Shiga toxin-associated hemolytic uremic syndrome: interleukin-1 beta enhancement of Shiga toxin cytotoxicity toward human vascular endothelial cells in vitro.

abstract：:Nontypeable Haemophilus influenzae (NTHi) is a commensal microorganism of the human nasopharynx, and yet is also an opportunistic pathogen of the upper and lower respiratory tracts. Host microenvironments influence gene expression patterns, likely critical for NTHi persistence. The host sequesters iron as a mechanism ...

journal_title：Infection and immunity

authors： Harrison A,Santana EA,Szelestey BR,Newsom DE,White P,Mason KM

更新日期：2013-04-01 00:00:00

abstract：:Normal cell polarity protects epithelial cells against Pseudomonas aeruginosa invasion and cytotoxicity. Using epithelial cell clones with selective defects in sorting of membrane constituents, and using hepatocyte growth factor pretreatment, we found that polarized susceptibility to P. aeruginosa can be altered witho...

journal_title：Infection and immunity

authors： Fleiszig SM,Vallas V,Jun CH,Mok L,Balkovetz DF,Roth MG,Mostov KE

更新日期：1998-07-01 00:00:00

abstract：:The antigenically variant Chlamydia trachomatis major outer membrane protein (MOMP) is a target of antibody-mediated neutralization in vitro, and it is an important protein for designing a subunit vaccine. Knowledge of MOMP T-cell determinants will be essential to elicit rapid and strong immune responses following an ...

journal_title：Infection and immunity

authors： Ishizaki M,Allen JE,Beatty PR,Stephens RS

更新日期：1992-09-01 00:00:00

abstract：:The antigenic relationship of six different strains of Paracoccidioides brasiliensis was investigated by the agar-gel immunodiffusion test. Soluble antigens prepared from the two morphological phases of the fungus were diffused against human sera obtained from eight patients with paracoccidioidomycosis (South American...

journal_title：Infection and immunity

authors： Restrepo-Moreno A

更新日期：1970-09-01 00:00:00

abstract：:Vaccine adjuvants exert critical and unique influences on the quality of immune responses induced during active immunizations. We investigated the mechanisms of action of immunological adjuvants in terms of their requirements for cytokine-mediated pathways for adjuvanticity. Antibody responses potentiated by several a...

journal_title：Infection and immunity

authors： Hui GS,Hashimoto CN

更新日期：1998-11-01 00:00:00

abstract：:We have studied polyacryl starch microparticles as an adjuvant in oral vaccination in mice. Secreted antigens from Salmonella enterica serovar Enteritidis were administered covalently conjugated to microparticles, or as free antigens, orally or intramuscularly and evaluated for their immunogenicity and ability to elic...

journal_title：Infection and immunity

authors： Strindelius L,Degling Wikingsson L,Sjöholm I

更新日期：2002-03-01 00:00:00

abstract：:A canine distemper virus (CDV), DESIGNATED R252, originally recovered from a dog with demyelinating encephalomyelitis was shown to reproduce this disease in gnotobiotic dogs with a high incidence as compared to other CDV strains, which produced an acute fatal infection. In this investigation, R252 was propagated for t...

journal_title：Infection and immunity

authors： Confer AW,Kahn DE,Koestner A,Krakowka S

更新日期：1975-04-01 00:00:00

abstract：:Immunization of BALB/c mice with a plasmid containing the gene for Trypanosoma cruzi trans-sialidase (TS) induced antibodies that inhibited TS enzymatic activity, CD4+ Th1 and CD8+ Tc1 cells, and protective immunity against infection. We used this model to obtain basic information on the requirement of CD4 or CD8 or B...

journal_title：Infection and immunity

authors： Fujimura AE,Kinoshita SS,Pereira-Chioccola VL,Rodrigues MM

更新日期：2001-09-01 00:00:00

abstract：:The literature on chronic mucocutaneous candidiasis contains multiple reports which suggest that loss of cell-mediated immunity in this disease may be related in part to the presence of an inhibitory factor(s) present in patient plasma. One such inhibitory factor has been suggested to be mannan polysaccharide released...

journal_title：Infection and immunity

authors： Nelson RD,Herron MJ,McCormack RT,Gehrz RC

更新日期：1984-03-01 00:00:00

abstract：:Ocular exposure of mice to live elementary bodies of Chlamydia trachomatis serovar A results in immunological sensitization of the mice. This reactivity is manifested by the development of early (5 h) and delayed-type (24 h) dermal reactivity and serovar-specific antibody formation against either live or irradiated (1...

journal_title：Infection and immunity

authors： Colley DG,Goodman TG,Barsoum IS

更新日期：1986-10-01 00:00:00

abstract：:Viral hepatitis caused by infection with murine hepatitis virus strain A59 has been shown to affect the mitotic response after partial hepatectomy in mice. Normal mice showed a delayed response, whereas nude mice did not show any response, even 5 days after partial hepatectomy. ...

journal_title：Infection and immunity

authors： Carthew P

更新日期：1981-08-01 00:00:00

abstract：:The rationale for the present study was to determine how different species of bacteria interact with cells of the human meninges in order to gain information that would have broad relevance to understanding aspects of the innate immune response in the brain. Neisseria lactamica is an occasional cause of meningitis in ...

journal_title：Infection and immunity

authors： Fowler MI,Yin KY,Humphries HE,Heckels JE,Christodoulides M

更新日期：2006-11-01 00:00:00

abstract：:We have previously described a new system for the delivery of recombinant antigens in live Salmonella vaccines as genetic fusions to the C terminus of fragment C of tetanus toxin (TetC) driven by the anaerobically inducible nirB promoter. It has been reported that preimmunization with tetanus toxoid (TT) can suppress ...

journal_title：Infection and immunity

authors： Chabalgoity JA,Villareal-Ramos B,Khan CM,Chatfield SN,de Hormaeche RD,Hormaeche CE

更新日期：1995-07-01 00:00:00

abstract：:The antihistoplasma activity of recombinant murine gamma interferon (rMuIFN-gamma)-treated macrophages of the RAW 264.7 cell line depends on the generation of nitric oxide (NO.) from L-arginine. Macrophages of the P388D1 cell line treated with rMuIFN-gamma do not produce NO. or inhibit the intracellular growth of Hist...

journal_title：Infection and immunity

authors： Lane TE,Otero GC,Wu-Hsieh BA,Howard DH

更新日期：1994-04-01 00:00:00

abstract：:Detailed structural studies were undertaken on five isolates of bovine rotavirus which showed variability in the migration patterns of their genome segments on electrophoresis in polyacrylamide gels. The individual genome segments of each isolate were characterized by partial digestion of terminally radiolabeled RNA w...

journal_title：Infection and immunity

authors： Clarke IN,McCrae MA

更新日期：1982-05-01 00:00:00

abstract：:Our previous studies identified two iron-regulated cytoplasmic membrane proteins of 32 and 36 kDa expressed by both Staphylococcus epidermidis and Staphylococcus aureus. In this study we show by Triton X-114 phase partitioning and tritiated palmitic acid labelling that these proteins are lipoproteins which are anchore...

journal_title：Infection and immunity

authors： Cockayne A,Hill PJ,Powell NB,Bishop K,Sims C,Williams P

更新日期：1998-08-01 00:00:00

abstract：:Lymphocytes derived from 72- to 90-day-old fetal piglet thymuses respond in vitro to phytohemagglutinin quantitatively greater than do spleen cell lymphocytes. ...

journal_title：Infection and immunity

authors： Rodey GE,Day N,Holmes-Gray B,Good RA

更新日期：1972-03-01 00:00:00

abstract：:Infection with tissue-migrating helminths is frequently associated with intense granulocyte infiltrations. Several host-derived factors are known to mediate granulocyte recruitment to the tissues, but less attention has been paid to how parasite-derived products trigger this process. Parasite-derived chemotactic facto...

journal_title：Infection and immunity

authors： Falcone FH,Rossi AG,Sharkey R,Brown AP,Pritchard DI,Maizels RM

更新日期：2001-06-01 00:00:00

abstract：:Sodium dodecyl sulfate-polyacrylamide gel electrophoresis patterns of proteins and externally exposed labeled surface constituents were analyzed in promastigotes of three etiological agents of kala azar (Leishmania donovani, HS70 strain from India; L. chagasi, Imperatriz strain from Brazil; L. infantum, ITMPA K263 str...

journal_title：Infection and immunity

authors： Lemesre JL,Rizvi FS,Afchain D,Sadigursky M,Capron A,Santoro F

更新日期：1985-10-01 00:00:00

abstract：:Cryptococcus neoformans is surrounded by a capsular polysaccharide. There are at least four known serotypes of the polysaccharide. The objective of this study was to produce monoclonal antibodies (MAbs) that could be used to study the distribution of epitopes among the serotypes of C. neoformans. BALB/c mice were immu...

journal_title：Infection and immunity

authors： Eckert TF,Kozel TR

更新日期：1987-08-01 00:00:00

abstract：:Chromosomal DNA from a uropathogenic strain of Escherichia coli was partially digested with the restriction enzyme EcoRI. The partial digests were ligated into a cosmid containing an ampicillin-resistant determinant and packaged into lambda phage particles. An ampicillin-resistant transductant of E. coli HB101 was fou...

journal_title：Infection and immunity

authors： Clegg S

更新日期：1982-11-01 00:00:00

abstract：:We have examined the ability of peptidoglycan (PepG) and lipoteichoic acid (LTA) isolated from Staphylococcus aureus to induce the release of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), and IL-10 in whole human blood and identified the cellular origins of these cytokines. Both PepG and LTA induced t...

journal_title：Infection and immunity

authors： Wang JE,Jørgensen PF,Almlöf M,Thiemermann C,Foster SJ,Aasen AO,Solberg R

更新日期：2000-07-01 00:00:00

abstract：:Agglutinogen 1 of Bordetella pertussis strain 353/Z (serotype 1) was separated from protective antigen and histamine-sensitizing factor by starch-block electrophoresis. Most of the agglutinogen 1 migrated towards the cathode in starch-block electrophoresis, although some remained near the origin. Fractions containing ...

journal_title：Infection and immunity

authors： Ross RF,Munoz J

更新日期：1971-02-01 00:00:00

abstract：:Rabbit lymphoid cells from spleen, peripheral blood, and peritoneal cavity lacked killer (K)-cell activity against cell lines of rabbit and human origin, including virus-infected human tumor cells. This lack of activity was not affected by antibody concentration, source of antibodies, effector/target cell ratio, or le...

journal_title：Infection and immunity

authors： Karavodin LM,Sidell N,Woan MC,Tompkins WA

更新日期：1982-02-01 00:00:00

abstract：:Vibrio cholerae O1 bacteria harvested directly from ligated or nonligated intestines of rabbits with experimental cholera expressed at least 7 to 8 novel, in vivo-specific cell envelope (env) proteins that were not found on vibrios after in vitro culture in various ordinary liquid media. At the same time, several of t...

journal_title：Infection and immunity

authors： Jonson G,Svennerholm AM,Holmgren J

更新日期：1989-06-01 00:00:00

abstract：:Intrauterine infections lead to serious complications for mother and fetus, including preterm birth, maternal and fetal death, and neurological sequelae in the surviving offspring. Improving maternal and child heath is a global priority. Yet, the development of strategies to prevent and treat pregnancy-related disease...

journal_title：Infection and immunity

authors： Lowe DE,Robbins JR,Bakardjiev AI

更新日期：2018-05-22 00:00:00

abstract：:Whole-genome sequencing analysis of ∼800 strains of group A Streptococcus (GAS) found that the gene encoding the multiple virulence gene regulator of GAS (mga) is highly polymorphic in serotype M59 strains but not in strains of other serotypes. To help understand the molecular mechanism of gene regulation by Mga and i...

journal_title：Infection and immunity

authors： Sanson M,Makthal N,Gavagan M,Cantu C,Olsen RJ,Musser JM,Kumaraswami M

更新日期：2015-06-01 00:00:00

abstract：:Monoclonal antibody MASC1-MR9 of isotype immunoglobulin M was generated in LOU/C rats by immunization with heat-killed Salmonella thompson (serogroup C1, O-antigen 6,7 lipopolysaccharide) bacteria which had been further enriched for O-antigen by coating with homologous lipopolysaccharide. Eight monoclonal antibodies w...

journal_title：Infection and immunity

authors： Nnalue NA,Weintraub A,Lindberg AA

更新日期：1991-01-01 00:00:00

abstract：:Ehrlichia chaffeensis, a tick-transmitted obligate intracellular rickettsial agent, causes human monocytic ehrlichiosis. In recent reports, we described substantial advances in developing random and targeted gene disruption methods to investigate the functions of E. chaffeensis genes. We reported earlier that the Hima...

journal_title：Infection and immunity

authors： Wang Y,Nair ADS,Alhassan A,Jaworski DC,Liu H,Trinkl K,Hove P,Ganta CK,Burkhardt N,Munderloh UG,Ganta RR

更新日期：2020-09-18 00:00:00

abstract：:The macrophage has previously been implicated in contributing to the renal inflammation associated with hemolytic-uremic syndrome (HUS). However, there is currently no in vivo model detailing the contribution of the renal macrophage to the kidney disease associated with HUS. Therefore, renal macrophage recruitment and...

journal_title：Infection and immunity

authors： Keepers TR,Gross LK,Obrig TG

更新日期：2007-03-01 00:00:00