Inactivation of the srtA gene affects localization of surface proteins and decreases adhesion of Streptococcus pneumoniae to human pharyngeal cells in vitro.

abstract：:The concept of translational research, which aims to facilitate the application of basic scientific discoveries in clinical and community settings, is currently in vogue. While there are powerful forces driving this trend, support for translational research must be accompanied by a robust investment in basic science, ...

journal_title：Infection and immunity

authors： Fang FC,Casadevall A

更新日期：2010-02-01 00:00:00

abstract：:The mechanism of adsorption of the Streptococcus mutans enzymes responsible for the synthesis of insoluble dextran-levan to the S. mutans cell-wall binding sites has been studied. Certain characteristics of these binding sites are presented. The adsorption of these enzymes to the cell surface occurred rapidly without ...

journal_title：Infection and immunity

authors： Mukasa H,Slade HD

更新日期：1974-02-01 00:00:00

abstract：:Although certain helminth infections preferentially induce type 2 T-cell responses, the immunological mechanisms responsible for type 2 T-cell polarization remain unclear. In the present study, we investigated the effects of excretory-secretory (ES) antigen from the nematode Nippostrongylus brasiliensis on cytokine pr...

journal_title：Infection and immunity

authors： Uchikawa R,Matsuda S,Arizono N

更新日期：2000-11-01 00:00:00

abstract：:Macrophage ribonucleic acid (RNA) synthesis is an important metabolic process intimately related to the function of these cells. Mouse peritoneal macrophage RNA was extracted with phenol in the presence of bentonite and electrophoresed on composite agarose-polyacrylamide gels. The pulse-chase technique was used to fol...

journal_title：Infection and immunity

authors： Soderberg LS,Tewari RP,Solotorovsky M

更新日期：1976-06-01 00:00:00

abstract：:A defect in lymphocyte function could be responsible for persistent infection by the equine infectious anemia virus. The number of lymphocytes bearing surface immunoglobulin, as detected by immunofluorescence, and lymphocyte response to mitogens were the same in uninfected and equine infectious anemia-infected animals...

journal_title：Infection and immunity

authors： Banks KL,Henson JB

更新日期：1973-10-01 00:00:00

abstract：:Thymidine kinase (TK) from herpes simplex virus type 1 (HSV-1) biochemically transformed HeLa cells, purified by affinity chromatography, has been characterized with respect to its electrophoretic mobility, molecular weight, activation energy, substrate specificity, and immunological specificity. TK purified from HSV-...

journal_title：Infection and immunity

authors： Cheng YC,Chadha KC,Hughes RG Jr

更新日期：1977-05-01 00:00:00

abstract：:Bacteria have evolved strategies to resist killing by antimicrobial peptides (APs), important effectors of innate immunity. The sap (sensitivity to antimicrobial peptides) operon confers resistance to AP-mediated killing of Salmonella. We have recently shown that sapA gene expression is upregulated in the middle ear i...

journal_title：Infection and immunity

authors： Mason KM,Munson RS Jr,Bakaletz LO

更新日期：2005-01-01 00:00:00

abstract：:Escherichia coli O157:H7 carries a chromosomal msbB1 and a plasmid-encoded msbB2 gene. We characterized msbB2 function as a homologue of msbB1 by examination of wild-type organisms and mutant strains that lacked functional msbB1, msbB2, and both msbB1 and msbB2. The msbB double-mutant strain generated pentaacyl lipid ...

journal_title：Infection and immunity

authors： Kim SH,Jia W,Bishop RE,Gyles C

更新日期：2004-02-01 00:00:00

abstract：:Haemophilus influenzae type b (Hib) is a significant pathogen for young children, and three Hib vaccines (named PRP-OMPC, HbOC, and PRP-T) are currently available for young children. Extensive studies of anti-Hib polysaccharide (PS) antibodies (Abs) have shown that the V regions of Abs against the Hib PS comprise a VH...

journal_title：Infection and immunity

authors： Chung GH,Kim KH,Daum RS,Insel RA,Siber GR,Sood S,Gupta RK,Marchant C,Nahm MH

更新日期：1995-11-01 00:00:00

abstract：:Phagocytosis, H2O2 production, Mac-1 expression, and in vivo elimination of Listeria monocytogenes were enhanced in granulocyte colony-stimulating factor (G-CSF)-treated mice. Transfer of polymorphonuclear leukocytes prolonged survival of mice infected with a lethal dose of L. monocytogenes. G-CSF augments the functio...

journal_title：Infection and immunity

authors： Shinomiya N,Tsuru S,Katsura Y,Kayashima S,Nomoto K

更新日期：1991-12-01 00:00:00

abstract：:Initiation of a gonococcal infection involves attachment of Neisseria gonorrhoeae to the plasma membrane of an epithelial cell in the mucosal epithelium and its internalization, transepithelial trafficking, and exocytosis from the basal membrane. Piliation and expression of certain Opa proteins and the immunoglobulin ...

journal_title：Infection and immunity

authors： Hopper S,Wilbur JS,Vasquez BL,Larson J,Clary S,Mehr IJ,Seifert HS,So M

更新日期：2000-02-01 00:00:00

abstract：:The study of how bacteria respond to and obtain divalent metal ions provides insight into the regulation of virulence factors in the host environment. Regulation of metal permease operons in gram-positive bacteria may involve the binding of metal-responsive repressors to palindromic domains in their control regions. T...

journal_title：Infection and immunity

authors： Oetjen J,Fives-Taylor P,Froeliger EH

更新日期：2002-10-01 00:00:00

abstract：:Mutant analysis was used to identify Moraxella catarrhalis gene products necessary for biofilm development in a crystal violet-based assay involving 24-well tissue culture plates. The wild-type M. catarrhalis strains that formed the most extensive biofilms in this system proved to be refractory to transposon mutagenes...

journal_title：Infection and immunity

authors： Pearson MM,Laurence CA,Guinn SE,Hansen EJ

更新日期：2006-03-01 00:00:00

abstract：:The ability of intracellular pathogens to sense and adapt to the hostile environment of the host is an important factor governing virulence. We have sequenced the operon encoding the major heat shock proteins GroES and GroEL in the gram-positive food-borne pathogen Listeria monocytogenes. The operon has a conserved or...

journal_title：Infection and immunity

authors： Gahan CG,O'Mahony J,Hill C

更新日期：2001-06-01 00:00:00

abstract：:In previous work (Jones, Infect, Immun. 30:78-89, 1980) a major cytoplasmic antigen of Candida albicans was identified. In both humans and experimental animals, this antigen is released from C. albicans during the course of an invasive C. albicans infection and elicits a specific antibody response. In this study, we u...

journal_title：Infection and immunity

authors： Greenfield RA,Jones JM

更新日期：1981-11-01 00:00:00

abstract：:Human enterotoxigenic Escherichia coli (ETEC) producing colonization factor antigen III (CFA/III) and coli surface antigens 4, 5, and 6 (CS4, CS5, and CS6) of CFA/IV were examined ultrastructurally and for ability to adhere to human small intestinal enterocytes and to cultured human intestinal mucosa. Strains of serot...

journal_title：Infection and immunity

authors： Knutton S,McConnell MM,Rowe B,McNeish AS

更新日期：1989-11-01 00:00:00

abstract：:Commercial fluid used for peritoneal lavage in peritonitis and in peritoneal dialysis suppressed the activity of peripheral blood leukocytes as measured by chemiluminescence, phagocytosis, and bacterial killing. Suppression was found to be due to the low pH and high osmolality of the fluid. The pH was adjusted to noni...

journal_title：Infection and immunity

authors： Duwe AK,Vas SI,Weatherhead JW

更新日期：1981-07-01 00:00:00

abstract：:Lipopolysaccharides (LPSs) of Gram-negative bacteria comprise lipid A, core, and O-polysaccharide (OPS) components. Studies have demonstrated that LPSs isolated from the pathogenic species Burkholderia pseudomallei and Burkholderia mallei and from less-pathogenic species, such as Burkholderia thailandensis, are potent...

journal_title：Infection and immunity

authors： Sengyee S,Yoon SH,West TE,Ernst RK,Chantratita N

更新日期：2019-11-18 00:00:00

abstract：:Recent studies have established the importance of neutrophils in innate resistance to Listeria monocytogenes infection in mice. The purpose of this study was to determine the importance of neutrophils in acquired resistance to L. monocytogenes infection. Previously immunized mice that were depleted of neutrophils by a...

journal_title：Infection and immunity

authors： Czuprynski CJ,Brown JF,Wagner RD,Steinberg H

更新日期：1994-11-01 00:00:00

abstract：:This study examined apoptotic cell death associated with Shiga-like toxin (Stx)-producing Escherichia coli. Renal cortices from three children with postenteropathic hemolytic-uremic syndrome (HUS) and from mice infected with E. coli O157:H7 and pediatric renal tubular epithelial cells stimulated with Stx and E. coli O...

journal_title：Infection and immunity

authors： Karpman D,Håkansson A,Perez MT,Isaksson C,Carlemalm E,Caprioli A,Svanborg C

更新日期：1998-02-01 00:00:00

abstract：:The innate and the adaptive arms of the mucosal immune system must be coordinated to facilitate the control of pathogenic invasion while maintaining immune homeostasis. Toll-like receptors, able to activate the cell to produce bactericidal and inflammatory cytokines but also able to upregulate antigen (Ag)-presenting ...

journal_title：Infection and immunity

authors： Muthukuru M,Cutler CW

更新日期：2008-02-01 00:00:00

abstract：:Neonatal animals are generally very susceptible to infection with bacterial pathogens. However, we recently reported that neonatal mice are highly resistant to orogastric infection with Yersinia enterocolitica. Here, we show that proinflammatory responses greatly exceeding those in adults arise very rapidly in the mes...

journal_title：Infection and immunity

authors： Siefker DT,Echeverry A,Brambilla R,Fukata M,Schesser K,Adkins B

更新日期：2014-02-01 00:00:00

abstract：:A single intradermal administration of recombinant interleukin-7 (IL-7) has been shown to aggravate the course of murine schistosomiasis, to favor the development of Th2-associated antibodies specific for the parasite, and to alter migration kinetics and/or migratory route of the parasite within its vertebrate host. H...

journal_title：Infection and immunity

authors： Wolowczuk I,Nutten S,Roye O,Delacre M,Capron M,Murray RM,Trottein F,Auriault C

更新日期：1999-08-01 00:00:00

abstract：:Brucellosis is a bacterial disease of animals and humans. Brucella abortus barely activates the innate immune system at the onset of infection, and this bacterium is resistant to the microbicidal action of complement. Since complement stands as the first line of defense during bacterial invasions, we explored the role...

journal_title：Infection and immunity

authors： González-Espinoza G,Barquero-Calvo E,Lizano-González E,Alfaro-Alarcón A,Arias-Gómez B,Chaves-Olarte E,Lomonte B,Moreno E,Chacón-Díaz C

更新日期：2018-09-21 00:00:00

abstract：:Arthritis is a frequent and major complication of infection with Borrelia burgdorferi sensu stricto. The antigens responsible for the induction of arthritis are unknown. Here we provide direct evidence that a major surface protein, outer surface protein A (OspA), can induce arthritis. Hamsters were vaccinated with 30,...

journal_title：Infection and immunity

authors： Croke CL,Munson EL,Lovrich SD,Christopherson JA,Remington MC,England DM,Callister SM,Schell RF

更新日期：2000-02-01 00:00:00

abstract：:Recent reports have demonstrated that Bordetella pertussis has invasive behavior in vivo and in vitro. In this study, we investigated the ability of a virulent strain, avirulent mutants, and mutants deficient in specific virulence factors to enter and survive intracellularly in human macrophages in vitro. Uptake of vi...

journal_title：Infection and immunity

authors： Friedman RL,Nordensson K,Wilson L,Akporiaye ET,Yocum DE

更新日期：1992-11-01 00:00:00

abstract：:Our previous work suggests that one mechanism through which connective tissue breakdown might occur in periodontal diseases is the production of metalloproteinases, including collagenase, by gingival fibroblasts. In this study we investigated whether highly purified preparations of lipopolysaccharide (LPS) and lipotei...

journal_title：Infection and immunity

authors： Heath JK,Atkinson SJ,Hembry RM,Reynolds JJ,Meikle MC

更新日期：1987-09-01 00:00:00

abstract：:Klebsiella pneumoniae is a leading cause of both community-acquired and nosocomial gram-negative-bacterial pneumonia. A further clinical complication of pulmonary K. pneumoniae infection is dissemination of bacteria from the lung into the peripheral blood, resulting in bacteremia concurrent with the localized pulmonar...

journal_title：Infection and immunity

authors： Moore TA,Perry ML,Getsoian AG,Newstead MW,Standiford TJ

更新日期：2002-11-01 00:00:00

abstract：:Several trivalent cations, including lanthanum (La3+), inhibited the secretion (enterosorption) induced by the enterotoxins of Vibrio cholerae and Escherichia coli in the rabbit ileum in vivo. High concentrations (greater than 10 mM) of La3+ were required to inhibit cholera enterotoxin (CE)-induced enterosorption, pro...

journal_title：Infection and immunity

authors： Leitch GJ,Amer MS

更新日期：1975-05-01 00:00:00

abstract：:Human peripheral blood monocytes become apoptotic following phagocytosis of Staphylococcus aureus. In this study, we investigated the mechanisms involved in this phenomenon. Cells exposed to bacteria were examined for the surface expression of Fas and Fas ligand (FasL). The level of soluble form of FasL was also measu...

journal_title：Infection and immunity

authors： Baran J,Weglarczyk K,Mysiak M,Guzik K,Ernst M,Flad HD,Pryjma J

更新日期：2001-03-01 00:00:00