Abstract:
:Escherichia coli F-18, isolated from the feces of a healthy human in 1977, is an excellent colonizer of the streptomycin-treated mouse large intestine and displays normal motility and chemotaxis ability. A chemotaxis-defective derivative of E. coli F-18, E, coli F-18 CheA-, and a nonflagellated derivative, E. coli F-18 Fla-, were constructed. These strains were found to colonize the streptomycin-treated mouse large intestine as well as E. coli F-18 when mice were fed both E. coli F-18 and either the CheA- or Fla- derivative at high levels (10(10) CFU of each strain per mouse) or low levels (10(4) CFU of each strain per mouse). Furthermore, E. coli F-18 lost motility and chemotaxis ability when grown in colonic or cecal mucus in vitro despite retaining the ability to synthesize flagella. Thus, it appears that neither motility nor chemotaxis plays a role in the ability of E. coli F-18 to colonize because this strain becomes functionally nonmotile upon growth in the streptomycin-treated mouse large intestine.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
McCormick BA,Laux DC,Cohen PSdoi
10.1128/IAI.58.9.2957-2961.1990subject
Has Abstractpub_date
1990-09-01 00:00:00pages
2957-61issue
9eissn
0019-9567issn
1098-5522journal_volume
58pub_type
杂志文章abstract::The mechanism of activation of intestinal guanylate cyclase by Escherichia coli heat-stable enterotoxin (STa) has been studied by using isolated rat intestinal epithelial cells and purified brush border membrane (BBM) preparations. Inhibitors of prostaglandin biosynthesis, quinacrine and 5,8,11,14-eicosatetraynoic aci...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.44.2.493-501.1984
更新日期:1984-05-01 00:00:00
abstract::One of the chromosomal segments associated with the virulence of Shigella flexneri and transferred to Escherichia coli K-12 by conjugation has been shown to code for the production of aerobactin and for the synthesis of an iron-regulated 76,000-dalton (76K) outer membrane protein. Analysis of various E. coli K-12-S. f...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.49.1.67-71.1985
更新日期:1985-07-01 00:00:00
abstract::Slime production is not a generally recognized feature of Staphylococcus epidermidis. In a recent outbreak of S. epidermidis intravascular catheter-associated sepsis, we noted that 63% of clinically implicated strains grew as a slimy film coating the culture tube walls when propagated in tryptic soy broth. Only 37% of...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.37.1.318-326.1982
更新日期:1982-07-01 00:00:00
abstract::Glaesserella (Haemophilus) parasuis is a commensal bacterium of the upper respiratory tract in pigs and also the causative agent of Glässer's disease, which causes significant morbidity and mortality in pigs worldwide. Isolates are characterized into 15 serovars by their capsular polysaccharide, which has shown a corr...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00879-19
更新日期:2020-04-20 00:00:00
abstract::Several immunological, hematological, and pathological responses associated with Marek's disease were determined. Four-week-old Marek's disease-infected and control chickens were injected with Salmonella pullorum antigen. About one-half of all infected chickens tested were unresponsive to antigenic challenge. Antibody...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.4.5.567-574.1971
更新日期:1971-11-01 00:00:00
abstract::Streptococcus pneumoniae is a fermentative microorganism and causes serious diseases in humans, including otitis media, bacteremia, meningitis, and pneumonia. However, the mechanisms enabling pneumococcal survival in the host and causing disease in different tissues are incompletely understood. The available evidence ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02005-14
更新日期:2014-12-01 00:00:00
abstract::An established cell line (Vero) defective in interferon production was used to evaluate the role of interferon in chronic rubella virus infections of cell cultures. Inoculation of Vero cells with a low multiplicity of virus resulted in the development of carrier cultures which had the characteristics of a regulated in...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.2.2.132-138.1970
更新日期:1970-08-01 00:00:00
abstract::We investigated the effect of the extracellular protease of Serratia marcescens on human serum constituents such as immunoglobulins, fibronectin, alpha 1-protease inhibitor, alpha 2-macroglobulin, lysozyme, and transferrin. At a very low concentration of Serratia 56-kilodalton protease (56K protease), purified human p...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.53.3.522-529.1986
更新日期:1986-09-01 00:00:00
abstract::The invasion of red blood cells (RBCs) by Plasmodium falciparum is dependent on multiple molecular interactions between erythrocyte receptors and parasite ligands. Invasion studies using culture-adapted parasite strains have indicated significant receptor heterogeneity. It is not known whether this heterogeneity refle...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.10.5886-5891.2004
更新日期:2004-10-01 00:00:00
abstract::Gamma interferon (IFN-gamma) plays an important role in experimental Trypanosoma cruzi infections, presumably by controlling the early replication of parasites in host macrophages. In this work, we show that NK cells represent an important cell type responsible for the production of most of the IFN-gamma in the early ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.1.128-134.1996
更新日期:1996-01-01 00:00:00
abstract::Pertussis is a severe respiratory disease caused by Bordetella pertussis The classic symptoms of pertussis include paroxysmal coughing with an inspiratory whoop, posttussive vomiting, cyanosis, and persistent coryzal symptoms. Infants under 2 months of age experience more severe disease, with most deaths occurring in ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00511-18
更新日期:2018-10-25 00:00:00
abstract::The innate and the adaptive arms of the mucosal immune system must be coordinated to facilitate the control of pathogenic invasion while maintaining immune homeostasis. Toll-like receptors, able to activate the cell to produce bactericidal and inflammatory cytokines but also able to upregulate antigen (Ag)-presenting ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00100-07
更新日期:2008-02-01 00:00:00
abstract::Pneumolysin is an important virulence factor of Streptococcus pneumoniae, interacting with the membranes of host cells to elicit a multitude of inflammatory responses. We used cDNA microarrays to identify genes which are responsive to S. pneumoniae in a pneumolysin-dependent and -independent fashion. The THP-1 human m...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.4.2087-2094.2003
更新日期:2003-04-01 00:00:00
abstract::Peru-15 is a live attenuated oral vaccine derived from a Vibrio cholerae O1 El Tor Inaba strain by a series of deletions and modifications, including deletion of the entire CT genetic element. Peru-15 is also a stable, motility-defective strain and is unable to recombine with homologous DNA. We wished to determine whe...
journal_title:Infection and immunity
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1128/iai.70.4.1965-1970.2002
更新日期:2002-04-01 00:00:00
abstract::The genes for outer membrane protein P2 of four nontypeable Haemophilus influenzae strains were cloned and sequenced. The derived amino acid sequences were compared with the outer membrane protein P2 sequence from H. influenzae type b MinnA and the sequences of P2 from three additional nontypeable H. influenzae strain...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.6.2639-2643.1994
更新日期:1994-06-01 00:00:00
abstract::Epitope mapping of outer surface protein C (OspC) by using sera from patients with neuroborreliosis led to the identification of one single major immunodominant epitope within the C-terminal 10 amino acid residues. Peptide binding studies and alanine replacement scanning of the C-terminal decapeptide, PVVAESPKKP, reve...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract::It is currently accepted that malaria-parasitized red blood cells (pRBC) are eliminated, like senescent erythrocytes, phagocytically by macrophages in the red pulp of the spleen. Here, however, we show that self-healing Plasmodium chabaudi malaria activates spleen closure in C57BL/6 mice. Confocal laser scanning micro...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.10.6390-6398.2005
更新日期:2005-10-01 00:00:00
abstract::Heat shock protein (HSP) expression was examined in murine bone marrow-derived macrophages infected with stationary-phase promastigotes of Leishmania donovani. Immunoblotting performed with a rabbit polyclonal antiserum raised against HSP60 from Heliothis virescens (moth) revealed the de novo appearance of 65- and 67-...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.8.3265-3272.1993
更新日期:1993-08-01 00:00:00
abstract::The effect of the secondary infection with Toxoplasma gondii on antibody responses to unrelated antigens was examined in mice. A reinfection with 5 X 10(3) organisms did not affect either primary anti-sheep erythrocyte antibody responses, or anti-dinitrophenol antibody responses to dinitrophenylated keyhole limpet hem...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.48.3.686-689.1985
更新日期:1985-06-01 00:00:00
abstract::The indigenous microbial flora of the middle ear cavity of Mongolian gerbils, Meriones unguiculatus, was isolated, characterized, and identified, showing it to be sparse and transitory. Organisms, when found in the middle ear cavity, were most likely to be Staphylococcus epidermidis-like organisms. Cerumen from the ex...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.32.3.1113-1118.1981
更新日期:1981-06-01 00:00:00
abstract::Streptococcus pneumoniae (the pneumococcus), a leading cause of bacterial disease, is most commonly carried in the human nasopharynx. Colonization induces inflammation that promotes the organism's growth and transmission. This inflammatory response is dependent on intracellular sensing of bacterial components that acc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00224-15
更新日期:2015-08-01 00:00:00
abstract::Clostridium difficile causes pseudomembranous colitis through the action of Rho-modifying proteins, toxins A and B. Antibodies directed against C. difficile toxin A prevent or limit C. difficile-induced colitis. We engineered plasmid pETR14, containing the hlyB and hlyD genes of the Escherichia coli hemolysin operon, ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.7.2941-2949.1997
更新日期:1997-07-01 00:00:00
abstract::Clostridium difficile causes pseudomembranous colitis in humans. The enterotoxin (i.e., toxin A) from this organism is believed to be responsible for the initial intestinal pathology associated with this disease. Previous work shows that this toxin binds to carbohydrates that contain Gal alpha 1-3Gal beta 1-4GlcNAc. H...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.1.73-78.1991
更新日期:1991-01-01 00:00:00
abstract::The major outer membrane protein (P2) of Haemophilus influenzae type b (Hib) with an apparent molecular weight of 37,000 to 40,000 has been previously shown to function as a porin and also as a target for antibodies protective against experimental Hib disease. The gene encoding the Hib P2 protein was cloned by using a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.10.2709-2716.1988
更新日期:1988-10-01 00:00:00
abstract::Streptococcus mutans, a major oral pathogen responsible for dental caries formation, possesses a variety of mechanisms for survival in the human oral cavity, where the conditions of the external environment are diverse and in a constant state of flux. The formation of biofilms, survival under conditions of acidic pH, ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01627-07
更新日期:2008-07-01 00:00:00
abstract::Stimulation of the rabbit reticuloendothelial system with viable Mycobacterium bovis (strain BCG), and other agents, had no effect on the development of syphilitic lesions after intradermal or intravenous inoculation with graded doses of Treponema pallidum (virulent Nichol's strain; mean infective doses less than 10)....
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.12.5.1029-1036.1975
更新日期:1975-11-01 00:00:00
abstract::We have recently found that strain B31 infection-immune rabbits are completely protected against homologous challenge with large numbers (>10(6)) of host-adapted Borrelia burgdorferi (HAB) (E. S. Shang, C. I. Champion, X. Wu, J. T. Skare, D. B. Blanco, J. N. Miller, and M. A. Lovett, Infect. Immun. 68:4189-4199, 2000)...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.1.593-598.2001
更新日期:2001-01-01 00:00:00
abstract::As reported elsewhere, an enterotoxigenic strain of Escherichia coli serotype O25:K98:NM was epidemiologically incriminated as the etiological agent in a shipboard outbreak of diarrheal illness. This enterotoxigenic E. coli strain and possibly other enteric isolates were found to produce heat-labile toxin and not heat...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.24.3.793-797.1979
更新日期:1979-06-01 00:00:00
abstract::Hypoferremia, the reduction of plasma transferrin iron levels during infection, has been shown to control Neisseria meningitidis infection in mice. The exact nature of the mechanism that regulates this response has been obscure. We have previously shown that hypoferremia does not result from an accelerated removal of ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.44.2.320-325.1984
更新日期:1984-05-01 00:00:00
abstract::Chronic helminth infections are known to be associated with the modulation of antigen-specific T-cell responses. Strongyloides stercoralis infection is characterized by the downmodulation of antigen-specific Th1 and Th17 responses and the upregulation of Th2 and Th9 responses. Immune homeostasis is partially maintaine...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00469-19
更新日期:2019-11-18 00:00:00