Abstract:
:Three strains of anaerobic, dextranase-producing, gram-positive, rod-shaped bacteria were isolated from human dental plaque associated with root carious lesions. The isolates produced a molar ratio of acetate to lactate from glucose fermentation ranging from 1.1 to 1.9. Each strain also produced fructose-6-phosphate phosphoketolase. The isolates were identified as belonging to the genus Bifidobacterium, but from their carbohydrate fermentation patterns they did not appear to be strains of Bifidobacterium dentium. These microorganisms fermented high-molecular-weight dextrans. A partial characterization of the dextranase activity was included in this study and revealed an extracellular dextranase with a pH optimum of 7.1. Analysis of the dextran degradation products demonstrated the liberation of saccharides larger than 1 glucose unit. It was concluded that this enzyme used an endohydrolytic mode of dextran cleavage.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Kaster AG,Brown LRdoi
10.1128/IAI.42.2.716-720.1983subject
Has Abstractpub_date
1983-11-01 00:00:00pages
716-20issue
2eissn
0019-9567issn
1098-5522journal_volume
42pub_type
杂志文章abstract::Vibrio mimicus 61892, isolated in 1977 from a case of watery diarrhea in Bangladesh, produces an enterotoxin which possesses activity in Y-1 mouse adrenal cells and in rabbit ileal loops which is identical to the prototype cholera toxin (CT) produced by Vibrio cholerae 569B. The neutralization of the adrenal cell acti...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.42.2.501-509.1983
更新日期:1983-11-01 00:00:00
abstract::Toll-like receptor (TLR) signal transduction is a central component of the innate immune response to pathogenic challenge. Although recent studies have begun to elucidate differences in acquired immunity in tissues of the human female reproductive tract, there is a relative paucity of work regarding innate defense mec...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.10.5799-5806.2004
更新日期:2004-10-01 00:00:00
abstract::Brucella abortus injected into CBA mice replicated primarily in the spleen and liver, reaching a peak bacterial count in both organs about 7 days postinfection. The organism was eliminated from the liver but declined to a chronic phase in the spleen. The infection caused hepatosplenomegaly. An influx of macrophages in...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.4.1465-1472.1992
更新日期:1992-04-01 00:00:00
abstract::Attention has recently been focused on immunoglobulin A1 (IgA1) protease production as a possible virulence factor of bacteria implicated in meningitis and gonorrhea. This report demonstrates that suspected principal etiological agents in destructive periodontal disease include bacteria capable of degrading IgA1, IgA2...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.34.3.757-765.1981
更新日期:1981-12-01 00:00:00
abstract::The intravenous administration of hydrogen peroxide has been reported to benefit patients with pneumonia and to reduce Plasmodium parasitemia in experimentally infected mice. We assessed the antibacterial activity of intravenously infused hydrogen peroxide against hydrogen peroxide-susceptible Escherichia coli (MBC of...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.48.3.607-610.1985
更新日期:1985-06-01 00:00:00
abstract::Cigarette smoke exposure increases the risk of pulmonary and invasive infections caused by Streptococcus pneumoniae, the most commonly isolated organism from patients with community-acquired pneumonia. Despite this association, the mechanisms by which cigarette smoke exposure diminishes host defense against S. pneumon...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00963-09
更新日期:2010-03-01 00:00:00
abstract::Rabbits were immunized with the synthetic peptide EENVEHDA or (EENV)2, corresponding to a tandemly repeated sequence in the C-terminal part of the Plasmodium falciparum antigen Pf155/RESA, or with Escherichia coli-derived fusion proteins containing the corresponding repeats. For all sera, the capacity of the total imm...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.9.2815-2820.1990
更新日期:1990-09-01 00:00:00
abstract::Antibodies against mumps virus have been studied by using immunoglobulin class-specific indicators labeled with (125)I in the radioimmunoassay (RIA) procedure. The immunoglobulins in paired acute and convalescent sera were allowed to react with mumps virus in a solid-phase RIA system. Class-specific immunoglobulin ind...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.7.3.380-385.1973
更新日期:1973-03-01 00:00:00
abstract::Vibrio parahaemolyticus is a leading cause of seafood-borne gastroenteritis; however, its virulence mechanisms are not well understood. The identification of type III secreted proteins has provided candidate virulence factors whose functions are still being elucidated. Genotypic strain variability contributes a level ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01704-07
更新日期:2008-05-01 00:00:00
abstract::The genes for outer membrane protein P2 of four nontypeable Haemophilus influenzae strains were cloned and sequenced. The derived amino acid sequences were compared with the outer membrane protein P2 sequence from H. influenzae type b MinnA and the sequences of P2 from three additional nontypeable H. influenzae strain...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.6.2639-2643.1994
更新日期:1994-06-01 00:00:00
abstract::The adhesion of gram-positive bacteria to extracellular matrix (ECM) proteins is regarded as an important determinant of pathogenicity. A comparison of the adhesion of Streptococcus agalactiae strain O90R to different ECM proteins showed that the most pronounced binding could be observed for immobilized fibrinogen. To...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.70.5.2434-2440.2002
更新日期:2002-05-01 00:00:00
abstract::Endotoxemia in rats is associated with the accumulation of neutrophils (polymorphonuclear leukocytes) within the airspaces of the lung. Polymorphonuclear leukocyte influx appears to be regulated by the intrapulmonary accumulation of chemotactic activity. Since alveolar macrophages (AMS) are prevalent cells in the airs...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.3.810-816.1989
更新日期:1989-03-01 00:00:00
abstract::Immunologically competent mice and mice with defined immunological deficiencies were infected with Plasmodium yoelii. Splenomegaly, enhanced phagocytosis, and anemia were most marked in infected mice having intact thymic tissue. Whereas the spleens of infected nude mice increased minimally in size, the relative blood ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.20.3.728-731.1978
更新日期:1978-06-01 00:00:00
abstract::The fungus Cryptococcus neoformans has emerged as a major cause of meningoencephalitis worldwide. Host response to the fungus involves both innate and adaptive immunity, but fungal genes that modulate these processes are poorly understood. Previous studies demonstrated attenuated virulence of a mutant of a virulence-a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00821-12
更新日期:2013-03-01 00:00:00
abstract::Mast cell-deficient W/Wv mice and their mast cell-sufficient littermates were given infections of Trichinella spiralis. W/Wv mice were slower than their littermates to expel adult T. spiralis. Repair of the mast cell deficiency of W/Wv mice by bone marrow grafting was accompanied by accelerated expulsion of T. spirali...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.41.1.445-447.1983
更新日期:1983-07-01 00:00:00
abstract::Inbred mouse strains differ in their susceptibility to infection with the facultative intracellular bacterium Listeria monocytogenes, largely due to delayed or deficient innate immune responses. Previous antibody depletion studies suggested that neutrophils (polymorphonuclear leukocytes [PMN]) were particularly import...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00085-18
更新日期:2018-03-22 00:00:00
abstract::The enteric pathogens enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli employ a type 3 secretion system (T3SS) to manipulate the host inflammatory response during infection. Previously, it has been reported that EPEC, in a T3SS-dependent manner, induces an early proinflammatory response through a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02131-14
更新日期:2014-11-01 00:00:00
abstract::Biological properties of two strains of simian virus 40 (SV40) from brains of two patients with progressive multifocal leukoencephalopathy (PML) have been compared to those of a standard laboratory strain of SV40. Infectivity of both SV40-PML viruses was resistant to treatment with chloroform, low pH, and 50 C for 120...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.1.173-179.1974
更新日期:1974-07-01 00:00:00
abstract::Using polystyrene microspheres coated with heparin or heparan sulfate, it was shown that coated microspheres specifically bound eukaryotic cells and were endocytosed by nonprofessional phagocytic cells. Coated microspheres displayed properties of binding to eukaryotic cells that were similar to those of chlamydiae, an...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.3.1080-1085.2000
更新日期:2000-03-01 00:00:00
abstract::Enteropathogenic strains of Yersinia enterocolitica harbor a virulence plasmid (70 kilobases) which specifies, at 37 degrees C, a calcium requirement for growth, autoagglutinability, resistance to the bactericidal activity of human serum, and the expression of some outer membrane proteins (OMPs). To map the genes enco...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.48.3.782-786.1985
更新日期:1985-06-01 00:00:00
abstract::Escherichia coli heat-stable enterotoxin (ST) binds to receptors on rat intestinal cells and brush border membranes (BBM). We devised experiments to examine the reversibility of ST binding. We found that both 125I-labeled ST and native ST were spontaneously dissociable from the BBM receptor. Radiolabeled ST bound to B...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.2.329-334.1987
更新日期:1987-02-01 00:00:00
abstract::Increased incidence of bovine tuberculosis (TB) in the United Kingdom caused by infection with Mycobacterium bovis is a cause of considerable economic loss to farmers and the government. The Eurasian badger (Meles meles) represents a wildlife source of recurrent M. bovis infections of cattle in the United Kingdom, and...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00052-08
更新日期:2008-08-01 00:00:00
abstract::Neutrophil collagenase (matrix metalloproteinase 8 [MMP-8]) is an important mediator of tissue destruction in inflammatory diseases. Studies of anaerobic periodontal infections have shown that active MMP-8 in gingival crevicular fluid is associated with the degradation of periodontal tissues in progressive periodontit...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.5.2319-2326.1999
更新日期:1999-05-01 00:00:00
abstract::Severe combined immunodeficient (SCID)-beige mice inoculated with the intracellular parasite Eimeria papillata produced significantly more oocysts during primary infections than inoculated immunodeficient SCID mice. Therefore, the addition of the beige mutation, which detrimentally affects neutrophil and natural kille...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.8.3165-3170.1997
更新日期:1997-08-01 00:00:00
abstract::This study was designed to evaluate the immunogenicity and the protective efficacy of a divalent fusion DNA vaccine encoding both the Brucella abortus L7/L12 protein (ribosomal protein) and Omp16 protein (outer membrane lipoprotein), designated pcDNA3.1-L7/L12-Omp16. Intramuscular injection of this divalent DNA vaccin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.5.2734-2741.2006
更新日期:2006-05-01 00:00:00
abstract::Infection with Cryptosporidium parvum, a ubiquitous protozoan parasite of virtually all mammals, can cause mild to severe diarrhea in immunocompetent hosts and life-threatening diarrhea in immunocompromised hosts. Passive immunotherapy of experimentally infected animals and naturally infected humans with hyperimmune b...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.58.9.2962-2965.1990
更新日期:1990-09-01 00:00:00
abstract::Genome sequencing of the relapsing fever spirochetes Borrelia hermsii and Borrelia turicatae identified three open reading frames (ORFs) on the chromosomes that contained internal, tandemly repeated amino acid sequences that were absent in the Lyme disease spirochete Borrelia burgdorferi. The predicted amino acid sequ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.5.3025-3037.2005
更新日期:2005-05-01 00:00:00
abstract::Considerable evidence supports the concept that CD4(+) T cells are important in sarcoidosis pathogenesis, but the antigens responsible for the observed Th1 immunophenotype remain elusive. The epidemiologic association with bioaerosols and the presence of granulomatous inflammation support consideration of mycobacteria...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00142-09
更新日期:2009-09-01 00:00:00
abstract::Cytomegalovirus (CMV) infections are common in renal transplant recipients. We studied 23 recipients prospectively to determine whether infections by other herpes-group and non-herpes-group viruses were also present. Sera, obtained at the time of surgery and periodically thereafter, were tested for antibody to CMV, he...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.14.4.970-975.1976
更新日期:1976-10-01 00:00:00
abstract::Pathogenic leptospires have the ability to survive and disseminate to multiple organs after penetrating the host. Several pathogens, including spirochetes, have been shown to express surface proteins that interact with the extracellular matrix (ECM). This adhesin-mediated binding process seems to be a crucial step in ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00460-06
更新日期:2006-11-01 00:00:00