Low-dose lipopolysaccharide (LPS) pretreatment of mouse macrophages modulates LPS-dependent interleukin-6 production in vitro.

abstract：:Subtilase cytotoxin (SubAB) was first isolated from a Shiga toxigenic Escherichia coli (STEC) strain that was responsible for an outbreak of hemolytic-uremic syndrome and is the prototype of a new family of AB(5) cytotoxins. SubAB is a subtilase-like serine protease, and upon uptake by host cells, it is trafficked to ...

journal_title：Infection and immunity

authors： May KL,Paton JC,Paton AW

更新日期：2010-11-01 00:00:00

abstract：:Cure of amebic liver abscess is associated with resistance to recurrent invasive amebiasis and the development of a humoral and cell-mediated immune response. We determined whether human immune sera contain blocking antibody for the 170-kilodalton (kDa) galactose or N-acetylgalactosamine (Gal/GalNAc)-binding lectin of...

journal_title：Infection and immunity

authors： Petri WA Jr,Joyce MP,Broman J,Smith RD,Murphy CF,Ravdin JI

更新日期：1987-10-01 00:00:00

abstract：:Salmonella enterica serovar Typhimurium causes self-limiting gastroenteritis in humans and a typhoid-like disease in mice that serves as a model for typhoid infections in humans. A critical step in Salmonella pathogenesis is the invasion of enterocytes and M cells of the small intestine via expression of a type III se...

journal_title：Infection and immunity

authors： Boddicker JD,Jones BD

更新日期：2004-04-01 00:00:00

abstract：:Previous studies have suggested that the Pseudomonas aeruginosa PAK pilus adhesin moiety resides in an epithelial cell-binding domain located in the C-terminal region of the PAK pilin structural protein. Synthetic peptides Ac17red (a synthetic peptide with a sequence identical to that of PAK pilin residues 128 to 144,...

journal_title：Infection and immunity

authors： Irvin RT,Doig P,Lee KK,Sastry PA,Paranchych W,Todd T,Hodges RS

更新日期：1989-12-01 00:00:00

abstract：:The filarial nematode Onchocerca volvulus is the causative organism of river blindness. Our previous studies demonstrated an essential role for endosymbiotic Wolbachia bacteria in corneal disease, which is characterized by neutrophil infiltration into the corneal stroma and the development of corneal haze. To determin...

journal_title：Infection and immunity

authors： Gillette-Ferguson I,Daehnel K,Hise AG,Sun Y,Carlson E,Diaconu E,McGarry HF,Taylor MJ,Pearlman E

更新日期：2007-12-01 00:00:00

abstract：:The interferon-inducing capabilities of the three molecular segments of bacteriophage phi6 double-stranded ribonucleic acid increased with increasing molecular weight. ...

journal_title：Infection and immunity

authors： Kleinschmidt WJ,Van Etten JL,Vidaver AK

更新日期：1974-07-01 00:00:00

abstract：:Oligopeptides play important roles in bacterial nutrition and signaling. Using sequences from the available genome database for Mycobacterium tuberculosis H37Rv, the oligopeptide permease operon (oppBCDA) of Mycobacterium bovis BCG was cloned from a cosmid library. An opp mutant strain was constructed by homologous re...

journal_title：Infection and immunity

authors： Green RM,Seth A,Connell ND

更新日期：2000-02-01 00:00:00

abstract：:The extracellular cysteine protease from Streptococcus pyogenes is a virulence factor that plays a significant role in host-pathogen interaction. Streptococcal protease is expressed as an inactive 40-kDa precursor that is autocatalytically converted into a 28-kDa mature (active) enzyme. Replacement of the single cyste...

journal_title：Infection and immunity

authors： Matsuka YV,Pillai S,Gubba S,Musser JM,Olmsted SB

更新日期：1999-09-01 00:00:00

abstract：:Herein we report an important role for the ferric uptake regulator (Fur) in the resistance of Salmonella enterica serovar Typhimurium to the reactive nitrogen species produced by inducible nitric oxide (NO) synthase in an NRAMP1(r) murine model of acute systemic infection. The expression of fur protected Salmonella gr...

journal_title：Infection and immunity

authors： Husain M,Jones-Carson J,Liu L,Song M,Saah JR,Troxell B,Mendoza M,Hassan H,Vázquez-Torres A

更新日期：2014-01-01 00:00:00

abstract：:Help from CD4 T cells is often important for the establishment of primary and memory CD8 T-cell responses. However, it has yet to be determined whether T helper polarization affects the delivery of help and/or whether responding CD8 T cells helped by Th1 or Th2 cells express distinct effector properties. To address th...

journal_title：Infection and immunity

authors： Ekkens MJ,Shedlock DJ,Jung E,Troy A,Pearce EL,Shen H,Pearce EJ

更新日期：2007-05-01 00:00:00

abstract：:Lipooligosaccharide (LOS) is a major surface component of Moraxella catarrhalis and a possible virulence factor in the pathogenesis of human infections caused by this organism. The presence of LOS on the bacterium is an obstacle to the development of vaccines derived from whole cells or outer membrane components of th...

journal_title：Infection and immunity

authors： Peng D,Hong W,Choudhury BP,Carlson RW,Gu XX

更新日期：2005-11-01 00:00:00

abstract：:Mutation of sarA resulted in a reduced capacity to form a biofilm in six of the eight Staphylococcus aureus strains we tested (UAMS-1, UAMS-601, SA113, SC-01, S6C, and DB). The exceptions were Newman, which formed a poor biofilm under all conditions, and RN6390, which consistently formed a biofilm only after mutation ...

journal_title：Infection and immunity

authors： Beenken KE,Blevins JS,Smeltzer MS

更新日期：2003-07-01 00:00:00

abstract：:Mutation of tryptophan-101 in Clostridium difficile toxin A, a 308-kDa glucosyltransferase, resulted in a 50-fold-reduced cytopathic activity in cell culture experiments. The mutant toxin A was characterized and applied to distinguish between glucosyltransferase-dependent and -independent effects with respect to RhoB ...

journal_title：Infection and immunity

authors： Teichert M,Tatge H,Schoentaube J,Just I,Gerhard R

更新日期：2006-10-01 00:00:00

abstract：:Clostridium perfringens enterotoxin (CPE), a single polypeptide of 319 amino acids, has a unique multistep mechanism of action. In the first step, CPE binds to claudin proteins and/or a 50-kDa eukaryotic membrane protein receptor, forming a small ( approximately 90-kDa) complex. This small complex apparently then asso...

journal_title：Infection and immunity

authors： Kokai-Kun JF,Benton K,Wieckowski EU,McClane BA

更新日期：1999-11-01 00:00:00

abstract：:Salmonella is a widespread zoonotic enteropathogen that causes gastroenteritis and fatal typhoidal disease in mammals. During systemic infection of mice, Salmonella enterica serovar Typhimurium resides and replicates in macrophages within the "Salmonella-containing vacuole" (SCV). It is surprising that the substrates ...

journal_title：Infection and immunity

authors： Bowden SD,Rowley G,Hinton JC,Thompson A

更新日期：2009-07-01 00:00:00

abstract：:The outcome of infection is determined by both the quantity and the quality of an induced immune response. In particular, it has been demonstrated for selected pathogens that induction of TH1 or TH2 type helper T-cell subsets determines whether an immune response gives rise to protective immunity or disease-associated...

journal_title：Infection and immunity

authors： Westbay TD,Dascher CC,Hsia RC,Zauderer M,Bavoil PM

更新日期：1995-04-01 00:00:00

abstract：:Trypanosoma brucei subsp. brucei and T. congolense incubated in homologous antibody at 0 degrees C for 30 min were lysed by subsequent addition of guinea pig complement. Trypanosomes incubated in antibody at 37 degrees C before complement treatment remained intact. Parasites bearing adsorbed antibody also remained int...

journal_title：Infection and immunity

authors： Balber AE,Bangs JD,Jones SM,Proia RL

更新日期：1979-06-01 00:00:00

abstract：:Natural killer (NK) cells are considered to be key players in the early innate responses to protozoan infections, primarily indirectly by producing gamma interferon (IFN-gamma) in response to cytokines, like interleukin 12 (IL-12). We demonstrate that live, as well as heat-inactivated, tachyzoites of Neospora caninum,...

journal_title：Infection and immunity

authors： Boysen P,Klevar S,Olsen I,Storset AK

更新日期：2006-02-01 00:00:00

abstract：:Despite the high prevalence of cutaneous infections, little is known about the role of host immune responsiveness during Staphylococcus aureus dermatitis. We have recently described a murine model of infectious dermatitis induced by superantigen-producing S. aureus. To assess the role of neutrophils in staphylococcal ...

journal_title：Infection and immunity

authors： Mölne L,Verdrengh M,Tarkowski A

更新日期：2000-11-01 00:00:00

abstract：:Macrophages are critical mediators of innate immunity and must be overcome for bacterial pathogens to cause disease. The Gram-positive bacterium Staphylococcus aureus produces virulence factors that impede macrophages and other immune cells. We previously determined that production of the metabolic cofactor lipoic aci...

journal_title：Infection and immunity

authors： Grayczyk JP,Alonzo F 3rd

更新日期：2019-09-19 00:00:00

abstract：:Campylobacter rectus is a putative periodontopathogen which expresses a proteinaceous surface layer (S-layer) external to the outer membrane. S-layers are considered to play a protective role for the microorganism in hostile environments. The S-layer proteins from six different C. rectus strains (five human isolates a...

journal_title：Infection and immunity

authors： Nitta H,Holt SC,Ebersole JL

更新日期：1997-02-01 00:00:00

abstract：:Most vaccines are still given parenterally. Mucosal vaccination would offer different advantages over parenteral immunization, including blocking of the pathogens at the portal of entry. In this paper, nontoxic Escherichia coli heat-labile enterotoxin (LT) mutants and Supramolecular Biovector systems (SMBV) were evalu...

journal_title：Infection and immunity

authors： Baudner BC,Balland O,Giuliani MM,Von Hoegen P,Rappuoli R,Betbeder D,Del Giudice G

更新日期：2002-09-01 00:00:00

abstract：:The Corynebacterium diphtheriae hmuO gene encodes a heme oxygenase that is involved in the utilization of heme as an iron source. Transcription of hmuO is activated by heme or hemoglobin and repressed by iron and DtxR. Previous studies with Escherichia coli showed that heme-dependent transcriptional activation of an h...

journal_title：Infection and immunity

authors： Bibb LA,King ND,Kunkle CA,Schmitt MP

更新日期：2005-11-01 00:00:00

abstract：:Specific proteolytic destruction of the human chemotaxin, C5a, is a property of group A and B streptococcal pathogens. Here we show that virulent group G streptococci from human sources also express C5a peptidase activity. The enzyme responsible for this activity is approximately the same size as and is antigenically ...

journal_title：Infection and immunity

authors： Cleary PP,Peterson J,Chen C,Nelson C

更新日期：1991-07-01 00:00:00

abstract：:Two fragments with molecular weights of 111,000 (fragment I) and 59,000 (fragment II) were separated from each other by gel filtration of dithiothreitol and urea-treated, trypsinized derivative toxin (molecular weight, 170,000) of the proteolytic Okra strain of Clostridium botulinum type B on a column of Sephadex G-20...

journal_title：Infection and immunity

authors： Kozaki S,Miyazaki S,Sakaguchi G

更新日期：1977-12-01 00:00:00

abstract：:A nonclonal population of Borrelia burgdorferi N40 (passage 3) that survived protective immunity following challenge inoculation of outer surface protein (Osp) A- or B-hyperimmunized mice were characterized for the molecular basis of evasion of immunity. Two of six B. burgdorferi isolates, cultured from OspA-immunized...

journal_title：Infection and immunity

authors： Fikrig E,Tao H,Barthold SW,Flavell RA

更新日期：1995-05-01 00:00:00

abstract：:Larvae of Toxocara canis, a nematode parasite of dogs, infect humans, causing visceral and ocular larva migrans. In noncanid hosts, larvae neither grow nor differentiate but endure in a state of arrested development. Reasoning that parasite protein production is orientated to immune evasion, we undertook a random sequ...

journal_title：Infection and immunity

authors： Tetteh KK,Loukas A,Tripp C,Maizels RM

更新日期：1999-09-01 00:00:00

abstract：:We produced anti-idiotype antibodies to antibody to lipid A from Eikenella corrodens. The ALA-1 monoclonal antibody (immunoglobulin M [IgM] isotype), which had already been produced in our laboratory (T. Kato, I. Takazoe, and K. Okuda, Infect. Immun. 57:656-659, 1989), had reacted strongly with lipid A from E. corrode...

journal_title：Infection and immunity

authors： Kato T,Takazoe I,Okuda K

更新日期：1990-02-01 00:00:00

abstract：:We investigated the cytokine/chemokine secretions and alteration of protein expression from peripheral blood mononuclear cells (PBMCs) cocultured with adult liver flukes (Opisthorchis viverrini) for 6 to 24 h. PBMC-derived proteins were identified by two-dimensional electrophoresis and mass spectrometry, and the cytok...

journal_title：Infection and immunity

authors： Hongsrichan N,Intuyod K,Pinlaor P,Khoontawad J,Yongvanit P,Wongkham C,Roytrakul S,Pinlaor S

更新日期：2014-05-01 00:00:00

abstract：:Bordetella dermonecrotizing toxin (DNT) stimulates the assembly of actin stress fibers and focal adhesions by deamidating Gln63 of the small GTPase Rho. To clarify the functional and structural organization of DNT, we cloned and sequenced the DNT gene and examined the functions of various DNT mutants. Our analyses of ...

journal_title：Infection and immunity

authors： Kashimoto T,Katahira J,Cornejo WR,Masuda M,Fukuoh A,Matsuzawa T,Ohnishi T,Horiguchi Y

更新日期：1999-08-01 00:00:00