Abstract:
:A significant depression in the phagocytic capacity of elicited peritoneal macrophages, pulmonary alveolar macrophages, and elicited peritoneal polymorphonucleated neutrophils was manifested when the cells were incubated in medium containing cadmium chloride. With the exception of the neutrophils, a similar influence was observed when the cells were exposed to cadmium acetate. The impaired phagocytic capacity was related to the concentration of the cadmium in the medium. Peritoneal macrophages and neutrophils did not demonstrate any alteration in their microbicidal activity (percentage of ingested yeast which were killed) in the presence of the cadmium salts. However, a significant suppression in the intracellular microbicidal activity of alveolar macrophages was observed when the cells were incubated in medium containing either cadmium chloride or cadmium acetate. This unique response to Cd2+ may be related to general metabolic characteristics of these cells living at an elevated O2 tension.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Loose LD,Silkworth JB,Simpson DWdoi
10.1128/IAI.22.2.378-381.1978subject
Has Abstractpub_date
1978-11-01 00:00:00pages
378-81issue
2eissn
0019-9567issn
1098-5522journal_volume
22pub_type
杂志文章abstract::Proteins from human polymorphonuclear leukocyte granules were extracted with 0.2 M acetate, pH 4.0, and fractionated by Sephadex G-100 column chromatography. The fractions demonstrated selective bactericidal action against a deep rough cell wall mutant of Escherichia coli O111:B4 with rough lipopolysacharide and cell ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.23.3.587-591.1979
更新日期:1979-03-01 00:00:00
abstract::The development of immunoglobulin-containing cells and antigen-specific plasma cells in retropharyngeal and bronchial lymph nodes, in lung tissue, and in nasal mucous membrane was followed during an experimental infection of pigs with Mycoplasma hyopneumoniae. An enzyme-linked immunosorbent assay was used to follow st...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.49.3.615-620.1985
更新日期:1985-09-01 00:00:00
abstract::Vitamin E protects nonimmunized and immunized mice against fatal Diplococcus pneumoniae type I (DpI) infection. A dietary supplementation of 180 mg of dl-alpha-tocopheryl acetate per kg of diet increased survival of nonimmunized mice from 20 to 80% when challenged with 20 organisms, and of mice immunized with 0.5 ng o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.6.1292-1295.1974
更新日期:1974-12-01 00:00:00
abstract::A plaque assay system for pathogenic rickettsiae, which utilizes primary chick embryo tissue cultures, is described. It proved to be a highly reproducible measure of infectiousness for Rickettsia rickettsi and R. typhi, which were employed in most studies; as well as for R. canada, R. prowazeki, R. sibirica, R. akari,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.5.5.715-722.1972
更新日期:1972-05-01 00:00:00
abstract::The immunoprotective activity of Klebsiella pneumoniae K2 cell surface preparations and purified capsular polysaccharide was tested in mice. The 50% protective dose (PD50), expressed as capsular polysaccharide content, was 2 ng for cell surface preparations and 50 ng for purified capsular polysaccharide. Both preparat...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.54.2.365-370.1986
更新日期:1986-11-01 00:00:00
abstract::Western blot (immunoblot) analysis of sera from cattle vaccinated with Brucella abortus S19 exhibit an elevated serologic response to Hsp62, the GroEL homolog (BaGroEL). Serologic screening of individual cows vaccinated with B. abortus S19 revealed no correlation between the immune response to BaGroEL and protection a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.10.4396-4400.1996
更新日期:1996-10-01 00:00:00
abstract::The in vivo role of endogenous interleukin 12 (IL-12) in modulating intrapulmonary growth of Legionella pneumophila was assessed by using a murine model of replicative L. pneumophila lung infection. Intratracheal inoculation of A/J mice with virulent bacteria (10(6) L. pneumophila cells per mouse) resulted in inductio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.1.65-69.1998
更新日期:1998-01-01 00:00:00
abstract::The need for agents designed to modify immune response in the treatment of patients with viral infection, immunodeficiency, or cancer prompted the present study on the mechanisms of action of isoprinosine, a compound developed for antiviral use and whose therapeutic activity may involve the immune system. The effect o...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.2.382-387.1976
更新日期:1976-02-01 00:00:00
abstract::We investigated the effect of a pH 4-treated human immunoglobulin preparation for intravenous use (pH4-G) on the production of tumor necrosis factor alpha (TNF-alpha) in vivo. The level of TNF-alpha in the sera of rabbits receiving pH4-G before lipopolysaccharide (LPS) injection was lower than that in rabbits receivin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.5.1384-1390.1990
更新日期:1990-05-01 00:00:00
abstract::Poly-N-acetyl-glucosamine (PNAG) is a staphylococcal surface polysaccharide influencing biofilm formation that is also under investigation for its vaccine potential. Antibodies that bind to PNAG with either low (<15%) or high (>90%) levels of acetate are superior at opsonic and protective activity compared with antibo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00078-07
更新日期:2007-07-01 00:00:00
abstract::Characteristics of four transmissible gastroenteritis (TGE) virus field strains (Miller, Purdue, Bl, and V203) and four cell culture-attenuated strains (Purdue, SH, CKp, and Bl) were studied to find methods of differentiation between the two groups of viruses. TGE field virus strains did not replicate as well as atten...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.13.6.1642-1646.1976
更新日期:1976-06-01 00:00:00
abstract::Borrelia burgdorferi-induced arthritis in mice is characterized by tendonitis, synovitis, and inflammatory-cell infiltrate, predominantly of neutrophils. Because genetic deficiency in E and P selectins results in delayed recruitment of neutrophils to sites of inflammation, mice with this deficiency were tested for the...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::Toxigenic Vibrio cholerae strains are lysogens of CTXPhi, a filamentous phage which encodes cholera toxin. The receptor for CTXPhi for invading V. cholerae cells is the toxin-coregulated pilus (TCP), the genes for which reside in a larger genetic element, the TCP pathogenicity island. We analyzed 146 CTX-negative stra...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.66.12.5819-5825.1998
更新日期:1998-12-01 00:00:00
abstract::Thirteen Habs-serotype strains could be classified into 11 groups depending on the characteristic patterns of 2-amino sugar composition; strains of serotypes 2, 5, and 7 had the same pattern, and each other serotype strain had its own distinctive pattern. In our classification, fucosamine and quinovosamine were of imp...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.15.3.692-697.1977
更新日期:1977-03-01 00:00:00
abstract::Toxoplasma gondii infection in pregnant women may result in abortion or in fetal teratogenesis; however, the underlying mechanisms are still unclear. In this paper, based on a murine model, we showed that maternal infection with RH strain T. gondii tachyzoites induced elevated production of reactive oxygen species (RO...
journal_title:Infection and immunity
pub_type: 杂志文章,收录出版
doi:10.1128/IAI.06295-11
更新日期:2012-06-01 00:00:00
abstract::Acinetobacter baumannii is a pathogen of increasing medical importance with a propensity to be multidrug resistant, thereby making treatment challenging. Little is known of virulence traits in A. baumannii. To identify virulence factors and potential drug targets, random transposon (Tn) mutants derived from the A. bau...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00366-10
更新日期:2010-09-01 00:00:00
abstract::The identification of genes with increased expression in vivo may lead to the identification of novel or unrecognized virulence traits and/or recognition of environmental signals involved in modulating gene expression. Our laboratory is studying an extraintestinal isolate of Escherichia coli as a model pathogen. We ha...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.10.5306-5314.1999
更新日期:1999-10-01 00:00:00
abstract::The bundle-forming pilus (BFP) of enteropathogenic Escherichia coli (EPEC) is an important virulence factor. We examined the role of divergent alleles of bfpA encoding bundlin, the BFP pilin protein, in pilus biogenesis, pilus interactions, and immune responses. We found that the BFP biogenesis machine from an EPEC st...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00009-07
更新日期:2007-10-01 00:00:00
abstract::A toxin associated with Toxoplasma gondii infection was obtained from the trophozoites and culture medium used to propagate the parasite in cell cultures. The toxin, named Toxofactor (TF), administered parenterally or nonparenterally in adult mice, produces transient symptoms of lethargy, ruffled fur, and body weight ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.42.3.1126-1135.1983
更新日期:1983-12-01 00:00:00
abstract::Lipid X, a precursor in the biosynthesis of lipid A, has been claimed to possess most of the immunostimulatory activity but none of the toxicity of endotoxin. However, recent work shows that synthetic lipid X can be contaminated with small amounts of N,O-acylated disaccharide-1-phosphate (H. Aschauer, A. Grob, J. Hild...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.7.2351-2358.1991
更新日期:1991-07-01 00:00:00
abstract::After oral feeding of mice with avirulent Salmonella, Escherichia coli, or hybrid strains, only certain bacterial strains were able to multiply and persist within the small intestinal Peyer's patches. After oral vaccination alone, or oral priming and subsequent parenteral boosting, antibody class and titers were detec...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.25.1.27-33.1979
更新日期:1979-07-01 00:00:00
abstract::We have investigated the role of lipoteichoic acid in mediating the adherence of different serotypes of group B streptococci to human adult and neonatal epithelial cells. Pretreatment of neonatal buccal and vaginal epithelial cells with lipoteichoic acid, but not with deacylated lipoteichoic acid, induced a marked inh...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.12.3057-3064.1987
更新日期:1987-12-01 00:00:00
abstract::The roles of different ribonucleotide reductases (RNRs) in bacterial pathogenesis have not been studied systematically. In this work we analyzed the importance of the different Pseudomonas aeruginosa RNRs in pathogenesis using the Drosophila melanogaster host-pathogen interaction model. P. aeruginosa codes for three d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01212-10
更新日期:2011-07-01 00:00:00
abstract::The pathogenicities of three proteases from Serratia marcescens, two proteases from Pseudomonas aeruginosa, and one thermolysin from Bacillus stearothermophilus were examined. All proteases tested caused acute liquefactive necrosis of the cornea and descemetocele formation in guinea pig eyes after intrastromal injecti...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.10.2509-2517.1987
更新日期:1987-10-01 00:00:00
abstract::Since the pH of the gingival crevice increases from below neutrality in health to above pH 8 in disease, we decided to investigate the effect of environmental pH on the growth and enzyme activity of Bacteroides gingivalis W50. Cells were grown in a chemostat under hemin-excess conditions over a range of pH values; sta...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.5.1096-1100.1988
更新日期:1988-05-01 00:00:00
abstract::Chronic helminth infections are known to be associated with the modulation of antigen-specific T-cell responses. Strongyloides stercoralis infection is characterized by the downmodulation of antigen-specific Th1 and Th17 responses and the upregulation of Th2 and Th9 responses. Immune homeostasis is partially maintaine...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00469-19
更新日期:2019-11-18 00:00:00
abstract::Larvae of Toxocara canis, a nematode parasite of dogs, infect humans, causing visceral and ocular larva migrans. In noncanid hosts, larvae neither grow nor differentiate but endure in a state of arrested development. Reasoning that parasite protein production is orientated to immune evasion, we undertook a random sequ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.9.4771-4779.1999
更新日期:1999-09-01 00:00:00
abstract::Escherichia coli F-18, isolated from the feces of a healthy human in 1977, is an excellent colonizer of the streptomycin-treated mouse large intestine and displays normal motility and chemotaxis ability. A chemotaxis-defective derivative of E. coli F-18, E, coli F-18 CheA-, and a nonflagellated derivative, E. coli F-1...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.9.2957-2961.1990
更新日期:1990-09-01 00:00:00
abstract::The adherence of several strains of Escherichia coli to human buccal epithelial cells was studied, using cells obtained from five groups: healthy adults, healthy children, children with acute diarrhea, children with persistent diarrhea associated with cryptosporidial parasites, and children with noncryptosporidial per...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.11.4793-4800.1992
更新日期:1992-11-01 00:00:00
abstract::Thirty percent of Streptococcus pneumoniae isolates contain pilus islet 1, coding for a pilus composed of the backbone subunit RrgB and two ancillary proteins, RrgA and RrgC. RrgA is the major determinant of in vitro adhesion associated with pilus 1, is protective in vivo in mouse models, and exists in two variants (c...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00601-10
更新日期:2010-12-01 00:00:00