Detection of antigens with affinity for host cell membrane polypeptides in culture supernatants of Trypanosoma cruzi.

abstract：:Clostridium difficile causes pseudomembranous colitis through the action of Rho-modifying proteins, toxins A and B. Antibodies directed against C. difficile toxin A prevent or limit C. difficile-induced colitis. We engineered plasmid pETR14, containing the hlyB and hlyD genes of the Escherichia coli hemolysin operon, ...

journal_title：Infection and immunity

authors： Ryan ET,Butterton JR,Smith RN,Carroll PA,Crean TI,Calderwood SB

更新日期：1997-07-01 00:00:00

abstract：:Gnotobiotic calves were inoculated with an O5:K4:H-, urease-positive strain of Escherichia coli isolated from a 2-day-old calf with diarrhea. The calves developed elevated temperatures and passed loose mucoid feces, with or without blood. The E. coli strain was negative for heat-stable and heat-labile enterotoxins but...

journal_title：Infection and immunity

authors： Moxley RA,Francis DH

更新日期：1986-08-01 00:00:00

abstract：:Random minitransposon mutagenesis was used to identify genes involved in the survival of Bordetella bronchiseptica within eukaryotic cells. One of the mutants which exhibited a reduced ability to survive intracellularly harbored a minitransposon insertion in a locus (ris) which displays a high degree of homology to tw...

journal_title：Infection and immunity

authors： Jungnitz H,West NP,Walker MJ,Chhatwal GS,Guzmán CA

更新日期：1998-10-01 00:00:00

abstract：:The response to reinfection with Ethiopian Leishmania donovani was evaluated in genetically determined noncure (H-2d) B10.D2 mice that are able to resolve infection due to sublethal irradiation pretreatment after inoculation with a low parasite dose and in C57BL/10 mice that demonstrate the genetically determined cure...

journal_title：Infection and immunity

authors： Ulczak OM,Ghadirian E,Skamene E,Blackwell JM,Kongshavn PA

更新日期：1989-09-01 00:00:00

abstract：:Attachment of Fusobacterium nucleatum to various oral surfaces is mediated by several adhesins anchored on its outer surface. Monoclonal antibodies (MAbs) were prepared and used to identify the putative galactose-binding adhesin of F. nucleatum PK1594. Four unique MAbs, 8G7, 26B9, 28G11, and 29D4, were isolated on the...

journal_title：Infection and immunity

authors： Shaniztki B,Hurwitz D,Smorodinsky N,Ganeshkumar N,Weiss EI

更新日期：1997-12-01 00:00:00

abstract：:Incubation of large granular lymphocytes (LGL) with glutaraldehyde-fixed bacteria stimulated in the supernatant the production of interferon (IFN), which proved to be mainly IFN-gamma. Even though IFN-gamma was produced upon exposure of LGL to bacteria, anti-IFN-gamma antibodies failed to interfere with induction of c...

journal_title：Infection and immunity

authors： Tarkkanen J,Saksela E

更新日期：1991-08-01 00:00:00

abstract：:B-cell-deficient C57B1/6J mice (suppressed from birth with goat anti-mu) and controls (treated from birth with normal goat serum) were infected with Trypanosoma rhodesiense. There was a significant (P less than 0.01) decrease in duration of survival of the mu-suppressed mice compared with that of controls. Whereas bot...

journal_title：Infection and immunity

authors： Campbell GH,Esser KM,Weinbaum FI

更新日期：1977-11-01 00:00:00

abstract：:Anti-NMDA receptor (NMDAR) autoantibodies have been postulated to play a role in the pathogenesis of NMDAR hypofunction, which contributes to the etiology of psychotic symptoms. Toxoplasma gondii is a pathogen implicated in psychiatric disorders and associated with elevation of NMDAR autoantibodies. However, it remain...

journal_title：Infection and immunity

authors： Li Y,Viscidi RP,Kannan G,McFarland R,Pletnikov MV,Severance EG,Yolken RH,Xiao J

更新日期：2018-09-21 00:00:00

abstract：:Cysteine proteases, including Arg-gingipain of Porphyromonas gingivalis, have been implicated as important virulence factors in periodontal diseases. These enzymes are also involved in the hemagglutinating activity of the organisms. In order to determine the role of proteases in the colonization of the gingival margin...

journal_title：Infection and immunity

authors： Tokuda M,Duncan M,Cho MI,Kuramitsu HK

更新日期：1996-10-01 00:00:00

abstract：:Smoking is associated with increased susceptibility to tuberculosis and influenza. However, little information is available on the mechanisms underlying this increased susceptibility. Mice were left unexposed or were exposed to cigarette smoke and then infected with Mycobacterium tuberculosis by aerosol or influenza A...

journal_title：Infection and immunity

authors： Feng Y,Kong Y,Barnes PF,Huang FF,Klucar P,Wang X,Samten B,Sengupta M,Machona B,Donis R,Tvinnereim AR,Shams H

更新日期：2011-01-01 00:00:00

abstract：:Previous reports from our laboratory have shown that 7 days after infection of C3HeB/FeJ mice with an attenuated strain of Salmonella typhimurium, there is profound suppression of responses to B- and T-cell mitogens and suppression of the capacity of spleen cells to mount a primary, in vitro plaque-forming-cell (PFC) ...

journal_title：Infection and immunity

authors： Huang D,Schwacha MG,Eisenstein TK

更新日期：1996-09-01 00:00:00

abstract：:Citrobacter rodentium, an attaching-effacing bacterial pathogen, establishes an acute infection of the murine colonic epithelium and induces a mild colitis in immunocompetent mice. This study describes the role of T-cell subsets and B lymphocytes in immunity to C. rodentium. C57Bl/6 mice orally infected with C. rodent...

journal_title：Infection and immunity

authors： Simmons CP,Clare S,Ghaem-Maghami M,Uren TK,Rankin J,Huett A,Goldin R,Lewis DJ,MacDonald TT,Strugnell RA,Frankel G,Dougan G

更新日期：2003-09-01 00:00:00

abstract：:A murine model system was established to study immune responses to the Pnu-Imune vaccine, which is made up of 23 different pneumococcal capsular polysaccharides. In this animal model, antibody-forming cell responses to 21 of 23 individual polysaccharides in the vaccine were detected. The Pnu-Imune vaccine elicited goo...

journal_title：Infection and immunity

authors： Garg M,Subbarao B

更新日期：1992-06-01 00:00:00

abstract：:Neutrophils play a major role in defending the periodontium against infection by oral, gram-negative, facultative bacteria, such as Actinobacillus actinomycetemcomitans, Eikenella corrodens, and Capnocytophaga spp. We examined the sensitivity of these bacteria to a mixture of low-molecular-weight peptides and highly p...

journal_title：Infection and immunity

authors： Miyasaki KT,Bodeau AL,Ganz T,Selsted ME,Lehrer RI

更新日期：1990-12-01 00:00:00

abstract：:The adhesion of gram-positive bacteria to extracellular matrix (ECM) proteins is regarded as an important determinant of pathogenicity. A comparison of the adhesion of Streptococcus agalactiae strain O90R to different ECM proteins showed that the most pronounced binding could be observed for immobilized fibrinogen. To...

journal_title：Infection and immunity

authors： Spellerberg B,Rozdzinski E,Martin S,Weber-Heynemann J,Lütticken R

更新日期：2002-05-01 00:00:00

abstract：:Murine hybridoma cell lines were developed which synthesized monoclonal antibodies against Actinobacillus actinomycetemcomitans-associated antigens. Monoclonal antibodies specific for an antigen(s) common to all A. actinomycetemcomitans isolates tested but not detected on other gram-negative oral plaque microorganisms...

journal_title：Infection and immunity

authors： Place DA,Scidmore NC,McArthur WP

更新日期：1988-05-01 00:00:00

abstract：:Ureaplasma urealyticum has previously been isolated from the cultured cerebrospinal fluid of 13 of 418 newborn infants; additional bloodstream isolates were obtained from the same population. Ten of the 13 cerebrospinal fluid and 3 bloodstream isolates were available for serotyping in the present study. By the use of ...

journal_title：Infection and immunity

authors： Zheng X,Watson HL,Waites KB,Cassell GH

更新日期：1992-08-01 00:00:00

abstract：:Candida albicans secreted aspartyl proteinases (Saps) are considered virulence-associated factors. Several members of the Sap family were claimed to play a significant role in the progression of candidiasis established by the hematogenous route. This assumption was based on the observed attenuated virulence of sap-nul...

journal_title：Infection and immunity

authors： Correia A,Lermann U,Teixeira L,Cerca F,Botelho S,da Costa RM,Sampaio P,Gärtner F,Morschhäuser J,Vilanova M,Pais C

更新日期：2010-11-01 00:00:00

abstract：:The attachment of isogenic fimbriated and nonfimbriated Haemophilus influenzae type b variants to human cells was studied by using a radioactive assay and an indirect immunofluorescent assay. As described previously, fimbriated H. influenzae variants adhered to a greater extent than nonfimbriated variants to human buc...

journal_title：Infection and immunity

authors： Sable NS,Connor EM,Hall CB,Loeb MR

更新日期：1985-04-01 00:00:00

abstract：:Human immunodeficiency virus (HIV)-infected individuals are predisposed to recurrent oral candidiasis, and, although it has been assumed that this is because of deficient mucosal immune responses, this has not been properly established. The present study aimed to compare the concentrations and secretion rates of immun...

journal_title：Infection and immunity

authors： Coogan MM,Sweet SP,Challacombe SJ

更新日期：1994-03-01 00:00:00

abstract：:The induction of interleukin-8 (IL-8) in vitro has been suggested to correlate with the reactogenicity of Vibrio cholerae vaccine candidates. V. cholerae vaccine candidate 638, a hemagglutinin protease/hap-defective strain, was recently reported to be well tolerated in human volunteers, suggesting a role for Hap in re...

journal_title：Infection and immunity

authors： Zhou X,Gao DQ,Michalski J,Benitez JA,Kaper JB

更新日期：2004-01-01 00:00:00

abstract：:Brucella abortus injected into CBA mice replicated primarily in the spleen and liver, reaching a peak bacterial count in both organs about 7 days postinfection. The organism was eliminated from the liver but declined to a chronic phase in the spleen. The infection caused hepatosplenomegaly. An influx of macrophages in...

journal_title：Infection and immunity

authors： Doyle AG,Halliday WJ,Barnett CJ,Dunn TL,Hume DA

更新日期：1992-04-01 00:00:00

abstract：:Potential vaccine components for protection against atrophic rhinitis in pigs were developed. This was achieved by deletion mutagenesis of the gene encoding the Pasteurella multocida toxin. Four purified toxin derivatives lacking different and widely separated regions in the amino acid sequence were characterized by a...

journal_title：Infection and immunity

authors： Petersen SK,Foged NT,Bording A,Nielsen JP,Riemann HK,Frandsen PL

更新日期：1991-04-01 00:00:00

abstract：:Francisella tularensis is a facultative intracellular bacterial pathogen and the causative agent of tularemia. After infection of macrophages, the organism escapes from its phagosome and replicates to high density in the cytosol, but the bacterial factors required for these aspects of virulence are incompletely define...

journal_title：Infection and immunity

authors： Long ME,Lindemann SR,Rasmussen JA,Jones BD,Allen LA

更新日期：2013-03-01 00:00:00

abstract：:Yersinia pseudotuberculosis inv mutant strains cured of the virulence plasmid exhibit thermoinducible adhesion to cultured mammalian cells. To identify the genes responsible for this phenotype, Y. pseudotuberculosis homologs of the Y. enterocolitica ail and the Y. pestis psa loci were identified. Mutations in the Y. p...

journal_title：Infection and immunity

authors： Yang Y,Merriam JJ,Mueller JP,Isberg RR

更新日期：1996-07-01 00:00:00

abstract：:Serum amyloid A protein (SAA) elevation accompanies induction of secondary amyloidosis in mice given Mycobacterium butyricum in Freund adjuvant. The synthesis of SAA by cultured hepatocytes is induced by a macrophage-derived mediator, which has been identified as interleukin 1. In these studies, SAA synthesis has been...

journal_title：Infection and immunity

authors： McAdam KP,Foss NT,Garcia C,DeLellis R,Chedid L,Rees RJ,Wolff SM

更新日期：1983-03-01 00:00:00

abstract：:The lymphogranuloma venereum (LGV) and trachoma biovars of Chlamydia trachomatis exhibit differences in biological properties both in vivo and in vitro. To identify analogous biochemical differences, we studied the molecular charges of chlamydial outer membrane proteins (OMPs) by means of isoelectric focusing and none...

journal_title：Infection and immunity

authors： Batteiger BE,Newhall WJ 5th,Jones RB

更新日期：1985-11-01 00:00:00

abstract：:Borrelia burgdorferi, a tick-borne bacterial pathogen, causes a disseminated infection involving multiple organs known as Lyme disease. Surface proteins can directly participate in microbial virulence by facilitating pathogen dissemination via interaction with host factors. We show here that a fraction of the B. burgd...

journal_title：Infection and immunity

authors： Nogueira SV,Smith AA,Qin JH,Pal U

更新日期：2012-01-01 00:00:00

abstract：:Toll-like receptor (TLR)-based signaling pathways in the host may be modulated by pathogens during the course of infection. We describe a novel immunomodulatory mechanism in which Aspergillus fumigatus conidia induce attenuation of TLR2- and TLR4-mediated interleukin (IL)-6 and IL-1beta proinflammatory responses in hu...

journal_title：Infection and immunity

authors： Chai LY,Kullberg BJ,Vonk AG,Warris A,Cambi A,Latgé JP,Joosten LA,van der Meer JW,Netea MG

更新日期：2009-05-01 00:00:00

abstract：:Cell-mediated immunity plays an important role in immunity to the pathogenic fungus Cryptococcus neoformans. However, the antigen specificity of the T-cell response to C. neoformans remains largely unknown. In this study, we used two approaches to determine the antigen specificity of the T-cell response to C. neoforma...

journal_title：Infection and immunity

authors： Lindell DM,Ballinger MN,McDonald RA,Toews GB,Huffnagle GB

更新日期：2006-08-01 00:00:00