Effect of iron on surface charge and hydrophobicity of Neisseria gonorrhoeae.

abstract：:Experiments outlined here investigate the role of nitric oxide (NO) in the pathogenesis of Plasmodium falciparum-induced malarial anemia (MA). The results show that ex vivo and in vitro NO synthase (NOS) activity in peripheral blood mononuclear cells (PBMCs) is significantly elevated in children with MA and inversely ...

journal_title：Infection and immunity

authors： Keller CC,Kremsner PG,Hittner JB,Misukonis MA,Weinberg JB,Perkins DJ

更新日期：2004-08-01 00:00:00

abstract：:Inbred mouse strains differ in their susceptibility to infection with the facultative intracellular bacterium Listeria monocytogenes, largely due to delayed or deficient innate immune responses. Previous antibody depletion studies suggested that neutrophils (polymorphonuclear leukocytes [PMN]) were particularly import...

journal_title：Infection and immunity

authors： Pitts MG,Combs TA,D'Orazio SEF

更新日期：2018-03-22 00:00:00

abstract：:The antiphagocytic effect of the Staphylococcus aureus capsule is known to be related to its ability to interfere with opsonization by normal human serum. In this study, evidence is presented with isolated cell surface components which indicates that the capsule hinders opsonization by masking cell wall peptidoglycan....

journal_title：Infection and immunity

authors： Wilkinson BJ,Peterson PK,Quie PG

更新日期：1979-02-01 00:00:00

abstract：:The mechanism by which Helicobacter pylori, which has little or no invasive activity, induces gastric-tissue inflammation and injury has not been well characterized. We have previously demonstrated that water-extracted proteins of H. pylori are capable of activating human monocytes by a lipopolysaccharide (LPS)-indepe...

journal_title：Infection and immunity

authors： Pérez-Pérez GI,Shepherd VL,Morrow JD,Blaser MJ

更新日期：1995-04-01 00:00:00

abstract：:A set of strain- and size-variant highly immunogenic membrane surface protein antigens of Mycoplasma bovis, which has been identified by a monoclonal antibody, is shown in this report to make up a family of antigenically and structurally related lipid-modified proteins, designated Vsps (variable surface proteins). By ...

journal_title：Infection and immunity

authors： Behrens A,Heller M,Kirchhoff H,Yogev D,Rosengarten R

更新日期：1994-11-01 00:00:00

abstract：:Transforming growth factor beta (TGF-beta) has been shown to be a central immunomodulator used by leishmaniae to escape effective mechanisms of protection in human and murine infections with these parasites. However, all the information is derived from studies of established infection, while little is known about TGF-...

journal_title：Infection and immunity

authors： Kariminia A,Bourreau E,Pascalis H,Couppié P,Sainte-Marie D,Tacchini-Cottier F,Launois P

更新日期：2005-09-01 00:00:00

abstract：:Localized juvenile periodontitis (LJP) runs in families, and a predisposition to develop disease appears to be inherited in an autosomal dominant fashion. Patients with LJP have elevated levels of serum immunoglobulin G2 (IgG2), and this is most striking in black LJP patients. We hypothesized that the markedly elevate...

journal_title：Infection and immunity

authors： Zhang JB,Quinn SM,Rausch M,Gunsolley JC,Schenkein HA,Tew JG

更新日期：1996-06-01 00:00:00

abstract：:This study compared infection and transformation of peripheral blood mononuclear cells (PBM) of Boran cattle and African buffalo in vitro to determine whether differences occurred which could account for the greater susceptibility of Boran cattle to infection with Theileria parva subsp. parva and T. parva subsp. lawre...

journal_title：Infection and immunity

authors： Baldwin CL,Malu MN,Kinuthia SW,Conrad PA,Grootenhuis JG

更新日期：1986-07-01 00:00:00

abstract：:Migration of the fungal pathogen Candida albicans across the endothelial cell layer is considered a prerequisite for the invasion of multiple organs occurring in systemic candidiasis. We developed an experimental system in which C. albicans migrates from a luminal compartment across a monolayer of bovine aortic endoth...

journal_title：Infection and immunity

authors： Zink S,Nass T,Rösen P,Ernst JF

更新日期：1996-12-01 00:00:00

abstract：:Phorbol myristate acetate stimulated oxidative metabolism in alveolar macrophages and blood neutrophils. This compound also stimulated lysozyme release from neutrophils but not from alveolar macrophages. These findings suggest that the regulation of lysozyme release from alveolar macrophages is different than for poly...

journal_title：Infection and immunity

authors： Biggar WD

更新日期：1978-08-01 00:00:00

abstract：:Serotype b-specific polysaccharide antigen (SPA) of Actinobacillus actinomycetemcomitans Y4 consists of D-fucose and L-rhamnose. To clarify the role of SPA in phagocytosis of the organism by human polymorphonuclear leukocytes (PMNs), monoclonal antibodies (MAbs) against SPA and SPA-defective mutants, which were constr...

journal_title：Infection and immunity

authors： Yamaguchi N,Kawasaki M,Yamashita Y,Nakashima K,Koga T

更新日期：1995-12-01 00:00:00

abstract：:Representative strains of serogroup A Neisseria meningitidis were chosen from all major meningitis epidemics worldwide since 1960 and subjected to analysis for the electrophoretic variation of 15 cytoplasmic allozymes and four outer membrane proteins. The 290 strains defined 84 unique electrophoretic types which were ...

journal_title：Infection and immunity

authors： Wang JF,Caugant DA,Li X,Hu X,Poolman JT,Crowe BA,Achtman M

更新日期：1992-12-01 00:00:00

abstract：:The outer membrane protein OmpU of Vibrio cholerae O1 strain 86B3 was characterized with reference to colonization of the intestine by the organism. The purified OmpU exhibited a pI of 3.6. Upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis, it migrated to 38, 32, and 110 kDa when the sample was heated at ...

journal_title：Infection and immunity

authors： Nakasone N,Iwanaga M

更新日期：1998-10-01 00:00:00

abstract：:Salivary proline-rich proteins (PRPs), which were purified from parotid saliva, were adsorbed onto 15-nm-diameter gold particles to visualize specific binding of the salivary molecules to Actinomyces viscosus type 1 fimbriae. Negatively stained preparations incubated with PRP-gold conjugates but not bovine serum album...

journal_title：Infection and immunity

authors： Leung KP,Nesbitt WE,Fischlschweiger W,Hay DI,Clark WB

更新日期：1990-06-01 00:00:00

abstract：:Under certain circumstances, soluble antigens, particulate antigens, and/or microorganisms have been shown to bind to primate erythrocytes via complement receptor 1 (CR1) in the presence of specific antibodies and complement. This immune adherence reaction, specific for CR1, can lead to neutralization of antigens in t...

journal_title：Infection and immunity

authors： Powers JH,Buster BL,Reist CJ,Martin E,Bridges M,Sutherland WM,Taylor RP,Scheld WM

更新日期：1995-04-01 00:00:00

abstract：:An enterotoxic factor isolated from cultures of Salmonella yielded reproducible results in the suckling mouse model in contrast to other animal models. The enterotoxin appears to possess properties similar to both the heat-stable and heat-labile enterotoxins of Escherichia coli. Preliminary results indicate that the t...

journal_title：Infection and immunity

authors： Koupal LR,Deibel RH

更新日期：1975-01-01 00:00:00

abstract：:A cytoplasmic 75-kDa immunogen from Chlamydia trachomatis serovar L2 has previously been characterized as being similar to the Escherichia coli heat shock protein DnaK. We have localized a linear epitope for one monoclonal antibody specific for C. trachomatis DnaK. By use of a recombinant DNA technique, the epitope wa...

journal_title：Infection and immunity

authors： Birkelund S,Larsen B,Holm A,Lundemose AG,Christiansen G

更新日期：1994-05-01 00:00:00

abstract：:Studies were carried out to determine whether treatment of mice with the synthetic adjuvant muramyl dipeptide afforded any resistance to infection with the obligate intracellular protozoan Toxoplasma gondii. Marked resistance to lethal challenge infection was observed in CBA but not C57BL/6 mice pretreated with muramy...

journal_title：Infection and immunity

authors： Krahenbuhl JL,Sharma SD,Ferraresi RW,Remington JS

更新日期：1981-02-01 00:00:00

abstract：:Vibrio cholerae responds to environmental changes by altering the protein composition of its outer membrane. In rich medium, V. cholerae expresses almost exclusively the outer membrane porin OmpU, whereas in minimal medium, OmpT is the dominant porin. The supplementation of a minimal medium with a mixture of asparagin...

journal_title：Infection and immunity

authors： Mey AR,Craig SA,Payne SM

更新日期：2012-02-01 00:00:00

abstract：:In mice infected with virulent blood (trypomastigote) forms of Trypanosoma cruzi, complement depletion with cobra venom factor caused a marked exacerbation of the disease evidenced by significantly increased parasitemia levels and early mortality as compared with those of untreated infected animals. The effect was gre...

journal_title：Infection and immunity

authors： Budzko DB,Pizzimenti MC,Kierszenbaum F

更新日期：1975-01-01 00:00:00

abstract：:Transgenic tobacco plants stably expressing recombinant FaeG, which is the major subunit and adhesin of K88ad fimbriae, were obtained. Analysis of sera from immunized mice indicates that in mice, the immunogenicity induced by plant-derived FaeG protein is comparable to that generated with traditional approaches. ...

journal_title：Infection and immunity

authors： Huang Y,Liang W,Pan A,Zhou Z,Huang C,Chen J,Zhang D

更新日期：2003-09-01 00:00:00

abstract：:The immune response of humans and mice to temperature-specific, plasmid- or chromosome-encoded proteins of yersinia pestis and Yersinia enterocolitica was investigated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting. Extracts from Y. pestis and Y. enterocolitica strains with and witho...

journal_title：Infection and immunity

authors： Mazza G,Karu AE,Kingsbury DT

更新日期：1985-06-01 00:00:00

abstract：:The genes of the lic1 operon (lic1A to lic1D) are responsible for incorporation of phosphocholine (PCho) into the lipopolysaccharide (LPS) of Haemophilus influenzae. PCho plays a multifaceted role in the commensal and pathogenic lifestyles of a range of mucosal pathogens, including H. influenzae. Structural studies of...

journal_title：Infection and immunity

authors： Fox KL,Li J,Schweda EK,Vitiazeva V,Makepeace K,Jennings MP,Moxon ER,Hood DW

更新日期：2008-02-01 00:00:00

abstract：:While investigating the virulence traits of Staphylococcus aureus adhering to the skin of atopic-dermatitis (AD) patients, we identified a novel open reading frame (ORF) with structural similarity to a superantigen from genome sequence data of an isolate from AD skin. Concurrently, the same ORF was identified in a bov...

journal_title：Infection and immunity

authors： Aziz F,Hisatsune J,Yu L,Kajimura J,Sato'o Y,Ono HK,Masuda K,Yamaoka M,Salasia SIO,Nakane A,Ohge H,Kusunoki Y,Sugai M

更新日期：2020-01-22 00:00:00

abstract：:Macrophage-dependent killing of facultative intracellular bacteria was markedly impaired by overt erythrocytic Plasmodium yoelii or Plasmodium berghei infection of mice. P. yoelii infection was capable of ablating not only the macrophage microbicidal capacity of "normal" animals but also the bactericidal capacities of...

journal_title：Infection and immunity

authors： Murphy JR

更新日期：1981-01-01 00:00:00

abstract：:The LuxS protein is required for the biosynthesis of the type 2 autoinducer (AI-2), which is involved in quorum sensing in a wide range of bacterial species. We have determined the effects of a defined luxS mutation on the virulence of Streptococcus pneumoniae. Although the luxS mutant displayed reduced virulence rela...

journal_title：Infection and immunity

authors： Stroeher UH,Paton AW,Ogunniyi AD,Paton JC

更新日期：2003-06-01 00:00:00

abstract：:The fucose-mannose ligand (FML) complex of Leishmania donovani is a promising vaccine candidate against murine and canine visceral leishmaniasis, and its main component is a 36-kDa nucleoside hydrolase (NH36). In this study, we tested the immune response and protection induced by the purified FML, the recombinant NH36...

journal_title：Infection and immunity

authors： Aguilar-Be I,da Silva Zardo R,Paraguai de Souza E,Borja-Cabrera GP,Rosado-Vallado M,Mut-Martin M,García-Miss Mdel R,Palatnik de Sousa CB,Dumonteil E

更新日期：2005-02-01 00:00:00

abstract：:Human defensins play a fundamental role in the initiation of innate immune responses to some microbial pathogens. Here we show that colonic epithelial model HCT116 cells respond to Trypanosoma cruzi infection by secreting defensin α-1, which reduces infection. We also report the early effects of defensin α-1 on invasi...

journal_title：Infection and immunity

authors： Johnson CA,Rachakonda G,Kleshchenko YY,Nde PN,Madison MN,Pratap S,Cardenas TC,Taylor C,Lima MF,Villalta F

更新日期：2013-11-01 00:00:00

abstract：:The purpose of the present study was to analyze Chlamydia pneumoniae-induced, antigen-specific, cell-mediated immunity. Peripheral blood mononuclear cells of four persons infected with C. pneumoniae Kajaani 6 and 17 healthy volunteers were stimulated with antigen composed of whole elementary bodies of C. pneumoniae Ka...

journal_title：Infection and immunity

authors： Surcel HM,Syrjälä H,Leinonen M,Saikku P,Herva E

更新日期：1993-05-01 00:00:00

abstract：:In this study, the role of the hepatobiliary system in the early pathogenesis of Salmonella enteritidis infection was investigated in a rat model. Intravenous (i.v.) challenge with lipopolysaccharide (LPS) has previously been shown to enhance the translocation of normal gut flora. We first confirmed that LPS can simil...

journal_title：Infection and immunity

authors： Islam AF,Moss ND,Dai Y,Smith MS,Collins AM,Jackson GD

更新日期：2000-01-01 00:00:00