Adherence of human vaginal lactobacilli to vaginal epithelial cells and interaction with uropathogens.

Abstract:

:Three strains of Lactobacillus, identified as Lactobacillus acidophilus, Lactobacillus gasseri, and Lactobacillus jensenii, were selected from among 70 isolates from the vaginas of healthy premenopausal women for properties relevant to mucosal colonization or antagonism. All three self-aggregated and adhered to epithelial vaginal cells, displacing well-known vaginal pathogens, such as G. vaginalis, and inhibiting the growth in vitro of Escherichia coli and Streptococcus agalactiae. The surface components involved in self-aggregation appeared to be proteins for L. gasseri and lipoproteins for L. acidophilus and L. jensenii, as judged by susceptibility to treatment with appropriate degrading enzymes. The factors responsible for adherence to epithelial vaginal cells seemed to be glycoproteins (L. acidophilus and L. gasseri) and carbohydrate (L. jensenii). The receptors of the vaginal cells were glycolipids, which presumably were the targets of the competition observed between the lactobacilli and the pathogenic microbes.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Boris S,Suárez JE,Vázquez F,Barbés C

doi

10.1128/IAI.66.5.1985-1989.1998

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

1985-9

issue

5

eissn

0019-9567

issn

1098-5522

journal_volume

66

pub_type

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