The twin arginine translocation system is essential for virulence of Yersinia pseudotuberculosis.

abstract：:Minimally manipulated nasal secretions, an accessible form of airway surface fluid, were tested against indigenous and added bacteria by using CFU assays. Antimicrobial activity was found to vary between donors and with different target bacteria and was markedly diminished by dilution of the airway secretions. Donor-t...

journal_title：Infection and immunity

authors： Cole AM,Dewan P,Ganz T

更新日期：1999-07-01 00:00:00

abstract：:Haemophilus ducreyi expresses 2 OmpA homologs, designated MOMP and OmpA2, whose genes are arranged in tandem on the chromosome. Northern blot analysis indicated that momp and ompA2 are transcribed independently. Sequences of the momp open reading frame (ORF) lacking the transcriptional start site were amplified by PCR...

journal_title：Infection and immunity

authors： Throm RE,Al-Tawfiq JA,Fortney KR,Katz BP,Hood AF,Slaughter CA,Hansen EJ,Spinola SM

更新日期：2000-05-01 00:00:00

abstract：:Mutation of sarA resulted in a reduced capacity to form a biofilm in six of the eight Staphylococcus aureus strains we tested (UAMS-1, UAMS-601, SA113, SC-01, S6C, and DB). The exceptions were Newman, which formed a poor biofilm under all conditions, and RN6390, which consistently formed a biofilm only after mutation ...

journal_title：Infection and immunity

authors： Beenken KE,Blevins JS,Smeltzer MS

更新日期：2003-07-01 00:00:00

abstract：:Cryptosporidial infections in severe combined immune deficient (SCID) mice produce a chronic disease state which in the later stages leads to extraintestinal involvement and hepatic dysfunction. To further characterize the infection dynamics in this model and monitor the changes in the hepatic system, a dose titration...

journal_title：Infection and immunity

authors： Mead JR,Ilksoy N,You X,Belenkaya Y,Arrowood MJ,Fallon MT,Schinazi RF

更新日期：1994-05-01 00:00:00

abstract：:The importance of CD4+ cells and gamma interferon (IFN-gamma) in the resolution of established Cryptosporidium parvum infection was investigated with a murine model of cryptosporidiosis in severe combined immunodeficient (SCID) mice. C. parvum-infected SCID mice were reconstituted with spleen cells from immunocompeten...

journal_title：Infection and immunity

authors： Chen W,Harp JA,Harmsen AG

更新日期：1993-09-01 00:00:00

abstract：:The primary effector for Shigella invasion of epithelial cells is IpaC, which is secreted via a type III secretion system. We recently reported that the IpaC N terminus is required for type III secretion and possibly other functions. In this study, mutagenesis was used to identify an N-terminal secretion signal and to...

journal_title：Infection and immunity

authors： Harrington AT,Hearn PD,Picking WL,Barker JR,Wessel A,Picking WD

更新日期：2003-03-01 00:00:00

abstract：:Genome sequencing of the relapsing fever spirochetes Borrelia hermsii and Borrelia turicatae identified three open reading frames (ORFs) on the chromosomes that contained internal, tandemly repeated amino acid sequences that were absent in the Lyme disease spirochete Borrelia burgdorferi. The predicted amino acid sequ...

journal_title：Infection and immunity

authors： Guyard C,Chester EM,Raffel SJ,Schrumpf ME,Policastro PF,Porcella SF,Leong JM,Schwan TG

更新日期：2005-05-01 00:00:00

abstract：:Mannheimia haemolytica, a commensal organism of the upper respiratory tract in cattle, is the principal bacterial pathogen associated with the bovine respiratory disease complex. Adherence to the respiratory mucosa is a crucial event in its pathogenesis. However, the bacterial components that contribute to this proces...

journal_title：Infection and immunity

authors： Kisiela DI,Czuprynski CJ

更新日期：2009-01-01 00:00:00

abstract：:Random-bred mice were immunized with a nonliving antigen prepared from mixed-blood forms of Plasmodium berghei, strain NYU-2, in combination with Corynebacterium parvum and/or living BCG. A high proportion of intravenously immunized mice survived virulent challenge, but subcutaneous vaccination was less effective. Vac...

journal_title：Infection and immunity

authors： Murphy JR,Lefford MJ

更新日期：1978-12-01 00:00:00

abstract：:Antisera were raised in rabbits with acid-treated Re mutant bacteria from Salmonella minnesota and Escherichia coli and tested in a passive hemolysis assay with di- and monophosphorylated free lipid A of E. coli (LipA-Ac and LipA-HCl, respectively) coated onto sheep erythrocytes. Depending on the acid used to prepare ...

journal_title：Infection and immunity

authors： Brade L,Brade H

更新日期：1985-06-01 00:00:00

abstract：:We examined the way the major outer membrane protein OmpA of Salmonella enterica serovar Typhimurium is recognized by the mouse immune system, by raising a panel of 12 monoclonal antibodies (MAbs) against this protein. Interaction between OmpA and these MAbs is competitively inhibited with several-hundredfold dilution...

journal_title：Infection and immunity

authors： Singh SP,Williams YU,Miller S,Nikaido H

更新日期：2003-07-01 00:00:00

abstract：:The ocular surface is continuously exposed to potential pathogens, including free-living amoebae. Acanthamoeba species are among the most ubiquitous amoebae, yet Acanthamoeba keratitis is remarkably rare. The pathogenesis of Acanthamoeba keratitis is a complex, sequential process. Here we show that Acanthamoeba kerati...

journal_title：Infection and immunity

authors： Alizadeh H,Neelam S,Hurt M,Niederkorn JY

更新日期：2005-02-01 00:00:00

abstract：:Inbred BALB/c mice were either immunized with Triton X-100-extracted antigens of blood-stage Plasmodium yoelii or infected with P. yoelii and cured in three successive schedules. Whereas the immunized BALB/c became only partially protected from subsequent challenge infection with blood-stage P. yoelii, the convalescen...

journal_title：Infection and immunity

authors： Kironde FA,Kumar A,Nayak AR,Kraikov JL

更新日期：1991-11-01 00:00:00

abstract：:Gamma interferon (IFN-gamma) plays an important role in experimental Trypanosoma cruzi infections, presumably by controlling the early replication of parasites in host macrophages. In this work, we show that NK cells represent an important cell type responsible for the production of most of the IFN-gamma in the early ...

journal_title：Infection and immunity

authors： Cardillo F,Voltarelli JC,Reed SG,Silva JS

更新日期：1996-01-01 00:00:00

abstract：:Toll-like receptor (TLR)-based signaling pathways in the host may be modulated by pathogens during the course of infection. We describe a novel immunomodulatory mechanism in which Aspergillus fumigatus conidia induce attenuation of TLR2- and TLR4-mediated interleukin (IL)-6 and IL-1beta proinflammatory responses in hu...

journal_title：Infection and immunity

authors： Chai LY,Kullberg BJ,Vonk AG,Warris A,Cambi A,Latgé JP,Joosten LA,van der Meer JW,Netea MG

更新日期：2009-05-01 00:00:00

abstract：:Salmonella infection can cause gastroenteritis in healthy individuals or a serious, systemic infection in immunocompromised patients and has a global impact. CD4 Th1 cells represent the main lymphocyte population that participates in bacterial clearance during both primary and secondary infections in mice of the H-2b ...

journal_title：Infection and immunity

authors： Labuda JC,Depew CE,Pham OH,Benoun JM,Ramirez NA,McSorley SJ

更新日期：2019-10-18 00:00:00

abstract：:Borrelia burgdorferi encodes a functional homolog of canonical Lon protease termed Lon-2. In addition, B. burgdorferi encodes a second Lon homolog called Lon-1. Recent studies suggest that Lon-1 may function differently from the prototypical Lon protease. However, the function of Lon-1 in B. burgdorferi biology remain...

journal_title：Infection and immunity

authors： Thompson C,Mason C,Parrilla S,Ouyang Z

更新日期：2020-05-20 00:00:00

abstract：:The lack of specific T-cell help in immune responses to thymus-independent antigens results in weak, predominantly immunoglobulin M-mediated immunity with little or no memory. In the work presented here we show how the exogenous stimulation of CD40 by monoclonal antibodies can mimic T-cell help, resulting in enhanced ...

journal_title：Infection and immunity

authors： Barr TA,Heath AW

更新日期：1999-07-01 00:00:00

abstract：:A Pasteurella haemolytica mutant incapable of producing leukotoxin was created by allelic replacement. Concentrated culture supernatants from wild-type P. haemolytica, but not from the mutant, contained the 102-kDa leukotoxin protein and lysed bovine lymphoma cells and sheep erythrocytes. Wild-type P. haemolytica demo...

journal_title：Infection and immunity

authors： Murphy GL,Whitworth LC,Clinkenbeard KD,Clinkenbeard PA

更新日期：1995-08-01 00:00:00

abstract：:Natural antibodies are those immunoglobulin molecules found in mammalian serum that arise in the absence of exposure to environmental pathogens and may comprise an early host defense against invading pathogens. The spirochete Borrelia burgdorferi first encounters natural antibodies when its arthropod vector, Ixodes sc...

journal_title：Infection and immunity

authors： Belperron AA,Bockenstedt LK

更新日期：2001-10-01 00:00:00

abstract：:The plasmid-encoded structural gene cofA necessary for the production of the major pilin subunit of pilus colonization factor antigen III (CFA/III) of human enterotoxigenic Escherichia coli was identified, and the nucleotide sequence of the gene was determined. cofA consists of 714 nucleotides encoding a 238-amino-aci...

journal_title：Infection and immunity

authors： Taniguchi T,Fujino Y,Yamamoto K,Miwatani T,Honda T

更新日期：1995-02-01 00:00:00

abstract：:The 18-kilodalton (kDa) antigen of Mycobacterium leprae was expressed as a fusion protein with a 2-kDa leader peptide and used in proliferation assays with peripheral blood cells. Fifty percent of untreated tuberculoid leprosy patients and 93% of long-term leprosy contacts responded to the recombinant protein in lymph...

journal_title：Infection and immunity

authors： Dockrell HM,Stoker NG,Lee SP,Jackson M,Grant KA,Jouy NF,Lucas SB,Hasan R,Hussain R,McAdam KP

更新日期：1989-07-01 00:00:00

abstract：:In vivo accumulation of D-serine by Escherichia coli CFT073 leads to elevated expression of PAP fimbriae and hemolysin by an unknown mechanism. Loss of D-serine catabolism by CFT073 leads to a competitive advantage during murine urinary tract infection (UTI), but loss of both D- and L-serine catabolism results in atte...

journal_title：Infection and immunity

authors： Anfora AT,Halladin DK,Haugen BJ,Welch RA

更新日期：2008-12-01 00:00:00

abstract：:Recent efforts to develop a vaccine against the diarrheal disease cholera have focused on the use of live attenuated strains of the causative organism, Vibrio cholerae. The Ogawa lipopolysaccharide phenotype is expressed by many epidemic strains, and motility defects reduce the risk of reactive diarrhea in vaccine rec...

journal_title：Infection and immunity

authors： Chiang SL,Mekalanos JJ

更新日期：2000-11-01 00:00:00

abstract：:Proteins were extracted at pH 2.5 from carefully washed brain homogenates of patients with subacute sclerosing panencephalitis. Immunoglobulin G was isolated from the extracts by gel filtration and immunoadsorbent chromatography and was 125I radioiodinated. The labeled immunoglobulin G was reacted with purified measle...

journal_title：Infection and immunity

authors： Weil ML,Norrby E,Itabashi HH,Wilson R,Tourtellotte WW,Heiner DC

更新日期：1979-04-01 00:00:00

abstract：:The nonacylated form of protein D (PDm) of Haemophilus influenzae has been shown to induce the production of antibodies that are bactericidal to homologous and heterologous nontypeable H. influenzae (NTHi) strains. In this study, immunization of rats with lipoprotein D (LPD) induced higher levels of anti-protein D imm...

journal_title：Infection and immunity

authors： Akkoyunlu M,Melhus A,Capiau C,van Opstal O,Forsgren A

更新日期：1997-12-01 00:00:00

abstract：:Mice given Mycobacterium tuberculosis bacilli via the respiratory route succumbed much sooner to infection than mice given 1,000 times more bacilli via the intravenous route. Vaccination provided increased protection to an M. tuberculosis challenge infection; however, mice infected via the respiratory route remained m...

journal_title：Infection and immunity

authors： North RJ,LaCourse R,Ryan L

更新日期：1999-04-01 00:00:00

abstract：:Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglob...

journal_title：Infection and immunity

authors： Collin M,Olsén A

更新日期：2001-11-01 00:00:00

abstract：:The mechanism by which hamsters acquire resistance to yaws or frambesia is poorly understood. This investigation has shown that immune lymphoid cells (spleen and lymph node) could confer on hamsters resistance to infection with Treponema pertenue. Treatment of these immune cells with a specific antithymocyte serum (AT...

journal_title：Infection and immunity

authors： Chan JK,Schell RF,LeFrock JL

更新日期：1979-07-01 00:00:00

abstract：:The effect of human-specific antibody on surface membrane antigens of trypomastigotes of Trypanosoma cruzi was studied in vitro by using immunofluorescence methods. Immune sera induced aggregation of surface antigens in trypomastigotes to form polar cell caps. ...

journal_title：Infection and immunity

authors： Schmuñis GA,Szarfman A,Langembach T,de Souza W

更新日期：1978-05-01 00:00:00