Role of a cell surface-associated protein in adherence and dental caries.

abstract：:Moraxella catarrhalis is a causative agent of otitis media in children and lower respiratory tract infections in adults suffering from chronic obstructive pulmonary disease (COPD). This strict human pathogen continues to be a significant cause of disease in this broad spectrum of patients because there is no available...

journal_title：Infection and immunity

authors： Schwingel JM,Edwards KJ,Cox AD,Masoud H,Richards JC,St Michael F,Tekwe CD,Sethi S,Murphy TF,Campagnari AA

更新日期：2009-10-01 00:00:00

abstract：:Streptococcus mutans is one of the best-known biofilm-forming organisms associated with humans. We investigated the role of the sortase gene (srtA) in monospecies biofilm formation and observed that inactivation of srtA caused a decrease in biofilm formation. Genes encoding three putative sortase-dependent proteins we...

journal_title：Infection and immunity

authors： Lévesque CM,Voronejskaia E,Huang YC,Mair RW,Ellen RP,Cvitkovitch DG

更新日期：2005-06-01 00:00:00

abstract：:Actinobacillus actinomycetemcomitans SUNY 465, the invasion prototype strain, enters epithelial cells by an actin-dependent mechanism, escapes from the host cell vacuole, and spreads intracellularly and to adjacent epithelial cells via intercellular protrusions. Internalized organisms also egress from host cells into ...

journal_title：Infection and immunity

authors： Meyer DH,Rose JE,Lippmann JE,Fives-Taylor PM

更新日期：1999-12-01 00:00:00

abstract：:The Plasmodium falciparum liver-stage antigen 3 (LSA3), a recently identified preerythrocytic antigen, induces protection against malaria in chimpanzees. Using antibodies from individuals with hyperimmunity to malaria affinity purified on recombinant or synthetic polypeptides of LSA3, we identified four non-cross-reac...

journal_title：Infection and immunity

authors： Brahimi K,Badell E,Sauzet JP,BenMohamed L,Daubersies P,Guérin-Marchand C,Snounou G,Druilhe P

更新日期：2001-06-01 00:00:00

abstract：:A hemagglutinin with an M(r) of 67,000 (pMGA) from Mycoplasma gallisepticum S6 was purified by using monoclonal antibody affinity chromatography. Purified pMGA was treated with a number of enzymes, the resultant peptides were purified, and their amino acid sequence was determined by using an Applied Biosystems (model ...

journal_title：Infection and immunity

authors： Markham PF,Glew MD,Whithear KG,Walker ID

更新日期：1993-03-01 00:00:00

abstract：:A study of the rise and fall in circulating tetanus antitoxin in a group of 15 adults after basic and booster immunization indicates that although individuals vary greatly in their responsiveness to toxoid, the falloff in antitoxin appears to be fractionally constant for each individual, and over periods of 5 to 6 yea...

journal_title：Infection and immunity

authors： Trinca JC

更新日期：1974-07-01 00:00:00

abstract：:Under certain circumstances, soluble antigens, particulate antigens, and/or microorganisms have been shown to bind to primate erythrocytes via complement receptor 1 (CR1) in the presence of specific antibodies and complement. This immune adherence reaction, specific for CR1, can lead to neutralization of antigens in t...

journal_title：Infection and immunity

authors： Powers JH,Buster BL,Reist CJ,Martin E,Bridges M,Sutherland WM,Taylor RP,Scheld WM

更新日期：1995-04-01 00:00:00

abstract：:Whole blood and plasma from animals in the acute stage of leptospirosis contained a toxic factor which produced a cytopathic effect on fibroblastic L cell monolayers. Firm adsorption of cytotoxic factor (CTF) to L cells occurred within 1 h. The highest titer of CTF in plasma was reached at 24 h and declined after 48 h...

journal_title：Infection and immunity

authors： Knight LL,Miller NG,White RJ

更新日期：1973-09-01 00:00:00

abstract：:T cell-independent antibody responses develop rapidly, within 3 to 4 days, and are critical for preventing blood-borne pathogens from evolving into life-threatening infections. The interaction of BAFF, also known as BLyS, with its receptors BAFFR and TACI on B cells is critical for B cell homeostasis and function. Usi...

journal_title：Infection and immunity

authors： Dickinson GS,Sun G,Bram RJ,Alugupalli KR

更新日期：2014-01-01 00:00:00

abstract：:Monoclonal antibody WM-25 inhibited the in vitro growth of 13 F38 isolates from goats with contagious caprine pleuropneumonia but not 7 heterologous mycoplasma isolates representing four different species. In contrast to results with polyclonal antisera, growth inhibition by monoclonal antibody WM-25 was specific for ...

journal_title：Infection and immunity

authors： Rurangirwa FR,McGuire TC,Musoke AJ,Kibor A

更新日期：1987-12-01 00:00:00

abstract：:Larvae of the helminth parasite Schistosoma mansoni are efficiently killed in vitro by lymphokine-activated macrophages, leading to the hypothesis that these cells may participate in the effector mechanism of protective immunity against schistosomiasis. Larvacidal activity has also been demonstrated in the IC-21 macro...

journal_title：Infection and immunity

authors： James SL,Glaven JA

更新日期：1987-12-01 00:00:00

abstract：:The majority of strains of Actinobacillus actinomycetemcomitans isolated from patients with periodontal diseases secrete a leukotoxin that destroys human myeloid cells within minutes but has no effect on viability of peripheral blood lymphocytes in culture for 1.5 h. However, since this organism persists in the gingiv...

journal_title：Infection and immunity

authors： Mangan DF,Taichman NS,Lally ET,Wahl SM

更新日期：1991-09-01 00:00:00

abstract：:Shiga-like toxins (SLTs), which are produced by certain strains of Escherichia coli, are composed of enzymatically active A and B subunit multimers responsible for the toxin's binding. We have previously purified large amounts of the SLT-I B subunit by using a hyperexpression vector in Vibrio cholerae under the contro...

journal_title：Infection and immunity

authors： Acheson DW,De Breucker SA,Jacewicz M,Lincicome LL,Donohue-Rolfe A,Kane AV,Keusch GT

更新日期：1995-01-01 00:00:00

abstract：:EspG is a conserved protein encoded by the locus of enterocyte effacement (LEE) of attaching and effacing (A/E) pathogens, including enteropathogenic and enterohemorrhagic Escherichia coli and Citrobacter rodentium. EspG is delivered into infected host cells by a type III secretion system. The role of EspG in virulenc...

journal_title：Infection and immunity

authors： Hardwidge PR,Deng W,Vallance BA,Rodriguez-Escudero I,Cid VJ,Molina M,Finlay BB

更新日期：2005-05-01 00:00:00

abstract：:Coxiella burnetii, the agent of Q fever, enters human monocytes through alpha(v)beta(3) integrin and survives inside host cells. In addition, C. burnetii stimulates the synthesis of inflammatory cytokines including tumor necrosis factor (TNF) by monocytes. We studied the role of the interaction of C. burnetii with THP...

journal_title：Infection and immunity

authors： Dellacasagrande J,Ghigo E,Hammami SM,Toman R,Raoult D,Capo C,Mege JL

更新日期：2000-10-01 00:00:00

abstract：:It was shown in this work that the infectivity of metacyclic forms of Trypanosoma cruzi was affected upon interaction with the monoclonal antibody (10D8), which reacts with a carbohydrate epitope of the 35- and 50-kilodalton (kDa) surface glycoconjugates. The invasion of Vero cells by metacyclic forms of strains Tulah...

journal_title：Infection and immunity

authors： Yoshida N,Mortara RA,Araguth MF,Gonzalez JC,Russo M

更新日期：1989-06-01 00:00:00

abstract：:We constructed the expression vector pSK-SCP containing the streptococcal exotoxin B gene (spe b) which expressed protease activity. We showed that the recombinant streptococcal pyogenic exotoxin B/streptococcal cysteine protease (rSPE B/SCP) was secreted into the culture supernatant of the transformant and retained i...

journal_title：Infection and immunity

authors： Watanabe Y,Todome Y,Ohkuni H,Sakurada S,Ishikawa T,Yutsudo T,Fischetti VA,Zabriskie JB

更新日期：2002-07-01 00:00:00

abstract：:Active immunization with Porphyromonas gingivalis whole-cell preparations has been shown to prevent P. gingivalis infection and oral bone loss. Employing passive antibody transfer and opsonization, we demonstrate with this study that immunization-elicited P. gingivalis-specific immunoglobulin G facilitates clearance o...

journal_title：Infection and immunity

authors： Gibson FC 3rd,Gonzalez DA,Wong J,Genco CA

更新日期：2004-04-01 00:00:00

abstract：:Swine were infected orally with pure cultures of Treponema hyodysenteriae, and the humoral antibody response was measured by a passive hemolysis test (passive hemagglutination test with the use of complement). Antibody to T. hyodysenteriae was detected as early as 1 week and later on at 4 months after exposure. Howeve...

journal_title：Infection and immunity

authors： Jenkins EM,Sinha PP,Vance RT,Reese GL

更新日期：1976-10-01 00:00:00

abstract：:Little is known about the underlying mechanisms that result in a sexually dimorphic response to Vibrio vulnificus endotoxic shock. V. vulnificus is a gram-negative bacterium, considered one of the most invasive and rapidly fatal human pathogens known. However, 85% of individuals that develop endotoxic shock from V. vu...

journal_title：Infection and immunity

authors： Merkel SM,Alexander S,Zufall E,Oliver JD,Huet-Hudson YM

更新日期：2001-10-01 00:00:00

abstract：:In a previous report (Y. Ohmori, S. Hanazawa, S. Amano, T. Miyoshi, K. Hirose, and S. Kitano, infect. Immun. 55:947-954, 1987), we showed that human gingival fibroblasts spontaneously produce thymocyte-activating factor (FTAF), which stimulates mitogen-induced thymocyte proliferation. In the present study, we examined...

journal_title：Infection and immunity

authors： Hanazawa S,Hirose K,Ohmori Y,Amano S,Kitano S

更新日期：1988-01-01 00:00:00

abstract：:Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by a strong Th1 response that leads to skin lesion development. In areas where L. braziliensis transmission is endemic, up to 15% of healthy subjects have tested positive for delayed-type hypersensitivity to soluble leishmania antigen (SLA...

journal_title：Infection and immunity

authors： Cardoso TM,Machado Á,Costa DL,Carvalho LP,Queiroz A,Machado P,Scott P,Carvalho EM,Bacellar O

更新日期：2015-03-01 00:00:00

abstract：:In Vibrio cholerae, the transmembrane DNA binding proteins, ToxR and TcpP, activate expression of the regulatory gene toxT in response to specific environmental signals. The resulting enhanced level of ToxT leads to a coordinated increase in the production of a subset of virulence factors, including cholera toxin (CT)...

journal_title：Infection and immunity

authors： Krishnan HH,Ghosh A,Paul K,Chowdhury R

更新日期：2004-07-01 00:00:00

abstract：:The humoral and cell-mediated immune responses of murine lymphocytes exposed to lead in vivo and in vitro were investigated. In vivo Pb was administered via the drinking water (0 to 10 mM) for 1 to 10 weeks. In vivo exposure of the mice to Pb did not alter significantly their plaque-forming cell response to sheep eryt...

journal_title：Infection and immunity

authors： Lawrence DA

更新日期：1981-01-01 00:00:00

abstract：:ATP and UTP have been proposed for use as therapeutic treatment of the abnormal ion transport in the airway epithelium in cystic fibrosis (CF), the most characteristic feature of which is permanent infection by Pseudomonas aeruginosa. As for diverse gram-negative bacteria, this pathogenic bacterium accumulates diffusi...

journal_title：Infection and immunity

authors： Saleh A,Figarella C,Kammouni W,Marchand-Pinatel S,Lazdunski A,Tubul A,Brun P,Merten MD

更新日期：1999-10-01 00:00:00

abstract：:The Lyme disease spirochete, Borrelia burgdorferi, is introduced into human hosts via tick bites. Among the cell types present in the skin which may initially contact spirochetes are mast cells. Since spirochetes are known to activate a variety of cell types in vitro, we tested whether B. burgdorferi spirochetes could...

journal_title：Infection and immunity

authors： Talkington J,Nickell SP

更新日期：1999-03-01 00:00:00

abstract：:Accurate diagnosis and early treatment of tuberculosis (TB) and latent TB infection (LTBI) are vital to prevent and control TB. The lack of specific biomarkers hinders these efforts. This study's purpose was to screen immunological markers that discriminate Mycobacterium tuberculosis infection outcomes in a setting wh...

journal_title：Infection and immunity

authors： Teklu T,Kwon K,Wondale B,HaileMariam M,Zewude A,Medhin G,Legesse M,Pieper R,Ameni G

更新日期：2018-03-22 00:00:00

abstract：:Three monoclonal antibodies (MAbs), all of the immunoglobulin G1 subclass, were raised against Cryptococcus neoformans by using the technique of cyclophosphamide ablation of B-cell responses against shared epitopes of the cross-reactive fungus Trichosporon beigelii. MAb 3C2 was reactive against the encapsulated and no...

journal_title：Infection and immunity

authors： Hamilton AJ,Jeavons L,Hobby P,Hay RJ

更新日期：1992-01-01 00:00:00

abstract：:Otitis media developed in 67% of chinchillas inoculated intranasally with type 7 Streptococcus pneumoniae and influenza A virus. Only 4% of chinchillas inoculated with influenza alone and 21% of chinchillas inoculated with S. pneumoniae alone developed otitis media. Among the chinchillas that developed otitis media af...

journal_title：Infection and immunity

authors： Giebink GS,Berzins IK,Marker SC,Schiffman G

更新日期：1980-11-01 00:00:00

abstract：:Resurgence is a major concern after malaria elimination. After the initiation of the elimination program on Aneityum Island in 1991, microscopy showed that Plasmodium falciparum disappeared immediately, whereas P. vivax disappeared from 1996 onward, until P. vivax cases were reported in January 2002. By conducting mal...

journal_title：Infection and immunity

authors： Kaneko A,Chaves LF,Taleo G,Kalkoa M,Isozumi R,Wickremasinghe R,Perlmann H,Takeo S,Tsuboi T,Tachibana S,Kimura M,Björkman A,Troye-Blomberg M,Tanabe K,Drakeley C

更新日期：2014-01-01 00:00:00