Impact of methoxymycolic acid production by Mycobacterium bovis BCG vaccines.

abstract：:Brucella abortus 2308 derivatives with mini-Tn5 insertions in purE, purL, and purD display significant attenuation in the BALB/c mouse model, while isogenic mutants with mini-Tn5 insertions in pheA, trpB, and dagA display little or no attenuation in cultured murine macrophages or mice. These experimental findings conf...

journal_title：Infection and immunity

authors： Alcantara RB,Read RD,Valderas MW,Brown TD,Roop RM 2nd

更新日期：2004-08-01 00:00:00

abstract：:A modified version of the Bacteroides fragilis transposon Tn4400, designated Tn4400', enabling rapid isolation and analysis of B. fragilis mutants has been constructed. To identify potential virulence factors, Tn4400'-generated mutants were screened by a new method; this resulted in the isolation of 21 mutant strains ...

journal_title：Infection and immunity

authors： Tang YP,Malamy MH

更新日期：2000-01-01 00:00:00

abstract：:The antigenicities of Mycobacterium bovis strain BCG and an isoniazid (INH) - resistant mutant were compared. Sonic extracts of heat-killed, washed bacteria were injected into rabbits, and antisera were produced (anti-BCG and anti-BCG-R). The sonic extracts were also subjected to ultracentrifugation, and test antigens...

journal_title：Infection and immunity

authors： Minden P,McClatchy JK,Bardana EJ,Farr RS

更新日期：1971-04-01 00:00:00

abstract：:Mycoplasma salivarium cells propagated in PPLO broth (Difco Laboratories, Detroit, Mich.) supplemented with rabbit serum (10% [vol/vol]) and harvested by centrifugation were shown to contain rabbit immunoglobulin G (IgG) (approximately 4 to 10% of total cell proteins) and to produce IgM autoantibodies to IgG when inoc...

journal_title：Infection and immunity

authors： Watanabe T,Shibata K,Hasegawa K

更新日期：1987-01-01 00:00:00

abstract：:The need for agents designed to modify immune response in the treatment of patients with viral infection, immunodeficiency, or cancer prompted the present study on the mechanisms of action of isoprinosine, a compound developed for antiviral use and whose therapeutic activity may involve the immune system. The effect o...

journal_title：Infection and immunity

authors： Hadden JW,Hadden EM,Coffey RG

更新日期：1976-02-01 00:00:00

abstract：:The protozoan parasite Cryptosporidium parvum is a significant cause of diarrheal disease worldwide. Attachment to and invasion of host intestinal epithelial cells by C. parvum sporozoites are crucial steps in the pathogenesis of cryptosporidiosis. The molecular basis of these initial interactions is unknown. In order...

journal_title：Infection and immunity

authors： Cevallos AM,Bhat N,Verdon R,Hamer DH,Stein B,Tzipori S,Pereira ME,Keusch GT,Ward HD

更新日期：2000-09-01 00:00:00

abstract：:The ability of hemagglutinating and poorly hemagglutinating strains of the gastroduodenal pathogen Helicobacter pylori to bind 125I-radiolabelled laminin was quantitated in a liquid phase assay. Although all strains bound laminin, some hemagglutinating strains were good binders of laminin (maximum of 31% binding), whe...

journal_title：Infection and immunity

authors： Valkonen KH,Wadström T,Moran AP

更新日期：1994-09-01 00:00:00

abstract：:Cholera enterotoxin and the related heat-labile enterotoxins of Escherichia coli enter their target cells through noncoated vesicles, but how the toxins are processed intracellularly and how they get to their targeted enzyme, adenylate cyclase, remain to be defined. Brefeldin A, an inhibitor of the trans-Golgi network...

journal_title：Infection and immunity

authors： Donta ST,Beristain S,Tomicic TK

更新日期：1993-08-01 00:00:00

abstract：:Advanced human periodontitis is considered to be a B-cell lesion, but the cellular infiltrate contains several cell types, the distribution of which has not been determined. This experiment was designed to characterize and identify the immunocompetent cells on histological sections and in eluates from diseased human g...

journal_title：Infection and immunity

authors： Okada H,Kida T,Yamagami H

更新日期：1983-07-01 00:00:00

abstract：:Porphyromonas gingivalis is reportedly capable of stimulating the expression of host cell matrix metalloproteinases (MMP), contributing to tissue destruction. However, the impact of this bacterium on specific molecules remains to be determined. In this study, we evaluate the effect of P. gingivalis on regulation of MM...

journal_title：Infection and immunity

authors： Fravalo P,Ménard C,Bonnaure-Mallet M

更新日期：1996-12-01 00:00:00

abstract：:We have determined the amounts of specific anti-class 1 outer membrane protein antibodies in sera from 25 patients during the course of systemic meningococcal disease, using purified class 1 protein as the sensitizing antigen in an enzyme-linked immunosorbent assay. The class 1 protein was obtained from a variant of s...

journal_title：Infection and immunity

authors： Guttormsen HK,Wetzler LM,Solberg CO

更新日期：1994-04-01 00:00:00

abstract：:The interactions between Capnocytophaga ochracea ATCC 33596 and Streptococcus sanguis H1, Actinomyces naeslundii PK984, or Actinomyces israelii PK16 are dependent on specific recognitions between heat-sensitive adhesins on C. ochracea and heat-stable structures (probably carbohydrate-containing receptors) on the surfa...

journal_title：Infection and immunity

authors： Weiss EI,London J,Kolenbrander PE,Kagermeier AS,Andersen RN

更新日期：1987-05-01 00:00:00

abstract：:Differences in molecular composition of lipopolysaccharides (LPS) between serum-sensitive (S) clinical isolates of Escherichia coli and serum-resistant (R) clones derived by serial passage in serum were demonstrated to determine sensitivity or resistance to killing by normal human serum (NHS). LPS from R clones had a ...

journal_title：Infection and immunity

authors： Porat R,Johns MA,McCabe WR

更新日期：1987-02-01 00:00:00

abstract：:The pattern of meningococcal surface structure expression in different microenvironments following bloodstream invasion in vivo is not known. We used immunohistochemistry to determine the expression of capsule, type IV pili, and PorA by meningococci residing in the skin lesions of children with purpura fulminans. All ...

journal_title：Infection and immunity

authors： Harrison OB,Robertson BD,Faust SN,Jepson MA,Goldin RD,Levin M,Heyderman RS

更新日期：2002-09-01 00:00:00

abstract：:Peptic ulcer disease (PUD) occurs after a long-term Helicobacter pylori infection. However, the disease can develop earlier, and rare cases have been observed in children, suggesting that these H. pylori strains may be more virulent. We used suppressive subtractive hybridization for comparative genomics between H. pyl...

journal_title：Infection and immunity

authors： Oleastro M,Monteiro L,Lehours P,Mégraud F,Ménard A

更新日期：2006-07-01 00:00:00

abstract：:Cellular resistance to facultative intracellular parasites has been studied by determining the antimycobacterial activity and the amount of fatty acids in sera and in heptane extracts of freshly collected and 24-h-cultured normal and activated guinea pig alveolar macrophages and liver cells. The quantity and the antim...

journal_title：Infection and immunity

authors： Hemsworth GR,Kochan I

更新日期：1978-01-01 00:00:00

abstract：:A total of 224 strains were serogrouped by coagglutination (COA) and serotyped by protein I enzyme-linked immunosorbent assay (ELISA). Of these strains, 61 were from patients with disseminated gonococcal infection, 21 were from patients with pelvic inflammatory disease, and 115 were from patients with uncomplicated go...

journal_title：Infection and immunity

authors： Sandstrom EG,Knapp JS,Buchanan TB

更新日期：1982-01-01 00:00:00

abstract：:Yersinia pestis causes bubonic, pneumonic, and septicemic plague, diseases that are rapidly lethal to most mammals, including humans. Plague develops as a consequence of bacterial neutralization of the host's innate immune response, which permits uncontrolled growth and causes the systemic hyperactivation of the infla...

journal_title：Infection and immunity

authors： Dhariwala MO,Olson RM,Anderson DM

更新日期：2017-10-18 00:00:00

abstract：:Cryptococcus neoformans is a facultative intracellular opportunistic pathogen and the leading cause of fungal meningitis in humans. In the absence of a protective cellular immune response, the inhalation of C. neoformans cells or spores results in pulmonary infection. C. neoformans cells produce a polysaccharide capsu...

journal_title：Infection and immunity

authors： Geunes-Boyer S,Oliver TN,Janbon G,Lodge JK,Heitman J,Perfect JR,Wright JR

更新日期：2009-07-01 00:00:00

abstract：:Experimental infection of mice with a virulent strain of Mycobacterium avium leads to a slowly progressive disease, which we have previously shown culminates in loss of gamma interferon (IFN-gamma) production by T lymphocytes and death of the animals approximately 40 weeks after infection. Here we investigated the cha...

journal_title：Infection and immunity

authors： Mannering SI,Cheers C

更新日期：2002-01-01 00:00:00

abstract：:Patients with chronic mucocutaneous candidiasis (CMC) are selectively unable to clear the yeast Candida, which results in persistent debilitating infections affecting the skin, nails, and mucous membranes. The underlying defect is unknown. Recent animal studies highlighted the importance of type 1 cytokines in protect...

journal_title：Infection and immunity

authors： Lilic D,Gravenor I,Robson N,Lammas DA,Drysdale P,Calvert JE,Cant AJ,Abinun M

更新日期：2003-10-01 00:00:00

abstract：:Ehrlichia chaffeensis, an obligatory intracellular bacterium of monocytes or macrophages, is the etiologic agent of human monocytic ehrlichiosis. Our previous study showed that gamma interferon (IFN-gamma) added prior to or at early stage of infection inhibited infection of human monocytes with E. chaffeensis; however...

journal_title：Infection and immunity

authors： Lee EH,Rikihisa Y

更新日期：1998-06-01 00:00:00

abstract：:Streptococcus suis has received increasing attention for its involvement in severe human infections worldwide as well as in multidrug resistance. Two-component signaling systems (TCSSs) play important roles in bacterial adaptation to various environmental stimuli. In this study, we identified a novel TCSS located in S...

journal_title：Infection and immunity

authors： Zhong X,Zhang Y,Zhu Y,Dong W,Ma J,Pan Z,Roy S,Lu C,Yao H

更新日期：2018-06-21 00:00:00

abstract：:Clostridium perfringens enterotoxin is the major virulence factor involved in the pathogenesis of C. perfringens type A food poisoning and several non-food-borne human gastrointestinal illnesses. The enterotoxin gene, cpe, is located on the chromosome of food-poisoning isolates but is found on a large plasmid in non-f...

journal_title：Infection and immunity

authors： Brynestad S,Sarker MR,McClane BA,Granum PE,Rood JI

更新日期：2001-05-01 00:00:00

abstract：:Production of the Kanagawa hemolysin by patient strains of Vibrio parahaemolyticus was found to respond to the pH rather than to the type of carbohydrate present in the growth medium. Regardless of the carbohydrate present, hemolysin production in peptone broth cultures occurred only when the pH was between 6.5 and 5....

journal_title：Infection and immunity

authors： Cherwonogrodzky JW,Clark AG

更新日期：1981-10-01 00:00:00

abstract：:Neisseria meningitidis crosses the blood-brain barrier (BBB) following the activation of the β2-adrenergic receptor by the type IV pili (TFP). Two components of the type IV pili recruit the β2-adrenergic receptor, the major pilin PilE and the minor pilin PilV. Here, we report that a strain deleted of PilX, one of the ...

journal_title：Infection and immunity

authors： Brissac T,Mikaty G,Duménil G,Coureuil M,Nassif X

更新日期：2012-09-01 00:00:00

abstract：:A monoclonal antibody was used to characterize a 135-kDa surface-located membrane protein (Lmp1) generally present in Mycoplasma hominis strains. The monoclonal antibody, 552, was applied to identify the corresponding gene in an expression library of M. hominis PG21 DNA. The M. hominis PG21 lmp1 gene was sequenced, an...

journal_title：Infection and immunity

authors： Ladefoged SA,Birkelund S,Hauge S,Brock B,Jensen LT,Christiansen G

更新日期：1995-01-01 00:00:00

abstract：:Purified R-28 antigen from an M-protein-poor, R-antigen-rich strain of group A Streptococcus was prepared by sequential treatment of an acid extract of whole cells with ammonium sulfate fractionation and hydroxylapatite (HA) column chromatography. Purified R-28 antigen was eluted only with 0.10 M sodium phosphate, pH ...

journal_title：Infection and immunity

authors： Johnson RH

更新日期：1975-10-01 00:00:00

abstract：:The response of ferrets after intranasal inoculation of inactivated A/Hong Kong/68 (H3N2) influenza virus vaccines is reported. Normal ferrets given either saline vaccine in drops or freeze-dried vaccine in an aerosol intranasally did not produce detectable serum or nasal hemagglutination inhibiting antibody and were ...

journal_title：Infection and immunity

authors： McLaren C,Potter CW,Jennings R

更新日期：1974-06-01 00:00:00

abstract：:Exfoliatin caused skin loss in hairless mutant mice only while they lacked hair, but older mice were more resistant to this effect than neonates. ...

journal_title：Infection and immunity

authors： Kapral FA,Miller MM

更新日期：1972-11-01 00:00:00