Bordetella pertussis adenylate cyclase-hemolysin induces interleukin-6 secretion by human tracheal epithelial cells.

abstract：:Iron is limiting in the human host, and bacterial pathogens respond to this environment by regulating gene expression through the ferric uptake regulator protein (Fur). In vitro studies have demonstrated that Neisseria gonorrhoeae controls the expression of several critical genes through an iron- and Fur-mediated mech...

journal_title：Infection and immunity

authors： Agarwal S,King CA,Klein EK,Soper DE,Rice PA,Wetzler LM,Genco CA

更新日期：2005-07-01 00:00:00

abstract：:Gamma interferon (IFN-gamma)-primed human gingival fibroblasts (HGF) have been shown to produce higher levels of interleukin-8 (IL-8) upon stimulation with bacterial products and inflammatory cytokines than nonprimed controls. In this study, we examined whether priming of HGF with IFN-gamma up-regulates IL-8 productio...

journal_title：Infection and immunity

authors： Tamai R,Sakuta T,Matsushita K,Torii M,Takeuchi O,Akira S,Akashi S,Espevik T,Sugawara S,Takada H

更新日期：2002-03-01 00:00:00

abstract：:Some species of the genus Mycoplasma code for the arginine deiminase pathway (ADI), which enables these bacteria to produce ATP from arginine by the successive reaction of three enzymes: arginine deiminase (ArcA), ornithine carbamoyltransferase (ArcB), and carbamate kinase (ArcC). It so far appears that independently ...

journal_title：Infection and immunity

authors： Rechnitzer H,Rottem S,Herrmann R

更新日期：2013-10-01 00:00:00

abstract：:In vivo accumulation of D-serine by Escherichia coli CFT073 leads to elevated expression of PAP fimbriae and hemolysin by an unknown mechanism. Loss of D-serine catabolism by CFT073 leads to a competitive advantage during murine urinary tract infection (UTI), but loss of both D- and L-serine catabolism results in atte...

journal_title：Infection and immunity

authors： Anfora AT,Halladin DK,Haugen BJ,Welch RA

更新日期：2008-12-01 00:00:00

abstract：:Streptococcus pneumoniae (the pneumococcus), a leading cause of bacterial disease, is most commonly carried in the human nasopharynx. Colonization induces inflammation that promotes the organism's growth and transmission. This inflammatory response is dependent on intracellular sensing of bacterial components that acc...

journal_title：Infection and immunity

authors： Lemon JK,Miller MR,Weiser JN

更新日期：2015-08-01 00:00:00

abstract：:We isolated a monoclonal antibody directed against the ferric complex of aerobactin purified from Escherichia coli KH576. This antibody, which we designated MAb AERO1, was identified as an immunoglobulin G, subtype 2. A competitive enzyme-linked immunosorbent assay with MAb AERO1 had a limit of 10 nM for the detection...

journal_title：Infection and immunity

authors： le Roy D,Expert D,Razafindratsita A,Deroussent A,Cosme J,Bohuon C,Andremont A

更新日期：1992-03-01 00:00:00

abstract：:Virulence of the fungal pathogen Aspergillus fumigatus is in part based on the saprophytic lifestyle that this mold has evolved. A crucial function for saprophytism resides in secreted proteases that allow assimilation of proteinaceous substrates. The impact of extracellular proteolytic activities on the pathogenesis ...

journal_title：Infection and immunity

authors： Bergmann A,Hartmann T,Cairns T,Bignell EM,Krappmann S

更新日期：2009-09-01 00:00:00

abstract：:To produce chronic infection, microbial pathogens must escape host immune defenses. Infection with the human pathogenic fungus Cryptococcus neoformans is typically chronic. To understand the mechanism by which C. neoformans survives in tissue after the infection of immunocompetent hosts, we systematically studied the ...

journal_title：Infection and immunity

authors： Feldmesser M,Kress Y,Novikoff P,Casadevall A

更新日期：2000-07-01 00:00:00

abstract：:We examined the immunobiological responses to Histoplasma capsulatum in lungs of gamma interferon (IFN-gamma) knockout mice (GKO mice). Naive GKO mice succumbed by day 9 to intranasal challenge with 2.5 x 10(6) yeasts, whereas all wild-type (WT) mice survived for 45 days. Compared to lungs of WT mice, the lungs of acu...

journal_title：Infection and immunity

authors： Allendoerfer R,Deepe GS Jr

更新日期：1997-07-01 00:00:00

abstract：:CD8 T cells are effective mediators of specific immunity to infection by Listeria monocytogenes, a bacterial pathogen that initially infects macrophages in the spleen and liver and subsequently spreads to hepatocytes and unidentified parenchymal cells in the spleen. To identify the in vivo target cells of L. monocytog...

journal_title：Infection and immunity

authors： Harty JT,Bevan MJ

更新日期：1996-09-01 00:00:00

abstract：:Lipoprotein I (OprI) is one of the major proteins of the outer membrane of Pseudomonas aeruginosa. OprI is a candidate for a vaccine against P. aeruginosa, because it cross-reacts antigenically in all serotype strains of the International Antigenic Typing Scheme. We recently cloned and expressed the gene coding for Op...

journal_title：Infection and immunity

authors： Finke M,Duchêne M,Eckhardt A,Domdey H,von Specht BU

更新日期：1990-07-01 00:00:00

abstract：:The purpose of this study was to localize antigenic regions on the flagellin protein of Campylobacter jejuni 81116. This strain has two flagellin genes, flaA and flaB, which are 95% identical; only flaA seems to be expressed in motile C. jejuni 81116 cells. Fragments of flaA and flaB were cloned in the bacterial expre...

journal_title：Infection and immunity

authors： Nuijten PJ,van der Zeijst BA,Newell DG

更新日期：1991-03-01 00:00:00

abstract：:A DNA microarray containing fragments of 137 Borrelia burgdorferi B31 putative lipoprotein genes was used to examine Lyme disease spirochetes. DNA from B. burgdorferi sensu stricto B31, 297, and N40; Borrelia garinii IP90; and Borrelia afzelii P/Gau was fluorescently labeled and hybridized to the microarray, demonstra...

journal_title：Infection and immunity

authors： Liang FT,Nelson FK,Fikrig E

更新日期：2002-06-01 00:00:00

abstract：:The type III secretion system (TTSS) of Pseudomonas aeruginosa is induced in vivo upon contact with eukaryotic cells and in vitro by calcium depletion in culture medium. We have observed a previously identified protein, PsrA, necessary for full activation of TTSS gene expression in P. aeruginosa. Electrophoretic mobil...

journal_title：Infection and immunity

authors： Shen DK,Filopon D,Kuhn L,Polack B,Toussaint B

更新日期：2006-02-01 00:00:00

abstract：:Neutralizing antibodies were raised in mice that had been inoculated repeatedly with moderate quantities of human leukocyte interferon highly purified by affinity chromatography on immobilized anti-interferon globulins. Interferon preparations of lesser purity sensitized the mice to subsequent inoculations of interfer...

journal_title：Infection and immunity

authors： Dalton BJ,Ogburn CA,Paucker K

更新日期：1978-02-01 00:00:00

abstract：:Enterotoxigenic Escherichia coli (ETEC) is a major cause of traveler's diarrhea as well as of endemic diarrhea and stunting in children in developing areas. However, a small-mammal model has been badly needed to better understand and assess mechanisms, vaccines, and interventions. We report a murine model of ETEC diar...

journal_title：Infection and immunity

authors： Bolick DT,Medeiros PHQS,Ledwaba SE,Lima AAM,Nataro JP,Barry EM,Guerrant RL

更新日期：2018-06-21 00:00:00

abstract：:Burkholderia pseudomallei is a Gram-negative rod and the causative agent of melioidosis, an emerging infectious disease of tropical and subtropical areas worldwide. B. pseudomallei harbors a remarkable number of virulence factors, including six type VI secretion systems (T6SS). Using our previously described plaque as...

journal_title：Infection and immunity

authors： Hopf V,Göhler A,Eske-Pogodda K,Bast A,Steinmetz I,Breitbach K

更新日期：2014-05-01 00:00:00

abstract：:The effects of an ornithine-containing lipid [alpha-N-(3-acyloxyacyl)-ornithine (Orn-L)] or a serine-containing lipid [alpha-N-(3-acyloxyacyl)-serine (Ser-L)] from Flavobacterium meningosepticum on lethal endotoxemia in mice were examined. When 500 micrograms of Orn-L was intravenously administered 1 h before intraven...

journal_title：Infection and immunity

authors： Kawai Y,Kaneda K,Morisawa Y,Akagawa K

更新日期：1991-08-01 00:00:00

abstract：:Tularemia is caused by the Gram-negative bacterial pathogen Francisella tularensis Infection of macrophages and their subsequent death are believed to play important roles in the progression of disease. Because complement is a particularly effective opsonin for Francisella, we asked whether complement-dependent uptake...

journal_title：Infection and immunity

authors： Brock SR,Parmely MJ

更新日期：2017-09-20 00:00:00

abstract：:Monoclonal antibodies were raised against a bactericidal protein fraction that was purified from an extract of bovine neutrophil granules and that was previously shown (A. Savoini, R. Marzari, L. Dolzani, D. Serranò, G. Graziosi, R. Gennaro, and D. Romeo, Antimicrob. Agents Chemother. 26:405-407, 1984) to inhibit bact...

journal_title：Infection and immunity

authors： Marzari R,Scaggiante B,Skerlavaj B,Bittolo M,Gennaro R,Romeo D

更新日期：1988-08-01 00:00:00

abstract：:The intracellular protozoan Toxoplasma gondii is well known for its skill at invading and living within host cells. New discoveries are now also revealing the astounding ability of the parasite to inject effector proteins into the cytoplasm to seize control of the host cell. This review summarizes recent advances in o...

journal_title：Infection and immunity

authors： Denkers EY,Bzik DJ,Fox BA,Butcher BA

更新日期：2012-02-01 00:00:00

abstract：:In experimentally infected human volunteers, the cutaneous immune response to Haemophilus ducreyi is orchestrated by serum, polymorphonuclear leukocytes, macrophages, T cells, and myeloid dendritic cells (DC). This response either leads to spontaneous resolution of infection or progresses to pustule formation, which i...

journal_title：Infection and immunity

authors： Humphreys TL,Li L,Li X,Janowicz DM,Fortney KR,Zhao Q,Li W,McClintick J,Katz BP,Wilkes DS,Edenberg HJ,Spinola SM

更新日期：2007-12-01 00:00:00

abstract：:The ability of various strains of rats to produce interferon in response to polyriboinosinic-polyribocytodilic acid was investigated. ACI and DA (RT-1a), BN (RT-1n), Buffalo (RT-1b), August (RT-1c), and GH (RT-1l) strains produced low levels of interferon in response to intraperitoneal administration of polyriboinosin...

journal_title：Infection and immunity

authors： Davis CT,Blankenhorn EP,Murasko DM

更新日期：1984-02-01 00:00:00

abstract：:Infection with Histoplasma capsulatum results in a subclinical infection in immunocompetent hosts due to an effective cellular immune response. By contrast, immunodeficient individuals can have a severe disseminated and potentially fatal disease. In a previous study, it was demonstrated that normal mice infected intra...

journal_title：Infection and immunity

authors： Zhou P,Sieve MC,Tewari RP,Seder RA

更新日期：1997-03-01 00:00:00

abstract：:Nerve damage is a clinical hallmark of leprosy and a major source of patient morbidity. We investigated the possibility that human Schwann cells are susceptible to cell death through the activation of Toll-like receptor 2 (TLR2), a pattern recognition receptor of the innate immune system. TLR2 was detected on the surf...

journal_title：Infection and immunity

authors： Oliveira RB,Ochoa MT,Sieling PA,Rea TH,Rambukkana A,Sarno EN,Modlin RL

更新日期：2003-03-01 00:00:00

abstract：:Chronic Helicobacter pylori infection is associated with mucosal inflammation. The aim of the present study was to assess human neutrophil and monocyte activation by H. pylori strains obtained from patients with different clinical presentations. Bacterial sonicates from 12 strains were used to stimulate phagocyte upre...

journal_title：Infection and immunity

authors： Hansen PS,Go MF,Varming K,Andersen LP,Genta RM,Graham DY,Nielsen H

更新日期：1999-06-01 00:00:00

abstract：:Scrub typhus immunogens were prepared by exposing infected yolk sac suspensions of Rickettsia tsutsugamushi to various doses of gamma radiation. Mouse lethality was abolished at doses greater than 200 krads, whereas immunogenicity of the suspensions, as shown by mouse protection tests, was diminished relatively little...

journal_title：Infection and immunity

authors： Eisenberg GH Jr,Osterman JV

更新日期：1977-01-01 00:00:00

abstract：:Enterohemorrhagic Escherichia coli (EHEC) is a prominent, food-borne cause of diarrhea, bloody diarrhea, and the hemolytic uremic syndrome in industrialized countries. Most strains of EHEC carry the locus for enterocyte effacement (LEE) pathogenicity island, but a proportion of isolates from patients with severe disea...

journal_title：Infection and immunity

authors： Leyton DL,Sloan J,Hill RE,Doughty S,Hartland EL

更新日期：2003-11-01 00:00:00

abstract：:Collectins play important roles in host defense against infectious microorganisms. We now demonstrate that the serum collectins mannose-binding lectin (MBL) and conglutinin have less ability to bind to, aggregate, and enhance neutrophil uptake of several strains of gram-negative and gram-positive bacteria than pulmona...

journal_title：Infection and immunity

authors： Hartshorn KL,White MR,Crouch EC

更新日期：2002-11-01 00:00:00

abstract：:Numerous bacterial pathogens use type III secretion systems (T3SSs) or T4SSs to inject or translocate virulence proteins into eukaryotic cells. Several different reporter systems have been developed to measure the translocation of these proteins. In this study, a peptide tag-based reporter system was developed and use...

journal_title：Infection and immunity

authors： Garcia JT,Ferracci F,Jackson MW,Joseph SS,Pattis I,Plano LR,Fischer W,Plano GV

更新日期：2006-10-01 00:00:00