Abstract:
:Differences in susceptibility to persistent cryptosporidial infection between two strains of adult athymic nude mice prompted us to investigate the immune mechanism(s) that may control resistance to infection in these T-cell-deficient mice. We studied fecal oocyst shedding, serum and fecal parasite-specific antibody responses, and fecal immunoglobulin levels in athymic C57BL/6J nude and athymic BALB/cJ nude mice following oral inoculation with Cryptosporidium parvum oocysts at 8 to 9 weeks of age. C57BL/6J nude mice had significantly higher fecal parasite-specific immunoglobulin A (IgA) (days 27, 31, 35, and 42 postinoculation) and IgM (days 10, 17, 24, 28, 31, 38, 42, and 48 postinoculation) levels than BALB/cJ nude mice (P < 0.05) and significantly higher serum parasite-specific IgA levels at 63 days postinoculation (P < 0.03). Moreover, C57BL/6J nude mice shed significantly fewer C. parvum oocysts than BALB/cJ nude mice from days 52 to 63 postinoculation (P < 0.05). In contrast, BALB/cJ nude mice had higher levels of non-parasite-specific IgA (days 38 to 63 postinoculation) and IgM (days 24, 35, 38, and 52 postinoculation) than C57BL/6J nude mice in feces (P < 0.05). These data suggest that parasite-specific fecal antibodies may be associated with resistance to C. parvum in C57BL/6J nude mice.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Adjei AA,Jones JT,Riggs MW,Enriquez FJdoi
10.1128/IAI.67.8.3947-3951.1999keywords:
subject
Has Abstractpub_date
1999-08-01 00:00:00pages
3947-51issue
8eissn
0019-9567issn
1098-5522journal_volume
67pub_type
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.37.3.935-939.1982
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journal_title:Infection and immunity
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doi:10.1128/IAI.01943-06
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.49.3.664-669.1985
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journal_title:Infection and immunity
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doi:10.1128/IAI.57.11.3646-3652.1989
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.2.504-511.1993
更新日期:1993-02-01 00:00:00
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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journal_title:Infection and immunity
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更新日期:2006-01-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.10.3097-3105.1989
更新日期:1989-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.4.909-915.1987
更新日期:1987-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.46.1.98-104.1984
更新日期:1984-10-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.31.1.487-494.1981
更新日期:1981-01-01 00:00:00
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更新日期:1992-11-01 00:00:00
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journal_title:Infection and immunity
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doi:10.1128/IAI.00139-07
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.36.3.1023-1027.1982
更新日期:1982-06-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.24.2.571-572.1979
更新日期:1979-05-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
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journal_title:Infection and immunity
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更新日期:2011-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.4.772-774.1974
更新日期:1974-04-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
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更新日期:2009-10-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.43.3.1114-1116.1984
更新日期:1984-03-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.7.2643-2648.1996
更新日期:1996-07-01 00:00:00