Abstract:
:Listeria monocytogenes colonized the gastrointestinal tract of adult germfree rats (10(10) to 10(11)/g, dry weight) within 24 h after oral exposure. Between 3 and 14 days after monoassociation, L. monocytogenes caused a self-limiting pseudomembranous colitis, bacteremia, and infection of the spleen and liver. Monoassociation of rats with Listeria for 8 weeks stimulated 32- and 4-fold increases in serum immunoglobulin A (IgA) and IgG, respectively, whereas serum IgM decreased 2-fold. The normal microbial flora was inhibitory to Listeria colonization, since L. monocytogenes was cleared from the gastrointestinal tract of formerly monoassociated rats within 20 days after conventionalization and did not colonize the gastrointestinal tract of conventional rats after intragastric instillation of 10(8) viable L. monocytogenes. Listeria-monoassociated rats delivered large litters of healthy pups whose gastrointestinal tracts were slowly colonized with L. monocytogenes. between 3 and 60 days of age, Listeria-monoassociated rat pups exhibited eight- and fourfold increases in serum IgG and IgM, respectively; however, serum IgA was elevated (16-fold) only at 9 to 15 days of age. Adult Listeria-monoassociated rats had acquired cellular resistance to intravenous challenge with L. monocytogenes. Prolonged monoassociation of L. monocytogenes in rats attenuated its virulence for conventional rats.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Czuprynski CJ,Balish Edoi
10.1128/IAI.32.1.323-331.1981subject
Has Abstractpub_date
1981-04-01 00:00:00pages
323-31issue
1eissn
0019-9567issn
1098-5522journal_volume
32pub_type
杂志文章abstract::To determine the protective efficacy of human hyperimmune globulin to Haemophilus influenzae type b disease in an infant rat model, we compared hyperimmune globulin containing 600 mug of anti-polyribophosphate (PRP) antibody per ml to conventional immune globulin containing 66 mug of anti-PRP antibody per ml. The hype...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.39.2.709-714.1983
更新日期:1983-02-01 00:00:00
abstract::The phenotypic and functional changes of glycolipid presented by CD1d(glycolipid/CD1d) specific Valpha14+ T cells in the liver of mice at early stages of bacterial infection were investigated. After Listeria monocytogenes infection or interleukin-12 (IL-12) treatment, alpha-galactosylceramide/CD1d tetramer-reactive (a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00311-06
更新日期:2006-10-01 00:00:00
abstract::In vivo accumulation of D-serine by Escherichia coli CFT073 leads to elevated expression of PAP fimbriae and hemolysin by an unknown mechanism. Loss of D-serine catabolism by CFT073 leads to a competitive advantage during murine urinary tract infection (UTI), but loss of both D- and L-serine catabolism results in atte...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00618-08
更新日期:2008-12-01 00:00:00
abstract::Group A streptococcal pyrogenic exotoxins A, B, and C (also known as scarlet fever toxins and erythrogenic toxins) were evaluated for relatedness to another streptococcus-derived lymphocyte mitogen, blastogen A. Streptococcal pyrogenic exotoxin A and blastogen A were immunologically cross-reactive and shared the same ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.6.1865-1867.1989
更新日期:1989-06-01 00:00:00
abstract::Complement receptor type 3 (CR3) was initially described as an opsonic receptor. Subsequently, CR3-mediated lectin-sugar recognition mechanisms have been shown to play a major role in the nonopsonic phagocytosis of several pathogens, among them Mycobacterium tuberculosis. Little is known about the binding and signal t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.8.4736-4745.2000
更新日期:2000-08-01 00:00:00
abstract::Black melanin-like pigments are produced by several neurotropic fungi, including Cryptococcus neoformans. Pigment production is associated with virulence. In media containing phenolic substrates such as L-dopa, C. neoformans cells become black as a result of pigment accumulation. Pigmented and nonpigmented C. neoforma...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.8.3131-3136.1995
更新日期:1995-08-01 00:00:00
abstract::The 23-membered Esx protein family is involved in the host-pathogen interactions of Mycobacterium tuberculosis. These secreted proteins are among the most immunodominant antigens recognized by the human immune system and have thus been used to develop vaccines and immunodiagnostic tests for tuberculosis (TB). Gene pai...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05344-11
更新日期:2011-10-01 00:00:00
abstract::In vitro or animal models have been used to investigate the pathogenesis of Helicobacter pylori infection. However, extrapolation to humans of results obtained with these heterologous models remains difficult. We have developed a new model for the study of H. pylori infection that uses human entire embryonic stomachs ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::A fibronectin (Fn)-binding adhesin of Staphylococcus aureus contains three tandem 37- or 38-amino-acid motifs (D1, D2, and D3), which function to bind Fn. Plasma from patients with S. aureus infections contain antibodies that preferentially recognize ligand induced binding sites in the D motifs and do not inhibit Fn b...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.3.1156-1163.2000
更新日期:2000-03-01 00:00:00
abstract::EspG is a conserved protein encoded by the locus of enterocyte effacement (LEE) of attaching and effacing (A/E) pathogens, including enteropathogenic and enterohemorrhagic Escherichia coli and Citrobacter rodentium. EspG is delivered into infected host cells by a type III secretion system. The role of EspG in virulenc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.5.2586-2594.2005
更新日期:2005-05-01 00:00:00
abstract::The P2 porin protein is the major outer membrane protein of nontypeable Haemophilus influenzae and is a potential target of a protective immune response. Nine monoclonal antibodies (MAbs) to P2 were developed by immunizing mice with nontypeable H. influenzae whole organisms. Each MAb reacted exclusively with the homol...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.9.3712-3722.1994
更新日期:1994-09-01 00:00:00
abstract::The pathogenic role of staphylococcal coagulase and clumping factor was investigated in the rat model of endocarditis. The coagulase-producing and clumping factor-producing parent strain Staphylococcus aureus Newman and a series of mutants defective in either coagulase, clumping factor, or both were tested for their a...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.12.4738-4743.1995
更新日期:1995-12-01 00:00:00
abstract::Studies were carried out to determine whether treatment of mice with the synthetic adjuvant muramyl dipeptide afforded any resistance to infection with the obligate intracellular protozoan Toxoplasma gondii. Marked resistance to lethal challenge infection was observed in CBA but not C57BL/6 mice pretreated with muramy...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.31.2.716-722.1981
更新日期:1981-02-01 00:00:00
abstract::Potassium thiocyanate extracts of a virulent Pasteurella multocida 3:A rabbit isolate were prepared and used as a vaccine in rabbits. The extract contained protein, carbohydrate, hyaluronic acid, lipopolysaccharide, DNA, and RNA. The protein and lipopolysaccharide profiles of the extract were similar to those of the P...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.12.2967-2976.1987
更新日期:1987-12-01 00:00:00
abstract::Infection with Trypanosoma cruzi, the agent of Chagas' disease, may induce antibodies and T cells reactive with self antigens (autoimmunity). Because autoimmunity is generally thought to develop during the chronic phase of infection, one hypothesis is that autoimmunity develops only after long-term, low-level stimulat...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.69.9.5643-5649.2001
更新日期:2001-09-01 00:00:00
abstract::This study was designed to evaluate the immunogenicity and the protective efficacy of a divalent fusion DNA vaccine encoding both the Brucella abortus L7/L12 protein (ribosomal protein) and Omp16 protein (outer membrane lipoprotein), designated pcDNA3.1-L7/L12-Omp16. Intramuscular injection of this divalent DNA vaccin...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.5.2734-2741.2006
更新日期:2006-05-01 00:00:00
abstract::Borrelia burgdorferi synthesizes a variety of differentially regulated outer surface lipoproteins in the tick vector and in vertebrate hosts. Among these is OspD, a protein that is highly induced in vitro by conditions that mimic the tick environment. Using genetically engineered strains in which ospD is deleted, we d...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00714-07
更新日期:2008-05-01 00:00:00
abstract::Oral inoculation of 5-day-old gnotobiotic pigs with Salmonella enterica serovar Typhimurium strain F98 resulted in severe enteritis and invasive disease. Preinoculation 24 h earlier with an avirulent mutant of Salmonella enterica serovar Infantis (1326/28) completely prevented disease for up to 14 days (when the exper...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.4.2182-2191.2003
更新日期:2003-04-01 00:00:00
abstract::The Streptococcus mutans serotype c gtfA gene encodes a 55-kilodalton sucrose-hydrolyzing enzyme. Analysis of S. mutans gtfA mutants revealed that the mutant strains were specifically impaired in the ability to use melibiose as a sole carbon source. S. mutans gtfA mutant strains synthesized less alpha-galactosidase ac...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.3.992-995.1989
更新日期:1989-03-01 00:00:00
abstract::Fibronectin binds to Streptococcus pyogenes, and this binding is inhibited by lipoteichoic acid (LTA). Previous studies have shown that LTA can be released from S. pyogenes by treatment with penicillin. Penicillin released LTA from both S. pyogenes and Staphylococcus aureus; however, the binding of fibronectin correla...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.51.2.529-535.1986
更新日期:1986-02-01 00:00:00
abstract::The bacterial pathogen Clostridium difficle synthesizes two high-molecular-weight toxins (A and B), which exhibit toxic effects in vivo and in vitro. Here, we present evidence that the major intracellular targets of these two toxins are the Rho GTPases. Overexpression of RhoA, RhoB, or RhoC GTPases in transfected HeLa...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.63.10.4063-4071.1995
更新日期:1995-10-01 00:00:00
abstract::The ability to bind Congo red (Crb+) is associated with virulence of Shigella flexneri and is encoded by a large, 220-kilobase plasmid. We cloned fragments of this plasmid to isolate the sequences encoding Congo red binding, to determine the degree of conservation of these sequences among S. flexneri strains, and to s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.54.2.435-443.1986
更新日期:1986-11-01 00:00:00
abstract::The role of CD19(+) CD5(+) and CD19(+) CD5(-) B cell subpopulations in the antibody response to pneumococcal capsular polysaccharides (caps-PSs) is controversial. In the present study, we evaluated the role of human CD19(+) CD5(+) and CD19(+) CD5(-) cell populations in the serotype-specific antibody response to caps-P...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00068-15
更新日期:2015-07-01 00:00:00
abstract::Iron acquisition from the host is an important step in the pathogenic process. While Yersinia pestis has multiple iron transporters, the yersiniabactin (Ybt) siderophore-dependent system plays a major role in iron acquisition in vitro and in vivo. In this study, we determined that the Ybt system is required for the us...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01236-09
更新日期:2010-05-01 00:00:00
abstract::Pathogenic biofilms have been associated with persistent infections due to their high resistance to antimicrobial agents, while commensal biofilms often fortify the host's immune system. Hence, controlling biofilm formation of both pathogenic bacteria and commensal bacteria is important in bacterium-related diseases. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.05580-11
更新日期:2011-12-01 00:00:00
abstract::Urogenital Chlamydia serovars replicating in reproductive epithelium pose a unique challenge to host immunity and vaccine development. Previous studies have shown that CD4 T cells are necessary and sufficient to clear primary Chlamydia muridarum genital tract infections in the mouse model, making a protective CD4 T ce...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.06339-11
更新日期:2012-06-01 00:00:00
abstract::Cytokine gene expression in cells migrating in afferent and efferent intestinal lymph was monitored for extended time periods in individual sheep experimentally infected with the nematode Trichostrongylus colubriformis. Animals from stable selection lines with increased levels of either genetic resistance (R) or susce...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.73.4.2175-2183.2005
更新日期:2005-04-01 00:00:00
abstract::Little data are available regarding L-form phagocyte interactions. Due to difficulty with more conventional methods, a serum-free technique of surface phagocytosis employing cellulose ester micropore filters, fluorochrome staining, and reflecting fluorescence microscopy was developed. Intracellular localization of L-f...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.5.6.976-981.1972
更新日期:1972-06-01 00:00:00
abstract::Heat shock protein (HSP) expression was examined in murine bone marrow-derived macrophages infected with stationary-phase promastigotes of Leishmania donovani. Immunoblotting performed with a rabbit polyclonal antiserum raised against HSP60 from Heliothis virescens (moth) revealed the de novo appearance of 65- and 67-...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.8.3265-3272.1993
更新日期:1993-08-01 00:00:00
abstract::Local gingival immunization was attempted in an effort to confine the immune response to the oral cavity and bypass the systemic immune response. A low-molecular-weight (3.8K) streptococcal antigen (SA) I/II was applied 10 times over a period of 1 year to the gingival crevices of rhesus monkeys. The antigen was mainta...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.52.3.682-687.1986
更新日期:1986-06-01 00:00:00