Abstract:
:A 2.9-kilobase pair locus in Neisseria meningitidis was identified as containing transcriptionally linked open reading frames encoding TolC- and HlyD-like proteins. Although the meningococcal TolC protein was required for extracellular production of the repeats-in-toxin (RTX) FrpC toxin, it could not functionally replace the MtrE protein as the outer membrane protein channel for drug export by the MtrC-MtrD-MtrE efflux pump.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Kamal N,Rouquette-Loughlin C,Shafer WMdoi
10.1128/IAI.01995-06subject
Has Abstractpub_date
2007-12-01 00:00:00pages
6008-12issue
12eissn
0019-9567issn
1098-5522pii
IAI.01995-06journal_volume
75pub_type
杂志文章abstract::Recent reports have demonstrated that Bordetella pertussis has invasive behavior in vivo and in vitro. In this study, we investigated the ability of a virulent strain, avirulent mutants, and mutants deficient in specific virulence factors to enter and survive intracellularly in human macrophages in vitro. Uptake of vi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.11.4578-4585.1992
更新日期:1992-11-01 00:00:00
abstract::We previously showed that the Uganda Palo Alto line of Plasmodium falciparum propagated in Saimiri monkeys and the line maintained in culture in human erythrocytes for many years in our laboratory are genetically unrelated (T. Fandeur, S. Bonnefoy, and O. Mercereau-Puijalon, Mol. Biochem. Parasitol. 47:167, 1991). Whe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.4.1390-1396.1992
更新日期:1992-04-01 00:00:00
abstract::Citrobacter rodentium is an attaching and effacing pathogen which causes transmissible colonic hyperplasia in mice. Infection with C. rodentium serves as a model for infection of humans with enteropathogenic and enterohemorrhagic Escherichia coli. To identify novel colonization factors of C. rodentium, we screened a s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00770-08
更新日期:2008-11-01 00:00:00
abstract::The selC tRNA gene is a common site for the insertion of pathogenicity islands in a variety of bacterial enteric pathogens. We demonstrate here that Escherichia coli that produces Shiga toxin 2d and does not harbor the locus of enterocyte effacement (LEE) contains, instead, a novel genomic island. In one representativ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.11.6863-6873.2001
更新日期:2001-11-01 00:00:00
abstract::Humoral immune responses in experimental African trypanosomiasis were assessed in rabbits infected with Trypanosoma rhodesiense. Immune complexes as measured by a Clq binding assay or a Clq solid-phase assay were detected by day 10 and increased progressively through day 28. Immune complexes analyzed by double diffusi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.33.2.407-414.1981
更新日期:1981-08-01 00:00:00
abstract::Helicobacter pylori colonizes the gastric epithelium of at least 50% of the world's human population, playing a causative role in the development of chronic gastritis, peptic ulcers, and gastric adenocarcinoma. Current evidence indicates that H. pylori can invade epithelial cells in the gastric mucosa. However, relati...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01085-06
更新日期:2006-12-01 00:00:00
abstract::Feto-placental infections represent a major cause of pregnancy complications, and yet the underlying molecular and cellular mechanisms of vertical transmission are poorly understood. Listeria monocytogenes, a facultative intracellular pathogen, is one of a group of pathogens that are known to cause feto-placental infe...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.72.1.489-497.2004
更新日期:2004-01-01 00:00:00
abstract::The immune response of humans and mice to temperature-specific, plasmid- or chromosome-encoded proteins of yersinia pestis and Yersinia enterocolitica was investigated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting. Extracts from Y. pestis and Y. enterocolitica strains with and witho...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.48.3.676-685.1985
更新日期:1985-06-01 00:00:00
abstract::Transposon Tn916 was used to insertionally inactivate a coaggregation-relevant locus of Streptococcus gordonii DL1 (Challis). One mutant (F11) was isolated that lost the ability to coaggregate with the streptococcal partners of DL1 but retained the ability to coaggregate with partners belonging to other genera. A prob...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.10.4137-4142.1996
更新日期:1996-10-01 00:00:00
abstract::In this study we have investigated the antibody and CD4 T-cell responses to the well-characterized malaria vaccine candidate MSP-1 during the course of a primary Plasmodium chabaudi chabaudi (AS) infection. Specific antibody responses can be detected within the first week of infection, and CD4 T cells can be detected ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.4.2245-2251.2001
更新日期:2001-04-01 00:00:00
abstract::It has been postulated that systemic cell-mediated immunity (CMI) is an important host defense mechanism against Candida infections of the vagina. However, in an estrogen-dependent murine model of experimental vaginal candidiasis, we recently showed that systemic Candida-specific Th1-type CMI induced by immunization w...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.2.547-553.1995
更新日期:1995-02-01 00:00:00
abstract::Mycoplasma salivarium cells propagated in PPLO broth (Difco Laboratories, Detroit, Mich.) supplemented with rabbit serum (10% [vol/vol]) and harvested by centrifugation were shown to contain rabbit immunoglobulin G (IgG) (approximately 4 to 10% of total cell proteins) and to produce IgM autoantibodies to IgG when inoc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.1.263-265.1987
更新日期:1987-01-01 00:00:00
abstract::Filarial infection is initiated by mosquito-derived third-stage larvae (L3) deposited on the skin that transit through the epidermis, which contains Langerhans cells (LC) and keratinocytes (KC), among other cells. This earliest interaction between L3 and the LC likely conditions the priming of the immune system to the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01301-12
更新日期:2013-05-01 00:00:00
abstract::A series of experiments was conducted to study the influence of embryonal bursectomy (EBX) on the early and late pathogenesis of Marek's disease (MD). The early lytic infection in the lymphoid organs normally associated with oncogenic MD virus infection in intact chickens was not seen in EBX chickens. Therefore, the d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.31.1.199-207.1981
更新日期:1981-01-01 00:00:00
abstract::The bundle-forming pilus (BFP) of enteropathogenic Escherichia coli (EPEC) is an important virulence factor. We examined the role of divergent alleles of bfpA encoding bundlin, the BFP pilin protein, in pilus biogenesis, pilus interactions, and immune responses. We found that the BFP biogenesis machine from an EPEC st...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00009-07
更新日期:2007-10-01 00:00:00
abstract::Helicobacter pylori is an important human pathogen that causes gastritis and is strongly associated with gastric ulcers, gastric adenocarcinomas, and mucosa-associated lymphoid tissue lymphomas. In response to H. pylori, interleukin-8 (IL-8) is secreted from host cells to attract components of the innate and adaptive ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.3.1523-1531.2005
更新日期:2005-03-01 00:00:00
abstract::We have previously shown that malaria parasites liberate exoantigens which, through a phospholipid component, stimulate mouse macrophages to secrete tumor necrosis factor (TNF), which are toxic to D-galactosamine-sensitized mice, and which therefore might be involved in pathology. Plasmodium yoelii exoantigens detoxif...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.5.1894-1901.1992
更新日期:1992-05-01 00:00:00
abstract::An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01326-06
更新日期:2007-03-01 00:00:00
abstract::The mammalian host response to infection includes the production and secretion of antimicrobial peptides from phagocytes and epithelial cells. Protegrins, a group of broadly microbicidal peptides isolated originally from porcine neutrophil lysates, were found to be stored as inactive proforms in porcine neutrophil gra...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.8.3611-3617.1998
更新日期:1998-08-01 00:00:00
abstract::By using in vitro assays, a group of related, filamentous gram-negative bacteria isolated from subgingival plaque deposits of patients with periodontal disease were found to colonize intact teeth. Tentatively identified as members of the genus Cytophaga, these isolates exhibited a preference for colonizing the cementu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.26.1.15-18.1979
更新日期:1979-10-01 00:00:00
abstract::Aeromonas salmonicida causes furunculosis in salmonids and is a threat to Atlantic salmon aquaculture. The epithelial surfaces that the pathogen colonizes are covered by a mucus layer predominantly comprised of secreted mucins. By using mass spectrometry to identify mucin glycan structures with and without enzymatic r...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00189-17
更新日期:2017-07-19 00:00:00
abstract::The antibacterial properties of lysozyme were investigated with oral microorganisms representing the seven serotypes (a through g) of Streptococcus mutans, Veillonella alcalescens, and the virulent (V) and avirulent (AV) strains of Actinomyces viscosus T14. Growth of bacteria in defined medium was monitored spectropho...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-08-01 00:00:00
abstract::Pneumolysin is an important virulence factor of Streptococcus pneumoniae, interacting with the membranes of host cells to elicit a multitude of inflammatory responses. We used cDNA microarrays to identify genes which are responsive to S. pneumoniae in a pneumolysin-dependent and -independent fashion. The THP-1 human m...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.4.2087-2094.2003
更新日期:2003-04-01 00:00:00
abstract::Migration of the fungal pathogen Candida albicans across the endothelial cell layer is considered a prerequisite for the invasion of multiple organs occurring in systemic candidiasis. We developed an experimental system in which C. albicans migrates from a luminal compartment across a monolayer of bovine aortic endoth...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.12.5085-5091.1996
更新日期:1996-12-01 00:00:00
abstract::By using the powerful separation technique of capillary gas chromatography combined with the selectivity of mass spectrometric detection, muramic acid was not detectable in purified elementary bodies of Chlamydia psittaci Cal 10 (less than or equal to 0.006%) or C. trachomatis serovar E (less than or equal to 0.02%). ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.3.835-837.1990
更新日期:1990-03-01 00:00:00
abstract::Invasive aspergillosis is a serious fungal infection caused by the proliferation and invasion of Aspergillus hyphae in tissue. Neutrophils (PMNs) are the most important line of defense against Aspergillus hyphae. To investigate the role of granulocyte colony-stimulating factor (G-CSF) and gamma interferon (IFN-gamma) ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.4.1185-1193.1993
更新日期:1993-04-01 00:00:00
abstract::Peru-15 is a live attenuated oral vaccine derived from a Vibrio cholerae O1 El Tor Inaba strain by a series of deletions and modifications, including deletion of the entire CT genetic element. Peru-15 is also a stable, motility-defective strain and is unable to recombine with homologous DNA. We wished to determine whe...
journal_title:Infection and immunity
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1128/iai.70.4.1965-1970.2002
更新日期:2002-04-01 00:00:00
abstract::Recent epidemiological observations suggest that clinical evolution of Plasmodium falciparum infections might be influenced by the concurrent presence of another Plasmodium species, and such mixed-species infections are now known to occur frequently in residents of most areas of endemicity. We used mice infected with ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.8.4777-4786.2005
更新日期:2005-08-01 00:00:00
abstract::A common concern with many autoimmune diseases of unknown etiology is the extent to which tissue T-lymphocyte infiltrates, versus a nonspecific infiltrate, reflect a response to the causative agent. Lyme arthritis can histologically resemble rheumatoid synovitis, particularly the prominent infiltration by T lymphocyte...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.3.1092-1099.1998
更新日期:1998-03-01 00:00:00
abstract::The cell surface hydrophobicity of 10 pigmented and 4 nonpigmented clinical Serratia marcescens strains was studied, based on the ability of the strains to adhere to hydrocarbons and to polystyrene. The cell surface hydrophobicity depended greatly on growth temperature; all of the strains tested were adherent followin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.51.3.932-935.1986
更新日期:1986-03-01 00:00:00