Effects of cell source, mouse strain, and immunosuppressive treatment on production of virulent and attenuated murine cytomegalovirus.

abstract：:A total of 133 Listeria monocytogenes isolates were characterized by ribotyping and allelic analysis of the virulence genes hly, actA, and inlA to uncover linkages between independent phylogenetic and specific virulence markers. PCR-restriction fragment length polymorphisms revealed 8 hly, 11 inl4, and 2 actA alleles....

journal_title：Infection and immunity

authors： Wiedmann M,Bruce JL,Keating C,Johnson AE,McDonough PL,Batt CA

更新日期：1997-07-01 00:00:00

abstract：:In studies of immunity to malaria, the absence of febrile malaria is commonly considered evidence of "protection." However, apparent "protection" may be due to a lack of exposure to infective mosquito bites or due to immunity. We studied a cohort that was given curative antimalarials before monitoring began and docume...

journal_title：Infection and immunity

authors： Bejon P,Warimwe G,Mackintosh CL,Mackinnon MJ,Kinyanjui SM,Musyoki JN,Bull PC,Marsh K

更新日期：2009-05-01 00:00:00

abstract：:Bordetella pertussis 165-9K/129G, which produces a nontoxic form of pertussis toxin (PT), was used to prepare a whole-cell diphtheria-tetanus-pertussis (DTP) vaccine. The in vivo potency and the serological response induced by this vaccine were comparable to those of the conventional DTP vaccine which contains active ...

journal_title：Infection and immunity

authors： Marsili I,Pizza M,Giovannoni F,Volpini G,Bartalini M,Olivieri R,Rappuoli R,Nencioni L

更新日期：1992-03-01 00:00:00

abstract：:The flavivirus dengue and the arenavirus Junin are both associated with a hemorrhagic shock syndrome in man. We have demonstrated the replication of these viruses in vitro in both rabbit and human endothelial cells by viral titers and immunofluorescent antibody studies. Rabbit endothelium established in continuous cul...

journal_title：Infection and immunity

authors： Andrews BS,Theofilopoulos AN,Peters CJ,Loskutoff DJ,Brandt WE,Dixon FJ

更新日期：1978-06-01 00:00:00

abstract：:One of the first steps in the development of cerebral toxoplasmosis is the penetration of the blood-brain barrier, which is comprised of microvascular endothelial cells. We examined the capacity of human brain microvascular endothelial cells (HBMEC) to interact with Toxoplasma gondii. We found that stimulation of HBME...

journal_title：Infection and immunity

authors： Däubener W,Spors B,Hucke C,Adam R,Stins M,Kim KS,Schroten H

更新日期：2001-10-01 00:00:00

abstract：:Alpha-toxin, the major cytolysin of Staphylococcus aureus, preferentially attacks human platelets and cultured monocytes, thereby promoting coagulation and the release of interleukin-1 and tumor necrosis factor. Titers of naturally occurring antibodies in human blood are not high enough to substantially inhibit these ...

journal_title：Infection and immunity

authors： Bhakdi S,Mannhardt U,Muhly M,Hugo F,Ronneberger H,Hungerer KD

更新日期：1989-10-01 00:00:00

abstract：:Helicobacter pylori infection of the stomach causes an active immune response that includes stimulation of inducible nitric oxide (NO) synthase (iNOS) expression. Although NO can kill H. pylori, the bacterium persists indefinitely, suggesting that NO production is inadequate. We determined if the NO derived from iNOS ...

journal_title：Infection and immunity

authors： Chaturvedi R,Asim M,Lewis ND,Algood HM,Cover TL,Kim PY,Wilson KT

更新日期：2007-09-01 00:00:00

abstract：:The coagulase-negative species Staphylococcus lugdunensis is an emerging cause of serious and potentially life-threatening infections, such as infective endocarditis. The pathogenesis of these infections is characterized by the ability of S. lugdunensis to form biofilms on either biotic or abiotic surfaces. To elucida...

journal_title：Infection and immunity

authors： Rajendran NB,Eikmeier J,Becker K,Hussain M,Peters G,Heilmann C

更新日期：2015-12-01 00:00:00

abstract：:Previous studies demonstrated that Mycoplasma arthritidis strain 158 acquired a high degree of virulence upon lysogenization with bacteriophage MAV1. In the present study, the association between MAV1 and virulence was reexamined by creating new lysogens of 158 and of a relatively avirulent mutant, strain 158-1. In th...

journal_title：Infection and immunity

authors： Clapper B,Tu AH,Simmons WL,Dybvig K

更新日期：2004-12-01 00:00:00

abstract：:Recent evidence suggests that immune-mediated gastric epithelial cell apoptosis through Fas-Fas ligand interactions participates in Helicobacter pylori disease pathogenesis. To define the role of Fas signaling in vivo, H. pylori strain SS1 infection in C57BL/6 mice was compared to that in mice deficient in the Fas lig...

journal_title：Infection and immunity

authors： Jones NL,Day AS,Jennings H,Shannon PT,Galindo-Mata E,Sherman PM

更新日期：2002-05-01 00:00:00

abstract：:Using a murine respiratory infection model, we have demonstrated previously that infection with Bordetella pertussis or immunization with a whole-cell pertussis vaccine induced antigen-specific Th1 cells, which conferred a high level of protection against aerosol challenge. In contrast, immunization with an acellular ...

journal_title：Infection and immunity

authors： Mahon BP,Ryan MS,Griffin F,Mills KH

更新日期：1996-12-01 00:00:00

abstract：:We investigated the cytokine/chemokine secretions and alteration of protein expression from peripheral blood mononuclear cells (PBMCs) cocultured with adult liver flukes (Opisthorchis viverrini) for 6 to 24 h. PBMC-derived proteins were identified by two-dimensional electrophoresis and mass spectrometry, and the cytok...

journal_title：Infection and immunity

authors： Hongsrichan N,Intuyod K,Pinlaor P,Khoontawad J,Yongvanit P,Wongkham C,Roytrakul S,Pinlaor S

更新日期：2014-05-01 00:00:00

abstract：:The porcine immunoglobulins M (IgM), A (IgA), and G (IgG) were isolated and purified and some of the properties of the porcine milk IgA were examined. Monospecific antisera which were prepared against these immunoglobulins in rabbits were then used to absorb a particular class of immunoglobulin from sow serum, colostr...

journal_title：Infection and immunity

authors： Saif LJ,Bohl EH,Gupta RK

更新日期：1972-10-01 00:00:00

abstract：:Mycobacterium tuberculosis grows within the phagocytic vacuoles of macrophages, where it encounters a moderately acidic and possibly nutrient-restricted environment. Other mycobacterial species encounter acidic conditions in soil and aquatic environments. We have evaluated the influence of pH and divalent cation level...

journal_title：Infection and immunity

authors： Piddington DL,Kashkouli A,Buchmeier NA

更新日期：2000-08-01 00:00:00

abstract：:Previous studies have suggested that the Pseudomonas aeruginosa PAK pilus adhesin moiety resides in an epithelial cell-binding domain located in the C-terminal region of the PAK pilin structural protein. Synthetic peptides Ac17red (a synthetic peptide with a sequence identical to that of PAK pilin residues 128 to 144,...

journal_title：Infection and immunity

authors： Irvin RT,Doig P,Lee KK,Sastry PA,Paranchych W,Todd T,Hodges RS

更新日期：1989-12-01 00:00:00

abstract：:Mammalian hosts often develop distinct immune response against the diverse parasitic helminths that have evolved for immune evasion. Interleukin-25 (IL-25), an IL-17 cytokine family member, plays a key role in initiating the protective immunity against several parasitic helminths; however, the involvement and underlyi...

journal_title：Infection and immunity

authors： Angkasekwinai P,Srimanote P,Wang YH,Pootong A,Sakolvaree Y,Pattanapanyasat K,Chaicumpa W,Chaiyaroj S,Dong C

更新日期：2013-10-01 00:00:00

abstract：:In this analysis we have examined in detail the effects of low concentrations of zinc on the growth and dimorphism of Candida albicans. Evidence is presented that micromolar concentrations of zinc added to growth cultures grown at 25 degrees C (i) cause a twofold increase in the final concentration of spheres at satio...

journal_title：Infection and immunity

authors： Bedell GW,Soll DR

更新日期：1979-10-01 00:00:00

abstract：:Internalization of Staphylococcus aureus in bovine endothelial cells (BEC) is increased by tumor necrosis factor alpha stimulation and NF-κB activation. Because the phosphoinositide-3-kinase (PI3K)-Akt signaling pathway also modulates NF-κB activity, we considered whether the internalization of S. aureus by BEC is ass...

journal_title：Infection and immunity

authors： Oviedo-Boyso J,Cortés-Vieyra R,Huante-Mendoza A,Yu HB,Valdez-Alarcón JJ,Bravo-Patiño A,Cajero-Juárez M,Finlay BB,Baizabal-Aguirre VM

更新日期：2011-11-01 00:00:00

abstract：:Previous research in this laboratory, using photoactivatable radioiodinated lipopolysaccharide derivatized with sulfosuccinimidyl-2-(p-azidosalicylamide)-1,3'-dithiopropionate (125I-ASD-LPS), has resulted in the identification of a specific LPS receptor with a molecular mass of approximately 73 kDa on murine lymphocyt...

journal_title：Infection and immunity

authors： Halling JL,Hamill DR,Lei MG,Morrison DC

更新日期：1992-03-01 00:00:00

abstract：:Sephadex G-200 filtration was used for fractionating dengue type 2 (DEN-2)-infected suckling mouse brain (SMB) supernatant fluids. The high-molecular-weight fraction, which was eluted in the void volume, showed no increase in type specificity when tested against immune ascitic fluid to the four prototype dengue viruse...

journal_title：Infection and immunity

authors： Cornesky RA,Hammon WM,Atchison RW,Sather GE

更新日期：1972-12-01 00:00:00

abstract：:Differences in susceptibility to persistent cryptosporidial infection between two strains of adult athymic nude mice prompted us to investigate the immune mechanism(s) that may control resistance to infection in these T-cell-deficient mice. We studied fecal oocyst shedding, serum and fecal parasite-specific antibody r...

journal_title：Infection and immunity

authors： Adjei AA,Jones JT,Riggs MW,Enriquez FJ

更新日期：1999-08-01 00:00:00

abstract：:Conjunctival infection of guinea pigs by the chlamydial agent of guinea pig inclusion conjunctivitis confers immunity. However, the mechanism of resistance to this intracellular pathogen is not yet defined. In the study reported here, serum immunoglobulin was passively transferred with resultant titers in excess of th...

journal_title：Infection and immunity

authors： Watson RR,Mull JD,MacDonald AB,Thompson SE 3rd,Bear SE

更新日期：1973-04-01 00:00:00

abstract：:A nonproteolytic strain of Clostridium botulinum type B produces two toxins of different molecular weight (16S and 12S) that are indistinguishable from the corresponding toxins of a proteolytic strain in molecular weight and construction but differ in potential toxicity, activation ratio, and hemagglutinability. Succe...

journal_title：Infection and immunity

authors： Miyazaki S,Kozaki S,Sakaguchi S,Sakaguchi G

更新日期：1976-03-01 00:00:00

abstract：:The virulence plasmids of Salmonella typhimurium and other invasive Salmonella serovars have long been associated with the ability of these bacteria to cause systemic infection beyond the intestines in orally inoculated animals. Genetic analysis of virulence genes on the high-molecular-weight plasmids has revealed tha...

journal_title：Infection and immunity

authors： Gulig PA,Doyle TJ

更新日期：1993-02-01 00:00:00

abstract：:Active immunization with Porphyromonas gingivalis whole-cell preparations has been shown to prevent P. gingivalis infection and oral bone loss. Employing passive antibody transfer and opsonization, we demonstrate with this study that immunization-elicited P. gingivalis-specific immunoglobulin G facilitates clearance o...

journal_title：Infection and immunity

authors： Gibson FC 3rd,Gonzalez DA,Wong J,Genco CA

更新日期：2004-04-01 00:00:00

abstract：:The Legionella pneumophila major secretory protein (Msp) is a Zn2+ metalloprotease whose function in pathogenesis is unknown. The structural gene for the Msp protease, mspA, was isolated from an L. pneumophila genomic library. In Escherichia coli which contain plasmids with the mspA gene, Msp protein and activity are ...

journal_title：Infection and immunity

authors： Szeto L,Shuman HA

更新日期：1990-08-01 00:00:00

abstract：:Pseudomonas aeruginosa, an important opportunistic pathogen of humans, exploits epithelial damage to establish infection. We have rigorously explored the role of N-glycoproteins and heparan sulfate proteoglycans (HSPGs) in P. aeruginosa-mediated attachment and subsequent downstream events at the apical (AP) and basola...

journal_title：Infection and immunity

authors： Bucior I,Mostov K,Engel JN

更新日期：2010-03-01 00:00:00

abstract：:A key function of monocytes/macrophages (Mphi) is to present antigens to T cells. However, upon interaction with bacteria, Mphi lose their ability to effectively present soluble antigens. This functional loss was associated with alterations in the expression of adhesion molecules and CD14 and a reduction in the uptake...

journal_title：Infection and immunity

authors： Wyant TL,Tanner MK,Sztein MB

更新日期：1999-03-01 00:00:00

abstract：:The eib genes of Escherichia coli encode surface-exposed proteins which bind immunoglobulins (Ig) such as the Fc fragment of human IgG (IgG Fc) in a nonimmune manner. The Eib proteins belong to a family which includes YadA of Yersinia, UspA2 of Moraxella, and DsrA of Haemophilus ducreyi. This family of surface-exposed...

journal_title：Infection and immunity

authors： Sandt CH,Hill CW

更新日期：2001-12-01 00:00:00

abstract：:To investigate the correlation between the incA I47T mutation in Chlamydia trachomatis and the nonfusogenic phenotype, the incA genes of 25 isolates were sequenced. Four major sequence types were identified. Seven isolates (28%) had the I47T mutation. Isolates representing the four sequence types expressed IncA in the...

journal_title：Infection and immunity

authors： Pannekoek Y,van der Ende A,Eijk PP,van Marle J,de Witte MA,Ossewaarde JM,van den Brule AJ,Morré SA,Dankert J

更新日期：2001-07-01 00:00:00