Induction of resistance with heat-killed compact-type strains of Staphylococcus aureus against challenge with the diffuse variant of the Smith strain of Staphylococcus aureus.

abstract：:Buruli ulcer, caused by Mycobacterium ulcerans, is characterized by deep and necrotizing skin lesions, mostly on the arms and legs. Together with tuberculosis and leprosy, this mycobacterial disease has become a major health problem in tropical and subtropical regions, particularly in central and western Africa. No sp...

journal_title：Infection and immunity

authors： Tanghe A,Content J,Van Vooren JP,Portaels F,Huygen K

更新日期：2001-09-01 00:00:00

abstract：:Chlamydia trachomatis infections can lead to severe chronic complications, including trachoma, ectopic pregnancy, and infertility. The only effective approach to disease control is vaccination. The goal of this work was to identify new potential vaccine candidates through a proteomics approach. We constructed a protei...

journal_title：Infection and immunity

authors： Cruz-Fisher MI,Cheng C,Sun G,Pal S,Teng A,Molina DM,Kayala MA,Vigil A,Baldi P,Felgner PL,Liang X,de la Maza LM

更新日期：2011-01-01 00:00:00

abstract：:The biological response to endotoxin mediated through the Toll-like receptor 4 (TLR4)-MD-2 receptor complex is directly related to lipid A structure or configuration. Endotoxin structure may also influence activation of the MyD88-dependent and -independent signaling pathways of TLR4. To address this possibility, human...

journal_title：Infection and immunity

authors： Zughaier SM,Zimmer SM,Datta A,Carlson RW,Stephens DS

更新日期：2005-05-01 00:00:00

abstract：:Schistosoma mansoni-infected wild-type (WT) mice develop a Th2 response and chronic disease. In contrast, infected interleukin-4 double-deficient (IL-4(-/-)) mice develop a Th1-like response and an acute, lethal syndrome. Disease severity in these animals correlates with excessive and prolonged production of nitric ox...

journal_title：Infection and immunity

authors： Patton EA,La Flamme AC,Pedras-Vasoncelos JA,Pearce EJ

更新日期：2002-01-01 00:00:00

abstract：:Neisseria gonorrhoeae is an obligate human pathogen that causes the common sexually transmitted infection gonorrhea. Gonococcal infections cause significant morbidity, particularly among women, as the organism ascends to the upper reproductive tract, resulting in pelvic inflammatory disease, ectopic pregnancy, and inf...

journal_title：Infection and immunity

authors： Hollander A,Mercante AD,Shafer WM,Cornelissen CN

更新日期：2011-12-01 00:00:00

abstract：:Toxic protein(s) neutralized with anti-C2 toxic serum was extracted from Clostridium botulinum type C spores treated with an alkaline mercaptoethanol solution. C2 toxicity in the spores was located in the spore coat fraction and was more heat stable than that found in culture fluid. ...

journal_title：Infection and immunity

authors： Yamakawa K,Nishida S,Nakamura S

更新日期：1983-08-01 00:00:00

abstract：:Little is known about the underlying mechanisms that result in a sexually dimorphic response to Vibrio vulnificus endotoxic shock. V. vulnificus is a gram-negative bacterium, considered one of the most invasive and rapidly fatal human pathogens known. However, 85% of individuals that develop endotoxic shock from V. vu...

journal_title：Infection and immunity

authors： Merkel SM,Alexander S,Zufall E,Oliver JD,Huet-Hudson YM

更新日期：2001-10-01 00:00:00

abstract：:The cytotoxic effects of bacterial lipopolysaccharides (LPS) on mouse leukocytes have been examined in vivo and in vitro. Intraperitoneal injection of LPS into C57BL/6 mice greatly reduced the recovery of mononuclear cells; LPS was cytotoxic for macrophages, but had a mitogenic effect on lymphocytes. Similar effects o...

journal_title：Infection and immunity

authors： Peavy DL,Baughn RE,Musher DM

更新日期：1978-07-01 00:00:00

abstract：:Human sera were examined by an enzyme-linked immunosorbent assay for immunoglobulin G (IgG) and IgM antibodies to purified type III polysaccharide of group B streptococci. The antigen-binding capacity of a reference human serum was determined by a radioimmunoassay, and the total antibody content was determined by quan...

journal_title：Infection and immunity

authors： Anthony BF,Concepcion NF,Wass CA,Heiner DC

更新日期：1984-10-01 00:00:00

abstract：:When Streptococcus pyogenes group A type 3 strain C203 (M+) and its M-protein-lacking derivative, strain C203S (M-), were treated with normal human serum in the presence of magnesium-EGTA [ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid], virulent M+ bacteria bound only 10 to 30% as much C3 and f...

journal_title：Infection and immunity

authors： Hong K,Kinoshita T,Takeda J,Kozono H,Pramoonjago P,Kim YU,Inoue K

更新日期：1990-08-01 00:00:00

abstract：:Toll-like receptors 2 and 4 (TLR2 and TLR4) have been found to transduce signals of peptidoglycan (PGN) and lipopolysaccharide (LPS), respectively, for NF-kappa B activation. However, little is known about the expression and regulation of the TLR2 gene in monocytes/macrophages in response to the two typical bacterial ...

journal_title：Infection and immunity

authors： Liu Y,Wang Y,Yamakuchi M,Isowaki S,Nagata E,Kanmura Y,Kitajima I,Maruyama I

更新日期：2001-05-01 00:00:00

abstract：:Individual strains of Staphylococcus aureus have different capacities to become internalized by osteoblasts. Here we report that the levels of sigma(B) expressed by S. aureus correlate with the capacity of this bacterium to be internalized by osteoblasts. However, sigma(B) is not essential for internalization and does...

journal_title：Infection and immunity

authors： Nair SP,Bischoff M,Senn MM,Berger-Bächi B

更新日期：2003-07-01 00:00:00

abstract：:Visceral leishmaniasis is a severe and lethal disease caused by the protozoan parasites of the genus Leishmania. In areas where leishmaniasis is endemic, most infected individuals control the infection and remain asymptomatic; chemotherapy of visceral leishmaniasis restores some immunity which protects against relapse...

journal_title：Infection and immunity

authors： Mary C,Auriault V,Faugère B,Dessein AJ

更新日期：1999-11-01 00:00:00

abstract：:Gonococci from opaque colonies have cell wall outer membrane proteins that are lacking from organisms which form transparent colonies. These "colony opacity-associated" proteins are among a group of "minor" proteins that exhibit heat modification of their apparent subunit molecular sizes, are easily extracted by deoxy...

journal_title：Infection and immunity

authors： Swanson J

更新日期：1980-04-01 00:00:00

abstract：:Human and rat C-reactive proteins, major acute-phase reactants, bind to sporozoites and inhibit their in vitro development in hepatocytes (A. Nussler, S. Pied, M. Pontet, F. Miltgen, L. Renia, M. Gentilini, and D. Mazier, Exp. Parasitol. 72:1-7, 1991, and S. Pied, A. Nussler, M. Pontet, F. Miltgen, H. Matile, P.-H. La...

journal_title：Infection and immunity

authors： Rénia L,Xia D,Samols D,Nussenzweig V

更新日期：1993-01-01 00:00:00

abstract：:The antigens of Haemophilus somnus recognized by convalescent bovine serum were studied by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting with a protein A-peroxidase conjugate. The same two 76K and 40K antigens were predominant in whole-bacterium preparations and in outer-membrane-enric...

journal_title：Infection and immunity

authors： Corbeil LB,Arthur JE,Widders PR,Smith JW,Barbet AF

更新日期：1987-06-01 00:00:00

abstract：:Whole-genome sequencing analysis of ∼800 strains of group A Streptococcus (GAS) found that the gene encoding the multiple virulence gene regulator of GAS (mga) is highly polymorphic in serotype M59 strains but not in strains of other serotypes. To help understand the molecular mechanism of gene regulation by Mga and i...

journal_title：Infection and immunity

authors： Sanson M,Makthal N,Gavagan M,Cantu C,Olsen RJ,Musser JM,Kumaraswami M

更新日期：2015-06-01 00:00:00

abstract：:Endocarditis isolates of Enterococcus faecalis produced biofilm significantly more often than nonendocarditis isolates, and 39% of 79 versus 6% of 84 isolates produced strong biofilm (P < 0.0001). esp was not required, but its presence was associated with higher amounts of biofilm (P < 0.001). Mutants disrupted in dlt...

journal_title：Infection and immunity

authors： Mohamed JA,Huang W,Nallapareddy SR,Teng F,Murray BE

更新日期：2004-06-01 00:00:00

abstract：:Streptococcus pyogenes is one of the most frequent human pathogens. Recent studies have identified dendritic cells (DCs) as important contributors to host defense against S. pyogenes. The objective of this study was to identify the receptors involved in immune recognition of S. pyogenes by DCs. To determine whether To...

journal_title：Infection and immunity

authors： Loof TG,Goldmann O,Medina E

更新日期：2008-06-01 00:00:00

abstract：:Toll-like receptor (TLR) signal transduction is a central component of the innate immune response to pathogenic challenge. Although recent studies have begun to elucidate differences in acquired immunity in tissues of the human female reproductive tract, there is a relative paucity of work regarding innate defense mec...

journal_title：Infection and immunity

authors： Pioli PA,Amiel E,Schaefer TM,Connolly JE,Wira CR,Guyre PM

更新日期：2004-10-01 00:00:00

abstract：:Natural killer (NK) cells are considered to be key players in the early innate responses to protozoan infections, primarily indirectly by producing gamma interferon (IFN-gamma) in response to cytokines, like interleukin 12 (IL-12). We demonstrate that live, as well as heat-inactivated, tachyzoites of Neospora caninum,...

journal_title：Infection and immunity

authors： Boysen P,Klevar S,Olsen I,Storset AK

更新日期：2006-02-01 00:00:00

abstract：:Mammalian hosts often develop distinct immune response against the diverse parasitic helminths that have evolved for immune evasion. Interleukin-25 (IL-25), an IL-17 cytokine family member, plays a key role in initiating the protective immunity against several parasitic helminths; however, the involvement and underlyi...

journal_title：Infection and immunity

authors： Angkasekwinai P,Srimanote P,Wang YH,Pootong A,Sakolvaree Y,Pattanapanyasat K,Chaicumpa W,Chaiyaroj S,Dong C

更新日期：2013-10-01 00:00:00

abstract：:Acquisition of genomic elements by horizontal gene transfer represents an important mechanism in the evolution of bacterial species. Pathogenicity islands are a subset of horizontally acquired elements present in various pathogens. These elements are frequently located adjacent to tRNA genes. We performed a comparativ...

journal_title：Infection and immunity

authors： Hansen-Wester I,Hensel M

更新日期：2002-05-01 00:00:00

abstract：:Lactoperoxidase catalyzes the oxidation of thiocyanate by hydrogen peroxide into hypothiocyanite, a reaction which can protect bacterial and mammalian cells from killing by hydrogen peroxide. The present study demonstrates, however, that lactoperoxidase in the presence of thiocyanate can actually potentiate the bacter...

journal_title：Infection and immunity

authors： Carlsson J,Edlund MB,Hänström L

更新日期：1984-06-01 00:00:00

abstract：:Protein-malnourished rats had greater numbers of bacteria in their livers and spleens compared with numbers in control rats following a sublethal intraperitoneal dose of Salmonella typhimurium. However, the febrile responses of both groups of rats to infection were similar. The ability to mount a normal febrile respon...

journal_title：Infection and immunity

authors： Bradley SF,Kauffman CA

更新日期：1988-04-01 00:00:00

abstract：:The cellular source of interleukin-6 (IL-6) during infection of mice with Listeria monocytogenes was investigated both in vitro and in vivo. Peritoneal cells taken at intervals from infected mice and cultured in vitro without added stimulus produced high titers of IL-6 peaking 2 days postinfection in a time course sim...

journal_title：Infection and immunity

authors： Liu Z,Cheers C

更新日期：1993-06-01 00:00:00

abstract：:The eib genes of Escherichia coli encode surface-exposed proteins which bind immunoglobulins (Ig) such as the Fc fragment of human IgG (IgG Fc) in a nonimmune manner. The Eib proteins belong to a family which includes YadA of Yersinia, UspA2 of Moraxella, and DsrA of Haemophilus ducreyi. This family of surface-exposed...

journal_title：Infection and immunity

authors： Sandt CH,Hill CW

更新日期：2001-12-01 00:00:00

abstract：:Mucosal exposure to Escherichia coli elicits an inflammatory response in the urinary tract. Interleukin-6 (IL-6) is secreted into the urine, and polymorphonuclear leukocytes (PMNLs) are recruited to the site of infection. This study analyzed the ability of mucosally administered bacterial components to activate IL-6 a...

journal_title：Infection and immunity

authors： Linder H,Engberg I,Hoschützky H,Mattsby-Baltzer I,Svanborg C

更新日期：1991-12-01 00:00:00

abstract：:Monoclonal antibodies have been generated to the unique distal sugar epitopes on the oligosaccharide haptens of the glycopeptidolipid antigens of clinically prominent members of the Mycobacterium avium serocomplex. Thus, antibodies are described that recognize the distal O-acetyl-alpha-L-rhamnopyranosyl residue of the...

journal_title：Infection and immunity

authors： Rivoire B,Ranchoff BJ,Chatterjee D,Gaylord H,Tsang AY,Kolk AH,Aspinall GO,Brennan PJ

更新日期：1989-10-01 00:00:00

abstract：:We have constructed an improved recombination-based in vivo expression technology (RIVET) and used it as a screening method to identify Vibrio cholerae genes that are transcriptionally induced during infection of infant mice. The improvements include the introduction of modified substrate cassettes for resolvase that ...

journal_title：Infection and immunity

authors： Osorio CG,Crawford JA,Michalski J,Martinez-Wilson H,Kaper JB,Camilli A

更新日期：2005-02-01 00:00:00