Abstract:
:C57BL/6 mice infected with Leishmania mexicana showed depression of the in vitro immunoglobulin M-plaque-forming cell response to sheep erythrocytes. Immunodepression was present 3 weeks after inoculation and was maximal at 11 weeks. Thereafter, there was a gradual return to normal immunoresponsiveness correlated with the resolution of lesions. At the time of maximal immunodepression, spleen cells from infected mice diminished the plaque-forming cell response to sheep erythrocytes of normal spleen cells. On the other hand, specific responses, as exemplified by protective immunity to a challenge infection and delayed hypersensitivity responses to parasite antigens, were apparently unaffected. These responses were both present in mice bearing primary lesions and were maximal in recovered mice. The significance of these findings is discussed in relation to a current hypothesis on parasite-induced immunodepression.
journal_name
Infect Immunjournal_title
Infection and immunityauthors
Pérez H,Pocino M,Malavé Idoi
10.1128/IAI.32.2.415-419.1981subject
Has Abstractpub_date
1981-05-01 00:00:00pages
415-9issue
2eissn
0019-9567issn
1098-5522journal_volume
32pub_type
杂志文章abstract::The effect of a deficiency in the C5 component of complement on the pathophyisology of infection with the fungal pathogen Candida albicans was studied by using the A/J inbred mouse strain and the BcA17 congenic mouse strain. Acute infection caused by intravenous injection of C. albicans blastospores is associated with...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00159-06
更新日期:2006-08-01 00:00:00
abstract::We have developed an in vitro assay to study the intramacrophage replication of Mycobacterium tuberculosis or Mycobacterium bovis BCG. In this assay, extracellular mycobacterial replication was avoided by using a small infecting inoculum and a new method for efficiently removing nonphagocytocytized bacilli. The abilit...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.37.2.786-793.1982
更新日期:1982-08-01 00:00:00
abstract::The expression of T cell differentiation markers is known to increase during Mycobacterium tuberculosis infection, and yet the biological role of such markers remains unclear. We examined the requirement of the T cell differentiation marker killer cell lectin-like receptor G1 (KLRG1) during M. tuberculosis infection u...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01199-12
更新日期:2013-04-01 00:00:00
abstract::Dentilisin is a major surface protease and virulence factor of the bacterium Treponema denticola. In this study, we found that T. denticola reduced inflammatory cytokines, including interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor alpha, in peripheral blood mononuclear cells through degradation by dentili...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.4.2462-2467.2006
更新日期:2006-04-01 00:00:00
abstract::Clostridium perfringens type B causes enteritis and enterotoxemia in domestic animals. By definition, these bacteria must produce alpha toxin (CPA), beta toxin (CPB) and epsilon toxin (ETX) although most type B strains also produce perfringolysin O (PFO) and beta2 toxin (CPB2). A recently identified Agr-like quorum-se...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00438-12
更新日期:2012-09-01 00:00:00
abstract::No studies to date clearly define the interactions between Porphyromonas gingivalis and human peripheral blood polymorphonuclear leukocytes (PMN), nor has a protective role for antibody to P. gingivalis been defined. Using a fluorochrome phagocytosis microassay, we investigated PMN phagocytosis and killing of P. gingi...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.59.6.2097-2104.1991
更新日期:1991-06-01 00:00:00
abstract::The P8 proteoglycolipid complex (P8 PGLC) is a glyconjugate expressed by Leishmania mexicana complex parasites. We previously have shown that vaccination with P8 PGLC provides protection against cutaneous leishmaniasis in susceptible BALB/c mice. However, the biological importance of this complex remains unknown. Here...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.01528-07
更新日期:2008-05-01 00:00:00
abstract::Infantile gastroenteritis virus (orbi-group) recovered from stools of infants with acute nonbacterial gastroenteritis was administered per os to germfree and conventional piglets. Virus was found subsequently in stools and in the mucosal epithelial cells of the small intestine of these animals. Some animals developed ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.12.6.1276-1280.1975
更新日期:1975-12-01 00:00:00
abstract::Neonates born to female guinea pigs of either a highly susceptible (C4D) or a resistant (Albany) strain, infected prior to or during pregnancy with a single dose of Treponema pallidum, showed in their sera from the first day of life immunoglobulin M (IgM) antibodies to T. pallidum, circulating immune complexes consist...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.60.1.271-277.1992
更新日期:1992-01-01 00:00:00
abstract::Rabbit synovial cells (SC), articular chondrocytes (AC), and epiphyseal (EC) chondrocytes were grown in vitro. A portion of the spectrum of human pathogenic viruses infective for the cells was determined. Responses of the cells to different viruses or a chemical inducer of interferon varied, with EC responding vigorou...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.8.3.425-429.1973
更新日期:1973-09-01 00:00:00
abstract::Rickettsia rickettsii and R. australis formed infectious antibody complexes when reacted with homologous convalescent serum. The addition of antiglobulin to these complexes showed neutralization of plaques proportional to the concentration of rickettsial immune serum. ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.5.966-968.1974
更新日期:1974-05-01 00:00:00
abstract::Only listeriolysin O (LLO)-producing strains of Listeria monocytogenes generate protective immunity in mice. Based on the findings that endogenous gamma interferon (IFN-gamma) production was induced only by such strains and that purified LLO could induce IFN-gamma from NK cells, we have postulated that LLO may play a ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.67.2.568-575.1999
更新日期:1999-02-01 00:00:00
abstract::Group A streptococci isolated from skin adhere in greater numbers to human skin epithelial cells than to cells obtained from buccal mucosa whereas streptococci isolated from a throat tend to adhere in greater numbers to buccal epithelial cells than to skin epithelial cells in vitro. M protein-producing strains of grou...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.18.2.555-557.1977
更新日期:1977-11-01 00:00:00
abstract::The Lyme disease spirochete, Borrelia burgdorferi, controls protein expression patterns during its tick-mammal infection cycle. Earlier studies demonstrated that B. burgdorferi synthesizes 4,5-dihydroxy-2,3-pentanedione (autoinducer-2 [AI-2]) and responds to AI-2 by measurably changing production of several infection-...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00032-15
更新日期:2015-04-01 00:00:00
abstract::Leukosis viruses of seven subgroups were tested for oncogenicity in chickens susceptible to virus infection and to development of lymphoid leukosis (LL) tumors. All subgroup A viruses and the subgroup B virus tested produced a high incidence of LL and other related neoplasms. Viruses of subgroup C and RAV-61 of subgro...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.15.2.423-428.1977
更新日期:1977-02-01 00:00:00
abstract::Binding of radiolabeled human fibrinogen and aggregated beta-microglobulin was measured in 60 strains of beta-hemolytic group B streptococci. Positive fibrinogen binding was detected in seven of the strains. Six of the group B strains showed an uptake of aggregated beta 2-microglobulin. Four individual strains carried...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.31.3.856-861.1981
更新日期:1981-03-01 00:00:00
abstract::Relapsing fever (RF) is a spirochetal infection characterized by relapses of a febrile illness and spirochetemia due to the sequential appearance and disappearance of isogenic serotypes in the blood. The only difference between isogenic serotypes is the variable major outer membrane lipoprotein. In the absence of spec...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00538-06
更新日期:2006-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.02006-06
更新日期:2007-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.50.2.483-487.1985
更新日期:1985-11-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.12.7367-7373.2004
更新日期:2004-12-01 00:00:00
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journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.10.6.1292-1295.1974
更新日期:1974-12-01 00:00:00
abstract::Chlamydia trachomatis is an obligate intracellular pathogen that causes sexually transmitted disease. In women, chlamydial infections may cause pelvic inflammatory disease (PID), ectopic pregnancy, and infertility. The role of antibodies in protection against a primary Chlamydia infection is unclear and was a focus of...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00413-20
更新日期:2020-12-15 00:00:00
abstract::Yersinia species pathogenic to humans have been extensively characterized with respect to type III secretion and its essential role in virulence. This study concerns the twin arginine translocation (Tat) pathway utilized by gram-negative bacteria to secrete folded proteins across the bacterial inner membrane into the ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.74.3.1768-1776.2006
更新日期:2006-03-01 00:00:00
abstract::Development of hemolytic uremic syndrome (HUS) after infection by Shigella dysenteriae 1 or enterohemorrhagic Escherichia coli has been associated with the production of Shiga toxins (verotoxins). The putative target of Shiga toxins in HUS is the renal microvascular endothelium. This report shows that preincubation of...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.61.9.3886-3891.1993
更新日期:1993-09-01 00:00:00
abstract::We compared the immune defense of mice with chronic granulomatous disease (CGD mice) with that of wild-type C57BL/6 mice for their response to Sporothrix schenckii. A subcutaneous injection of 5 x 10(4) CFU S. schenckii strain IFM41598 into CGD mice resulted in systemic infection and death within 84 days. In contrast,...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.9.5073-5079.2004
更新日期:2004-09-01 00:00:00
abstract::Microsporidia are obligate intracellular parasites that are ubiquitous in nature and have been recognized as causing an important emerging disease among immunocompromised individuals. Limited knowledge exists about the immune response against these organisms, and virtually nothing is known about the receptors involved...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.00733-08
更新日期:2008-10-01 00:00:00
abstract::The antigenic relationship of six different strains of Paracoccidioides brasiliensis was investigated by the agar-gel immunodiffusion test. Soluble antigens prepared from the two morphological phases of the fungus were diffused against human sera obtained from eight patients with paracoccidioidomycosis (South American...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.2.3.268-273.1970
更新日期:1970-09-01 00:00:00
abstract::Eight chlamydial isolates of ovine origin were tested in a plaque reduction system using homologous and heterologous rooster antisera. The eight isolates could be separated into two separate immunotypes. Type 1 included isolates associated with ovine abortion and one agent recovered from the feces of an apparently nor...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.9.1.92-94.1974
更新日期:1974-01-01 00:00:00
abstract::In a cross-sectional survey of 187 Gambian children and adults, we have analyzed prevalence, fine specificity, and 19-kilodalton merozoite surface protein 1 (MSP-1(19))-specific erythrocyte invasion inhibitory activity of antibodies to MSP-1(19) but find no significant association between any of these parameters and p...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.72.10.6185-6189.2004
更新日期:2004-10-01 00:00:00
abstract::A novel immunobiologically active fraction was prepared from a phenol-water extract of Prevotella intermedia ATCC 25611 by Sephadex G-100 column chromatography. The fraction consisted mainly of carbohydrate and protein and was devoid of fatty acid. The fraction showed high-molecular-weight bands (10,000 to 12,000) on ...
journal_title:Infection and immunity
pub_type: 杂志文章
doi:10.1128/IAI.65.11.4531-4538.1997
更新日期:1997-11-01 00:00:00