Vibrio cholerae expresses cell surface antigens during intestinal infection which are not expressed during in vitro culture.

abstract：:The antigenically variant Chlamydia trachomatis major outer membrane protein (MOMP) is a target of antibody-mediated neutralization in vitro, and it is an important protein for designing a subunit vaccine. Knowledge of MOMP T-cell determinants will be essential to elicit rapid and strong immune responses following an ...

journal_title：Infection and immunity

authors： Ishizaki M,Allen JE,Beatty PR,Stephens RS

更新日期：1992-09-01 00:00:00

abstract：:Variation has been observed in the structural polypeptides of swine vesicular disease viruses isolated from the United Kingdom and Hong Kong. Despite the limited number of isolates examined, several distinct polypeptide patterns were obtained when the virus structural proteins were examined by polyacrylamide gel elect...

journal_title：Infection and immunity

authors： Harris TJ,Underwood BO,Knowles NJ,Crowther JR,Brown F

更新日期：1979-06-01 00:00:00

abstract：:3-O-methylmannose isolated from Coccidioides immitis was characterized by gas chromatographic comparison of derivatives with those of synthetic 3-O-methylmannose. Gas chromatographic behavior of three derivatives of the natural and synthetic sugars was identical. ...

journal_title：Infection and immunity

authors： Porter JF,Scheer ER,Wheat RW

更新日期：1971-11-01 00:00:00

abstract：:The immune response of humans and mice to temperature-specific, plasmid- or chromosome-encoded proteins of yersinia pestis and Yersinia enterocolitica was investigated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting. Extracts from Y. pestis and Y. enterocolitica strains with and witho...

journal_title：Infection and immunity

authors： Mazza G,Karu AE,Kingsbury DT

更新日期：1985-06-01 00:00:00

abstract：:Two murine monoclonal antibodies (immunoglobulin M) evoked against human kidney tissue were examined for cross-reactivity with group A streptococci. A glomerulus-specific antibody, PMII.40.H.2, cross-reacted in an enzyme-linked immunosorbent assay with purified pepsin-extracted M proteins from type 6 and 12 streptococ...

journal_title：Infection and immunity

authors： Goroncy-Bermes P,Dale JB,Beachey EH,Opferkuch W

更新日期：1987-10-01 00:00:00

abstract：:To study responses to Mycobacterium leprae antigens, we developed an in vitro model system in which latex particles coated with M. leprae sonic extract (MLSON) antigen were presented to monocytes. Uptake and oxidative response as measured by superoxide production to these antigens were investigated. Phagocytosis of ML...

journal_title：Infection and immunity

authors： Hasan RS,Dockrell HM,Jamil S,Chiang TJ,Hussain R

更新日期：1993-09-01 00:00:00

abstract：:Human granulocytic anaplasmosis (HGA) is caused by the obligate intracellular bacterium Anaplasma phagocytophilum. The critical role of gamma interferon (IFN-gamma) for induction of severe inflammatory histopathology, even in the absence of a significant bacterial load, was previously demonstrated in a murine model of...

journal_title：Infection and immunity

authors： Choi KS,Webb T,Oelke M,Scorpio DG,Dumler JS

更新日期：2007-06-01 00:00:00

abstract：:A significant clinical complication of pulmonary infections with Klebsiella pneumoniae is peripheral blood dissemination, resulting in a systemic infection concurrent with the localized pulmonary infection. In this context, little is known about the role of tumor necrosis factor receptor 1 (TNFR1)-mediated innate immu...

journal_title：Infection and immunity

authors： Moore TA,Perry ML,Getsoian AG,Monteleon CL,Cogen AL,Standiford TJ

更新日期：2003-09-01 00:00:00

abstract：:We examined the association of Herpesvirus saimiri with lymphocyte subsets and the functional integrity and distribution of these populations in owl monkeys with chronic, disease-free infections, in uninoculated, control animals, and in one monkey with H. saimiri-induced lymphoma. The lymphocyte subpopulations examine...

journal_title：Infection and immunity

authors： Neubauer RH,Dunn FE,Rabin H

更新日期：1981-05-01 00:00:00

abstract：:A system is described for studying adoptive immunity to tuberculosis in syngeneic mice. Donor mice were immunized with 10(4) BCG intravenously, and lymphoid cells were harvested 28 days later. Adoptive immunity was measured in recipient mice in terms of the inhibition of growth of BCG in the liver and spleen following...

journal_title：Infection and immunity

authors： Lefford MJ

更新日期：1975-06-01 00:00:00

abstract：:Microbial survival in a host is usually dependent on the ability of a pathogen to undergo changes that promote escape from host defense mechanisms. The human-pathogenic fungus Cryptococcus neoformans undergoes phenotypic switching in vivo that promotes persistence in tissue. By microarray and real-time PCR analyses, t...

journal_title：Infection and immunity

authors： Jain N,Li L,Hsueh YP,Guerrero A,Heitman J,Goldman DL,Fries BC

更新日期：2009-01-01 00:00:00

abstract：:The ability of intracellular pathogens to sense and adapt to the hostile environment of the host is an important factor governing virulence. We have sequenced the operon encoding the major heat shock proteins GroES and GroEL in the gram-positive food-borne pathogen Listeria monocytogenes. The operon has a conserved or...

journal_title：Infection and immunity

authors： Gahan CG,O'Mahony J,Hill C

更新日期：2001-06-01 00:00:00

abstract：:The mechanism by which capsular polysaccharides inhibit phagocytosis is not clearly understood. We investigated the association between a negative surface charge and inhibition of phagocytosis by the capsular polysaccharide of Cryptococcus neoformans. A two-polymer aqueous-phase system containing phosphate ions was us...

journal_title：Infection and immunity

authors： Kozel TR,Reiss E,Cherniak R

更新日期：1980-08-01 00:00:00

abstract：:Broth culture supernatants from Tox+ Helicobacter pylori strains induce vacuolation of HeLa cells in vitro and contain VacA in concentrations that are higher than those found in supernatants from Tox- H. pylori strains. To investigate the basis for this phenomenon, we analyzed the transcription of the vacuolating cyto...

journal_title：Infection and immunity

authors： Forsyth MH,Atherton JC,Blaser MJ,Cover TL

更新日期：1998-07-01 00:00:00

abstract：:Trichomonas vaginalis is a sexually transmitted protozoan parasite that undergoes phenotypic variation for numerous surface proteins. A monoclonal antibody (MAb) was used to isolate an approximately 400-bp cDNA encoding a fragment of an important phenotypically varying immunogen of T. vaginalis (Mr = 270 kDa; P270). T...

journal_title：Infection and immunity

authors： Dailey DC,Alderete JF

更新日期：1991-06-01 00:00:00

abstract：:BCG, the attenuated strain of Mycobacterium bovis, has been widely used as a vaccine against tuberculosis and is thus an important candidate as a live carrier for multiple antigens. With the aim of developing a recombinant BCG (rBCG) vaccine against diphtheria, pertussis, and tetanus (DPT), we analyzed the potential o...

journal_title：Infection and immunity

authors： Miyaji EN,Mazzantini RP,Dias WO,Nascimento AL,Marcovistz R,Matos DS,Raw I,Winter N,Gicquel B,Rappuoli R,Leite LC

更新日期：2001-02-01 00:00:00

abstract：:Once Candida albicans comes in contact with endothelial cells, it induces cellular injury. This endothelial cell injury may be a mechanism by which blood-borne organisms escape from the intravascular compartment and invade the tissue parenchyma during hematogenous infection. We have been investigating the ability of c...

journal_title：Infection and immunity

authors： Fratti RA,Ghannoum MA,Edwards JE Jr,Filler SG

更新日期：1996-11-01 00:00:00

abstract：:Recombinant major surface antigen (P30), which was produced as a glutathione S-transferase (EC 2.5.1.18) fusion protein of Toxoplasma gondii, was found to be able to activate macrophages to kill T. gondii in vitro. The macrophage activation was due to P30 in the fusion protein, not to glutathione S-transferase. ...

journal_title：Infection and immunity

authors： Makioka A,Kobayashi A

更新日期：1991-08-01 00:00:00

abstract：:The disruption of a specific gene in Candida albicans is commonly used to determine the function of the gene product. We disrupted AAF1, a gene of C. albicans that causes Saccharomyces cerevisiae to flocculate and adhere to endothelial cells. We then characterized multiple heterozygous and homozygous mutants. These nu...

journal_title：Infection and immunity

authors： Rieg G,Fu Y,Ibrahim AS,Zhou X,Filler SG,Edwards JE Jr

更新日期：1999-07-01 00:00:00

abstract：:Genomics revealed the sequence of 3924 genes of the H37Rv strain of Mycobacterium tuberculosis. Proteomics complements genomics in showing which genes are really expressed, and here we show the expression of six genes not predicted by genomics, as proved by two-dimensional electrophoresis and matrix-assisted laser des...

journal_title：Infection and immunity

authors： Jungblut PR,Müller EC,Mattow J,Kaufmann SH

更新日期：2001-09-01 00:00:00

abstract：:The clinical and histopathological manifestations of syphilis and the invasive behavior of Treponema pallidum in tissue culture systems reflect the propensity for treponemes to migrate through skin, hematogenously disseminate, and invade targeted tissues. Treponemal motility is believed to be essential to this process...

journal_title：Infection and immunity

authors： Hagman KE,Porcella SF,Popova TG,Norgard MV

更新日期：1997-05-01 00:00:00

abstract：:Two distinct and complementary pathways, one mediated by perforin and the other dependent upon CD95 (Fas), effect cell-mediated cytotoxicity. We examined the relative roles of these pathways in host defenses against the intracellular bacterial pathogen Listeria monocytogenes by using murine listeriosis as a model syst...

journal_title：Infection and immunity

authors： Jensen ER,Glass AA,Clark WR,Wing EJ,Miller JF,Gregory SH

更新日期：1998-09-01 00:00:00

abstract：:Salmonellae with differences only in the O-antigenic polysaccharide of their lipopolysaccharide were previously shown to differentially activate complement via the alternative pathway, causing them to be ingested at different rates by the mouse macrophage-like cell line J774. We now show that this mechanism could expl...

journal_title：Infection and immunity

authors： Liang-Takasaki CJ,Saxén H,Mäkelä PH,Leive L

更新日期：1983-08-01 00:00:00

abstract：:The yields of exotoxin A in Pseudomonas aeruginosa cultures were influenced by the concentration of iron in the culture media. When the iron concentration of the culture media was increased from 0.05 to 1.5 microgram/ml, there was at least a 90% decrease in exotoxin A (measured both by enzymatic activity and by mouse ...

journal_title：Infection and immunity

authors： Bjorn MJ,Iglewski BH,Ives SK,Sadoff JC,Vasil ML

更新日期：1978-03-01 00:00:00

abstract：:Parasite antigens which bind to host cell molecules of approximately 32 and 34 kilodaltons (kDa) were identified in supernatant fluids obtained from axenic cultures of Trypanosoma cruzi. These parasite components were first detected in culture supernatants obtained after 2 weeks in culture. Immunoblot analysis of cult...

journal_title：Infection and immunity

authors： Davis CD,Kuhn RE

更新日期：1990-06-01 00:00:00

abstract：:Alveolar bone destruction is a characteristic feature of periodontitis. Treponema denticola is known to be involved in periodontitis. To elucidate the role of T. denticola in alveolar bone destruction in periodontitis, the effects of lipooligosaccharide (LOS) from T. denticola on osteoclast formation and on expression...

journal_title：Infection and immunity

authors： Choi BK,Lee HJ,Kang JH,Jeong GJ,Min CK,Yoo YJ

更新日期：2003-01-01 00:00:00

abstract：:The antiinflammatory cytokine response during urosepsis was determined by measurement of concentrations of soluble tumor necrosis factor receptor (sTNFR) types I and II, interleukin 1 receptor antagonist (IL-1ra), soluble IL-1 receptor type II (sIL-1RII), and interleukin 10 in sera and urine of 30 patients with cultur...

journal_title：Infection and immunity

authors： Olszyna DP,Prins JM,Buis B,van Deventer SJ,Speelman P,van der Poll T

更新日期：1998-08-01 00:00:00

abstract：:Borrelia burgdorferi undergoes differential gene expression during transmission from its tick vector to a vertebrate host. The addition of blood to a spirochete culture at 35 degrees C for 48 h had a dramatic effect on gene expression of this organism. Utilizing B. burgdorferi whole genome DNA arrays, we compared the ...

journal_title：Infection and immunity

authors： Tokarz R,Anderton JM,Katona LI,Benach JL

更新日期：2004-09-01 00:00:00

abstract：:The American Heart Association supports an association between periodontal diseases and atherosclerosis but not a causal association. This study explores the use of the integrin β6(-/-) mouse model to study the causality. We investigated the ability of a polymicrobial consortium of Porphyromonas gingivalis, Treponema ...

journal_title：Infection and immunity

authors： Velsko IM,Chukkapalli SS,Rivera-Kweh MF,Zheng D,Aukhil I,Lucas AR,Larjava H,Kesavalu L

更新日期：2015-12-01 00:00:00

abstract：:Platelets aggregate in response to an adhesin and the platelet aggregation-associated protein (PAAP) expressed on the cell surfaces of certain strains of Streptococcus sanguis. We sought to identify the corresponding PAAP receptor and accessory adhesin binding sites on platelets. Since the adhesion(s) of S. sanguis fo...

journal_title：Infection and immunity

authors： Gong K,Wen DY,Ouyang T,Rao AT,Herzberg MC

更新日期：1995-09-01 00:00:00