The fibronectin-binding protein Fnm contributes to adherence to extracellular matrix components and virulence of Enterococcus faecium.

abstract：:Once in the cytoplasm of mammalian cells, Shigella flexneri expresses a motile phenotype caused by polar directional assembly of actin. This process depends on accumulation of IcsA (VirG), a 120-kDa protein with ATPase activity, at the pole of the bacterium opposite to that at which ongoing septation occurs. IcsA is a...

journal_title：Infection and immunity

authors： d'Hauteville H,Dufourcq Lagelouse R,Nato F,Sansonetti PJ

更新日期：1996-02-01 00:00:00

abstract：:To study the specific role of transmembrane tumor necrosis factor (tmTNF) in protective and pathological responses against the gastrointestinal helminth Trichinella spiralis, we compared the immune responses of TNF-alpha/lymphotoxin alpha (LTalpha)(-/-) mice expressing noncleavable transgenic tmTNF to those of TNF-alp...

journal_title：Infection and immunity

authors： Ierna MX,Scales HE,Mueller C,Lawrence CE

更新日期：2009-09-01 00:00:00

abstract：:Whole-genome sequencing analysis of ∼800 strains of group A Streptococcus (GAS) found that the gene encoding the multiple virulence gene regulator of GAS (mga) is highly polymorphic in serotype M59 strains but not in strains of other serotypes. To help understand the molecular mechanism of gene regulation by Mga and i...

journal_title：Infection and immunity

authors： Sanson M,Makthal N,Gavagan M,Cantu C,Olsen RJ,Musser JM,Kumaraswami M

更新日期：2015-06-01 00:00:00

abstract：:The fibronectin-degrading ability of 116, mainly oral, strains was assayed by using plasma-derived fibronectin adsorbed to a polystyrene surface. Ability to degrade fibronectin was revealed in strains of Bacteroides gingivalis, Bacteroides intermedius, Bacteroides loeschii, Staphylococcus aureus, Staphylococcus epider...

journal_title：Infection and immunity

authors： Wikström M,Linde A

更新日期：1986-02-01 00:00:00

abstract：:Of 202 captive hares studied, many of which had lesions on their external genital organs or testicular atrophy or both, 27% had positive serological tests for syphilis although dark-field examination of extracts of atrophic testes was negative. A total of 12 hares that were nonreactive for the serological test for syp...

journal_title：Infection and immunity

authors： Horvath I,Kemenes F,Molnar L,Szeky A,Racz I

更新日期：1980-01-01 00:00:00

abstract：:Modulation of cytosolic (intracellular) Ca(2+) concentration (Ca(i)) may be an important host response when airway epithelial cells are exposed to Pseudomonas aeruginosa. We measured Ca(i) in Calu-3 cells exposed from the apical or basolateral surface to cytotoxic and noncytotoxic strains of P. aeruginosa. Apical addi...

journal_title：Infection and immunity

authors： Jacob T,Lee RJ,Engel JN,Machen TE

更新日期：2002-11-01 00:00:00

abstract：:Treatment with nontoxic monophosphoryl lipid A (MPL), which was derived from a polysaccharide-deficient, heptoseless Re mutant of Salmonella typhimurium, was found to inactivate suppressor T-cell activity, as evidenced by a decrease in the degree of low-dose immunological paralysis expressed and an increase in the mag...

journal_title：Infection and immunity

authors： Baker PJ,Hiernaux JR,Fauntleroy MB,Prescott B,Cantrell JL,Rudbach JA

更新日期：1988-05-01 00:00:00

abstract：:Seven antigens of Borrelia hermsii, B. parkeri, and B. turicatae with isoelectric points in the range of 4.4 to 5.0 and molecular masses of 40 to 43 kilodaltons played a role in the relapse phenomenon of relapsing fever. Based upon location of the antigens in the outer envelope, the molecular weight, and Western blot ...

journal_title：Infection and immunity

authors： Kehl KS,Farmer SG,Komorowski RA,Knox KK

更新日期：1986-12-01 00:00:00

abstract：:The pattern of invasion of human hair in vitro by the dermatophyte Microsporum gypseum was studied by transmission and scanning electron microscopy. Mycelia that invaded the hair cortex through the edge of cuticles showed a flattened "frond" growth in contrast to the filamentous form seen on ordinary laboratory media....

journal_title：Infection and immunity

authors： Kanbe T,Tanaka K

更新日期：1982-11-01 00:00:00

abstract：:The distinctive properties of Brucella outer membrane have been considered to be critical for Brucella sp. virulence. Among the outer membrane molecules possibly related to these properties, Omp10 and Omp19 are immunoreactive outer membrane lipoproteins. Moreover, these proteins of Brucella could constitute a new fami...

journal_title：Infection and immunity

authors： Tibor A,Wansard V,Bielartz V,Delrue RM,Danese I,Michel P,Walravens K,Godfroid J,Letesson JJ

更新日期：2002-10-01 00:00:00

abstract：:Controversy persists over the role that the capsular polysaccharide plays in the pathogenesis of Staphylococcus aureus infections. To address this issue, we compared the mouse virulence of S. aureus Reynolds and capsule-defective mutant strains cultivated under conditions of high or low capsule expression. Strain Reyn...

journal_title：Infection and immunity

authors： Thakker M,Park JS,Carey V,Lee JC

更新日期：1998-11-01 00:00:00

abstract：:A genomic library of meningococcal DNA from a clinical isolate of Neisseria meningitidis was constructed in the expression vector lambda gt11. Outer membrane complex was prepared from the same strain and used to immunize rabbits to raise polyclonal anti-outer membrane complex serum. The amplified library was probed wi...

journal_title：Infection and immunity

authors： Barlow AK,Heckels JE,Clarke IN

更新日期：1987-11-01 00:00:00

abstract：:Yersinia pestis is a highly pathogenic Gram-negative organism and the causative agent of bubonic and pneumonic plague. Y. pestis is capable of causing major epidemics; thus, there is a need for vaccine targets and a greater understanding of the role of these targets in pathogenesis. Two prime Y. pestis vaccine candida...

journal_title：Infection and immunity

authors： Weening EH,Cathelyn JS,Kaufman G,Lawrenz MB,Price P,Goldman WE,Miller VL

更新日期：2011-02-01 00:00:00

abstract：:The response of the intracellular pathogen Rhodococcus equi to H(2)O(2) treatment, a situation potentially encountered after the oxidative burst of alveolar macrophages, was analyzed. Compared to other bacteria, including Deinococcus radiodurans, R. equi showed exceptionally high resistance to this stress. A proteomic...

journal_title：Infection and immunity

authors： Benoit S,Benachour A,Taouji S,Auffray Y,Hartke A

更新日期：2002-07-01 00:00:00

abstract：:Human lactoferrin is an iron-binding glycoprotein that is particularly prominent in exocrine secretions and leukocytes and is also found in serum, especially during inflammation. It is able to sequester iron from microbes and has immunomodulatory functions, including inhibition of both complement activation and cytoki...

journal_title：Infection and immunity

authors： Håkansson A,Roche H,Mirza S,McDaniel LS,Brooks-Walter A,Briles DE

更新日期：2001-05-01 00:00:00

abstract：:A number of polymorphonuclear leukocyte (PMN) chemotactic factors derived from complement components have been described. We sought to determine which of these factors accounted for the majority of PMN chemotactic activity in rabbit serum and guinea pig serum treated with preformed immune complexes. Normal rabbit sera...

journal_title：Infection and immunity

authors： Snyderman R,Phillips J,Mergenhagen SE

更新日期：1970-06-01 00:00:00

abstract：:At least five proteins are secreted extracellularly by enteropathogenic Escherichia coli (EPEC), a leading cause of infant diarrhea in developing countries. However only one, EspC, is known to be secreted independently of the type III secretion apparatus encoded by genes located within the 35.6-kb locus of enterocyte ...

journal_title：Infection and immunity

authors： Mellies JL,Navarro-Garcia F,Okeke I,Frederickson J,Nataro JP,Kaper JB

更新日期：2001-01-01 00:00:00

abstract：:The protective immunity conferred by T-cell subsets against infection with Treponema pallidum subsp. pertenue was studied. We demonstrated that hamster T cells can be separated into two subsets by monoclonal antibody (MAb) GK 1.5 (anti-L3T4) and MAb 38. Eighty-five percent of hamster thymocytes were L3T4+ and 87% were...

journal_title：Infection and immunity

authors： Liu H,Alder JD,Steiner BM,Stein-Streilein J,Lim L,Schell RF

更新日期：1991-02-01 00:00:00

abstract：:The ScpC protease of Streptococcus pyogenes degrades interleukin-8 (IL-8), a chemokine that mediates neutrophil transmigration and activation. The ability to degrade IL-8 differs dramatically among clinical isolates of S. pyogenes. Bacteria expressing ScpC overcome immune clearance by preventing the recruitment of neu...

journal_title：Infection and immunity

authors： Sjölinder H,Lövkvist L,Plant L,Eriksson J,Aro H,Jones A,Jonsson AB

更新日期：2008-09-01 00:00:00

abstract：:Effector mechanisms resulting from alternative complement pathway (ACP) activation cannot act efficiently against Yersinia enterocolitica serotype O3, as indicated by poor C3 to C9 consumption and by survival in EGTA (ethyleneglycoldiaminetetraacetic acid) Mg-serum. These results were not influenced by the lack or pre...

journal_title：Infection and immunity

authors： Wachter E,Brade V

更新日期：1989-07-01 00:00:00

abstract：:CS31A is a K88-related capsule-like surface protein that mediates Escherichia coli and Klebsiella pneumoniae adhesion to the human Caco-2 and Intestine-407 cell lines. In this study, we demonstrate that ClpG, the major subunit of CS31A, contains the adhesive domain of the polymerized structure. We mapped this domain w...

journal_title：Infection and immunity

authors： Di Martino P,Girardeau JP,Der Vartanian M,Joly B,Darfeuille-Michaud A

更新日期：1997-02-01 00:00:00

abstract：:The disruption of a specific gene in Candida albicans is commonly used to determine the function of the gene product. We disrupted AAF1, a gene of C. albicans that causes Saccharomyces cerevisiae to flocculate and adhere to endothelial cells. We then characterized multiple heterozygous and homozygous mutants. These nu...

journal_title：Infection and immunity

authors： Rieg G,Fu Y,Ibrahim AS,Zhou X,Filler SG,Edwards JE Jr

更新日期：1999-07-01 00:00:00

abstract：:During the infection of mice with Listeria monocytogenes, there is a profound depletion of T (Thy-1+ Ig-) lymphocytes between days 1 and 4, followed by an increase in T cells to three times normal levels by day 9. The recovery of T cell numbers required cell proliferation, being sensitive to vinblastin and cyclophosph...

journal_title：Infection and immunity

authors： Chan YY,Cheers C

更新日期：1982-11-01 00:00:00

abstract：:Proliferation of Bordetella pertussis in the lungs of infant mice challenged by the intranasal route was examined. The bacteria rapidly proliferated in the lungs of mice challenged with a sublethal dose of a wild-type strain (BP338) or a filamentous hemagglutinin mutant (BPM409) from 500 at day 0 to 10(7) at day 15. T...

journal_title：Infection and immunity

authors： Goodwin MS,Weiss AA

更新日期：1990-10-01 00:00:00

abstract：:With large amounts of parasite gene sequence available, additional bioinformatic tools to screen these sequences for identifying genes encoding antigens are needed. Proteins containing tandem repeat (TR) domains are often B-cell antigens, and antibody responses toward TR domains of the proteins are dominant in human i...

journal_title：Infection and immunity

authors： Goto Y,Coler RN,Reed SG

更新日期：2007-02-01 00:00:00

abstract：:The ability of various strains of rats to produce interferon in response to polyriboinosinic-polyribocytodilic acid was investigated. ACI and DA (RT-1a), BN (RT-1n), Buffalo (RT-1b), August (RT-1c), and GH (RT-1l) strains produced low levels of interferon in response to intraperitoneal administration of polyriboinosin...

journal_title：Infection and immunity

authors： Davis CT,Blankenhorn EP,Murasko DM

更新日期：1984-02-01 00:00:00

abstract：:Pathogenic species of the spotted fever group Rickettsia are subjected to repeated exposures to the host complement system through cyclic infections of mammalian and tick hosts. The serum complement machinery is a formidable obstacle for bacteria to overcome if they endeavor to endure this endozoonotic cycle. We have ...

journal_title：Infection and immunity

authors： Riley SP,Patterson JL,Martinez JJ

更新日期：2012-08-01 00:00:00

abstract：:We have developed sensitive and specific solid-phase radioimmunoassays to quantitate the distribution and persistence of bacterial antigen in rats developing arthritis in response to a single injection of streptococcal cell wall material. Three separate assays were specific for either the A polysaccharide (N-acetyl-D-...

journal_title：Infection and immunity

authors： Eisenberg R,Fox A,Greenblatt JJ,Anderle SK,Cromartie WJ,Schwab JH

更新日期：1982-10-01 00:00:00

abstract：:Campylobacter jejuni is a major cause of human inflammatory enteritis. During the course of human disease numerous proinflammatory cytokines are produced. Little is known, however, about the cytokine responses produced during the interaction of this bacterium with the avian host. Campylobacter has been considered a co...

journal_title：Infection and immunity

authors： Smith CK,Kaiser P,Rothwell L,Humphrey T,Barrow PA,Jones MA

更新日期：2005-04-01 00:00:00

abstract：:The serum antibody response and four different cellular immune responses (cytotoxic T cells, delayed-type hypersensitivity T cells, natural killer cells, and cytotoxic macrophage levels) induced in CBA/H mice were measured at different times after intranasal inoculation of a cold-adapted (ca) variant of influenza A vi...

journal_title：Infection and immunity

authors： Mak NK,Zhang YH,Ada GL,Tannock GA

更新日期：1982-10-01 00:00:00