Target organs of infection in guinea pigs with acquired congenital syphilis.

abstract：:Antioxidants are protective against septic shock in animal models. Recently, free radical scavengers have been found to inhibit the activation of the NF-kappa B protein in a number of cell lines. This transcriptional regulatory protein binds to the promoters of the proinflammatory cytokines tumor necrosis factor, inte...

journal_title：Infection and immunity

authors： Kelly KA,Hill MR,Youkhana K,Wanker F,Gimble JM

更新日期：1994-08-01 00:00:00

abstract：:Cell surface proteins SspA and SspB in Streptococcus gordonii and SpaP in Streptococcus mutans are members of the antigen I/II family of polypeptides produced by oral streptococci. These proteins are adhesins and mediate species-specific binding of cells to a variety of host and bacterial receptors. Here we show that ...

journal_title：Infection and immunity

authors： Love RM,McMillan MD,Jenkinson HF

更新日期：1997-12-01 00:00:00

abstract：:A murine monoclonal antibody was raised against the B95-8 strain of Epstein-Barr virus (EBV), which was isolated from a case of mononucleosis after blood transfusion (Hoffman et al. Proc. Natl. Acad. Sci. U.S.A. 77:2979, 1980). We provide evidence that neutralization of immortalization by this monoclonal antibody is v...

journal_title：Infection and immunity

authors： Miller G,Heston L,Hoffman G

更新日期：1982-09-01 00:00:00

abstract：:The obligate intracellular parasite Toxoplasma gondii critically relies on host cell invasion during infection. Proteins secreted from the apical micronemes are central components for host cell recognition, invasion, egress, and virulence. Although previous work established that the sporozoite protein with an altered ...

journal_title：Infection and immunity

authors： Huynh MH,Boulanger MJ,Carruthers VB

更新日期：2014-10-01 00:00:00

abstract：:Conditions for the release of streptococcal type 12 M protein from whole cells by cyanogen bromide are described; they demonstrated that methionine is not essential to the structural arrangements which account for some of its immunological and biological properties. The released M protein was separated from other prot...

journal_title：Infection and immunity

authors： Vosti KL,Williams WK

更新日期：1978-08-01 00:00:00

abstract：:The plasmid-encoded structural gene cofA necessary for the production of the major pilin subunit of pilus colonization factor antigen III (CFA/III) of human enterotoxigenic Escherichia coli was identified, and the nucleotide sequence of the gene was determined. cofA consists of 714 nucleotides encoding a 238-amino-aci...

journal_title：Infection and immunity

authors： Taniguchi T,Fujino Y,Yamamoto K,Miwatani T,Honda T

更新日期：1995-02-01 00:00:00

abstract：:The method of Garra and Baygorria, for localized antibody production, has been adapted for obtaining high-titered and monospecific antibodies against the murine toxin of Yersinia pestis. A hollow, perforated plastic golf ball surgically implanted under the skin of rabbits induced the formation of a granuloma. When the...

journal_title：Infection and immunity

authors： Hillam RP,Tengerdy RP,Brown GL

更新日期：1974-09-01 00:00:00

abstract：:Disruption of the healthy intestinal microbiome and homeostasis of the intestinal immune system, which are closely interactive, are two key factors for ulcerative colitis. Here, we show that MI-2, a selective inhibitor of mucosa-associated lymphoid tissue lymphoma translocation-1 (MALT1), alleviated excessive inflamma...

journal_title：Infection and immunity

authors： Lee KW,Kim M,Lee CH

更新日期：2018-11-20 00:00:00

abstract：:Allergic-type immune responses, particularly immunoglobulin E (IgE), correlate with protective immunity in human schistosomiasis. To better understand the mechanisms of parasite elimination we examined the immune correlates of protection in baboons (Papio cynocephalus anubis), which are natural hosts for Schistosoma m...

journal_title：Infection and immunity

authors： Nyindo M,Kariuki TM,Mola PW,Farah IO,Elson L,Blanton RE,King CL

更新日期：1999-02-01 00:00:00

abstract：:The innate and the adaptive arms of the mucosal immune system must be coordinated to facilitate the control of pathogenic invasion while maintaining immune homeostasis. Toll-like receptors, able to activate the cell to produce bactericidal and inflammatory cytokines but also able to upregulate antigen (Ag)-presenting ...

journal_title：Infection and immunity

authors： Muthukuru M,Cutler CW

更新日期：2008-02-01 00:00:00

abstract：:We developed a human inhibition monoclonal enzyme-linked immunosorbent assay (HIMELISA) to investigate the human immune response to the lipooligosaccharides (LOS) of Neisseria meningitidis. Monoclonal antibodies (MAb) were used to define seven epitopes on four LOS molecules of a meningococcal strain (126E) previously ...

journal_title：Infection and immunity

authors： Estabrook MM,Mandrell RE,Apicella MA,Griffiss JM

更新日期：1990-07-01 00:00:00

abstract：:Botulinum neurotoxins (BoNTs) and tetanus toxin (TeNT) are the most potent toxins for humans and elicit unique pathologies due to their ability to traffic within motor neurons. BoNTs act locally within motor neurons to elicit flaccid paralysis, while retrograde TeNT traffics to inhibitory neurons within the central ne...

journal_title：Infection and immunity

authors： Zuverink M,Chen C,Przedpelski A,Blum FC,Barbieri JT

更新日期：2015-07-01 00:00:00

abstract：:Various pathogenic bacteria with the capacity to live within eukaryotic cells activate an apoptotic program in infected host cells. Induction of apoptosis by Listeria monocytogenes in murine dendritic cells and hepatocytes has been described. Here we address the questions of whether and how the pathogen kills macropha...

journal_title：Infection and immunity

authors： Barsig J,Kaufmann SH

更新日期：1997-10-01 00:00:00

abstract：:Cryptococcus neoformans laccase expression during murine infection was investigated in lung tissue by immunohistochemistry and immunogold electron microscopy. Laccase was detected in the fungal cell cytoplasm, cell wall, and capsule in vivo. The amount of laccase found in different sites varied as a function of the ti...

journal_title：Infection and immunity

authors： Garcia-Rivera J,Tucker SC,Feldmesser M,Williamson PR,Casadevall A

更新日期：2005-05-01 00:00:00

abstract：:An attenuated influenza A candidate vaccine virus, derived from the A/Ann Arbor/6/60 (H2N2) cold-adapted (ca) donor virus and the A/Alaska/6/77 (H3N2) wild-type virus, was evaluated in adult seronegative volunteers (serum hemagglutination-inhibiting antibody titer, less than or equal to 1:8) for level of attenuation, ...

journal_title：Infection and immunity

authors： Clements ML,O'Donnell S,Levine MM,Chanock RM,Murphy BR

更新日期：1983-06-01 00:00:00

abstract：:An antigenically distinct serotype, type IV, has recently been added to the recognized serotypes of group B streptococci (GBS). We isolated and purified the capsular polysaccharide antigen from a prototype type IV GBS strain. The type IV capsular polysaccharide formed a precipitin line with rabbit antiserum to type IV...

journal_title：Infection and immunity

authors： Wessels MR,Benedí WJ,Jennings HJ,Michon F,DiFabio JL,Kasper DL

更新日期：1989-04-01 00:00:00

abstract：:Listeria monocytogenes colonized the gastrointestinal tract of adult germfree rats (10(10) to 10(11)/g, dry weight) within 24 h after oral exposure. Between 3 and 14 days after monoassociation, L. monocytogenes caused a self-limiting pseudomembranous colitis, bacteremia, and infection of the spleen and liver. Monoasso...

journal_title：Infection and immunity

authors： Czuprynski CJ,Balish E

更新日期：1981-04-01 00:00:00

abstract：:Significant resistance against influenza virus and Mycobacterium tuberculosis infections was induced when trehalose dimycolate from M. tuberculosis or M. bovis but not M. avium was combined with muramyl dipeptide. Trehalose dimycolate from M. tuberculosis, in contrast to that from M. avium, could confer resistance aga...

journal_title：Infection and immunity

authors： Masihi KN,Brehmer W,Lange W,Werner H,Ribi E

更新日期：1985-12-01 00:00:00

abstract：:Shiga-like toxins (SLTs), which are produced by certain strains of Escherichia coli, are composed of enzymatically active A and B subunit multimers responsible for the toxin's binding. We have previously purified large amounts of the SLT-I B subunit by using a hyperexpression vector in Vibrio cholerae under the contro...

journal_title：Infection and immunity

authors： Acheson DW,De Breucker SA,Jacewicz M,Lincicome LL,Donohue-Rolfe A,Kane AV,Keusch GT

更新日期：1995-01-01 00:00:00

abstract：:The coagulase-negative species Staphylococcus lugdunensis is an emerging cause of serious and potentially life-threatening infections, such as infective endocarditis. The pathogenesis of these infections is characterized by the ability of S. lugdunensis to form biofilms on either biotic or abiotic surfaces. To elucida...

journal_title：Infection and immunity

authors： Rajendran NB,Eikmeier J,Becker K,Hussain M,Peters G,Heilmann C

更新日期：2015-12-01 00:00:00

abstract：:Hybridomas secreting monoclonal antibodies against an apparent strain-specific cell surface antigen of Neisseria gonorrhoeae were produced. Spleen cells from BALB/c mice immunized with whole gonococci were fused with mouse myeloma cell line Sp2/0, and hybrid cells were selected in culture. One hybridoma that secreted ...

journal_title：Infection and immunity

authors： Nachamkin I,Cannon JG,Mittler RS

更新日期：1981-05-01 00:00:00

abstract：:The distribution of dengue-2 antigens was studied in infected monkey kidney cells (LLC MK2) using an indirect, horseradish peroxidase-conjugated immunoglobulin technique. This procedure allowed both light and electron microscopic examination of serial-step sections of individual cells cut in a plane perpendicular to t...

journal_title：Infection and immunity

authors： Cardiff RD,Lund JK

更新日期：1976-06-01 00:00:00

abstract：:Exposure of PAM cells, a spontaneously transformed mouse cell line, to brain homogenates from mice infected with scrapie caused a relative decrease in total cell yield, which persisted from passage 2 or 3 to passage 18 after treatment. The effect was elicited by each of the eight independent scrapie isolates tested. L...

journal_title：Infection and immunity

authors： Carp RI,Merz GS,Licursi PC

更新日期：1976-07-01 00:00:00

abstract：:A Mycobacterium tuberculosis strain disrupted in the AraC homologue Rv1931c was isolated. The mutant strain exhibited reduced survival both in macrophages and in a mouse infection model, with survival being restored on complementation with the Rv1931c gene. These results suggest that Rv1931c regulates genes important ...

journal_title：Infection and immunity

authors： Frota CC,Papavinasasundaram KG,Davis EO,Colston MJ

更新日期：2004-09-01 00:00:00

abstract：:The goal of this study was to determine the roles of eosinophils and neutrophils in innate and adaptive protective immunity to larval Strongyloides stercoralis in mice. The experimental approach used was to treat mice with an anti-CCR3 monoclonal antibody to eliminate eosinophils or to use CXCR2-/- mice, which have a ...

journal_title：Infection and immunity

authors： Galioto AM,Hess JA,Nolan TJ,Schad GA,Lee JJ,Abraham D

更新日期：2006-10-01 00:00:00

abstract：:Vesicular stomatitis virus (Indiana strain) will only grow in T lymphocytes which have been stimulated to undergo cell division. Evidence is presented that a considerable enrichment of the vesicular stomatitis virus-replicating T cells may be accomplished in the mouse spleen by passing the spleen cells over glass wool...

journal_title：Infection and immunity

authors： Webb DR,Munshi S,Banerjee AK

更新日期：1981-04-01 00:00:00

abstract：:Gamma interferon (IFN-gamma) plays an important role in experimental Trypanosoma cruzi infections, presumably by controlling the early replication of parasites in host macrophages. In this work, we show that NK cells represent an important cell type responsible for the production of most of the IFN-gamma in the early ...

journal_title：Infection and immunity

authors： Cardillo F,Voltarelli JC,Reed SG,Silva JS

更新日期：1996-01-01 00:00:00

abstract：:Bovine sera for tissue culture use were shown to contain heterophil antigen of the Paul-Bunnell-Davidsohn type by immune adherence hemagglutination tests with sera from patients with infectious mononucleosis. The antibody titers observed were comparable to those determined by two other methods; i.e., the immune adhere...

journal_title：Infection and immunity

authors： Lennette ET,Henle G,Henle W,Horwitz CA

更新日期：1978-03-01 00:00:00

abstract：:Arg-gingipains are extracellular cysteine proteases produced by the gram-negative periodontal pathogen Porphyromonas gingivalis and are encoded by rgpA and rgpB. Three Arg-gingipains, heterodimeric high-molecular-mass Arg-gingipain HRgpA comprising the alpha-catalytic chain and the beta-adhesin chain, the monomeric so...

journal_title：Infection and immunity

authors： Rangarajan M,Hashim A,Aduse-Opoku J,Paramonov N,Hounsell EF,Curtis MA

更新日期：2005-08-01 00:00:00

abstract：:Studies conducted with F1 and F2 progeny of crosses between strains of inbred mice that differ greatly in their capacity to make an antibody response to type III pneumococcal polysaccharide, dextran B-1355, and lipopolysaccharide from Escherichia coli 0113 have shown that multiple genes influence the magnitude of the ...

journal_title：Infection and immunity

authors： Baker PJ,Rudbach JA,Prescott B,Caldes G,Evans C,Stashak PW

更新日期：1984-07-01 00:00:00