Trypanosoma rhodesiense infection in congenitally athymic (nude) mice.

abstract：:Interferon regulatory factor 1-deficient (IRF-1(-/-)) mice infected with virulent Brucella abortus 2308 at 5 x 10(5) CFU developed acute hepatitis similar to many natural hosts but, unlike natural hosts, IRF-1(-/-) mice were unable to resolve infection and died. In contrast, IRF-1(-/-) mice survived when infected at 5...

journal_title：Infection and immunity

authors： Ko J,Gendron-Fitzpatrick A,Ficht TA,Splitter GA

更新日期：2002-12-01 00:00:00

abstract：:Syphilis has been recognized as a disease since the late 1400s, yet there is no practical vaccine available. One impediment to the development of a vaccine is the lack of understanding of multiple reinfections in humans despite the development of robust immune responses during the first episode. It has been shown that...

journal_title：Infection and immunity

authors： Morgan CA,Lukehart SA,Van Voorhis WC

更新日期：2003-10-01 00:00:00

abstract：:Western blot (immunoblot) analysis of sera from cattle vaccinated with Brucella abortus S19 exhibit an elevated serologic response to Hsp62, the GroEL homolog (BaGroEL). Serologic screening of individual cows vaccinated with B. abortus S19 revealed no correlation between the immune response to BaGroEL and protection a...

journal_title：Infection and immunity

authors： Lin J,Adams LG,Ficht TA

更新日期：1996-10-01 00:00:00

abstract：:Although there appears to be little if any role for specific antibodies in protection against intracellular bacteria, such as the model pathogen F. tularensis live vaccine strain (LVS), the role of B cells themselves in primary and secondary infection with such bacteria has not been examined directly. We show here tha...

journal_title：Infection and immunity

authors： Elkins KL,Bosio CM,Rhinehart-Jones TR

更新日期：1999-11-01 00:00:00

abstract：:We investigated the effect of the extracellular protease of Serratia marcescens on human serum constituents such as immunoglobulins, fibronectin, alpha 1-protease inhibitor, alpha 2-macroglobulin, lysozyme, and transferrin. At a very low concentration of Serratia 56-kilodalton protease (56K protease), purified human p...

journal_title：Infection and immunity

authors： Molla A,Matsumoto K,Oyamada I,Katsuki T,Maeda H

更新日期：1986-09-01 00:00:00

abstract：:Human polymorphonuclear leukocytes from normal subjects produced proinflammatory cytokines in response to stimulation with Cryptococcus neoformans yeast cells. The cytokines released after stimulation of neutrophils included interleukin-1beta (IL-1beta), IL-6, IL-8 and tumor necrosis factor alpha. The magnitude of the...

journal_title：Infection and immunity

authors： Retini C,Vecchiarelli A,Monari C,Tascini C,Bistoni F,Kozel TR

更新日期：1996-08-01 00:00:00

abstract：:Pyolysin (PLO), the hemolytic exotoxin expressed by Arcanobacterium (Actinomyces) pyogenes, is a member of the thiol-activated cytolysin family of bacterial toxins. Insertional inactivation of the plo gene results in loss of expression of PLO with a concomitant loss in hemolytic activity. The plo mutant, PLO-1, has an...

journal_title：Infection and immunity

authors： Jost BH,Songer JG,Billington SJ

更新日期：1999-04-01 00:00:00

abstract：:One of the chromosomal segments associated with the virulence of Shigella flexneri and transferred to Escherichia coli K-12 by conjugation has been shown to code for the production of aerobactin and for the synthesis of an iron-regulated 76,000-dalton (76K) outer membrane protein. Analysis of various E. coli K-12-S. f...

journal_title：Infection and immunity

authors： Griffiths E,Stevenson P,Hale TL,Formal SB

更新日期：1985-07-01 00:00:00

abstract：:The obligate intracellular parasite Toxoplasma gondii can actively infect any nucleated cell type, including cells from the immune system. The rapid transfer of T. gondii from infected dendritic cells to effector natural killer (NK) cells may contribute to the parasite's sequestration and shielding from immune recogni...

journal_title：Infection and immunity

authors： Sultana MA,Du A,Carow B,Angbjär CM,Weidner JM,Kanatani S,Fuks JM,Muliaditan T,James J,Mansfield IO,Campbell TM,Liu L,Kadri N,Lambert H,Barragan A,Chambers BJ

更新日期：2017-09-20 00:00:00

abstract：:The screening of several inbred strains of mice suggested that the capacity of their spleen cells to respond to the mitogenic effect of lipopolysaccharide (LPS) of gram-negative bacteria was correlated with their resistance to intraperitoneal infection with Salmonella typhimurium. An infection of LPS into mice caused ...

journal_title：Infection and immunity

authors： von Jeney N,Günther E,Jann K

更新日期：1977-01-01 00:00:00

abstract：:A mouse lacking CD28, a T-cell costimulatory molecule, and STAT6, a transcription factor that mediates interleukin-4 (IL-4) signaling, was developed from parental CD28- and STAT6-deficient mice. STAT6/CD28(-/-) BALB/c mice that were 8 weeks old had a normal phenotype, and IL-4 production was induced following infectio...

journal_title：Infection and immunity

authors： Liu Q,Arseculeratne C,Liu Z,Whitmire J,Grusby MJ,Finkelman FD,Darling TN,Cheever AW,Swearengen J,Urban JF,Gause WC

更新日期：2004-07-01 00:00:00

abstract：:The Fcγ receptor IIIb (FcγRIIIb) is a low-affinity receptor of IgG and is essential in neutrophil-mediated effector functions. Different allelic forms of FcγRIIIb carrying human neutrophil antigen (HNA-1a, -1b, -1c, and -1d) have been identified. Here, we have generated stable transfected HEK293 cell lines expressing ...

journal_title：Infection and immunity

authors： Simtong P,Romphruk AV,Traum A,Burg-Roderfeld M,Bein G,Jakubowski K,Dominik A,Theisen M,Kana IH,Sachs UJ,Santoso S

更新日期：2018-07-23 00:00:00

abstract：:Subpopulations of spleen cells from scrapie virus-infected mice were used to determine the average virus content of infected cells in vivo at a time when virus was rapidly increasing in titer in lymphoreticular tissues. Comparison of the mean lethal doses of lysed to intact cells indicated averages of 2 to 6 infectiou...

journal_title：Infection and immunity

authors： Lavelle GC

更新日期：1973-06-01 00:00:00

abstract：:Chronic granulomatous disease (CGD) is a genetic disorder of NADPH oxidase in which phagocytes are defective in generating reactive oxidants. CGD patients suffer from recurrent infections and exuberant and persistent tissue granuloma formation. We hypothesized that abnormal granulomata in CGD may result from aberrant ...

journal_title：Infection and immunity

authors： Segal BH,Doherty TM,Wynn TA,Cheever AW,Sher A,Holland SM

更新日期：1999-04-01 00:00:00

abstract：:Ehrlichia chaffeensis is a recently isolated minute gram-negative obligatory intracellular bacterium of monocytes/macrophages and is the etiologic agent of human monocytic ehrlichiosis. It is not known how macrophages respond when they encounter ehrlichiae in terms of cytokine production. In this study, we examined cy...

journal_title：Infection and immunity

authors： Lee EH,Rikihisa Y

更新日期：1996-10-01 00:00:00

abstract：:We have previously identified mgrA (rat) as a regulator of autolysis in Staphylococcus aureus. Besides its effect on autolytic activity, we recently found alterations in the expression of regulator and target virulence genes in the mgrA mutant. Northern analysis and transcription fusion assays showed that inactivation...

journal_title：Infection and immunity

authors： Ingavale S,van Wamel W,Luong TT,Lee CY,Cheung AL

更新日期：2005-03-01 00:00:00

abstract：:Two glucosyltransferase genes from Streptococcus mutans GS-5, gtfB and gtfC, have been previously isolated and sequenced in this laboratory. In the present communication a third gtf gene, gtfD, was isolated and characterized. Isolation of the gene involved a novel procedure utilizing the integration plasmid pVA891. A ...

journal_title：Infection and immunity

authors： Hanada N,Kuramitsu HK

更新日期：1989-07-01 00:00:00

abstract：:Cigarette smoke exposure increases the risk of pulmonary and invasive infections caused by Streptococcus pneumoniae, the most commonly isolated organism from patients with community-acquired pneumonia. Despite this association, the mechanisms by which cigarette smoke exposure diminishes host defense against S. pneumon...

journal_title：Infection and immunity

authors： Phipps JC,Aronoff DM,Curtis JL,Goel D,O'Brien E,Mancuso P

更新日期：2010-03-01 00:00:00

abstract：:Bovine septicemic Escherichia coli 31A agglutinates bovine, rabbit, and human erythrocytes and adheres in vitro to the brush border of bovine or ovine intestinal epithelial cells and to the human colon carcinoma Caco-2 cell line. The adhesion and hemagglutination of E. coli 31A are mediated by a chromosome-encoded fim...

journal_title：Infection and immunity

authors： Bertin Y,Girardeau JP,Darfeuille-Michaud A,Contrepois M

更新日期：1996-01-01 00:00:00

abstract：:Unmethylated CpG dinucleotide motifs present in bacterial genomes or synthetic oligodeoxynucleotides (ODNs) serve as strong immunostimulatory agents in mice, monkeys and humans. We determined the adjuvant effect of murine CpG ODN 1826 on the immunogenicity and protective efficacy of the Saccharomyces cerevisiae-expres...

journal_title：Infection and immunity

authors： Kumar S,Jones TR,Oakley MS,Zheng H,Kuppusamy SP,Taye A,Krieg AM,Stowers AW,Kaslow DC,Hoffman SL

更新日期：2004-02-01 00:00:00

abstract：:Infection with Cryptosporidium parvum, a ubiquitous protozoan parasite of virtually all mammals, can cause mild to severe diarrhea in immunocompetent hosts and life-threatening diarrhea in immunocompromised hosts. Passive immunotherapy of experimentally infected animals and naturally infected humans with hyperimmune b...

journal_title：Infection and immunity

authors： Fayer R,Guidry A,Blagburn BL

更新日期：1990-09-01 00:00:00

abstract：:Malaria toxin causes hypoglycemia and induction of tumor necrosis factor. Extracts of parasitized erythrocytes which were coeluted and copurified with one of the two subtypes of mammalian insulin-mimetic inositolphosphoglycans similarly induced fibroblast proliferation in the absence of serum. In addition, induction o...

journal_title：Infection and immunity

authors： Caro HN,Sheikh NA,Taverne J,Playfair JH,Rademacher TW

更新日期：1996-08-01 00:00:00

abstract：:Enteropathogenic strains of Yersinia enterocolitica harbor a virulence plasmid (70 kilobases) which specifies, at 37 degrees C, a calcium requirement for growth, autoagglutinability, resistance to the bactericidal activity of human serum, and the expression of some outer membrane proteins (OMPs). To map the genes enco...

journal_title：Infection and immunity

authors： Balligand G,Laroche Y,Cornelis G

更新日期：1985-06-01 00:00:00

abstract：:Active immunization of mice with high doses of heat-killed and autoclaved vaccine of unencapsulated strains of Staphylococcus aureus, which was grown in brain heart infusion media, protected against challenge with the Smith diffuse strain of Staphylococcus aureus. These organisms were capable of absorbing the protecti...

journal_title：Infection and immunity

authors： Yoshida K,Ichiman Y,Otomo T

更新日期：1975-11-01 00:00:00

abstract：:Antigen preparations derived from Plasmodium falciparum-infected erythrocytes (but not from uninfected erythrocytes) can stimulate the in vitro proliferation of peripheral blood lymphocytes from malaria-sensitized as well as nonsensitized donors. The possibility that the nonspecific responses might be due to a parasit...

journal_title：Infection and immunity

authors： Wyler DJ,Herrod HG,Weinbaum FI

更新日期：1979-04-01 00:00:00

abstract：:A clone bank of Pasteurella haemolytica A1 was constructed by partial digestion of the genomic DNA with Sau3A and ligation of 5- to 10-kilobase-pair fragments into the BamHI site of the plasmid vector pBR322. After transformation into Escherichia coli K-12, a total of 4 X 10(3) recombinant clones was obtained. These w...

journal_title：Infection and immunity

authors： Lo RY,Shewen PE,Strathdee CA,Greer CN

更新日期：1985-12-01 00:00:00

abstract：:Human monocytes displayed increased expression of CD40 following infection with virulent Mycobacterium tuberculosis. Nevertheless, soluble CD40 ligand (CD40L; also designated CD154) had no effect on the intracellular growth of the organism. Restriction of the intracellular growth of M. tuberculosis by peripheral blood...

journal_title：Infection and immunity

authors： Larkin R,Benjamin CD,Hsu YM,Li Q,Zukowski L,Silver RF

更新日期：2002-08-01 00:00:00

abstract：:Alveolar macrophages are the effector cells largely responsible for clearance of Pneumocystis carinii from the lungs. Binding of organisms to beta-glucan and mannose receptors has been shown to stimulate phagocytosis of the organisms. To further define the mechanisms used by alveolar macrophages for clearance of P. ca...

journal_title：Infection and immunity

authors： Hollifield M,Bou Ghanem E,de Villiers WJ,Garvy BA

更新日期：2007-08-01 00:00:00

abstract：:We report the cloning and expression of Ac-GST-1, a novel glutathione S-transferase from the adult hookworm Ancylostoma caninum, and its possible role in parasite blood feeding and as a vaccine target. The predicted Ac-GST-1 open reading frame contains 207 amino acids (mass, 24 kDa) and exhibited up to 65% amino acid ...

journal_title：Infection and immunity

authors： Zhan B,Liu S,Perally S,Xue J,Fujiwara R,Brophy P,Xiao S,Liu Y,Feng J,Williamson A,Wang Y,Bueno LL,Mendez S,Goud G,Bethony JM,Hawdon JM,Loukas A,Jones K,Hotez PJ

更新日期：2005-10-01 00:00:00

abstract：:In the present study, the role of virulence factors in and the effect of opsonization on the interactions between Bordetella pertussis and human monocytes were investigated. The methods used facilitated the distinction between attachment and ingestion of bacteria by monocytes. Nonopsonized virulent B. pertussis cells ...

journal_title：Infection and immunity

authors： Hazenbos WL,van den Berg BM,van't Wout JW,Mooi FR,van Furth R

更新日期：1994-11-01 00:00:00