Abstract:
:Infection of L cells with Chlamydia psittaci inhibited the burst of deoxyribonucleic acid synthesis that occurs when the host cells are released from a double thymidine block.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Tribby II,Moulder JWdoi
10.1128/IAI.3.2.363-364.1971keywords:
subject
Has Abstractpub_date
1971-02-01 00:00:00pages
363-4issue
2eissn
0019-9567issn
1098-5522journal_volume
3pub_type
杂志文章abstract::Strain superinfection occurs when a second pathogen strain infects a host already infected with a primary strain. The selective pressures that drive strain divergence, which underlies superinfection, and allow penetration of a new strain into a host population are critical knowledge gaps relevant to shifts in infectio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02537-14
更新日期:2014-12-01 00:00:00
abstract::We have compared the intraleukocytic survival of isogenic strains of Salmonella typhimurium, whose outer membrane lipopolysaccharide differed in O antigen and lipid A composition and whose susceptibility to nonoxidative antimicrobial granule proteins of human polymorphonuclear neutrophilis (PMN) could be established. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.57.12.3894-3900.1989
更新日期:1989-12-01 00:00:00
abstract::Microbial heat shock proteins (HSP) are dominant antigens for the host immune response. Because of the high sequence homology between mammalian and microbial HSP, their value as component of a subunit vaccine has been the subject of controversy. Previous work from this laboratory, however, demonstrated for the first t...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.64.8.2955-2961.1996
更新日期:1996-08-01 00:00:00
abstract::Dendritic cells (DC) suffer a maturation defect following interaction with erythrocytes infected with malaria parasites and become unable to induce protective malaria liver-stage immunity. Here we show that, by contrast, maturation-arrested DC in vitro are capable of the successful induction of antigen-specific gamma ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.9.5331-5339.2004
更新日期:2004-09-01 00:00:00
abstract::In order to plan for the wide-scale introduction of meningococcal C conjugate (MCC) vaccine for United Kingdom children up to 18 years old, phase II trials were undertaken to investigate whether there was any interaction between MCC vaccines conjugated to tetanus toxoid (TT) or a derivative of diphtheria toxin (CRM(19...
journal_title:Infection and immunity
pub_type: 临床试验,杂志文章
doi:10.1128/iai.70.9.4946-4954.2002
更新日期:2002-09-01 00:00:00
abstract::A substance with potent decomplementation activity was isolated from staphylococcal culture supernatants by polyethylene glycol precipitation, DEAE-ion-exchange and Sephacryl chromatography, and preparative sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The purified substance exhibited all the characterist...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.47.1.47-51.1985
更新日期:1985-01-01 00:00:00
abstract::Adherence of blastoconidia to epidermal corneocytes is an early event in Candida colonization and infection of the skin. Pathogenic species adhere more avidly than nonpathogenic species, transform to hyphal growth, and invade the stratum corneum of the skin. Adherence was studied by scanning electron microscopy of exp...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.56.8.1942-1949.1988
更新日期:1988-08-01 00:00:00
abstract::The kinetics of cytotoxic T lymphocyte antigen 4 (CTLA-4) expression on T cells responding to Cryptococcus neoformans and its role in regulating the T-cell response were examined. Using peripheral blood mononuclear cells stimulated with encapsulated or acapsular C. neoformans we showed that (i) the encapsulated strain...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.3.1508-1514.2001
更新日期:2001-03-01 00:00:00
abstract::The chemoattraction of Propionibacterium acnes lipase for neutrophils and the effect of lipase inhibitor and two antibiotic agents on the chemotaxis were evaluated. Of the various fractions tested, partially purified lipase (fraction 2c) was the most active cytotaxin produced by P. acnes. Serum mediators were not requ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.35.1.71-78.1982
更新日期:1982-01-01 00:00:00
abstract::C57BL/6 mice infected with Leishmania mexicana showed depression of the in vitro immunoglobulin M-plaque-forming cell response to sheep erythrocytes. Immunodepression was present 3 weeks after inoculation and was maximal at 11 weeks. Thereafter, there was a gradual return to normal immunoresponsiveness correlated with...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.32.2.415-419.1981
更新日期:1981-05-01 00:00:00
abstract::Escherichia coli C25 maintained population levels of 10(9) to 10(10) per g of cecum and translocated to 100% of the middle mesenteric lymph nodes in gnotobiotic mice monoassociated with E. coli C25. Intragastric inoculation of these mice with the cecal contents from specific-pathogen-free mice reduced the population l...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:
更新日期:1980-09-01 00:00:00
abstract::Hydrosalpinx induction in mice by Chlamydia muridarum infection, a model that has been used to study C. trachomatis pathogenesis in women, is known to depend on the cryptic plasmid that encodes eight genes designated pgp1 to pgp8. To identify the plasmid-encoded pathogenic determinants, we evaluated C. muridarum trans...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02576-14
更新日期:2014-12-01 00:00:00
abstract::Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection (STI) gonorrhea, is a growing public health threat for which a vaccine is urgently needed. We characterized the functional role of the gonococcal MetQ protein, which is the methionine binding component of an ABC transporter system, and as...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00898-16
更新日期:2017-01-26 00:00:00
abstract::We have determined the amounts of specific anti-class 1 outer membrane protein antibodies in sera from 25 patients during the course of systemic meningococcal disease, using purified class 1 protein as the sensitizing antigen in an enzyme-linked immunosorbent assay. The class 1 protein was obtained from a variant of s...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.62.4.1437-1443.1994
更新日期:1994-04-01 00:00:00
abstract::Exoenzyme S (ExoS), an ADP-ribosylating enzyme produced by the opportunistic pathogen Pseudomonas aeruginosa, is directly translocated into eukaryotic cells by bacterial contact. Within the cell, ExoS ADP-ribosylates the cell signaling protein Ras and causes inhibition of DNA synthesis and alterations in cytoskeletal ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.6.2847-2854.1999
更新日期:1999-06-01 00:00:00
abstract::A persistent Staphylococcus epidermidis infection in mice around a subcutaneous polyvinylpyrrolidone-grafted silicon elastomer catheter (SEpvp) but not around a conventional silicon elastomer catheter was observed. With SEpvp pericatheter tissue, protracted and exaggerated interleukin-1beta (IL-1beta) production was f...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.3.1692-1695.2000
更新日期:2000-03-01 00:00:00
abstract::Antimicrobial peptides (AMPs), such as β-defensins and cathelicidins, are essential components of innate and adaptive immunity owing to their extensive multifunctional activities. However, their role in fungal infection in vivo remains elusive. In this study, we investigated the protective effect of murine β-defensin ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00179-13
更新日期:2013-08-01 00:00:00
abstract::This study has demonstrated the extreme sensitivity of Chlamydia trachomatis growing in McCoy cells to small changes in external amino acid supply. In the absence of cycloheximide, a decrease in the amino acid concentration of medium to 75% of control values was sufficient to induce the growth of enlarged chlamydial f...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.68.3.1457-1464.2000
更新日期:2000-03-01 00:00:00
abstract::Ribosomes of strain NOR-7 of group B Neisseria meningitidis were isolated by a procedure that included treatment of the cells with sodium dodecyl sulfate, disruption in a French pressure cell, and differential centrifugation. These preparations consisted of 66% ribonucleic acid and 24% protein and sedimented as a sing...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.6.3.355-363.1972
更新日期:1972-09-01 00:00:00
abstract::Passive protection, the administration of antibodies to prevent infection, has garnered significant interest in recent years as a potential prophylactic countermeasure to decrease the prevalence of hospital-acquired infections. Pili, polymerized protein structures covalently anchored to the peptidoglycan wall of many ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01403-13
更新日期:2014-04-01 00:00:00
abstract::Sequestration of Plasmodium falciparum-infected erythrocytes to the capillary endothelium can cause obstruction and localized tissue damage. Occlusion of vessels in falciparum malaria infection has been related to two properties of the parasite: adhesion to endothelial cells and rosette formation. Our study on P. falc...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.11.4483-4490.1992
更新日期:1992-11-01 00:00:00
abstract::Nonviable Mycobacterium tuberculosis strain Jamaica suspended in oil-droplet emulsions was used to enhance resistance of mice against encephalomyocarditis virus (EMCV). The mycobacteria-injected mice were significantly resistant to 50,000 50% lethal doses of EMCV. Similar concentrations of virus in plasma of normal an...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.22.3.740-745.1978
更新日期:1978-12-01 00:00:00
abstract::Mice were rendered deficient in B-cell activity by treatment with anti-mu antibody from birth. These animals were then infected intranasally with murine Chlamydia trachomatis (murine pneumonitis agent [MoPn]). They produced neither local nor systemic antibody to MoPn but had intact delayed-type hypersensitivity to MoP...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.55.10.2387-2390.1987
更新日期:1987-10-01 00:00:00
abstract::Challenges with the production and suboptimal immunogenicity of malaria vaccine candidates have slowed the development of a Plasmodium falciparum multiantigen vaccine. Attempting to resolve these issues, we focused on the use of highly immunogenic merozoite surface protein 8 (MSP8) as a vaccine carrier protein. Previo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00486-17
更新日期:2017-12-19 00:00:00
abstract::The cellular source of interleukin-6 (IL-6) during infection of mice with Listeria monocytogenes was investigated both in vitro and in vivo. Peritoneal cells taken at intervals from infected mice and cultured in vitro without added stimulus produced high titers of IL-6 peaking 2 days postinfection in a time course sim...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.6.2626-2631.1993
更新日期:1993-06-01 00:00:00
abstract::Although protective immunity in C57BL/6 mice induced by a single dose of the radiation-attenuated schistosome vaccine is believed to be mediated by Th1-type immune responses, we here report that in BALB/c mice protection can also depend upon signaling via the interleukin-4 (IL-4) receptor which conventionally governs ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.69.1.228-236.2001
更新日期:2001-01-01 00:00:00
abstract::Glucan-binding protein B (GbpB) from Streptococcus mutans has been shown to induce protective immunity to dental caries in experimental models. Having recently sequenced the gbpB gene, our objective in this study was to identify immunogenic regions within the GbpB sequence for use in subunit vaccines. Potential region...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/iai.71.3.1179-1184.2003
更新日期:2003-03-01 00:00:00
abstract::The immunogenicity of a single dose of a whole-cell vaccine of inactivated Borrelia burgdorferi HSF (human spinal fluid isolate) was evaluated. Syrian hamsters were vaccinated subcutaneously and challenged by the intraperitoneal injection of 1,000 50% infectious doses of B. burgdorferi HSF 30 or 90 days postvaccinatio...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.54.3.897-898.1986
更新日期:1986-12-01 00:00:00
abstract::Mycoplasma gallisepticum is an avian respiratory and reproductive tract pathogen that has a significant economic impact on the poultry industry worldwide. Although membrane proteins of Mycoplasma spp. are thought to play crucial roles in host interactions, very few have had their biochemical function defined. In this ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00248-19
更新日期:2019-08-21 00:00:00
abstract::A murine model system was established to study immune responses to the Pnu-Imune vaccine, which is made up of 23 different pneumococcal capsular polysaccharides. In this animal model, antibody-forming cell responses to 21 of 23 individual polysaccharides in the vaccine were detected. The Pnu-Imune vaccine elicited goo...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.6.2329-2336.1992
更新日期:1992-06-01 00:00:00