Pneumolysin-dependent and -independent gene expression identified by cDNA microarray analysis of THP-1 human mononuclear cells stimulated by Streptococcus pneumoniae.

abstract：:The outer membrane (OM) of Gram-negative bacteria is an asymmetric lipid bilayer that consists of inner leaflet phospholipids and outer leaflet lipopolysaccharides (LPS). The asymmetric character and unique biochemistry of LPS molecules contribute to the OM's ability to function as a molecular permeability barrier tha...

journal_title：Infection and immunity

authors： Giordano NP,Cian MB,Dalebroux ZD

更新日期：2020-06-22 00:00:00

abstract：:GNA33 is a membrane-bound lipoprotein with murein hydrolase activity that is present in all Neisseria species and well conserved in different meningococcal isolates. The protein shows 33% identity to a lytic transglycolase (MltA) from Escherichia coli and has been shown to be involved in the degradation of both insolu...

journal_title：Infection and immunity

authors： Adu-Bobie J,Lupetti P,Brunelli B,Granoff D,Norais N,Ferrari G,Grandi G,Rappuoli R,Pizza M

更新日期：2004-04-01 00:00:00

abstract：:An impressive change in the epidemiology and severity of invasive group A streptococcal infections occurred in the 1980s, and the incidence of streptococcal toxic shock syndrome cases continues to rise. The reason for the resurgence of severe invasive cases remains a mystery-has there been a change in the pathogen or ...

journal_title：Infection and immunity

authors： Basma H,Norrby-Teglund A,Guedez Y,McGeer A,Low DE,El-Ahmedy O,Schwartz B,Kotb M

更新日期：1999-04-01 00:00:00

abstract：:Insertional inactivation of the Streptococcus mutans spaP gene was used to construct an isogenic mutant (834) of strain NG8 (serotype c) which lacked the major cell surface-associated protein referred to as P1 (15). Results of several studies suggest that P1 is involved in the adherence of S. mutans to saliva-coated a...

journal_title：Infection and immunity

authors： Bowen WH,Schilling K,Giertsen E,Pearson S,Lee SF,Bleiweis A,Beeman D

更新日期：1991-12-01 00:00:00

abstract：:Legionella pneumophila was mutagenized with Tn903dIIlacZ, and a collection of mutants was screened for defects in macrophage killing (Mak-). Of 4,564 independently derived mutants, 55 (1.2%) showed a reduced or complete lack in the ability to kill HL-60-derived human macrophages. Forty-nine of the Mak- mutants could b...

journal_title：Infection and immunity

authors： Sadosky AB,Wiater LA,Shuman HA

更新日期：1993-12-01 00:00:00

abstract：:The development of immunological responsiveness to a soluble cercarial antigenic preparation (CAP) from Schistosoma mansoni was analyzed in inbred CBA/J mice infected with cercariae, one or multiple times, or sensitized using CAP. Repeated exposure to 75 cercariae at three weekly intervals (3X-75) or subcutaneous admi...

journal_title：Infection and immunity

authors： Katz SP,Colley DG

更新日期：1976-08-01 00:00:00

abstract：:Active immunization with Escherichia coli-expressed recombinant outer surface protein C (OspC) of Borrelia burgdorferi has been demonstrated to confer protection against a tick-transmitted infection on laboratory animals. A previous study in this laboratory showed that OspC antibody raised against a denatured immunoge...

journal_title：Infection and immunity

authors： Gilmore RD Jr,Mbow ML

更新日期：1999-10-01 00:00:00

abstract：:Group A streptococcal cell walls inhibited phagocytosis of polystyrene latex particles by rat peritoneal macrophages in vitro. This inhibition was not accompanied by a measurable loss of cell viability. Group D streptococcal cell walls were relatively ineffective in altering phagocytosis. The effectiveness of group A ...

journal_title：Infection and immunity

authors： Smialowicz RJ,Schwab JH

更新日期：1978-04-01 00:00:00

abstract：:To evaluate the enteropathogenicity of Aeromonas hydrophila and Plesiomonas shigelloides, the rate of isolation of these organisms was compared among individuals with and without diarrhea in Thailand. In two groups of American travelers, A. hydrophila, but not P. shigelloides, was associated with episodes of travelers...

journal_title：Infection and immunity

authors： Pitarangsi C,Echeverria P,Whitmire R,Tirapat C,Formal S,Dammin GJ,Tingtalapong M

更新日期：1982-02-01 00:00:00

abstract：:The glycolipid haptens of Mycoplasma pneumoniae became immunogenic when bound to membrane proteins of Acholeplasma laidlawii by reaggregation. This process consisted of the solubilization of lipid-depleted A. laidlawii membranes and M. pneumoniae glycolipids in 20 mm sodium dodecyl sulfate and dialysis of the mixed so...

journal_title：Infection and immunity

authors： Razin S,Prescott B,James WD,Caldes G,Valdesuso J,Chanock RM

更新日期：1971-03-01 00:00:00

abstract：:Heat-labile enterotoxins from Escherichia coli strains of porcine and human origin polymerize on heating to form high-molecular-weight aggregates, "procoligenoids," analogous to procholeragenoid derived from the cholera enterotoxin. This aggregation is accompanied by loss of biological activity (toxicity). Further hea...

journal_title：Infection and immunity

authors： Finkelstein RA,Sciortino CV,Rieke LC,Burks MF,Boesman-Finkelstein M

更新日期：1984-08-01 00:00:00

abstract：:Routine culture of endothelial cells currently includes the use of heparin, which significantly reduces cell doubling time and increases cell population size. Heparin protects cultured arterial endothelial cells from damage by toxic oxygen metabolites produced by the action of xanthine and xanthine oxidase. Because of...

journal_title：Infection and immunity

authors： Silverman DJ,Santucci LA,Sekeyova Z

更新日期：1991-12-01 00:00:00

abstract：:The distinctive properties of Brucella outer membrane have been considered to be critical for Brucella sp. virulence. Among the outer membrane molecules possibly related to these properties, Omp10 and Omp19 are immunoreactive outer membrane lipoproteins. Moreover, these proteins of Brucella could constitute a new fami...

journal_title：Infection and immunity

authors： Tibor A,Wansard V,Bielartz V,Delrue RM,Danese I,Michel P,Walravens K,Godfroid J,Letesson JJ

更新日期：2002-10-01 00:00:00

abstract：:Only 20 to 40% of human blood monocytes were capable of responding to chemotaxins in vitro. This limit is not due to restrictions of the in vitro system, but is due to the existence of a migrating subpopulation. Over a wide range, the number of cells migrating toward a given concentration of chemotaxin was directly pr...

journal_title：Infection and immunity

authors： Falk W,Leonard EJ

更新日期：1980-09-01 00:00:00

abstract：:The Lyme disease spirochete, Borrelia burgdorferi, controls protein expression patterns during its tick-mammal infection cycle. Earlier studies demonstrated that B. burgdorferi synthesizes 4,5-dihydroxy-2,3-pentanedione (autoinducer-2 [AI-2]) and responds to AI-2 by measurably changing production of several infection-...

journal_title：Infection and immunity

authors： Arnold WK,Savage CR,Antonicello AD,Stevenson B

更新日期：2015-04-01 00:00:00

abstract：:Previous studies have indicated that the ability to bind to fibronectin is a key feature in successful cell invasion by Campylobacter jejuni. Given the spatial distribution of fibronectin and the architecture of the epithelium, this suggests the possibility that C. jejuni cell invasion might preferentially occur at th...

journal_title：Infection and immunity

authors： Monteville MR,Konkel ME

更新日期：2002-12-01 00:00:00

abstract：:Humoral immune responses in experimental African trypanosomiasis were assessed in rabbits infected with Trypanosoma rhodesiense. Immune complexes as measured by a Clq binding assay or a Clq solid-phase assay were detected by day 10 and increased progressively through day 28. Immune complexes analyzed by double diffusi...

journal_title：Infection and immunity

authors： Lindsley HB,Janecek LL,Gilman-Sachs AM,Hassanein KM

更新日期：1981-08-01 00:00:00

abstract：:Production of the Kanagawa hemolysin by patient strains of Vibrio parahaemolyticus was found to respond to the pH rather than to the type of carbohydrate present in the growth medium. Regardless of the carbohydrate present, hemolysin production in peptone broth cultures occurred only when the pH was between 6.5 and 5....

journal_title：Infection and immunity

authors： Cherwonogrodzky JW,Clark AG

更新日期：1981-10-01 00:00:00

abstract：:The ocular surface is continuously exposed to potential pathogens, including free-living amoebae. Acanthamoeba species are among the most ubiquitous amoebae, yet Acanthamoeba keratitis is remarkably rare. The pathogenesis of Acanthamoeba keratitis is a complex, sequential process. Here we show that Acanthamoeba kerati...

journal_title：Infection and immunity

authors： Alizadeh H,Neelam S,Hurt M,Niederkorn JY

更新日期：2005-02-01 00:00:00

abstract：:To determine the ability of gut antigens to induce a protective immune response against blood-feeding nematodes, isolated gut antigens were used to immunize goats against Haemonchus contortus. Immunization-induced antibody responses recognized parasite gut antigens which were associated predominantly with the microvil...

journal_title：Infection and immunity

authors： Jasmer DP,McGuire TC

更新日期：1991-12-01 00:00:00

abstract：:Analysis of the specificity of bactericidal antibodies in normal, convalescent, and postvaccination human sera is important in understanding human immunity to meningococcal infections and can aid in the design of an effective group B vaccine. A collection of human sera, including group C and group B convalescent-phase...

journal_title：Infection and immunity

authors： Schmiel DH,Moran EE,Keiser PB,Brandt BL,Zollinger WD

更新日期：2011-10-01 00:00:00

abstract：:Guinea pig peritoneal or alveolar macrophages were inoculated with Mycoplasma pneumoniae cells. Extracellular mycoplasms were killed by complement treatment, and the effect of macrophage action on the number of the remaining viable mycoplasmas was observed. The complement killing was to some extent inhibited by the pr...

journal_title：Infection and immunity

authors： Erb P,Bredt W

更新日期：1979-07-01 00:00:00

abstract：:Murine monoclonal and rabbit, murine, and human polyclonal antibodies against chlamydial lipopolysaccharide (LPS) were characterized by the passive hemolysis and passive hemolysis inhibition assays and by absorption experiments with LPSs of Chlamydia psittaci, Chlamydia trachomatis, and a recombinant strain of Salmone...

journal_title：Infection and immunity

authors： Brade L,Holst O,Kosma P,Zhang YX,Paulsen H,Krausse R,Brade H

更新日期：1990-01-01 00:00:00

abstract：:Sera from adult periodontitis patients were analyzed for antibody activity against surface antigens of Bacteroides gingivalis by immunoblotting analysis. ...

journal_title：Infection and immunity

authors： Naito Y,Okuda K,Takazoe I

更新日期：1987-03-01 00:00:00

abstract：:Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacterium Coxiella burnetii. Humans with Q fever may experience an acute flu-like illness and pneumonia and/or chronic hepatitis or endocarditis. Various markers demonstrate significant phylogenetic separation between and clus...

journal_title：Infection and immunity

authors： Russell-Lodrigue KE,Andoh M,Poels MW,Shive HR,Weeks BR,Zhang GQ,Tersteeg C,Masegi T,Hotta A,Yamaguchi T,Fukushi H,Hirai K,McMurray DN,Samuel JE

更新日期：2009-12-01 00:00:00

abstract：:This study focuses on the interaction of the three components of the Bacillus cereus Nhe enterotoxin with particular emphasis on the functional roles of NheB and NheC. The results demonstrated that both NheB and NheC were able to bind to Vero cells directly while NheA lacked this ability. It was also shown that Nhe-in...

journal_title：Infection and immunity

authors： Lindbäck T,Hardy SP,Dietrich R,Sødring M,Didier A,Moravek M,Fagerlund A,Bock S,Nielsen C,Casteel M,Granum PE,Märtlbauer E

更新日期：2010-09-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF) is thought to play a major role in the pathogenesis of septic shock. Anti-TNF antibody was preadministered in low-dose endotoxin lethality models in which BALB/c mice were challenged with small amounts of lipopolysaccharide following their sensitization with either carrageenan (CAR) o...

journal_title：Infection and immunity

authors： Franks AK,Kujawa KI,Yaffe LJ

更新日期：1991-08-01 00:00:00

abstract：:Adult murine models of Cryptosporidium infection involving Cryptosporidium muris and C. parvum were used to study immunity to cryptosporidiosis in the mammalian host. Immunocompetent BALB/c or C57BL/6 mice developed a highly patent infection with the RN 66 strain of C. muris but overcame the infection and were immune ...

journal_title：Infection and immunity

authors： McDonald V,Deer R,Uni S,Iseki M,Bancroft GJ

更新日期：1992-08-01 00:00:00

abstract：:Rabbit endogenous pyrogens were of about the same molecular size, but showed considerable heterogeneity of their isoelectric points. We attempted to show that this heterogeneity was attributable to variable glycosylation of a single polypeptide chain. When peritoneal exudate cells were stimulated to make pyrogens in t...

journal_title：Infection and immunity

authors： Murphy PA,Cebula TA,Windle BE

更新日期：1981-10-01 00:00:00

abstract：:Pasteurella multocida is the causative agent of fowl cholera in birds. In a previous study using signature-tagged mutagenesis, we identified a mutant, AL251, which was attenuated for virulence in mice and in the natural chicken host. Sequence analysis indicated that AL251 had an insertional inactivation of the gene wa...

journal_title：Infection and immunity

authors： Harper M,Cox AD,St Michael F,Wilkie IW,Boyce JD,Adler B

更新日期：2004-06-01 00:00:00