Abstract:
:Strain TG is a plasmidless exfoliative toxin (ET) producer. Strain ER201 contains a plasmid, whose loss had no apparent effect on ET production. The plasmid of ER201 was almost identical in size to the plasmid from strain UT0007, which carries an ET determinant.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Rosenblum ED,Tyrone Sdoi
10.1128/IAI.14.5.1259-1260.1976subject
Has Abstractpub_date
1976-11-01 00:00:00pages
1259-60issue
5eissn
0019-9567issn
1098-5522journal_volume
14pub_type
杂志文章abstract::An enterotoxin produced by Bacteroides fragilis was purified to homogeneity and characterized as to its biological activity and basic molecular properties. Toxin preparations were prepared by growing B. fragilis VPI 13784 in brain heart infusion broth to early stationary phase, immediately precipitating the culture su...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.4.1343-1350.1992
更新日期:1992-04-01 00:00:00
abstract::Escherichia coli O157:H7, a major Shiga toxin-producing pathogen, has a low infectious dose and causes serious illness in humans. The gastrointestinal tract of cattle is the primary reservoir of E. coli O157:H7, and thus, it is critical to eliminate or reduce E. coli O157:H7 gut colonization. Given that E. coli O157:H...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01589-13
更新日期:2014-05-01 00:00:00
abstract::We have shown that a member of the 70-kDa heat shock protein (Hsp70) family is a major target of the humoral immune response during Leishmania donovani infection. A recombinant fusion protein was recognized by sera from 92% (35 of 38) of patients with visceral leishmaniasis, including representatives from each of the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.7.2688-2693.1992
更新日期:1992-07-01 00:00:00
abstract::The protective efficacy of antibodies to the Staphylococcus aureus type 5 capsular polysaccharide (CP5) was examined in a modified model of catheter-induced endocarditis. Rats were catheterized by surgically passing a polyethylene catheter through the right carotid artery and aortic valve into the left ventricle. The ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.10.4146-4151.1997
更新日期:1997-10-01 00:00:00
abstract::Immunoglobulin class-specific antibodies were measured by a solid-phase radioimmunoassay in serum, bronchoalveolar washings (BAW), lung cell lysates, and spleen cell lysates in germfree mice after intranasal (i.n.) and intraperitoneal (i.p.) primary and secondary 10(5), 10(4), and 10(3) mean tissue culture infective d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.17.3.521-527.1977
更新日期:1977-09-01 00:00:00
abstract::Human multidrug efflux transporters are known for their ability to extrude antibiotics and toxic compounds out of cells, yet accumulating data indicate they have additional functions in diverse physiological processes not related to drug efflux. Here, we show that the human multidrug transporter P-glycoprotein (P-gp) ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00380-15
更新日期:2015-06-01 00:00:00
abstract::Monoclonal antibodies to Trichomonas vaginalis were prepared by immunizing mice with a cloned isolate of T. vaginalis. Eight antibodies reacted with the same four isolates or strains but did not react with the other T. vaginalis strains or isolates tested. All eight antibodies reacted uniformly with both the body and ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.43.1.270-275.1984
更新日期:1984-01-01 00:00:00
abstract::Immunization with live Plasmodium sporozoites under chloroquine prophylaxis (Spz plus CQ) induces sterile immunity against sporozoite challenge in rodents and, more importantly, in humans. Full protection is obtained with substantially fewer parasites than with the classic immunization with radiation-attenuated sporoz...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01415-09
更新日期:2010-05-01 00:00:00
abstract::Growing Streptococcus gordonii Spp+ phase variants, which have normal levels of glucosyltransferase (GTF) activity, use sucrose to promote their accumulation on surfaces by forming a cohesive bacterium-insoluble glucan polymer mass (BPM). Spp- phase variants, which have lower levels of GTF activity, do not form BPMs a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.10.4301-4308.1992
更新日期:1992-10-01 00:00:00
abstract::Candida albicans secreted aspartyl proteinases (Saps) are considered virulence-associated factors. Several members of the Sap family were claimed to play a significant role in the progression of candidiasis established by the hematogenous route. This assumption was based on the observed attenuated virulence of sap-nul...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00248-10
更新日期:2010-11-01 00:00:00
abstract::We have determined the amounts of specific anti-class 1 outer membrane protein antibodies in sera from 25 patients during the course of systemic meningococcal disease, using purified class 1 protein as the sensitizing antigen in an enzyme-linked immunosorbent assay. The class 1 protein was obtained from a variant of s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.4.1437-1443.1994
更新日期:1994-04-01 00:00:00
abstract::Expression of the Vwa+ phenotype of Yersinia pestis in vitro is known to reflect maximum induction of virulence (or V and W antigens) at 37 degrees C with concomitant restriction of cell division. Both phenomena are potentiated by 20 mM Mg2+ and prevented by cultivation at 26 or 37 degrees C with 2.5 mM Ca2+. We have ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.40.1.166-171.1983
更新日期:1983-04-01 00:00:00
abstract::The ability to bind and utilize hemin is a trait common to many human pathogens. Nevertheless, the relationship between Legionella pneumophila, the agent of Legionnaires' disease, and hemin has received little attention. Thus, we explored the capacity of a virulent, serogroup 1 strain of L. pneumophila to bind hemin a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.3.842-848.1996
更新日期:1996-03-01 00:00:00
abstract::A previously undescribed, immunoreactive, membranous spherule outer wall (SOW) fraction produced by Coccidioides immitis (strains 634 and 735) grown in culture was isolated. Both this fraction and intact spherules were reactive with sera from coccidioidomycosis patients, as demonstrated by immunofluorescence microscop...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.10.2686-2694.1988
更新日期:1988-10-01 00:00:00
abstract::Tox-+ staphylococcal strains, as opposed to Tox-minus strains, produce epidermal exfoliation within 18 h after direct subcutaneous or intraperitoneal injection into newborn mice. The extracellular product responsible for exfoliation is termed exfoliative toxin (ET). When culture supernatant fluid from the plasmid-cure...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.12.1.193-197.1975
更新日期:1975-07-01 00:00:00
abstract::Pneumocystis carinii is an ascomycete phylogenetically related to Schizosaccharomyces pombe. Little is known about gene regulation in P. carinii. The removal of introns from pre-mRNA requires spliceosomal recognition of the intron-exon boundary. In S. pombe and higher eukaryotes, this boundary and a branch site within...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.11.6157-6160.1999
更新日期:1999-11-01 00:00:00
abstract::Streptococcus pneumoniae is the most common pathogen associated with otitis media. To examine the role of Toll-like receptor 2 (TLR2) in host defense against Streptococcus pneumoniae infection in the middle ear, wild-type (WT; C57BL/6) and TLR2-deficient (TLR2(-/-)) mice were inoculated with Streptococcus pneumoniae (...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00204-09
更新日期:2009-07-01 00:00:00
abstract::This longitudinal prospective study shows that antibodies to the N-terminal block 2 region of the Plasmodium falciparum merozoite surface protein 1 (MSP-1) are associated with protection against clinical malaria in an area of stable but seasonal malaria transmission of Ghana. Antibodies to the block 2 region of MSP-1 ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.11.6492-6502.2004
更新日期:2004-11-01 00:00:00
abstract::Hamster respiratory epithelial cells were cultured in a monolayer format, and 20% of the cells were ciliated. Mycoplasma pneumoniae attached to the epithelial cells in a neuraminidase-specific fashion and induced ciliostasis and cytonecrosis. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.21.1.333-336.1978
更新日期:1978-07-01 00:00:00
abstract::Glucan-binding protein B (GbpB) from Streptococcus mutans has been shown to induce protective immunity to dental caries in experimental models. Having recently sequenced the gbpB gene, our objective in this study was to identify immunogenic regions within the GbpB sequence for use in subunit vaccines. Potential region...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.3.1179-1184.2003
更新日期:2003-03-01 00:00:00
abstract::In order to ascertain if Cryptococcus neoformans components can induce interleukin-6 (IL-6) production, we stimulated human whole blood with purified capsular products. Their potencies in stimulating IL-6 release were mannoproteins > galactoxylomannan = glucuronoxylomannan > alpha(1-3)glucan. IL-6 production was tumor...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.6.2454-2456.1997
更新日期:1997-06-01 00:00:00
abstract::Pyolysin (PLO), a cholesterol-dependent cytolysin expressed by Arcanobacterium pyogenes, is an important host-protective antigen. However, this molecule is toxic and requires inactivation prior to its use as a vaccine. Three genetically toxoided, nonhemolytic PLO molecules, HIS-PLO.F(497), HIS-PLO.Delta P(499), and HI...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.5.2966-2969.2003
更新日期:2003-05-01 00:00:00
abstract::Escherichia coli O157:H7 causes food and waterborne enteric infections that can result in hemorrhagic colitis and life-threatening hemolytic uremic syndrome. Intimate adherence of the bacteria to intestinal epithelial cells is mediated by intimin, but E. coli O157:H7 also possess several other putative adhesins, inclu...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05945-11
更新日期:2012-03-01 00:00:00
abstract::Streptococcus pyogenes is one of the most frequent human pathogens. Recent studies have identified dendritic cells (DCs) as important contributors to host defense against S. pyogenes. The objective of this study was to identify the receptors involved in immune recognition of S. pyogenes by DCs. To determine whether To...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01680-07
更新日期:2008-06-01 00:00:00
abstract::Respiratory epithelial cells play an active part in the host response to respiratory pathogens, such as Streptococcus pneumoniae, by releasing chemokines responsible for neutrophil recruitment. In order to investigate the role of specific pneumococcal virulence factors in eliciting CXC chemokine responses, type II pne...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00954-06
更新日期:2006-12-01 00:00:00
abstract::Rats kept under germfree conditions showed lower specific lysosomal enzyme activities in liver endothelial cells, but not in Kupffer cells. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.33.2.620-622.1981
更新日期:1981-08-01 00:00:00
abstract::Harvard caries-resistant rats (CR) monoassociated with cariogenic Streptococcus faecalis (SF) for 150 days developed early high levels of specific SF serum agglutinins, moderate levels of salivary antibody, and little or no caries activity. Harvard caries-susceptible (CS) SF-monoassociated rats developed serum antibod...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.16.3.805-811.1977
更新日期:1977-06-01 00:00:00
abstract::A complex of trehalose-6, 6'-dimycolate (cord factor) and methylated bovine serum albumin was prepared, and its effect on the toxicity of cord factor in mice was studied. Either the active immunization with cord factor-methylated bovine serum albumin complex or the passive transfer of sera of rabbits vaccinated with t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.5.2.203-212.1972
更新日期:1972-02-01 00:00:00
abstract::Conidia ingested by resident macrophages had an enhanced percentage of transformation to yeast cells compared with those in culture medium without macrophages. The yeast cells subsequently grew intracellularly by budding. Macrophages treated with cytokines from antigen-stimulated spleen cells from immunized mice signi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.5.2096-2100.1992
更新日期:1992-05-01 00:00:00
abstract::Minicells are small, anucleate cells resulting from aberrant cell divisions at the polar ends of bacilli. We have isolated minicell-producing mutant strains of Shigella flexneri 2a (MC-I) and Shigella dysenteriae 1 (MC-V) after mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine. Microscopically, broth cultures of M...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.30.1.297-302.1980
更新日期:1980-10-01 00:00:00