Phospholipase A activity associated with the growth of Rickettsia prowazekii in L929 cells.

abstract：:Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of beta(1-6)glucosamine disaccharide mono- or diphosphates showed high activities in most in vitro assays, and the lethality of a diphosphate derivative to galactosami...

journal_title：Infection and immunity

authors： Kotani S,Takada H,Tsujimoto M,Ogawa T,Harada K,Mori Y,Kawasaki A,Tanaka A,Nagao S,Tanaka S

更新日期：1984-07-01 00:00:00

abstract：:Studies concerned with the mechanisms responsible for relative resistance or susceptibility of strains of inbred mice to Trypanosoma musculi infections are presented. Treatment with 400 rads of ionizing radiation, silica dust, or trypan blue (reticuloendothelial blocking agents) rendered C3H mice unable to control the...

journal_title：Infection and immunity

authors： Albright JW,Albright JF

更新日期：1989-06-01 00:00:00

abstract：:Pseudomonas aeruginosa bacteremia in cancer patients develops from initial gastrointestinal (GI) colonization with translocation into the bloodstream in the setting of chemotherapy-induced neutropenia and GI mucosal damage. We established a reproducible mouse model of P. aeruginosa GI colonization and systemic spread ...

journal_title：Infection and immunity

authors： Koh AY,Priebe GP,Pier GB

更新日期：2005-04-01 00:00:00

abstract：:Tuberculosis remains the leading cause of death among infectious diseases, accounting for more than two million deaths annually. The incidence of the disease is increasing globally, partially because of the resurgence of drug-resistant strains of Mycobacterium tuberculosis. Calixarenes are macrocyclic oligomers, some ...

journal_title：Infection and immunity

authors： Colston MJ,Hailes HC,Stavropoulos E,Hervé AC,Hervé G,Goodworth KJ,Hill AM,Jenner P,Hart PD,Tascon RE

更新日期：2004-11-01 00:00:00

abstract：:The mechanisms of immunity to salmonellae conferred by immunization with live vaccines were studied by adoptive transfer using the mouse-virulent strain Salmonella typhimurium C5 and innately susceptible BALB/c (ltys) mice. This organism cannot establish a sublethal infection in naive BALB/c mice. Animals immunized 2 ...

journal_title：Infection and immunity

authors： Mastroeni P,Villarreal-Ramos B,Hormaeche CE

更新日期：1993-09-01 00:00:00

abstract：:A Gram-negative, filamentous, rod-shaped bacillus which failed to grow in cell-free media was isolated in apparently pure culture from the bronchial scraping and washing of a laboratory rat suffering from chronic respiratory disease by inoculating embryonated chicken eggs via the allantoic route. None of the embryos d...

journal_title：Infection and immunity

authors： Ganaway JR,Spencer TH,Moore TD,Allen AM

更新日期：1985-02-01 00:00:00

abstract：:The genes encoding alpha-hemolysin and mannose-resistant hemagglutination were shown to be closely linked in cloned DNA from two Escherichia coli urinary tract isolates of serotypes O4 (J96) and O6 (C1212). DNA hybridization experiments demonstrated that the hly and mrh gene clusters of other E. coli O6 serotypes were...

journal_title：Infection and immunity

authors： Low D,David V,Lark D,Schoolnik G,Falkow S

更新日期：1984-01-01 00:00:00

abstract：:Toxic protein(s) neutralized with anti-C2 toxic serum was extracted from Clostridium botulinum type C spores treated with an alkaline mercaptoethanol solution. C2 toxicity in the spores was located in the spore coat fraction and was more heat stable than that found in culture fluid. ...

journal_title：Infection and immunity

authors： Yamakawa K,Nishida S,Nakamura S

更新日期：1983-08-01 00:00:00

abstract：:Although serum amyloid P component (SAP) is known to bind many ligands, its biological function is not yet clear. Recently, it was demonstrated that SAP binds to lipopolysaccharide (LPS). In the present study, SAP was shown to bind to gram-negative bacteria expressing short types of LPS or lipo-oligosaccharide (LOS), ...

journal_title：Infection and immunity

authors： de Haas CJ,van Leeuwen EM,van Bommel T,Verhoef J,van Kessel KP,van Strijp JA

更新日期：2000-04-01 00:00:00

abstract：:A Mycoplasma pneumoniae cytadhesin P1 gene with novel nucleotide sequence variation has been identified. Four clinical strains of M. pneumoniae were found to carry this type of P1 gene. This new P1 gene is similar to the known group II P1 genes but possesses novel sequence variation of approximately 300 bp in the RepM...

journal_title：Infection and immunity

authors： Kenri T,Taniguchi R,Sasaki Y,Okazaki N,Narita M,Izumikawa K,Umetsu M,Sasaki T

更新日期：1999-09-01 00:00:00

abstract：:The American opossum is the only experimental animal that regularly develops bacterial endocarditis spontaneously. There was no relation between the ability of opossums to clear bacteria from the bloodstream and the subsequent development of endocarditis. ...

journal_title：Infection and immunity

authors： Musher DM,Richie Y

更新日期：1974-06-01 00:00:00

abstract：:Immunity to infection with Eimeria vermiformis was transferred in NIH mice by both the nylon wool-adherent (B-cell-enriched) and nonadherent (T-cell-enriched) fractions of lymphocytes (spleen and mesenteric lymph node) taken from infected donors. Transfer was more variable with the adherent fraction, and when contamin...

journal_title：Infection and immunity

authors： Rose ME,Joysey HS,Hesketh P,Grencis RK,Wakelin D

更新日期：1988-07-01 00:00:00

abstract：:Most patients with juvenile periodontitis manifest serum antibodies, sometimes at very high titers, to antigens of Actinobacillus actinomycetemcomitans, but the antigens inducing the immune response have been only partly characterized. We separated A. actinomycetemcomitans serotype b cells into protein, lipopolysaccha...

journal_title：Infection and immunity

authors： Page RC,Sims TJ,Engel LD,Moncla BJ,Bainbridge B,Stray J,Darveau RP

更新日期：1991-10-01 00:00:00

abstract：:Brucellosis is a costly disease of water buffaloes (Bubalus bubalis). Latent infections and prolonged incubation of the pathogen limit the efficacy of programs based on the eradication of infected animals. We exploited genetic selection for disease resistance as an approach to the control of water buffalo brucellosis....

journal_title：Infection and immunity

authors： Borriello G,Capparelli R,Bianco M,Fenizia D,Alfano F,Capuano F,Ercolini D,Parisi A,Roperto S,Iannelli D

更新日期：2006-04-01 00:00:00

abstract：:Three MudJ prototrophs demonstrated that intracellular replication is a Salmonella virulence trait (K. Y. Leung and B. B. Finlay, Proc. Natl. Acad. Sci. USA, 88:11470-11474, 1991). mutS and mutH are disrupted in mutants 3-11 and 12-23, and ssaQ is disrupted in mutant 17-21. Further analysis revealed that loss of Salmo...

journal_title：Infection and immunity

authors： Suvarnapunya AE,Zurawski DV,Guy RL,Stein MA

更新日期：2003-04-01 00:00:00

abstract：:Malaria toxin causes hypoglycemia and induction of tumor necrosis factor. Extracts of parasitized erythrocytes which were coeluted and copurified with one of the two subtypes of mammalian insulin-mimetic inositolphosphoglycans similarly induced fibroblast proliferation in the absence of serum. In addition, induction o...

journal_title：Infection and immunity

authors： Caro HN,Sheikh NA,Taverne J,Playfair JH,Rademacher TW

更新日期：1996-08-01 00:00:00

abstract：:The American Heart Association supports an association between periodontal diseases and atherosclerosis but not a causal association. This study explores the use of the integrin β6(-/-) mouse model to study the causality. We investigated the ability of a polymicrobial consortium of Porphyromonas gingivalis, Treponema ...

journal_title：Infection and immunity

authors： Velsko IM,Chukkapalli SS,Rivera-Kweh MF,Zheng D,Aukhil I,Lucas AR,Larjava H,Kesavalu L

更新日期：2015-12-01 00:00:00

abstract：:Development of an effective vaccine against Leishmania infection is a priority of tropical disease research. We have recently demonstrated protection against Leishmania major in the murine and nonhuman primate models with individual or combinations of purified leishmanial recombinant antigens delivered as plasmid DNA ...

journal_title：Infection and immunity

authors： Coler RN,Skeiky YA,Bernards K,Greeson K,Carter D,Cornellison CD,Modabber F,Campos-Neto A,Reed SG

更新日期：2002-08-01 00:00:00

abstract：:Immunochemically identical components were isolated from water-soluble phases of five Staphylococcus aureus strains by affinity chromatography on fibrinogen-linked Sepharose 4B. The elution was performed with 1 M MgCl2. The component could be isolated from sonicated preparations of whole cells, cell walls, and extrace...

journal_title：Infection and immunity

authors： Espersen F,Clemmensen I,Barkholt V

更新日期：1985-09-01 00:00:00

abstract：:Yersinia pestis, the causative agent of plague, autoaggregates within a few minutes of cessation of shaking when grown at 28 degrees C. To identify the autoaggregation factor of Y. pestis, we performed mariner-based transposon mutagenesis. Autoaggregation-defective mutants from three different pools were identified, e...

journal_title：Infection and immunity

authors： Felek S,Muszyński A,Carlson RW,Tsang TM,Hinnebusch BJ,Krukonis ES

更新日期：2010-03-01 00:00:00

abstract：:To study the specific role of transmembrane tumor necrosis factor (tmTNF) in protective and pathological responses against the gastrointestinal helminth Trichinella spiralis, we compared the immune responses of TNF-alpha/lymphotoxin alpha (LTalpha)(-/-) mice expressing noncleavable transgenic tmTNF to those of TNF-alp...

journal_title：Infection and immunity

authors： Ierna MX,Scales HE,Mueller C,Lawrence CE

更新日期：2009-09-01 00:00:00

abstract：:Relapsing fever (RF) is a spirochetal infection characterized by periods of sickness with fever at time of high bacteremia that alternate with afebrile periods of relative well being during low bacteremia. Patients with epidemic RF who are doing relatively well have extraordinarily high levels of interleukin-10 (IL-10...

journal_title：Infection and immunity

authors： Londoño D,Marques A,Hornung RL,Cadavid D

更新日期：2008-12-01 00:00:00

abstract：:Most vaccines are still given parenterally. Mucosal vaccination would offer different advantages over parenteral immunization, including blocking of the pathogens at the portal of entry. In this paper, nontoxic Escherichia coli heat-labile enterotoxin (LT) mutants and Supramolecular Biovector systems (SMBV) were evalu...

journal_title：Infection and immunity

authors： Baudner BC,Balland O,Giuliani MM,Von Hoegen P,Rappuoli R,Betbeder D,Del Giudice G

更新日期：2002-09-01 00:00:00

abstract：:Thirty-two clinical isolates of Shiga-like toxin (SLT)-producing Escherichia coli associated with single cases or outbreaks of bloody diarrhea, hemorrhagic colitis, the hemolytic uremic syndrome, or edema disease of swine were examined for multiple copies of genes belonging to the slt-I or slt-II toxin families. Five ...

journal_title：Infection and immunity

authors： Schmitt CK,McKee ML,O'Brien AD

更新日期：1991-03-01 00:00:00

abstract：:The blood-stage development of malaria parasites is initiated by the invasion of merozoites into susceptible erythrocytes. Specific receptor-ligand interactions must occur for the merozoites to first attach to and then invade erythrocytes. Because the invasion process is essential for the parasite's survival and the m...

journal_title：Infection and immunity

authors： Tsuboi T,Kappe SH,al-Yaman F,Prickett MD,Alpers M,Adams JH

更新日期：1994-12-01 00:00:00

abstract：:Anopheles gambiae is the major African vector of Plasmodium falciparum, the most deadly species of human malaria parasite and the most prevalent in Africa. Several strategies are being developed to limit the global impact of malaria via reducing transmission rates, among which are transmission-blocking vaccines (TBVs)...

journal_title：Infection and immunity

authors： Lavazec C,Boudin C,Lacroix R,Bonnet S,Diop A,Thiberge S,Boisson B,Tahar R,Bourgouin C

更新日期：2007-04-01 00:00:00

abstract：:Fractionation of the culture medium showed that Streptococcus salivarius ATCC 25975 secreted a glucosyltransferase (Gtf) that was primer independent. On the basis of this observation, a gene library of S. salivarius chromosomal DNA cloned into lambda L47.1 was screened for a gene(s) coding for such an activity. As a r...

journal_title：Infection and immunity

authors： Simpson CL,Giffard PM,Jacques NA

更新日期：1995-02-01 00:00:00

abstract：:The effects of tolerance to Escherichia coli endotoxin on the phagocytic and bactericidal activity of the hepatic reticuloendothelial system against viable E. coli were examined using ex vivo perfused rat livers. Livers were isolated from control and endotoxin-tolerant rats and perfused with a medium containing 5% hom...

journal_title：Infection and immunity

authors： Ruggiero G,Andreana A,Utili R,Galante D

更新日期：1980-03-01 00:00:00

abstract：:Bacterial superantigens (SAgs) have been implicated in inflammatory disease, and SAg-treated mice have increased jejunal T cells. Here we show that T84 cells (a human epithelial cell line) display increased MCP-1 and RANTES mRNA expression and protein production in response to conditioned medium from Staphylococcus au...

journal_title：Infection and immunity

authors： Jedrzkiewicz S,Kataeva G,Hogaboam CM,Kunkel SL,Strieter RM,McKay DM

更新日期：1999-11-01 00:00:00

abstract：:Neisseria gonorrhoeae enters cultured human mucosal cells following binding of a distinct gonococcal opacity (Opa) outer membrane protein to cell surface proteoglycan receptors. We examined the route of internalization that is activated by Opa-expressing gonococci (strain VP1). Microscopy of infected Chang epithelial ...

journal_title：Infection and immunity

authors： Grassmé HU,Ireland RM,van Putten JP

更新日期：1996-05-01 00:00:00