Transplacental transmission of Venezuelan equine encephalomyelitis virus in mice.

Abstract:

:Transplacental infection of mouse fetuses with Venezuelan equine encephalomyelitis was produced by intraperitoneal injection of dams at various stages of gestation with 10(3) suckling mouse intracerebral median lethal doses of an attenuated strain (TC-83). Virus inoculation, at times ranging from 6 days prior to mating to 9 days after conception, had no effect on conception rate, litter size, or survival of the newborn. Inoculation of the dam from the 10th to 13th days of gestation resulted in decreased litter size, an increase in stillbirths, and a decrease in birth-to-weaning survival. Inoculation of the dams later in gestation only decreased the birth-to-weaning survival. No evidence of morphologic abnormality was noted in any of the newborn.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Spertzel RO,Crabbs CL,Vaughn RE

doi

10.1128/IAI.6.3.339-343.1972

subject

Has Abstract

pub_date

1972-09-01 00:00:00

pages

339-43

issue

3

eissn

0019-9567

issn

1098-5522

journal_volume

6

pub_type

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