Prevention of endotoxin-induced acute lethality in Propionibacterium acnes-primed rabbits by an antibody to leukocyte integrin beta 2 with concomitant reduction of cytokine production.

abstract：:An enhanced memory response, as shown by increased titers of specific immunoglobulin A (IgA), was seen in intestinal secretions from isolated Thiry-Vella loops in rabbits primed orally with live, locally invasive Shigella sp. X16 and challenged 60 days later with a single oral dose of the same antigen. Heat-killed shi...

journal_title：Infection and immunity

authors： Keren DF,McDonald RA,Scott PJ,Rosner AM,Strubel E

更新日期：1985-01-01 00:00:00

abstract：:The lipid A portion has been identified as the active center responsible for lipopolysaccharide (LPS)-induced macrophage activation. However, we found that Salmonella (Salmonella enterica serovars Abortusequi, Minnesota, and Typhimurium) lipid A is inactive in human macrophages, despite its LPS being highly active. Th...

journal_title：Infection and immunity

authors： Muroi M,Tanamoto K

更新日期：2002-11-01 00:00:00

abstract：:Mycoplasma genitalium is a sexually transmitted pathogen associated with several acute and chronic reproductive tract disease syndromes in men and women. To evaluate the suitability of a pig-tailed macaque model of M. genitalium infection, we inoculated a pilot animal with M. genitalium strain G37 in the uterine cervi...

journal_title：Infection and immunity

authors： Wood GE,Iverson-Cabral SL,Patton DL,Cummings PK,Cosgrove Sweeney YT,Totten PA

更新日期：2013-08-01 00:00:00

abstract：:Members of our group reported recently that neisseria infection of human epithelial cells results in accelerated degradation of the major lysosomal integral membrane protein LAMP1 and that this is due to hydrolysis of this glycoprotein at its immunoglobulin A1 (IgA1)-like hinge by the neisseria type 2 IgA1 protease (L...

journal_title：Infection and immunity

authors： Ayala P,Lin L,Hopper S,Fukuda M,So M

更新日期：1998-10-01 00:00:00

abstract：:The immunoprotective activity of Klebsiella pneumoniae K2 cell surface preparations and purified capsular polysaccharide was tested in mice. The 50% protective dose (PD50), expressed as capsular polysaccharide content, was 2 ng for cell surface preparations and 50 ng for purified capsular polysaccharide. Both preparat...

journal_title：Infection and immunity

authors： Robert A,Jouin H,Fournier JM

更新日期：1986-11-01 00:00:00

abstract：:Helicobacter pylori maintains colonization in its human host using a limited set of taxis sensors. TlpD is a proposed energy taxis sensor of H. pylori and dominant under environmental conditions of low bacterial energy yield. We studied the impact of H. pylori TlpD on colonization in vivo using a gerbil infection mode...

journal_title：Infection and immunity

authors： Behrens W,Schweinitzer T,Bal J,Dorsch M,Bleich A,Kops F,Brenneke B,Didelot X,Suerbaum S,Josenhans C

更新日期：2013-10-01 00:00:00

abstract：:Randomly bred guinea pigs were infected with Listeria monocytogenes using the intracardial, intravenous and intraperitoneal routes of infection. Doses of Listeria ranged from 5 to 1,000 x the 50% lethal dose based on the 50% lethal dose for intracardially injected Listeria. A complete necropsy was performed on all ani...

journal_title：Infection and immunity

authors： Dustoor M,Croft W,Fulton A,Blazkovec A

更新日期：1977-03-01 00:00:00

abstract：:Temperate bacteriophage can transfer toxin-encoding genes between bacteria, often resulting in acquired pathogenicity. However, little is known regarding the effects of the eukaryotic host on the phage-pathogen interaction. Using Streptococcus pyogenes as a model, we demonstrate, both in vitro and in vivo, that the eu...

journal_title：Infection and immunity

authors： Broudy TB,Fischetti VA

更新日期：2003-07-01 00:00:00

abstract：:Hydrogen sulfide (H(2)S) is a major metabolic end product detected in deep periodontal pockets that is produced by resident periodontopathic microbiota associated with the progression of periodontitis. Treponema denticola, a member of the subgingival biofilm at disease sites, produces cystalysin, an enzyme that catabo...

journal_title：Infection and immunity

authors： Chu L,Dong Z,Xu X,Cochran DL,Ebersole JL

更新日期：2002-03-01 00:00:00

abstract：:A synthetic peptide whose sequence was derived from the circumsporozoite protein of Plasmodium knowlesi coupled to bovine gamma globulin has been shown to be immunogenic when administered with Freund complete adjuvant. The present experiments were designed to test the immunogenicity of the peptide when attached to a t...

journal_title：Infection and immunity

authors： Clough ER,Audibert FM,Barnwell JW,Schlesinger DH,Arnon R,Chedid LA

更新日期：1985-06-01 00:00:00

abstract：:Virus population dynamics in the lungs, trachea, and nasopharynx of Swiss-ICR mice were studied after respiratory challenge with mouse-adapted preparations of strain A2/Aichi/2/68 influenza virus. Markedly higher doses of virus were required to produce infection with nasopharyngeal challenge than with bronchoalveolar ...

journal_title：Infection and immunity

authors： Larson EW,Dominik JW,Rowberg AH,Higbee GA

更新日期：1976-02-01 00:00:00

abstract：:The blood-stage development of malaria parasites is initiated by the invasion of merozoites into susceptible erythrocytes. Specific receptor-ligand interactions must occur for the merozoites to first attach to and then invade erythrocytes. Because the invasion process is essential for the parasite's survival and the m...

journal_title：Infection and immunity

authors： Tsuboi T,Kappe SH,al-Yaman F,Prickett MD,Alpers M,Adams JH

更新日期：1994-12-01 00:00:00

abstract：:Antibodies induced in sera and saliva of rats and rabbits immunized with ribosomal preparations from Streptococcus mutans 6715 inhibited transport of glucose by the phosphotransferase system by greater than 60%, acid production from sucrose by greater than 95%, and growth of the homologous S. mutans by greater than 59...

journal_title：Infection and immunity

authors： Gregory RL,Michalek SM,Shechmeister IL,McGhee JR

更新日期：1984-07-01 00:00:00

abstract：:The intracellular pathogen Listeria monocytogenes replicates mainly in resting macrophages and hepatocytes residing in infected tissues. Both innate and acquired resistance strongly depend on activation of listericidal capacities of macrophages by gamma interferon (IFN-gamma) produced by natural killer cells and T lym...

journal_title：Infection and immunity

authors： Szalay G,Hess J,Kaufmann SH

更新日期：1995-08-01 00:00:00

abstract：:Transcutaneous immunization (TCI) is a new method for vaccine delivery that has been shown to induce immunity relevant to enteric disease vaccines. We evaluated the clinical safety and immunogenicity of a recombinant subunit vaccine against enterotoxigenic Escherichia coli (ETEC) delivered by TCI. Adult volunteers rec...

journal_title：Infection and immunity

authors： Güereña-Burgueño F,Hall ER,Taylor DN,Cassels FJ,Scott DA,Wolf MK,Roberts ZJ,Nesterova GV,Alving CR,Glenn GM

更新日期：2002-04-01 00:00:00

abstract：:Salmonella pathogenicity island 12 (SPI-12) of Salmonella enterica serovar Typhimurium is a 15-kb region that encompasses genes STM2230 to STM2245 and encodes a remnant phage known to contribute to bacterial virulence. In mouse infection experiments and replication assays in macrophages, we demonstrated a role for fou...

journal_title：Infection and immunity

authors： Tomljenovic-Berube AM,Henriksbo B,Porwollik S,Cooper CA,Tuinema BR,McClelland M,Coombes BK

更新日期：2013-07-01 00:00:00

abstract：:We characterized outer membrane proteins (OMPs) from selected Campylobacter jejuni, C. coli, and C. fetus strains by two-dimensional gel electrophoresis (2DGE), using isoelectric focusing and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), and by immunoblotting with immune rabbit serum. The flage...

journal_title：Infection and immunity

authors： Dunn BE,Blaser MJ,Snyder EL

更新日期：1987-07-01 00:00:00

abstract：:Lipopolysaccharides obtained from Brucella abortus, B. melitensis, and B. suis, but not B. canis, were found to contain amino sugars identified as glucosamine and quinovosamine by cation exchange and thin-layer cellulose chromatography and ninhydrin degradation. ...

journal_title：Infection and immunity

authors： Bowser DV,Wheat RW,Foster JW,Leong D

更新日期：1974-04-01 00:00:00

abstract：:Chlamydia trachomatis is a strict human pathogen producing infections that cause medically important chronic inflammatory diseases, such as blinding trachoma and tubal factor infertility. Isolates exist as serotypes that fall into distinct biologic and pathological groups corresponding to differences in infection tiss...

journal_title：Infection and immunity

authors： Carlson JH,Hughes S,Hogan D,Cieplak G,Sturdevant DE,McClarty G,Caldwell HD,Belland RJ

更新日期：2004-12-01 00:00:00

abstract：:We have previously shown that individuals infected with Chlamydia trachomatis can develop a robust antibody response to a chlamydia-secreted protein (designated chlamydial proteasome/protease-like activity factor [CPAF]). We now report that sera collected from these infected individuals neutralized the proteolytic act...

journal_title：Infection and immunity

authors： Sharma J,Dong F,Pirbhai M,Zhong G

更新日期：2005-07-01 00:00:00

abstract：:The roles of different ribonucleotide reductases (RNRs) in bacterial pathogenesis have not been studied systematically. In this work we analyzed the importance of the different Pseudomonas aeruginosa RNRs in pathogenesis using the Drosophila melanogaster host-pathogen interaction model. P. aeruginosa codes for three d...

journal_title：Infection and immunity

authors： Sjöberg BM,Torrents E

更新日期：2011-07-01 00:00:00

abstract：:In vitro experimentation indicates that periodontitis-associated bacteria contain potent polyclonal B-cell activators (PBA). We reasoned that if PBA were operative in vivo, plasma cells specific for nonoral antigens should be present in the inflamed gingival tissues, which are characterized by a plasma cell infiltrate...

journal_title：Infection and immunity

authors： Mallison SM 3rd,Szakal AK,Ranney RR,Tew JG

更新日期：1988-04-01 00:00:00

abstract：:Macrophages can undergo apoptosis after infection with Mycobacterium tuberculosis. This macrophage response deprives the bacillus of its niche cell and supports the host response through better antigen presentation. The intracellular pathways of apoptosis that elaborate this macrophage response are not well understood...

journal_title：Infection and immunity

authors： O'Sullivan MP,O'Leary S,Kelly DM,Keane J

更新日期：2007-04-01 00:00:00

abstract：:A dialyzable factor(s) in human serum is known to stimulate gonococcal oxygen consumption. Its effect on other human pathogens was investigated. A 10% serum solution increased peak O2 consumption for Escherichia coli and Staphylococcus aureus to 157% (P less than 0.05) and 199% (P less than 0.02), respectively, of the...

journal_title：Infection and immunity

authors： Britigan BE,Cohen MS

更新日期：1986-06-01 00:00:00

abstract：:C-reactive protein (CRP) has long been known to appear in the sera of individuals with inflammatory processes, but its role in host defense against bacterial infection is unclear. We have recently demonstrated that CRP in the presence of the classical complement pathway markedly enhances the opsonization of Streptococ...

journal_title：Infection and immunity

authors： Mold C,Edwards KM,Gewurz H

更新日期：1982-09-01 00:00:00

abstract：:Immunoglobulin M antibody to hepatitis A virus (IgM anti-HAV) is found in most patients with acute type A hepatitis. To determine the duration of this IgM response as well as to confirm that IgM anti-HAV is a specific marker for acute infection, we developed a solid-phase radioimmunoassay for IgM anti-HAV. This new as...

journal_title：Infection and immunity

authors： Lemon SM,Brown CD,Brooks DS,Simms TE,Bancroft WH

更新日期：1980-06-01 00:00:00

abstract：:Tuberculous pleurisy allows the study of human cells at the site of active Mycobacterium tuberculosis infection. In this study, we found that among pleural fluid (PF) lymphocytes, natural killer (NK) cells are a major source of early gamma interferon (IFN-gamma) upon M. tuberculosis stimulation, leading us to investig...

journal_title：Infection and immunity

authors： Schierloh P,Yokobori N,Alemán M,Landoni V,Geffner L,Musella RM,Castagnino J,Baldini M,Abbate E,de la Barrera SS,Sasiain MC

更新日期：2007-11-01 00:00:00

abstract：:The effect of infection with low-virulence, tissue culture-propagated strains of reticuloendotheliosis virus (REV) on protective vaccinal immunity against Marek's disease (MD) lymphomas was investigated. Vaccinated chickens inoculated at hatching with greater than 10(4) focus-forming units of REV and challenged with M...

journal_title：Infection and immunity

authors： Witter RL,Lee LF,Bacon LD,Smith EJ

更新日期：1979-10-01 00:00:00

abstract：:Whereas infections of macrophages by promastigote forms of Leishmania mexicana pifanoi induce the production of superoxide, infections by amastigotes barely induce superoxide production. Several approaches were employed to gain insight into the mechanism by which amastigotes avoid eliciting superoxide production. Firs...

journal_title：Infection and immunity

authors： Pham NK,Mouriz J,Kima PE

更新日期：2005-12-01 00:00:00

abstract：:Yersinia pestis causes bubonic, pneumonic, and septicemic plague, diseases that are rapidly lethal to most mammals, including humans. Plague develops as a consequence of bacterial neutralization of the host's innate immune response, which permits uncontrolled growth and causes the systemic hyperactivation of the infla...

journal_title：Infection and immunity

authors： Dhariwala MO,Olson RM,Anderson DM

更新日期：2017-10-18 00:00:00