Abstract:
:Most Escherichia coli isolates can express type 1 fimbriae with mannose-specific adhesins. These adhesins bind to the oligosaccharide chains of secretory immunoglobulin A (IgA). Thus, in addition to specific antibody activity, secretory IgA possesses a broad reactivity with bacteria expressing type 1 fimbriae. The absence of secretory IgA in colonic secretions, as seen in IgA deficiency, might therefore alter the ability of type 1-fimbriated E. coli to colonize the large intestines of these individuals. In the present study, 10 E. coli isolates from each of 17 IgA-deficient and 17 age-matched control individuals were assessed for the carriage of the fim gene cluster by DNA-DNA hybridization and for the expression of type 1 fimbriae by hemagglutination of guinea pig erythrocytes. The contribution of type 1-fimbria-mediated adherence to HT-29 colonic cells was also analyzed. The proportion of fim+ E. coli isolates was lower in IgA-deficient than in control individuals (74 versus 94%, P < 0.05), as was the proportion of isolates expressing type 1 fimbriae in vitro (69% versus 85%, P < 0.05). The median mannose-sensitive adherence to HT-29 cells was lower for isolates from IgA-deficient individuals than from the controls (9 versus 26 bacteria per cell, P < 0.05). Isolates expressing type 1 fimbriae showed lower adherence to HT-29 cells when they were derived from IgA-deficient individuals than when they were derived from control individuals (15 versus 27 bacteria per cell, P < 0.05). The results suggest that the interaction of type 1 fimbriae with secretory IgA contributes to the large intestinal colonization by these bacteria.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Friman V,Adlerberth I,Connell H,Svanborg C,Hanson LA,Wold AEdoi
10.1128/IAI.64.7.2794-2798.1996subject
Has Abstractpub_date
1996-07-01 00:00:00pages
2794-8issue
7eissn
0019-9567issn
1098-5522journal_volume
64pub_type
杂志文章abstract::Sensitized mouse spleen cells decrease the spread of herpes simplex virus infection in cell culture lines derived from human and murine tissues. These washed, sensitized cells act alone and additively in combination with antibody to diminish the ability of single virus-infected cells to spread infection to contiguous ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.7.6.898-904.1973
更新日期:1973-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.3.406-411.1973
更新日期:1973-09-01 00:00:00
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更新日期:2001-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.21.3.879-885.1978
更新日期:1978-09-01 00:00:00
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更新日期:2002-10-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2005-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.11.2701-2705.1987
更新日期:1987-11-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2001-11-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2001-09-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.4.1240-1247.1989
更新日期:1989-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00917-19
更新日期:2020-03-23 00:00:00
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更新日期:2000-10-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.38.3.1078-1087.1982
更新日期:1982-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-02-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.5.1374-1379.1989
更新日期:1989-05-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.01579-06
更新日期:2007-04-01 00:00:00
abstract::Antimicrobial peptides play an important role in host defense against Vibrio cholerae Generally, the V. cholerae O1 classical biotype is polymyxin B (PB) sensitive and El Tor is relatively resistant. Detection of classical biotype traits like the production of classical cholera toxin and PB sensitivity in El Tor strai...
journal_title:Infection and immunity
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doi:10.1128/IAI.00080-20
更新日期:2020-04-20 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.33.1.171-177.1981
更新日期:1981-07-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.66.10.4788-4796.1998
更新日期:1998-10-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.31.1.136-143.1981
更新日期:1981-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.32.1.111-117.1981
更新日期:1981-04-01 00:00:00
abstract::Nontypeable Haemophilus influenzae (NTHi) is a commensal microorganism of the human nasopharynx, and yet is also an opportunistic pathogen of the upper and lower respiratory tracts. Host microenvironments influence gene expression patterns, likely critical for NTHi persistence. The host sequesters iron as a mechanism ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01227-12
更新日期:2013-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.12.7247-7256.2004
更新日期:2004-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.1.21-26.1995
更新日期:1995-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.11.4937-4939.1993
更新日期:1993-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.16.1.258-262.1977
更新日期:1977-04-01 00:00:00
abstract::The mechanism by which hamsters acquire resistance to yaws or frambesia is poorly understood. This investigation has shown that immune lymphoid cells (spleen and lymph node) could confer on hamsters resistance to infection with Treponema pertenue. Treatment of these immune cells with a specific antithymocyte serum (AT...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.25.1.208-212.1979
更新日期:1979-07-01 00:00:00
abstract::The role of cysteine proteinases in adherence of Trichomonas vaginalis NYH 286 to HeLa and human vaginal epithelial cells was evaluated. Only pretreatment of trichomonads, but not epithelial cells, with N-alpha-p-tosyl-L-lysine chloromethyl ketone (TLCK), an inhibitor of trichomonad cysteine proteinases, greatly dimin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.10.2991-2997.1989
更新日期:1989-10-01 00:00:00