Chromosomal rearrangement in Candida stellatoidea results in a positive effect on phenotype.

Abstract:

:When type I Candida stellatoidea is plated onto sucrose agar at levels in excess of 10(8) cells, some isolates spontaneously form sucrose-positive colonies. These isolates do not display typical type I phenotypes but instead exhibit phenotypes intermediate between type I C. stellatoidea and C. albicans. Also, this phenotypic change only occurs in conjunction with a chromosomal rearrangement. These rearrangements have been studied in a strain naturally marked for methionine auxotrophy. Chromosome-size DNA bands separated by pulsed-field gel electrophoresis were probed with genes cloned from C. albicans. The hybridization pattern indicated that the genes on several chromosomes underwent extensive rearrangement.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Wickes BL,Golin JE,Kwon-Chung KJ

doi

10.1128/IAI.59.5.1762-1771.1991

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

1762-71

issue

5

eissn

0019-9567

issn

1098-5522

journal_volume

59

pub_type

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