Biochemical and immunological characterization of deoxythymidine kinase of thymidine kinaseless HeLa cells biochemically transformed by herpes simplex virus type.

abstract：:Recombinant major surface antigen (P30), which was produced as a glutathione S-transferase (EC 2.5.1.18) fusion protein of Toxoplasma gondii, was found to be able to activate macrophages to kill T. gondii in vitro. The macrophage activation was due to P30 in the fusion protein, not to glutathione S-transferase. ...

journal_title：Infection and immunity

authors： Makioka A,Kobayashi A

更新日期：1991-08-01 00:00:00

abstract：:Efficient utilization of heme as an iron (Fe) source by Bordetella avium requires bhuR, an Fe-regulated gene which encodes an outer membrane heme receptor. Upstream of bhuR is a 507-bp open reading frame, hereby designated rhuI (for regulator of heme uptake), which codes for a 19-kDa polypeptide. Whereas the 19-kDa po...

journal_title：Infection and immunity

authors： Kirby AE,Metzger DJ,Murphy ER,Connell TD

更新日期：2001-11-01 00:00:00

abstract：:The ability of intracellular pathogens to sense and adapt to the hostile environment of the host is an important factor governing virulence. We have sequenced the operon encoding the major heat shock proteins GroES and GroEL in the gram-positive food-borne pathogen Listeria monocytogenes. The operon has a conserved or...

journal_title：Infection and immunity

authors： Gahan CG,O'Mahony J,Hill C

更新日期：2001-06-01 00:00:00

abstract：:The immune response to the mycobacterial 65-kDa heat shock protein (hsp65) is considered an important event in the induction of adjuvant arthritis (AA) in rats; this induction probably occurs through a molecular mimicry mechanism involving cross-reactivity against the rat homolog hsp60. To analyze the role of mammalia...

journal_title：Infection and immunity

authors： López-Guerrero JA,López-Bote JP,Ortiz MA,Gupta RS,Páez E,Bernabeu C

更新日期：1993-10-01 00:00:00

abstract：:The purpose of this study was to localize antigenic regions on the flagellin protein of Campylobacter jejuni 81116. This strain has two flagellin genes, flaA and flaB, which are 95% identical; only flaA seems to be expressed in motile C. jejuni 81116 cells. Fragments of flaA and flaB were cloned in the bacterial expre...

journal_title：Infection and immunity

authors： Nuijten PJ,van der Zeijst BA,Newell DG

更新日期：1991-03-01 00:00:00

abstract：:Tuberculosis is one of the most important infectious diseases worldwide. The susceptibility to this disease depends to a great extent on the innate immune response against mycobacteria. Host defense peptides (HDP) are one of the first barriers to counteract infection. Cathelicidin (LL-37) is an HDP that has many immun...

journal_title：Infection and immunity

authors： Torres-Juarez F,Cardenas-Vargas A,Montoya-Rosales A,González-Curiel I,Garcia-Hernandez MH,Enciso-Moreno JA,Hancock RE,Rivas-Santiago B

更新日期：2015-12-01 00:00:00

abstract：:Streptococcus pneumoniae contains an inhibitor of human neutrophil elastase. The agent does not inhibit other proteases, including neutrophil cathepsin G and pancreatic elastase. It is active in the presence of insoluble elastin as well as synthetic elastase substrates. The inhibitor is present in the pneumococcal cel...

journal_title：Infection and immunity

authors： Vered M,Simon SR,Janoff A

更新日期：1985-07-01 00:00:00

abstract：:Infection by Shigella flexneri is characterized by infiltration of neutrophils in the intestinal mucosa and by a strong inflammatory reaction. Although neutrophils are constitutively programmed to die by apoptosis, we show that isolated human neutrophils undergo necrosis 2 h after infection with virulent S. flexneri s...

journal_title：Infection and immunity

authors： François M,Le Cabec V,Dupont MA,Sansonetti PJ,Maridonneau-Parini I

更新日期：2000-03-01 00:00:00

abstract：:The cell surface hydrophobicity of 10 pigmented and 4 nonpigmented clinical Serratia marcescens strains was studied, based on the ability of the strains to adhere to hydrocarbons and to polystyrene. The cell surface hydrophobicity depended greatly on growth temperature; all of the strains tested were adherent followin...

journal_title：Infection and immunity

authors： Rosenberg M,Blumberger Y,Judes H,Bar-Ness R,Rubinstein E,Mazor Y

更新日期：1986-03-01 00:00:00

abstract：:Interleukin-18 (IL-18) is a proinflammatory cytokine that plays an important role in natural killer cell activation and the T helper 1 (Th1) cell response, particularly in collaboration with IL-12. Since Th1 cells play a pivotal role in the host defense against infection with intracellular microbes, such as Leishmania...

journal_title：Infection and immunity

authors： Ohkusu K,Yoshimoto T,Takeda K,Ogura T,Kashiwamura S,Iwakura Y,Akira S,Okamura H,Nakanishi K

更新日期：2000-05-01 00:00:00

abstract：:Infection with Histoplasma capsulatum results in a subclinical infection in immunocompetent hosts due to an effective cellular immune response. By contrast, immunodeficient individuals can have a severe disseminated and potentially fatal disease. In a previous study, it was demonstrated that normal mice infected intra...

journal_title：Infection and immunity

authors： Zhou P,Sieve MC,Tewari RP,Seder RA

更新日期：1997-03-01 00:00:00

abstract：:Recombinant adenylate cyclase toxoids are shown to deliver inserted foreign CD4(+)-T-cell epitopes into the major histocompatibility complex class II presentation pathway, inducing a specific CD4(+)-T-cell response in vivo and yielding in vitro stimulation of specific CD4(+) T cells at a 100-times-higher molar efficie...

journal_title：Infection and immunity

authors： Loucká J,Schlecht G,Vodolánová J,Leclerc C,Sebo P

更新日期：2002-02-01 00:00:00

abstract：:The response to reinfection with Ethiopian Leishmania donovani was evaluated in genetically determined noncure (H-2d) B10.D2 mice that are able to resolve infection due to sublethal irradiation pretreatment after inoculation with a low parasite dose and in C57BL/10 mice that demonstrate the genetically determined cure...

journal_title：Infection and immunity

authors： Ulczak OM,Ghadirian E,Skamene E,Blackwell JM,Kongshavn PA

更新日期：1989-09-01 00:00:00

abstract：:The mechanism(s) of interaction between Mycoplasma pulmonis and eucaryotic cells was studied by adherence to and hemagglutination of erythrocytes. Simple and complex carbohydrates and glycoproteins were unable to inhibit either adherence or hemagglutination, indicating that neither was a lectin activity. Both interact...

journal_title：Infection and immunity

authors： Minion FC,Cassell GH,Pnini S,Kahane I

更新日期：1984-05-01 00:00:00

abstract：:Hamster trachea organ cultres were shown to consume measurable amounts of oxygen when incubated in a closed micro-chamber. Several simple and complex media were evaluated, and the optimal system involved incubating 2 to 4 mg of tracheal tissue in Tyrodes balanced salt solution at 37 C for 60 min, with oxygen activity ...

journal_title：Infection and immunity

authors： Gabridge MG

更新日期：1975-09-01 00:00:00

abstract：:Oral or intravenous inoculation of previously unexposed juvenile and adult ferrets with Campylobacter jejuni uniformly resulted in intestinal colonization lasting 2 to 12 days. Disease varied from mild to moderate diarrhea, which resolved in 2 to 3 days. Orally infected animals developed agglutinin titers of 8 to 256 ...

journal_title：Infection and immunity

authors： Bell JA,Manning DD

更新日期：1990-06-01 00:00:00

abstract：:Pyolysin (PLO), a cholesterol-dependent cytolysin expressed by Arcanobacterium pyogenes, is an important host-protective antigen. However, this molecule is toxic and requires inactivation prior to its use as a vaccine. Three genetically toxoided, nonhemolytic PLO molecules, HIS-PLO.F(497), HIS-PLO.Delta P(499), and HI...

journal_title：Infection and immunity

authors： Jost BH,Trinh HT,Songer JG,Billington SJ

更新日期：2003-05-01 00:00:00

abstract：:When type I Candida stellatoidea is plated onto sucrose agar at levels in excess of 10(8) cells, some isolates spontaneously form sucrose-positive colonies. These isolates do not display typical type I phenotypes but instead exhibit phenotypes intermediate between type I C. stellatoidea and C. albicans. Also, this phe...

journal_title：Infection and immunity

authors： Wickes BL,Golin JE,Kwon-Chung KJ

更新日期：1991-05-01 00:00:00

abstract：:(DBA/N[female] X CBA/2[male])F1 males have been reported to be deficient in producing antibodies against a number of antigens, including carbohydrates (I. Scher, Adv. Immunol. 35:1-71, 1982). We show that F1 male mice, in contrast to females, made less lipopolysaccharide (LPS)-specific antibodies after immunization wi...

journal_title：Infection and immunity

authors： Zweerink HJ,Gammon MC,Hutchison CF,Jackson JJ,Pier GB,Puckett JM,Sewell TJ,Sigal NH

更新日期：1988-05-01 00:00:00

abstract：:As part of a study of virulence gene regulation in Streptococcus pneumoniae, we have identified a gene encoding a homologue of the staphylococcal catabolite control protein CcpA in the pneumococcal genome sequence. The pneumococcal protein, designated RegM, has significant similarity to members of the LacI/GalR family...

journal_title：Infection and immunity

authors： Giammarinaro P,Paton JC

更新日期：2002-10-01 00:00:00

abstract：:Vesicular stomatitis virus (VSV) infection of beige (bg/bg) mice induced levels of natural killer cytolytic activity comparable to that of uninfected normal bg/+ controls, but considerably less than natural killer activity in VSV-infected bg/+ mice. In contrast, VSV-infected bg/bg and bg/+ mice had essentially equival...

journal_title：Infection and immunity

authors： McKinnon KP,Hale AH,Ruebush MJ

更新日期：1981-04-01 00:00:00

abstract：:Carbon storage regulator A (CsrA) is an RNA binding protein that has been characterized in many bacterial species to play a central regulatory role by modulating several metabolic processes. We recently showed that a homolog of CsrA in Borrelia burgdorferi (CsrA(Bb), BB0184) was upregulated in response to propagation ...

journal_title：Infection and immunity

authors： Karna SL,Sanjuan E,Esteve-Gassent MD,Miller CL,Maruskova M,Seshu J

更新日期：2011-02-01 00:00:00

abstract：:The fliA gene of Legionella pneumophila encoding the alternative sigma(28) factor was inactivated by introducing a kanamycin resistance cassette. Electron microscopy and Western blot analysis revealed that the fliA mutant strain is aflagellate and expresses no flagellin. Reporter gene assays indicated that the flaA pr...

journal_title：Infection and immunity

authors： Heuner K,Dietrich C,Skriwan C,Steinert M,Hacker J

更新日期：2002-03-01 00:00:00

abstract：:The mannose-resistant, Proteus-like (MR/P) fimbria, responsible for mannose-resistant hemagglutination, is a virulence factor for uropathogenic Proteus mirabilis. Based on known fimbrial gene organization, we postulated that MrpG, a putative minor subunit of the MR/P fimbria, functions as an adhesin responsible for he...

journal_title：Infection and immunity

authors： Li X,Zhao H,Geymonat L,Bahrani F,Johnson DE,Mobley HL

更新日期：1997-04-01 00:00:00

abstract：:Escherichia coli O157:H7 causes food and waterborne enteric infections that can result in hemorrhagic colitis and life-threatening hemolytic uremic syndrome. Intimate adherence of the bacteria to intestinal epithelial cells is mediated by intimin, but E. coli O157:H7 also possess several other putative adhesins, inclu...

journal_title：Infection and immunity

authors： Lloyd SJ,Ritchie JM,Rojas-Lopez M,Blumentritt CA,Popov VL,Greenwich JL,Waldor MK,Torres AG

更新日期：2012-03-01 00:00:00

abstract：:The localization and population levels of the indigenous bacterial flora of conventional rats were investigated by cultural and histological techniques. Lactobacilli predominate in the stomach and upper part of the small intestine and associate with keratinized cells of the nonglandular portion of stomach. Mixtures of...

journal_title：Infection and immunity

authors： Morotomi M,Watanabe T,Suegara N,Kawai Y,Mutai M

更新日期：1975-05-01 00:00:00

abstract：:Candida albicans is a major opportunistic pathogen in immunocompromised patients. Production of proinflammatory cytokines by host cells in response to C. albicans plays a critical role in the activation of immune cells and final clearance of the organism. Invasion of host cells and tissues is considered one of the vir...

journal_title：Infection and immunity

authors： Villar CC,Kashleva H,Mitchell AP,Dongari-Bagtzoglou A

更新日期：2005-08-01 00:00:00

abstract：:Several Shigella flexneri mutants with defects in aromatic amino acid and/or purine biosynthesis have been evaluated as vaccines in humans or in animal models. To be suitable as a vaccine, a mutant has to show virulence attenuation, minimal reactogenicity, and a good immunogenic potential in animal models. With this a...

journal_title：Infection and immunity

authors： Cersini A,Martino MC,Martini I,Rossi G,Bernardini ML

更新日期：2003-12-01 00:00:00

abstract：:A parasitic protozoan, Leishmania mexicana amazonensis, was previously made resistant to tunicamycin (J.A. Kink and K.-P. Chang, Proc. Natl. Acad. Sci. USA 84:1253-1257, 1987). In the present study, six different tunicamycin-resistant variants were biologically and biochemically compared with their parental wild type ...

journal_title：Infection and immunity

authors： Kink JA,Chang KP

更新日期：1987-07-01 00:00:00

abstract：:The Alexander hepatoma cell line, PLC/PRF/5, was studied for evidence of hepatitis B virus markers and alpha-fetoprotein. Only hepatitis B surface antigen and alpha-fetoprotein were detected. Induction experiments with 5-iodo-2'-deoxyuridine and inoculation of chimpanzees with whole cells or tissue culture fluid did n...

journal_title：Infection and immunity

authors： Daemer RJ,Feinstone SM,Alexander JJ,Tully JG,London WT,Wong DC,Purcell RH

更新日期：1980-11-01 00:00:00