Migration of the fungal pathogen Candida albicans across endothelial monolayers.

abstract：:Human lactoferrin is an iron-binding glycoprotein that is particularly prominent in exocrine secretions and leukocytes and is also found in serum, especially during inflammation. It is able to sequester iron from microbes and has immunomodulatory functions, including inhibition of both complement activation and cytoki...

journal_title：Infection and immunity

authors： Håkansson A,Roche H,Mirza S,McDaniel LS,Brooks-Walter A,Briles DE

更新日期：2001-05-01 00:00:00

abstract：:Suitability of the rhesus monkey (Macaca mulatta) as an experimental host for evaluation of vaccines against airborne infection with Mycobacterium tuberculosis strain H37Rv was investigated. Nonvaccinated monkeys were exposed to estimated doses of 12, 25, or 49 units of H37Rv in a modified Henderson apparatus, and the...

journal_title：Infection and immunity

authors： Barclay WR,Anacker RL,Brehmer W,Leif W,Ribi E

更新日期：1970-11-01 00:00:00

abstract：:Mycoplasma salivarium cells propagated in PPLO broth (Difco Laboratories, Detroit, Mich.) supplemented with rabbit serum (10% [vol/vol]) and harvested by centrifugation were shown to contain rabbit immunoglobulin G (IgG) (approximately 4 to 10% of total cell proteins) and to produce IgM autoantibodies to IgG when inoc...

journal_title：Infection and immunity

authors： Watanabe T,Shibata K,Hasegawa K

更新日期：1987-01-01 00:00:00

abstract：:Streptolysin-O (SLO) is a thiol-activated, membrane-damaging protein toxin of Mr 69,000 that is produced by most strains of beta-hemolytic group A streptococci. Native, primarily water-soluble toxin molecules bind to cholesterol-containing target membranes to assemble into supramolecular curved rod structures (25 to 1...

journal_title：Infection and immunity

authors： Bhakdi S,Tranum-Jensen J,Sziegoleit A

更新日期：1985-01-01 00:00:00

abstract：:Moraxella (Branhamella) catarrhalis is an important bacterial cause of otitis media in children and lower respiratory tract infections in adults. In this study, we describe the presence of a novel high-molecular-weight outer membrane protein (HMW-OMP). This protein varies from 350 to 720 kDa in apparent molecular mass...

journal_title：Infection and immunity

authors： Klingman KL,Murphy TF

更新日期：1994-04-01 00:00:00

abstract：:Streptococcus suis serotype 2 is a porcine and human pathogen with adhesive and invasive properties. In other streptococci, large surface-associated proteins (>100 kDa) of the MSCRAMM family (microbial surface components recognizing adhesive matrix molecules) are key players in interactions with host tissue. In this s...

journal_title：Infection and immunity

authors： Baums CG,Kaim U,Fulde M,Ramachandran G,Goethe R,Valentin-Weigand P

更新日期：2006-11-01 00:00:00

abstract：:Salmonella strains that lack or overproduce DNA adenine methylase (Dam) elicit a protective immune response to different Salmonella species. To generate vaccines against other bacterial pathogens, the dam genes of Yersinia pseudotuberculosis and Vibrio cholerae were disrupted but found to be essential for viability. O...

journal_title：Infection and immunity

authors： Julio SM,Heithoff DM,Provenzano D,Klose KE,Sinsheimer RL,Low DA,Mahan MJ

更新日期：2001-12-01 00:00:00

abstract：:Tritium-labeled, water-soluble components of Streptococcus pyogenes type M6 absorbed to cardiac tissue in vitro. Tissue binding was time dependent, saturable, and reversible. Chromatography of the crude bacterial extract on Bio-Gel P-300 indicated a molecular weight greater than 300,000 for the heart-binding component...

journal_title：Infection and immunity

authors： Stinson MW,Bergey EJ

更新日期：1982-01-01 00:00:00

abstract：:After interaction with tracheal epithelial cells, Bordetella pertussis induces the secretion of interleukin-6. This secretion is dependent on the expression of adenylate cyclase-hemolysin by the bacterium but not on the expression of other characterized bacterial toxins or adhesins. This finding confirms the important...

journal_title：Infection and immunity

authors： Bassinet L,Fitting C,Housset B,Cavaillon JM,Guiso N

更新日期：2004-09-01 00:00:00

abstract：:Purified and concentrated Venezuelan equine encephalitis (VEE) virus derived from tissue cultures, rendered noninfectious by ionizing radiation with retention of in vitro serological activity, also retained a high level of immunogenicity. In mice, fluid vaccines afforded excellent protection against lethal challenge w...

journal_title：Infection and immunity

authors： Gruber J

更新日期：1971-04-01 00:00:00

abstract：:Cysteine proteases, including Arg-gingipain of Porphyromonas gingivalis, have been implicated as important virulence factors in periodontal diseases. These enzymes are also involved in the hemagglutinating activity of the organisms. In order to determine the role of proteases in the colonization of the gingival margin...

journal_title：Infection and immunity

authors： Tokuda M,Duncan M,Cho MI,Kuramitsu HK

更新日期：1996-10-01 00:00:00

abstract：:Antimicrobial factors were analyzed in samples of whole saliva from 31 children, aged 0.8 to 3.8 years. When compared with the adult reference group, the children displayed similar levels of lysozyme, salivary peroxidase, and hypothiocyanite (OSCN-), whereas the amounts of immunoglobulins (isotypes A, G, and M), lacto...

journal_title：Infection and immunity

authors： Tenovuo J,Lehtonen OP,Aaltonen AS,Vilja P,Tuohimaa P

更新日期：1986-01-01 00:00:00

abstract：:Menstrually associated toxic shock syndrome (TSS) is attributed primarily to the effects of staphylococcal exotoxin toxic shock syndrome toxin 1 (TSST-1). A region of the 194-amino-acid toxin spanning residues 115 through 144 constitutes a biologically active site. Several point mutations in the TSST-1 gene in that re...

journal_title：Infection and immunity

authors： Bonventre PF,Heeg H,Cullen C,Lian CJ

更新日期：1993-03-01 00:00:00

abstract：:The in vivo induction of colony-stimulating activity (CSA) by N-acetylmuramyl-L-alanine-D-isoglutamine has been demonstrated recently. In this study we increased our understanding of this property by testing muramyl peptides of several structures and activities for their capacity to induce CSA in vivo. A comparison of...

journal_title：Infection and immunity

authors： Galelli A,Lefrancier P,Chedid L

更新日期：1984-11-01 00:00:00

abstract：:Leukosis viruses of seven subgroups were tested for oncogenicity in chickens susceptible to virus infection and to development of lymphoid leukosis (LL) tumors. All subgroup A viruses and the subgroup B virus tested produced a high incidence of LL and other related neoplasms. Viruses of subgroup C and RAV-61 of subgro...

journal_title：Infection and immunity

authors： Purchase HG,Okazaki W,Vogt PK,Hanafusa H,Burmester BR,Crittenden LB

更新日期：1977-02-01 00:00:00

abstract：:We have previously shown that a Pasteurella multocida cexA mutant (PBA875) was impaired in capsule export and highly attenuated in virulence for mice (J. D. Boyce and B. Adler, Infect. Immun. 68:3463-3468, 2000). In this study we show that immunization with high, but not low, doses of PBA875 can confer significant pro...

journal_title：Infection and immunity

authors： Boyce JD,Adler B

更新日期：2001-03-01 00:00:00

abstract：:The 25-kb linear plasmid lp25 and one of the 28-kb linear plasmids (lp28-1) are required for experimental infection in Borrelia burgdorferi, the etiologic agent of Lyme disease. The loss of these plasmids either eliminates infectivity (lp25) or significantly increases the 50% infective dose during a 2-week infection p...

journal_title：Infection and immunity

authors： Labandeira-Rey M,Seshu J,Skare JT

更新日期：2003-08-01 00:00:00

abstract：:The gram-negative bacterium nontypeable Haemophilus influenzae (NTHI) is the predominant pathogen in chronic otitis media with effusion and, with Streptococcus pneumoniae and Moraxella catarrhalis, is a causative agent of acute otitis media. To identify potential virulence determinants, bacterial gene expression was m...

journal_title：Infection and immunity

authors： Mason KM,Munson RS Jr,Bakaletz LO

更新日期：2003-06-01 00:00:00

abstract：:Quorum-sensing systems are critical regulators of the expression of virulence factors of various organisms, including Pseudomonas aeruginosa. Las and Rhl are two major quorum-sensing components, and they are regulated by their corresponding autoinducers, N-3-oxododecanoyl homoserine lactone (3-oxo-C(12)-HSL) and N-but...

journal_title：Infection and immunity

authors： Tateda K,Ishii Y,Horikawa M,Matsumoto T,Miyairi S,Pechere JC,Standiford TJ,Ishiguro M,Yamaguchi K

更新日期：2003-10-01 00:00:00

abstract：:Three antigenic determinants were revealed in H3 hemagglutinin of influenza A viruses isolated from 1968 to 1975. One of them was common for all viruses, and two others specified differences between the viruses possessing H3 hemagglutinin. ...

journal_title：Infection and immunity

authors： Rovnova ZI,Kosyakov PN,Berezina ON,Isayeva EI,Zhdanov VM

更新日期：1979-06-01 00:00:00

abstract：:Oral treponemes are considered to be important in the development and progression of periodontal diseases. We investigated the mechanisms of recognition and activation of human gingival epithelial cells (HGEC) with the oral treponemes Treponema denticola, Treponema vincentii, and Treponema medium and their outer membr...

journal_title：Infection and immunity

authors： Asai Y,Jinno T,Ogawa T

更新日期：2003-02-01 00:00:00

abstract：:The ethanol-insoluble product formed from sucrose by purified enzyme encoded by the gtfA gene from Streptococcus mutans, expressed in recombinant Escherichia coli, was analyzed by 13C and 31P nuclear magnetic resonance. The product was identified as alpha-D-glucose-1-phosphate, and it was concluded that the GTF-A enzy...

journal_title：Infection and immunity

authors： Russell RR,Mukasa H,Shimamura A,Ferretti JJ

更新日期：1988-10-01 00:00:00

abstract：:In a previous study we showed that the involvement of EP4 subtype of the prostaglandin E (PGE) receptor is crucial for lipopolysaccharide (LPS)-induced osteoclast formation in vitro. The present study was undertaken to test whether EP4 is actually associated with LPS-induced bone resorption in vivo. In wild-type (WT) ...

journal_title：Infection and immunity

authors： Sakuma Y,Tanaka K,Suda M,Komatsu Y,Yasoda A,Miura M,Ozasa A,Narumiya S,Sugimoto Y,Ichikawa A,Ushikubi F,Nakao K

更新日期：2000-12-01 00:00:00

abstract：:A superoxide dismutase (SOD) gene from the obligate intracellular bacterium Coxiella burnetii has been cloned, and its DNA sequence has been determined and expressed in Escherichia coli. The gene was identified on pSJR50, a pHC79-derived genomic clone, by using the polymerase chain reaction with degenerate oligonucleo...

journal_title：Infection and immunity

authors： Heinzen RA,Frazier ME,Mallavia LP

更新日期：1992-09-01 00:00:00

abstract：:Infection of C57BL/6 mice with the third-stage larvae of Brugia pahangi results in a rapid expansion of NK1.1(+) T cells in the spleen and draining lymph nodes. NK T cells produced interleukin-4 in the spleen within 24 h of infection, and these cells were CD4(-). ...

journal_title：Infection and immunity

authors： Balmer P,Devaney E

更新日期：2002-04-01 00:00:00

abstract：:Humans infected with the dimorphic fungus Blastomyces dermatitidis develop strong T-lymphocyte responses to WI-1, an immunodominant antigen that has been shown to elicit protective immunity in mice. In the present study, the T-cell epitopes of WI-1 and human leukocyte antigen (HLA) restricting elements that display th...

journal_title：Infection and immunity

authors： Chang WL,Audet RG,Aizenstein BD,Hogan LH,DeMars RI,Klein BS

更新日期：2000-02-01 00:00:00

abstract：:Immunity to reinfection in the genital tract of female guinea pigs with the agent of guinea pig inclusion conjunctivitis was found to be dependent upon an intact humoral immune response. Cell-mediated immunity in the absence of humoral immunity had no apparent role in resistance to challenge infection. ...

journal_title：Infection and immunity

authors： Rank RG,Barron AL

更新日期：1983-01-01 00:00:00

abstract：:We developed an in vitro model to study the temperature-regulated cytotoxicity and intracellular growth of Mycobacterium haemophilum in cultured human epithelial and endothelial cells. M. haemophilum associated with human epithelial and endothelial cells at similar rates when incubated at 33 and 37 degrees C, but only...

journal_title：Infection and immunity

authors： Fischer LJ,Quinn FD,White EH,King CH

更新日期：1996-01-01 00:00:00

abstract：:Pathogenic Leptospira spp. are likely to encounter higher concentrations of reactive oxygen species induced by the host innate immune response. In this study, we characterized Leptospira interrogans catalase (KatE), the only annotated catalase found within pathogenic Leptospira species, by assessing its role in resist...

journal_title：Infection and immunity

authors： Eshghi A,Lourdault K,Murray GL,Bartpho T,Sermswan RW,Picardeau M,Adler B,Snarr B,Zuerner RL,Cameron CE

更新日期：2012-11-01 00:00:00

abstract：:Treatment with nontoxic monophosphoryl lipid A (MPL), which was derived from a polysaccharide-deficient, heptoseless Re mutant of Salmonella typhimurium, was found to inactivate suppressor T-cell activity, as evidenced by a decrease in the degree of low-dose immunological paralysis expressed and an increase in the mag...

journal_title：Infection and immunity

authors： Baker PJ,Hiernaux JR,Fauntleroy MB,Prescott B,Cantrell JL,Rudbach JA

更新日期：1988-05-01 00:00:00