Abstract:
:Protein-malnourished rats had greater numbers of bacteria in their livers and spleens compared with numbers in control rats following a sublethal intraperitoneal dose of Salmonella typhimurium. However, the febrile responses of both groups of rats to infection were similar. The ability to mount a normal febrile response does not necessarily reflect the ability of the host to contain an infection.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Bradley SF,Kauffman CAdoi
10.1128/IAI.56.4.1000-1002.1988subject
Has Abstractpub_date
1988-04-01 00:00:00pages
1000-2issue
4eissn
0019-9567issn
1098-5522journal_volume
56pub_type
杂志文章abstract::Rabbits were immunized with the synthetic peptide EENVEHDA or (EENV)2, corresponding to a tandemly repeated sequence in the C-terminal part of the Plasmodium falciparum antigen Pf155/RESA, or with Escherichia coli-derived fusion proteins containing the corresponding repeats. For all sera, the capacity of the total imm...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.9.2815-2820.1990
更新日期:1990-09-01 00:00:00
abstract::We identified nonhemolytic mutants of Listeria monocytogenes that were severely deficient in their ability to invade mammalian nonprofessional phagocytes. These mutants were generated spontaneously or by means of transposon Tn916 mutagenesis. In terms of their extracellular proteins, the noninvasive mutants were defic...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.12.3988-3995.1990
更新日期:1990-12-01 00:00:00
abstract::An attenuated influenza A candidate vaccine virus, derived from the A/Ann Arbor/6/60 (H2N2) cold-adapted (ca) donor virus and the A/Alaska/6/77 (H3N2) wild-type virus, was evaluated in adult seronegative volunteers (serum hemagglutination-inhibiting antibody titer, less than or equal to 1:8) for level of attenuation, ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.3.1044-1051.1983
更新日期:1983-06-01 00:00:00
abstract::The short-term kinetics of fluoride uptake by cells from 20- to 22-h cultures of Streptococcus mutans strain 6715 were studied using rapid filtration and centrifugation techniques. Saline-suspended organisms were diluted with fluoride-containing solutions buffered at four different pH values (2.0, 4.0, 5.5, and 8.2). ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.18.3.680-687.1977
更新日期:1977-12-01 00:00:00
abstract::Comparative studies on the virulence of two strains of Pseudomonas aeruginosa isolated from otic pus and mink pneumonic lesion, respectively, were made by means of intranasal inoculation in mink. The minimal lethal dose of the former (strain NC-5, highly virulent for mice) was 10(10), and that of the latter (strain No...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.1.16-20.1974
更新日期:1974-07-01 00:00:00
abstract::Vaccine antigen-specific antibody-secreting cell (ASC) responses in peripheral blood of healthy adult volunteers were studied after oral immunization with a prototype enterotoxigenic Escherichia coli (ETEC) vaccine by means of the enzyme-linked immunospot technique. Three doses of vaccine consisting of formalin-killed...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.7.2605-2611.1992
更新日期:1992-07-01 00:00:00
abstract::Inbred strain 2 guinea pigs were vaccinated with Mycobacterium bovis BCG or were left unvaccinated and challenged 6 weeks later by the respiratory route with virulent Mycobacterium tuberculosis. By using a double rosette assay with isotype-specific antibody-coated ox and uncoated rabbit erythrocytes, the proportions o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.5.1374-1379.1989
更新日期:1989-05-01 00:00:00
abstract::Strain superinfection occurs when a second pathogen strain infects a host already infected with a primary strain. The selective pressures that drive strain divergence, which underlies superinfection, and allow penetration of a new strain into a host population are critical knowledge gaps relevant to shifts in infectio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02537-14
更新日期:2014-12-01 00:00:00
abstract::We demonstrate that transcription of the Staphylococcus aureus collagen adhesin gene (cna) is temporally regulated, with expression being highest in exponentially growing cultures and falling to almost undetectable levels as cultures enter the post-exponential-growth phase. The temporal regulation of cna transcription...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.4.1536-1540.1997
更新日期:1997-04-01 00:00:00
abstract::We have characterized the natural immune responses to the 19-kDa domain of merozoite surface protein 1 in individuals from an area of western Kenya in which malaria is holoendemic. We used the three known natural variant forms of the yeast-expressed recombinant 19-kDa fragment that are referred to as the E-KNG, Q-KNG,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.7.2716-2723.1996
更新日期:1996-07-01 00:00:00
abstract::We previously identified a cell wall-associated protein from Fusobacterium nucleatum, a Gram-negative bacterium of the oral cavity, that induces human beta defensin 2 (hBD-2) in primary human oral epithelial cells (HOECs) and designated it FAD-I (Fusobacterium-associated defensin inducer). Here, we report differential...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01311-15
更新日期:2016-04-22 00:00:00
abstract::Infection of C57BL/6 mice with the third-stage larvae of Brugia pahangi results in a rapid expansion of NK1.1(+) T cells in the spleen and draining lymph nodes. NK T cells produced interleukin-4 in the spleen within 24 h of infection, and these cells were CD4(-). ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.4.2215-2219.2002
更新日期:2002-04-01 00:00:00
abstract::Resistance to phagocytosis is a hallmark of virulent Streptococcus pyogenes (group A streptococcus). Surface-bound C5a peptidase reduces recruitment of phagocytes to the site of infection, and hyaluronic acid capsules and/or the M protein limit the uptake of streptococci. In this study the relative impact of M and M-l...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.11.5399-5405.1998
更新日期:1998-11-01 00:00:00
abstract::After lysing the phagocytic vacuole, Shigella spp. accumulate filaments of polymerized actin on their surface at one pole, leading to the formation of actin tails that enable them to move through the cytoplasm. We have recently demonstrated that the Shigella protein IcsA is located at the pole that is adjacent to the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.12.5664-5668.1994
更新日期:1994-12-01 00:00:00
abstract::Clostridium perfringens is an anaerobic, Gram-positive bacterium that causes a range of diseases in humans, including lethal gas gangrene. We have recently shown that strains of C. perfringens move across the surface of agar plates by a unique type IV pilus (TFP)-mediated social motility that had not been previously d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00909-10
更新日期:2011-08-01 00:00:00
abstract::Fibronectin binds to Streptococcus pyogenes, and this binding is inhibited by lipoteichoic acid (LTA). Previous studies have shown that LTA can be released from S. pyogenes by treatment with penicillin. Penicillin released LTA from both S. pyogenes and Staphylococcus aureus; however, the binding of fibronectin correla...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.51.2.529-535.1986
更新日期:1986-02-01 00:00:00
abstract::Resistance against acute and chronic infection with Taxoplasma gondii in BALB/c and CBA/Ca mice was compared. Intraperitoneal inoculation of either 20, 40, or 80 cysts of the ME49 strain resulted in mortality rates in BALB/c mice of 12% (2 of 17), 50% (6 of 12), and 75% (9 of 12), respectively, within 3 weeks after in...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.6.2284-2288.1993
更新日期:1993-06-01 00:00:00
abstract::Phagocytosis and killing by alveolar macrophages from humans, rabbits, rats, and hamsters, were compared in vitro. In the absence of serum opsonins, human alveolar macrophages could phagocytize Staphylococcus aureus Cowan I (protein A positive), but not S. aureus EMS (protein A negative) or Pseudomonas aeruginosa MN. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.36.2.504-509.1982
更新日期:1982-05-01 00:00:00
abstract::The plasmid-encoded structural gene cofA necessary for the production of the major pilin subunit of pilus colonization factor antigen III (CFA/III) of human enterotoxigenic Escherichia coli was identified, and the nucleotide sequence of the gene was determined. cofA consists of 714 nucleotides encoding a 238-amino-aci...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.2.724-728.1995
更新日期:1995-02-01 00:00:00
abstract::Nonspecific cross-reacting antigen (NCA) is a well-characterized membrane glycoprotein on granulocytes, macrophages, and lung epithelium. Structural studies at the protein and genomic levels have revealed that NCA is a member of the immunoglobulin supergene family, and hybridization studies showed that the transcript ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.7.2485-2493.1991
更新日期:1991-07-01 00:00:00
abstract::Macrophage ribonucleic acid (RNA) synthesis is an important metabolic process intimately related to the function of these cells. Mouse peritoneal macrophage RNA was extracted with phenol in the presence of bentonite and electrophoresed on composite agarose-polyacrylamide gels. The pulse-chase technique was used to fol...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.6.1531-1538.1976
更新日期:1976-06-01 00:00:00
abstract::Polymorphonuclear leukocytes (PMN) isolated from human blood were exposed to various levels of hydrogen sulfide. The effect on respiratory burst, myeloperoxidase activity, and capacity to phagocytose and kill bacteria were studied. A 1-h exposure of the PMN to 1 mM sulfide did not decrease their myeloperoxidase activi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.9.2776-2781.1989
更新日期:1989-09-01 00:00:00
abstract::Escherichia coli F-18 is a human fecal isolate that makes type 1 fimbriae, encoded by the fim gene cluster, and is an excellent colonizer of the streptomycin-treated mouse intestine. E. coli F-18 fimA::tet, lacking type 1 fimbriae, was constructed by bacteriophage P1 transduction of the fim region of the E. coli K-12 ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.9.3497-3503.1996
更新日期:1996-09-01 00:00:00
abstract::Serum amyloid A protein (SAA) elevation accompanies induction of secondary amyloidosis in mice given Mycobacterium butyricum in Freund adjuvant. The synthesis of SAA by cultured hepatocytes is induced by a macrophage-derived mediator, which has been identified as interleukin 1. In these studies, SAA synthesis has been...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.39.3.1147-1154.1983
更新日期:1983-03-01 00:00:00
abstract::The mucosal humoral immune response elicited following Shigella flexneri infection in patients living in Antananarivo districts (Madagascar Island) was evaluated by measuring the gut-derived, circulating immunoglobulin A (IgA) antibody-secreting cells (ASC) specific for the major bacterial antigen lipopolysaccharide (...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.69.9.5230-5234.2001
更新日期:2001-09-01 00:00:00
abstract::We have previously demonstrated that fibronectin mediates streptococcal adhesion to host cells and that streptococci interact primarily with the N-terminal domain of fibronectin. FBP54 is a 54-kDa protein from group A streptococci that binds fibronectin. In this report, we show that the N-terminal domain of fibronecti...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.7.2415-2419.1996
更新日期:1996-07-01 00:00:00
abstract::The addition of a sonic extract of Capnocytophaga sputigena to the culture fluid to human fibroblasts resulted in an inhibition of cell proliferation. The inhibition was dose-related (200 micrograms/ml caused a 90% inhibition, and 1,000 micrograms/ml caused a complete cessation of growth). The growth inhibition was no...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.27.1.271-275.1980
更新日期:1980-01-01 00:00:00
abstract::Eight chlamydial isolates of ovine origin were tested in a plaque reduction system using homologous and heterologous rooster antisera. The eight isolates could be separated into two separate immunotypes. Type 1 included isolates associated with ovine abortion and one agent recovered from the feces of an apparently nor...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.1.92-94.1974
更新日期:1974-01-01 00:00:00
abstract::The genes encoding alpha-hemolysin and mannose-resistant hemagglutination were shown to be closely linked in cloned DNA from two Escherichia coli urinary tract isolates of serotypes O4 (J96) and O6 (C1212). DNA hybridization experiments demonstrated that the hly and mrh gene clusters of other E. coli O6 serotypes were...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.43.1.353-358.1984
更新日期:1984-01-01 00:00:00
abstract::Antigens shared between Streptococcus pyogenes and heart tissue may play an important role in autoimmune cardiac injury associated with acute rheumatic fever. Antiheart/antistreptococcal antibodies found in the disease react with antigens of S. pyogenes, including M protein and a 60-kDa antigen distinct from M protein...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.9.3932-3936.1992
更新日期:1992-09-01 00:00:00