko S,Haas R

更新日期：2009-09-01 00:00:00

abstract：:Iron is limiting in the human host, and bacterial pathogens respond to this environment by regulating gene expression through the ferric uptake regulator protein (Fur). In vitro studies have demonstrated that Neisseria gonorrhoeae controls the expression of several critical genes through an iron- and Fur-mediated mech...

journal_title：Infection and immunity

authors： Agarwal S,King CA,Klein EK,Soper DE,Rice PA,Wetzler LM,Genco CA

更新日期：2005-07-01 00:00:00

abstract：:The yeast form of the dimorphic fungus Histoplasma capsulatum survives within macrophages after phagocytosis. To do so, it must avoid, inhibit, or resist a variety of toxic oxygen metabolites. Using ferricytochrome c reduction to assay superoxide release, we examined the response of mouse macrophages to the yeast form...

journal_title：Infection and immunity

authors： Eissenberg LG,Goldman WE

更新日期：1987-01-01 00:00:00

abstract：:The two enteropathogens Yersinia pseudotuberculosis and Yersinia enterocolitica penetrate eukaryotic cells in vitro through invasin, a surface-exposed protein. In contrast, Yersinia pestis, the causative agent of plague, is unable to enter mammalian cell lines, although the inv gene is present on its chromosome. Altho...

journal_title：Infection and immunity

authors： Simonet M,Riot B,Fortineau N,Berche P

更新日期：1996-01-01 00:00:00

abstract：:The attachment of isogenic fimbriated and nonfimbriated Haemophilus influenzae type b variants to human cells was studied by using a radioactive assay and an indirect immunofluorescent assay. As described previously, fimbriated H. influenzae variants adhered to a greater extent than nonfimbriated variants to human buc...

journal_title：Infection and immunity

authors： Sable NS,Connor EM,Hall CB,Loeb MR

更新日期：1985-04-01 00:00:00

abstract：:Cholera toxin has been widely used to obtain insight into the cellular dynamics of the antigen-specific mucosal immune response. The present study was undertaken to clarify the influence of the organized intestinal lymphoid tissue (Peyer's patches [PP]) on the distribution of anti-cholera-toxin-containing cells (ACC) ...

journal_title：Infection and immunity

authors： Enders GA,Delius M,Ballhaus S,Brendel W

更新日期：1987-09-01 00:00:00

abstract：:We identified nonhemolytic mutants of Listeria monocytogenes that were severely deficient in their ability to invade mammalian nonprofessional phagocytes. These mutants were generated spontaneously or by means of transposon Tn916 mutagenesis. In terms of their extracellular proteins, the noninvasive mutants were defic...

journal_title：Infection and immunity

authors： Kathariou S,Pine L,George V,Carlone GM,Holloway BP

更新日期：1990-12-01 00:00:00

abstract：:The indigenous microbial flora of the middle ear cavity of Mongolian gerbils, Meriones unguiculatus, was isolated, characterized, and identified, showing it to be sparse and transitory. Organisms, when found in the middle ear cavity, were most likely to be Staphylococcus epidermidis-like organisms. Cerumen from the ex...

journal_title：Infection and immunity

authors： Thompson TA,Gardner D,Fulghum RS,Daniel HJ,Allen WE,Worthington JM,Williams PP

更新日期：1981-06-01 00:00:00

abstract：:It is currently accepted that malaria-parasitized red blood cells (pRBC) are eliminated, like senescent erythrocytes, phagocytically by macrophages in the red pulp of the spleen. Here, however, we show that self-healing Plasmodium chabaudi malaria activates spleen closure in C57BL/6 mice. Confocal laser scanning micro...

journal_title：Infection and immunity

authors： Krücken J,Mehnert LI,Dkhil MA,El-Khadragy M,Benten WP,Mossmann H,Wunderlich F

更新日期：2005-10-01 00:00:00

abstract：:Nonimmune binding of immunoglobulin to whole bacteria was quantitated for North American isolates of Haemophilus somnus recovered from cattle with pneumonia, reproductive failure (abortion), or thromboembolic meningoencephalitis or from the vagina or prepuce of carrier cattle. Quantitative binding activity covered a w...

journal_title：Infection and immunity

authors： Widders PR,Dorrance LA,Yarnall M,Corbeil LB

更新日期：1989-02-01 00:00:00

abstract：:Twenty monoclonal antibodies have been prepared to the erythrocytes from CBA/Ca mice infected with the rodent malaria Plasmodium chabaudi. By immunofluorescence, 15 of these antibodies recognized parasite antigens expressed only during the development of mature trophozoites to schizonts and merozoites, 2 recognized pa...

journal_title：Infection and immunity

authors： Boyle DB,Newbold CI,Smith CC,Brown KN

更新日期：1982-10-01 00:00:00

abstract：:The major antigenic determinants of the lipoglycans from Acholeplasma granularum and Acholeplasma axanthum were found to be the oligosaccharide sequences Glcp(beta 1 leads to 2)-Glcp(alpha 1 leads to 4)-Glcp and Glcp(beta 1 leads to 2)-Glcp(beta 1 leads to 2)-Glcp, respectively. The disaccharides sophorose and maltose...

journal_title：Infection and immunity

authors： Al-Samarrai TH,Smith PF,Lynn RJ

更新日期：1983-05-01 00:00:00

abstract：:This study was designed to define the lipopolysaccharide (LPS) sensitivity of aged mice in terms of lethality and cytokine production and to determine down-regulating responses of corticosterone and interleukin 10 (IL-10). The 50% lethal doses of LPS in young (6- to 7-week-old) and aged (98- to 102-week-old) mice were...

journal_title：Infection and immunity

authors： Tateda K,Matsumoto T,Miyazaki S,Yamaguchi K

更新日期：1996-03-01 00:00:00

abstract：:Rabbit synovial cells (SC), articular chondrocytes (AC), and epiphyseal (EC) chondrocytes were grown in vitro. A portion of the spectrum of human pathogenic viruses infective for the cells was determined. Responses of the cells to different viruses or a chemical inducer of interferon varied, with EC responding vigorou...

journal_title：Infection and immunity

authors： Craig CP,Gordon SL,Greer RB

更新日期：1973-09-01 00:00:00

abstract：:The immunogenicity of a single dose of a whole-cell vaccine of inactivated Borrelia burgdorferi HSF (human spinal fluid isolate) was evaluated. Syrian hamsters were vaccinated subcutaneously and challenged by the intraperitoneal injection of 1,000 50% infectious doses of B. burgdorferi HSF 30 or 90 days postvaccinatio...

journal_title：Infection and immunity

authors： Johnson RC,Kodner C,Russell M

更新日期：1986-12-01 00:00:00

abstract：:Infantile gastroenteritis virus (orbi-group) recovered from stools of infants with acute nonbacterial gastroenteritis was administered per os to germfree and conventional piglets. Virus was found subsequently in stools and in the mucosal epithelial cells of the small intestine of these animals. Some animals developed ...

journal_title：Infection and immunity

authors： Middleton PJ,Petric M,Szymanski MT

更新日期：1975-12-01 00:00:00