Protective humoral immunity elicited by a needle-free malaria vaccine comprised of a chimeric Plasmodium falciparum circumsporozoite protein and a Toll-like receptor 5 agonist, flagellin.

abstract：:Surface proteins in gram-positive bacteria are frequently required for virulence, and many are attached to the cell wall by sortase enzymes. Bacteria frequently encode more than one sortase enzyme and an even larger number of potential sortase substrates that possess an LPXTG-type cell wall sorting signal. In order to...

journal_title：Infection and immunity

authors： Comfort D,Clubb RT

更新日期：2004-05-01 00:00:00

abstract：:Herein we characterized various genetic markers and the biological behavior of a natural recombinant strain of Toxoplasma gondii (P-Br). From nine genetic markers analyzed, three (B1, ROP1, and SAG1) and three (cS10-A6, GRA6, and SAG3) markers belong to parasites from the type I and type III lineages, respectively. Th...

journal_title：Infection and immunity

authors： Fux B,Rodrigues CV,Portela RW,Silva NM,Su C,Sibley D,Vitor RW,Gazzinelli RT

更新日期：2003-11-01 00:00:00

abstract：:A large-scale DNA vaccination trial was performed with sheep to investigate whether an antigen targeted by CTLA-4 enhanced and accelerated the humoral immune response. Vaccination with genetically detoxified phospholipase D (DeltaPLD) has been shown to be effective, at least partially, against Corynebacterium pseudotu...

journal_title：Infection and immunity

authors： Chaplin PJ,De Rose R,Boyle JS,McWaters P,Kelly J,Tennent JM,Lew AM,Scheerlinck JP

更新日期：1999-12-01 00:00:00

abstract：:We previously showed that cytotoxic necrotizing factor 1 (CNF1) contributes to Escherichia coli K1 invasion of human brain microvascular endothelial cells (HBMEC) and interacts with the receptor on the surface of HBMEC. CNF1 is the cytoplasmic protein, and it remains incompletely understood how CNF1 is secreted across...

journal_title：Infection and immunity

authors： Yu H,Kim KS

更新日期：2010-02-01 00:00:00

abstract：:A method was developed to study the adhesion of Streptococcus pneumoniae to human pharyngeal epithelial cells. Epithelial cells from healthy persons, pneumococcal strains from patients with otitis media, meningitis, or septicemia, and pneumococcal cells from the nasopharynx of healthy carriers were used. Adhesion was ...

journal_title：Infection and immunity

authors： Andersson B,Eriksson B,Falsen E,Fogh A,Hanson LA,Nylén O,Peterson H,Svanborg Edén C

更新日期：1981-04-01 00:00:00

abstract：:The genetics of resistance to a naturally occurring respiratory infection caused by Sendai virus was examined in F1, F2, and backcross progeny of resistant C57BL/6J and susceptible DBA/2J mice and in 25 recombinant inbred strains. An intranasal inoculum of 0.1 50% tissue culture infective dose (low dose) of Sendai vir...

journal_title：Infection and immunity

authors： Brownstein DG

更新日期：1983-07-01 00:00:00

abstract：:We have determined the nucleotide sequence of the 1.4-kilobase DNA fragment containing the plasminogen activator gene (pla) of Yersinia pestis, which determines both plasminogen activator and coagulase activities of the species. The sequence revealed the presence of a 936-base-pair open reading frame that constitutes ...

journal_title：Infection and immunity

authors： Sodeinde OA,Goguen JD

更新日期：1989-05-01 00:00:00

abstract：:Endotoxemia in rats is associated with the accumulation of neutrophils (polymorphonuclear leukocytes) within the airspaces of the lung. Polymorphonuclear leukocyte influx appears to be regulated by the intrapulmonary accumulation of chemotactic activity. Since alveolar macrophages (AMS) are prevalent cells in the airs...

journal_title：Infection and immunity

authors： Christman JW,Petras SF,Vacek PM,Davis GS

更新日期：1989-03-01 00:00:00

abstract：:Porphyromonas gingivalis, a bacterium associated with active chronic periodontitis lesions, produces several proteolytic enzymes that are thought to be involved in host colonization, perturbation of the immune system, and tissue destruction. The aim of the present study was to investigate the contribution of Arg- and ...

journal_title：Infection and immunity

authors： Grenier D,Imbeault S,Plamondon P,Grenier G,Nakayama K,Mayrand D

更新日期：2001-08-01 00:00:00

abstract：:We report the cloning and expression of Ac-GST-1, a novel glutathione S-transferase from the adult hookworm Ancylostoma caninum, and its possible role in parasite blood feeding and as a vaccine target. The predicted Ac-GST-1 open reading frame contains 207 amino acids (mass, 24 kDa) and exhibited up to 65% amino acid ...

journal_title：Infection and immunity

authors： Zhan B,Liu S,Perally S,Xue J,Fujiwara R,Brophy P,Xiao S,Liu Y,Feng J,Williamson A,Wang Y,Bueno LL,Mendez S,Goud G,Bethony JM,Hawdon JM,Loukas A,Jones K,Hotez PJ

更新日期：2005-10-01 00:00:00

abstract：:In studies of experimental Lyme disease, a major obstacle has been the unavailability of a suitable animal model. We found that irradiated LSH/Ss Lak hamsters developed arthritis after injection of Borrelia burgdorferi in the hind paws. When nonirradiated hamsters were injected in the hind paws with B. burgdorferi, ac...

journal_title：Infection and immunity

authors： Schmitz JL,Schell RF,Hejka A,England DM,Konick L

更新日期：1988-09-01 00:00:00

abstract：:A DNA microarray containing fragments of 137 Borrelia burgdorferi B31 putative lipoprotein genes was used to examine Lyme disease spirochetes. DNA from B. burgdorferi sensu stricto B31, 297, and N40; Borrelia garinii IP90; and Borrelia afzelii P/Gau was fluorescently labeled and hybridized to the microarray, demonstra...

journal_title：Infection and immunity

authors： Liang FT,Nelson FK,Fikrig E

更新日期：2002-06-01 00:00:00

abstract：:To characterize the mechanism by which interleukin 10 (IL-10) inhibits Th1 responses to intracellular pathogens, we evaluated the interaction between IL-10 and Mycobacterium tuberculosis-induced gamma interferon (IFN-gamma) production by peripheral blood mononuclear cells from persons across the spectrum of tuberculou...

journal_title：Infection and immunity

authors： Gong JH,Zhang M,Modlin RL,Linsley PS,Iyer D,Lin Y,Barnes PF

更新日期：1996-03-01 00:00:00

abstract：:Human plasma was bactericidal for small numbers of Klebsiella pneumoniae, but larger numbers grew slowly over a period of 24 h. Human polymorphs in a clot of autologous plasma had a bacteriostatic effect on relatively large numbers of bacteria for up to 24 h and were much more effective than plasma alone. The bacteric...

journal_title：Infection and immunity

authors： Ward CG,Hammond JS,Bullen JJ

更新日期：1986-03-01 00:00:00

abstract：:Plasmodium falciparum's ability to invade erythrocytes is essential for its survival within the human host. Immune mechanisms that impair this ability are therefore expected to contribute to immunity against the parasite. Plasma of humans who are naturally exposed to malaria has been shown to have growth-inhibitory ac...

journal_title：Infection and immunity

authors： Rono J,Färnert A,Olsson D,Osier F,Rooth I,Persson KE

更新日期：2012-05-01 00:00:00

abstract：:Mutation of sarA resulted in a reduced capacity to form a biofilm in six of the eight Staphylococcus aureus strains we tested (UAMS-1, UAMS-601, SA113, SC-01, S6C, and DB). The exceptions were Newman, which formed a poor biofilm under all conditions, and RN6390, which consistently formed a biofilm only after mutation ...

journal_title：Infection and immunity

authors： Beenken KE,Blevins JS,Smeltzer MS

更新日期：2003-07-01 00:00:00

abstract：:Chlamydia trachomatis serovar L2 is an obligate intracellular bacterium which is internalized in target epithelial cells by endocytosis and resides within a membrane-bound vesicle. Over the next several hours following entry, individual serovar L2-containing vesicles fuse with one another to form a single membrane-bou...

journal_title：Infection and immunity

authors： Schramm N,Bagnell CR,Wyrick PB

更新日期：1996-04-01 00:00:00

abstract：:Acquired cellular immunity to infection with Mycobacterium tuberculosis is believed to reside in the capacity of mononuclear phagocytes of immunized animals to inhibit intracellular multiplication of the parasite. However, in macrophage tissue culture systems, it has been customary to employ streptomycin in the medium...

journal_title：Infection and immunity

authors： Patterson RJ,Youmans GP

更新日期：1970-01-01 00:00:00

abstract：:Cell walls from Streptococcus mutans were prepared by conventional technique and subjected to a series of extraction procedures involving classical protein solvents. The extracted walls contained several non-peptidoglycan amino acids and were also amenable to radiolabeling with [125I]sodium iodide and chloramine T. Th...

journal_title：Infection and immunity

authors： Nesbitt WE,Staat RH,Rosan B,Taylor KG,Doyle RJ

更新日期：1980-04-01 00:00:00

abstract：:Enterococcus faecalis strains are resident intestinal bacteria associated with invasive infections, inflammatory bowel diseases, and colon cancer. Although factors promoting E. faecalis colonization of intestines are not fully known, one implicated pathway is a phosphotransferase system (PTS) in E. faecalis strain OG1...

journal_title：Infection and immunity

authors： Fan TJ,Goeser L,Naziripour A,Redinbo MR,Hansen JJ

更新日期：2019-06-20 00:00:00

abstract：:In a previous study we showed that the involvement of EP4 subtype of the prostaglandin E (PGE) receptor is crucial for lipopolysaccharide (LPS)-induced osteoclast formation in vitro. The present study was undertaken to test whether EP4 is actually associated with LPS-induced bone resorption in vivo. In wild-type (WT) ...

journal_title：Infection and immunity

authors： Sakuma Y,Tanaka K,Suda M,Komatsu Y,Yasoda A,Miura M,Ozasa A,Narumiya S,Sugimoto Y,Ichikawa A,Ushikubi F,Nakao K

更新日期：2000-12-01 00:00:00

abstract：:We have investigated the possibility that nitric oxide (NO) synthesis may affect the course of a trypanosome infection via T-cell responses using mice deficient in inducible NO synthase (iNOS). Parasitemia levels increased at the same rate in both iNOS-deficient homozygous and control heterozygous mice, and peak paras...

journal_title：Infection and immunity

authors： Millar AE,Sternberg J,McSharry C,Wei XQ,Liew FY,Turner CM

更新日期：1999-07-01 00:00:00

abstract：:The immune response to the mycobacterial 65-kDa heat shock protein (hsp65) is considered an important event in the induction of adjuvant arthritis (AA) in rats; this induction probably occurs through a molecular mimicry mechanism involving cross-reactivity against the rat homolog hsp60. To analyze the role of mammalia...

journal_title：Infection and immunity

authors： López-Guerrero JA,López-Bote JP,Ortiz MA,Gupta RS,Páez E,Bernabeu C

更新日期：1993-10-01 00:00:00

abstract：:Ultrastructural immunoperoxidase studies were done in spinal cords of mice infected with wild type vesicular stomatitis virus or its temperature-sensitive (ts) mutant G31. Infected neurons showed subplasmalemmal staining of viral antigen and staining of viral particles budding from the neuronal membrane in wild-type v...

journal_title：Infection and immunity

authors： Dal Canto MC,Rabinowitz SG,Johnson TC,Hughes JV

更新日期：1979-04-01 00:00:00

abstract：:Meningococcal sodC encodes periplasmic copper- and zinc-cofactored superoxide dismutase (Cu,Zn SOD) which catalyzes the conversion of the superoxide radical anion to hydrogen peroxide, preventing a sequence of reactions leading to production of toxic hydroxyl free radicals. From its periplasmic location, Cu,Zn SOD was...

journal_title：Infection and immunity

authors： Wilks KE,Dunn KL,Farrant JL,Reddin KM,Gorringe AR,Langford PR,Kroll JS

更新日期：1998-01-01 00:00:00

abstract：:Borrelia burgdorferi produces a mitogen for murine B lymphocytes which can be measured in vitro by polyclonal stimulation of proliferation and immunoglobulin production (R. Schoenfeld, B. Araneo, Y. Ma, L. Yang, and J. J. Weis, Infect. Immun. 60:455-464, 1992). Sonicated B. burgdorferi cells also stimulated IL-6 produ...

journal_title：Infection and immunity

authors： Yang L,Ma Y,Schoenfeld R,Griffiths M,Eichwald E,Araneo B,Weis JJ

更新日期：1992-08-01 00:00:00

abstract：:Phagocytosis and killing by alveolar macrophages from humans, rabbits, rats, and hamsters, were compared in vitro. In the absence of serum opsonins, human alveolar macrophages could phagocytize Staphylococcus aureus Cowan I (protein A positive), but not S. aureus EMS (protein A negative) or Pseudomonas aeruginosa MN. ...

journal_title：Infection and immunity

authors： Nguyen BY,Peterson PK,Verbrugh HA,Quie PG,Hoidal JR

更新日期：1982-05-01 00:00:00

abstract：:Conventional dendritic cells (cDCs) are critical for protection against pulmonary infection with the opportunistic fungal pathogen Cryptococcus neoformans; however, the role of plasmacytoid dendritic cells (pDCs) is unknown. We show for the first time that murine pDCs have direct activity against C. neoformans via rea...

journal_title：Infection and immunity

authors： Hole CR,Leopold Wager CM,Mendiola AS,Wozniak KL,Campuzano A,Lin X,Wormley FL Jr

更新日期：2016-08-19 00:00:00

abstract：:The mechanism by which bacterial heat-stable enterotoxins (ST I STA) cause diarrhea in humans and animals has been linked to the activation of an intestinal membrane-bound guanylate cyclase. Guanylin, a recently discovered rat intestinal peptide, is homologous in structure to ST I and can activate guanylate cyclase pr...

journal_title：Infection and immunity

authors： Carpick BW,Gariépy J

更新日期：1993-11-01 00:00:00

abstract：:During bacterial infection of the bovine mammary gland, large numbers of leukocytes migrate into the udder, resulting in the establishment of a host response against the pathogen. Currently, the specific leukocyte populations mediating this immune response are not well defined. In the studies described here, we analyz...

journal_title：Infection and immunity

authors： Soltys J,Quinn MT

更新日期：1999-12-01 00:00:00